• These posters to be presented at the AACR Meeting focus on the investigational nucleic acid platform, UNITE™ (UNiversal Intracellular Targeted Expression) for two vaccines, ITI-3000 for Merkel cell carcinoma (targeting the large T antigen of the Merkel cell polyomavirus) and Her2/Neu-LAMP DNA vaccine, both of which fuse a tumor associated antigen with lysosomal associated membrane protein 1 (LAMP-1). (biospace.com)
  • Merkel cell carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma. (springeropen.com)
  • Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
  • A month later, this mass was surgically excised and the histology examination showed a poorly differentiated small cell carcinoma, with histopathologic features of a Merkel cell carcinoma. (springeropen.com)
  • Background: Merkel cell carcinoma (MCC) is a rare but highly aggressive neuroendocrine carcinoma of the skin. (medipol.edu.tr)
  • The Merkel Cell Carcinoma market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. (usmarketnewslatest.com)
  • Furthermore, launching various multiple-stage Merkel Cell Carcinoma pipeline products will significantly revolutionize the Merkel Cell Carcinoma market dynamics. (usmarketnewslatest.com)
  • DelveInsight's "Merkel Cell Carcinoma Market Insights, Epidemiology, and Market Forecast-2032″ report offers an in-depth understanding of the Merkel Cell Carcinoma, historical and forecasted epidemiology as well as the Merkel Cell Carcinoma market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. (usmarketnewslatest.com)
  • The Merkel Cell Carcinoma market report covers emerging drugs, current treatment practices, market share of the individual therapies, and current & forecasted market size from 2019 to 2032. (usmarketnewslatest.com)
  • Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with neuroendocrine features. (usmarketnewslatest.com)
  • As per "Skin Cancer Foundation", Merkel cell carcinoma (MCC) is 40 times more rare than melanoma, with an estimated one case per 130,000 people in the US. (usmarketnewslatest.com)
  • Epidemiologic data suggest that there are approximately 2500 new Merkel cell carcinoma cases per year within the European Union (EU), and approximately 1000 of these patients will die from their disease. (usmarketnewslatest.com)
  • Merkel Cell Carcinoma market report covers a descriptive overview and comprehensive insight of the Merkel Cell Carcinoma Epidemiology and Merkel Cell Carcinoma market in the 7MM (the United States, EU5 (Germany, Spain, France, Italy, UK) & Japan. (usmarketnewslatest.com)
  • The Merkel Cell Carcinoma market report provides insights on the current and emerging therapies. (usmarketnewslatest.com)
  • Merkel Cell Carcinoma market report provides a global historical and forecasted market covering drug outreach in 7MM. (usmarketnewslatest.com)
  • The Merkel Cell Carcinoma market report offers an edge that will help develop business strategies by understanding trends shaping and driving the Merkel Cell Carcinoma market. (usmarketnewslatest.com)
  • The dynamics of the Merkel Cell Carcinoma market are anticipated to change in the coming years owing to the expected launch of emerging therapies and others during the forecasted period 2019-2032. (usmarketnewslatest.com)
  • One of the issues most often raised in the field of Merkel cell carcinoma is 'why is there no mouse model for this polymavirus-driven cancer? (merkelcell.org)
  • This team has gone to extraordinary measures to identify the key components and overcome technical barriers to generate a mouse Merkel cell carcinoma that is driven by key oncoproteins from the Merkel virus. (merkelcell.org)
  • Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). (merkelcell.org)
  • The authoritative source on Merkel cell carcinoma. (merkelcell.org)
  • Treatments that include platinum-based chemotherapy are used in patients with squamous cell carcinoma. (medscape.com)
  • Small-Cell Carcinoma Versus Atypical Carcinoid Tumor Yoon E, Zhang X, Cai G . Small-Cell Carcinoma Versus Atypical Carcinoid Tumor. (yale.edu)
  • My research is on the translational application of next-generation sequencing technologies to breast cancer care: (1) the value of hereditary cancer genetic panel testing in clinical practice, (2) the mechanisms by which inherited genetic variants lead to breast cancer development, and (3) the analysis of somatic tumor sequencing data to inform understanding of breast tumorigenesis, metastasis, and development of resistance in response to therapeutics. (stanford.edu)
  • 2004). FAK is necessary for mammary tumor development also, intestinal tumorigenesis, as well as the androgen-independent development of neuroendocrine carcinoma inside a mouse style of prostate tumor (Ashton et?al. (ufe-eg.org)
  • 2005), and FAK inhibitors Escitalopram oxalate are becoming created as potential tumor therapeutics (Roberts et?al. (ufe-eg.org)
  • Pembrolizumab alone and pembrolizumab plus chemotherapy in previously treated, extrapulmonary poorly differentiated neuroendocrine carcinomas. (ucsf.edu)
  • ROCKVILLE, Md.--( BUSINESS WIRE )-- Immunomic Therapeutics Inc., ("ITI"), a privately-held clinical-stage biotechnology company pioneering the study of LAMP-mediated nucleic acid-based immunotherapy, announced today that the data from two posters are being presented at the American Association for Cancer Research (AACR) Annual Meeting 2022 held in New Orleans, Louisiana, from April 8-13. (biospace.com)
  • Oxidative damage has been suggested to play a role in the pathogenesis of basal cell carcinoma (BCC). (hindawi.com)
  • Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer (NMSC) worldwide, in particular, in fair-skinned population and its incidence has been rising over the past several years [ 1 - 3 ]. (hindawi.com)
  • The definition can be expanded to include other entities such as ataxia telangiectasia , incontinentia pigmenti, nevoid basal cell carcinoma syndrome (Gorlin syndrome), among others. (medscape.com)
  • It is unclear if the morphologic pattern and appearance of neuroendocrine differentiation varies based on the type of anti-androgen regimen. (healthyprostateclub.com)
  • More importantly, given the rise and progress in molecular pathology particularly in fields such as pulmonary adenocarcinomas, it is of great current interest to know any molecular variations in post ADT neuroendocrine differentiation and pure NEPC. (healthyprostateclub.com)
  • The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with MCC. (springeropen.com)
  • Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma Sun T, Gilani S, Jain D, Cai G. Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma. (yale.edu)
  • Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma Chen X, Chen H, Lin R, Li Y, Guo Y, Chen Q, Zhang Y, Cai G , Hu M, Chen G. Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma. (yale.edu)
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma , endometrial adenocarcinoma , and urothelial carcinoma based on Acrivon's OncoSignature® test status. (ucsd.edu)
  • Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma Baine M, Cai G , Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. (yale.edu)
  • This presentation reports results of pre-clinical mouse studies of a cancer vaccine that promotes potent, antigen-specific CD4 T cell responses to MCPγV-LT. The majority of Merkel cell carcinomas (MCC), a rare and highly aggressive type of neuroendocrine skin cancer, are associated with Merkel cell polyomavirus (MCPyV) infection. (biospace.com)
  • GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression Wang M, Chen P, Cai G . GATA3 expression in primary lung carcinomas: correlation with histopathologic features and TTF-1, napsin A, and p40 expression. (yale.edu)
  • Journal of Cancer Research and Therapeutics, 17(6), 1525-1529. (medipol.edu.tr)
  • Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. (nature.com)
  • The most significant advances in cancer therapy in recent years have involved the development of systemic therapeutics. (intechopen.com)
  • As the program leader for Development Therapeutics and the PI of a peer-reviewed basic science lab, my main focus is on translating preclinical findings into early-stage clinical trials with extensive PK and integration of PD correlative studies and molecular imaging for patients with advanced stage cancer. (ucsf.edu)
  • Dr Jennifer Low, head of therapeutics development at 23andMe, said: "We're pleased that 23ME-00610 has reached this next phase of clinical development and look forward to evaluating this drug candidate in a number of cancers that are inadequately treated with existing therapies. (pharmaphorum.com)
  • In an interview with Targeted Oncology , Li, an assistant clinical professor, Department of Medical Oncology and Therapeutics Research, and a medical oncologist at City of Hope, shed light on some of the currently available regimens and ongoing research efforts being conducted in HCC and NETs. (targetedonc.com)
  • Signatures of prior exposures to DNA damaging agents - including chemotherapy - tend to associate with drug resistance, while signatures of deficiencies in DNA repair tend to predict sensitivity towards particular therapeutics. (nature.com)
  • Non-Colorectal Non-Neuroendocrine Liver Metastasis Learn more about the surgical options for these types of liver metastases and outcomes in these patients. (medscape.com)
  • Our data establish that expression of MCPyV TAgs, in ATOH1-reprogrammed epidermal cells and their neuroendocrine progeny, initiates hair follicle-derived MCC tumorigenesis in adult mice. (merkelcell.org)
  • Background: Our aims were to investigate the treatment and clinicopathological variables in relation to prognosis in small cell neuroendocrine cervical carcinoma (SCNECC). (ncku.edu.tw)
  • Clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas. (edu.ni)
  • These data suggest that Rb loss is a critical event in the development of small cell carcinomas and may be a useful diagnostic and potential therapeutic target. (healthyprostateclub.com)
  • Not for use in diagnostic/therapeutics procedures. (abeomics.com)
  • Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G , Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. (yale.edu)
  • Molecular Differences Between MCPyV-Negative MCCs and NECs Differentiating Merkel cell polyomavirus-negative Merkel cell carcinomas from neuroendocrine carcinomas is challenging. (medscape.com)
  • Here we discuss the molecular mechanisms through which alimentary cues modulate metabolic, microbial and neuroendocrine circuitries and thus affect the probability of developing premalignant lesions that progress to clinically manifested disease and the response to therapeutic intervention. (nature.com)
  • Foundational studies of fibrosis mechanisms and hepatic stellate cell biology performed in the Mount Sinai fibrosis research laboratory over the past 15 years have laid the groundwork for active efforts to develop novel fibrosis diagnostics and therapeutics that will benefit millions of patients worldwide. (mssm.edu)
  • Behavioral endocrinology is the study of hormonal processes and neuroendocrine systems that influence or regulate behavior. (conferenceseries.com)