Therapeutic vitro. Medical search. Frequent questions

In addition, when translating in vitro cytotoxicity data to predict in vivo active clinical dose for blinatumomab, the choice of model leads to a notable difference in dose prediction. (springer.com)
The dose predicted by the 2D model aligns better with the approved clinical dose and the prediction is robust under variations in the in vitro to in vivo translation assumptions. (springer.com)
In this review we recorded several representative in vitro and in vivo studies performed in culture cell lines, in animal or clinical trials, indicating that the regular intake of EVOO is associated with enhanced neuroprotective, antioxidant, anti-inflammatory, anti-atherosclerotic, anti-cancer and anti-microbial properties. (researchgate.net)
This study is aimed at investigating the effect of probiotic Lactobacillus rhamnosus on esophageal cancer in vivo and in vitro . (hindawi.com)
The extra chosen F6 definition was completed for in vitro discharge energy, and in vivo strength examinations. (pharmacophorejournal.com)
Therefore, although C1r and C1s are targets of C1-inh, our in vitro data with human serum and in vivo data in rats suggest that the complement inhibition activity of C1-inh in serum is too low to confer clinical benefit in NMO. (chaen-rcah.ca)
Elevated oxygen concentrations in vitro and in vivo reduce lipid peroxidation and hepatotoxicity. (cdc.gov)
With the recent advances in human-cell cultivation techniques, allowing in vivo -like in vitro long-term functionality, there is a shift in focus towards the mechanistic details of the adverse effects "over time" aimed at a better understanding of the dynamics of biological processes. (brill.com)
Furthermore, we demonstrated that viable tumor tissue from ovarian cancer patients can be used to screen tumor radiosensitivity ex-vivo, enabling the direct assessment of therapeutic efficacy. (osti.gov)
Receptor desensitization and therapeutic efficacy has been demonstrated in vitro and in vivo. (nationaljewish.org)
Some biologic features of the SARS-CoV described in vivo and in vitro differ from those of other coronaviruses previously identified. (cdc.gov)
Os estudos in vitro estão livres da complexidade e fatores de confusão próprios dos modelos in vivo e ensaios clínicos. (bvsalud.org)

Efficacy of KBU2046 is demonstrated across several different in vitro models and across multiple murine models of human cancer metastasis, which includes decreased metastasis, decreased bone destruction, and prolonged survival. (nature.com)
Efficacy of Interferon and therapeutic. (cdc.gov)
Imatinib has shown preclinical activity against HRPC although minimal clinical therapeutic efficacy. (ingentaconnect.com)
Analogous studies in a murine syngeneic tumor model using surrogate antibodies demonstrated significant synergy between LAG-3 and PD-1 blockade-combination treatment led to a marked improvement in therapeutic efficacy, increased T-cell proliferation, IFNγ production, and elicited durable immunologic memory upon tumor rechallenge. (aacrjournals.org)
Controlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. (amrita.edu)

To gain insight into SARS-CoV biopathology, we analyzed the relevant features of SARS-CoV HSR1 growth in vitro, including the ultrastructural analysis of the consequences of virus replication in Vero cells. (cdc.gov)

Compared to the 3D binding model where the reactants are described in terms of concentration, the 2D model predicts less sensitivity of trimer formation to varying cell densities, which better matches changes in EC 50 from in vitro cytotoxicity assay data with varying E:T ratios. (springer.com)

Development, Characterization and In Vitro Evaluation of Single o. (ingentaconnect.com)

In addition, our results suggest both Fe3O4-TiO2 NPs and TiO2 NPs could induce oxidative stress and have a potential carcinogenetic effect in vitro. (cdc.gov)
Here, we employ cellular reprogramming to induce astrocytic differentiation as a therapeutic approach in GBM. (lu.se)
These anti-CD79 mAbs show therapeutic potential to induce reversible inhibition of BCR signaling and B cell function. (nationaljewish.org)
The ability to induce apoptosis, or cell death, is a promising tactic for therapeutic interventions in all types of cancer, she said. (sciencedaily.com)

Warfarin has its disadvantages though, just like heparin, such as a narrow therapeutic index and multiple food and drug interactions and it requires routine anticoagulation monitoring and dose adjustment. (wikipedia.org)

During the life cycle of an in vitro diagnostic (IVD), changes to the product, its manufacturing process or location, or the quality management system (QMS) under which it is produced may become necessary for technical or economic reasons. (who.int)
Theranostics are emerging as a pillar of cancer therapy that enable the use of single molecule constructs for diagnostic and therapeutic application. (osti.gov)

All therapeutic categories have been recorded - innovator and generic medicines, vaccines and in vitro diagnostics. (who.int)

While the SARS-CoV-2 pandemic is heavily hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. (frontiersin.org)
However, MSCs need to be expanded in vitro in order to obtain sufficient cells for clinical trials since they are extremely rare in various tissues. (hindawi.com)
AMA President Susan R. Bailey welcomes three physician leaders from the Food and Drug Administration (FDA) to discuss the state of therapeutic clinical trials worldwide, the challenge of obtaining robust therapeutic data and what the future holds based on current research. (ama-assn.org)
It includes: (a) mechanisms of human disease, (b), therapeutic interventions, (c) clinical trials, or (d) development of new technologies. (nih.gov)

In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. (brill.com)

Processes that drive the development of increased cell motility represent high-value therapeutic targets. (nature.com)
We hypothesized that we could use them to identify novel and selective sites that regulate cancer cell motility and that such sites would constitute high-value therapeutic targets. (nature.com)
therapeutic targets? (lu.se)

Therapeutic hypothermia has been shown to have a neuroprotective effect. (uic.edu)
She also received the investigational drug miltefosine, 7-9 and her brain swelling was aggressively managed with treatments that included cooling the body below normal body temperature (therapeutic hypothermia). (cdc.gov)

Methods: In this study, the in vitro enzyme inhibition potential of A. lividus on α-amylase, α-glucosidase, acetylcholinesterase (AChE), elastase, lipase, neuraminidase and tyrosinase was investigated for the first time. (istanbul.edu.tr)
Therapeutic hydrogen has been applied by different delivery methods including straightforward inhalation, drinking hydrogen dissolved in water and injection with hydrogen-saturated saline. (researchgate.net)

The formation of this trimolecular complex (i.e. trimer) mimics the immune synapse, leading to therapeutic-dependent T-cell activation and killing of tumor cells. (springer.com)

The patient described here was prob- of ribavirin (200 µM) given after infec- glutamic-pyruvic transaminase 72), a ably infected in Chile and more likely in tion of human oligodendroglial cells in moderate thrombocytopenia (platelet the Puerto Monte area, where HPS cases vitro (5). (cdc.gov)
In vitro evaluation of the toxicity and underlying molecular mechanisms of Janus Fe3O4-TiO2 nanoparticle s in human liver cells. (cdc.gov)
To evaluate the toxicity and underlying molecular mechanisms of Janus Fe3O4-TiO2 nanoparticle s, an in vitro study using a human liver cell line HL-7702 cells was conducted. (cdc.gov)
Mesenchymal stem cells (MSCs) possess great therapeutic potential. (hindawi.com)
Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
The aim of this study is to investigate potential synergistic effects of Flavopiridol and Lonfarnib inhibiting the proliferation of human ovarian cancer cells in vitro. (uni-marburg.de)
The Company will also have a poster presentation comparing the performance characteristics of liver cells in an in vitro setting between non-diseased and non-alcoholic fatty liver disease ("NAFLD") donors. (globenewswire.com)
NEW YORK, September 21, 2003 - New research from Memorial Sloan Kettering Cancer Center (MSKCC), Cornell University, and The University of Connecticut describes a novel way of producing therapeutic nerve cells that can cure mice with Parkinson's-like disease. (mskcc.org)
In the in vitro study, de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. (sciencedaily.com)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

BLFX proved to have a broad antibacterial spectrum, and its in vitro activity against gram-positive cocci, especially MRSA, was more potent than that of the other four reference quinolones. (elsevierpure.com)

We go on to demonstrate the therapeutic potential of the resultant probe, KBU2046. (nature.com)
Also, comprehensive pharmacokinetic and toxicity studies further support therapeutic potential. (nature.com)
Our results show that encapsulation preserves the therapeutic potential of CD and E. coli CD is equally effective for enzyme-prodrug therapy. (johnshopkins.edu)
The therapeutic potential for TQ in management of COVID-19 should be further evaluated. (biorxiv.org)
In recent years, molecular hydrogen treatment has the potential to preventive and therapeutic applications against many diseases due to its extensive effects, such as antioxidant, anti-inflammatory, antiapoptotic [16, 17]. (researchgate.net)

Serum and histopathologic evaluation of the implanted therapeutic tissue showed engraftment, retention and functionality through at least 35 days post-implantation, while also demonstrating the sustained presence of key human liver proteins such as albumin in the animal bloodstream. (globenewswire.com)

In vitro assays of NMO-IgG-dependent CDC showed C1-inh inhibition of human and rat complement, but with predicted minimal complement inhibition activity at a dose of 2000 units in humans. (chaen-rcah.ca)
We have generated a high affinity and selective humanized monoclonal IgG4 antibody, TSR-033, which binds human LAG-3 and serves as a functional antagonist, enhancing in vitro T-cell activation both in mixed lymphocyte reactions and staphylococcal enterotoxin B-driven stimulation assays. (aacrjournals.org)
Hyperbaric oxygen (HBO) has been found to play a therapeutic role in human and animal CCl 4 poisoning [Larcan et al. (cdc.gov)
With further technological developments, these human in vitro cellular models shall be highly useful in the screening of compounds for personalized medicine, allowing optimum therapy with minimum or no adverse effects, and in the study of adverse outcomes in different strata of population. (brill.com)
This study supports evidence in literature pointing to a certain activity of these drugs and at the same time emphasizes the different sensibility of human ovarian cancer cell lines to targeted therapeutics in vitro. (uni-marburg.de)
In later experiments they developed a proprietary monoclonal antibody against human CD79 (Curly 14) that has the capacity to desensitize the BCR in vitro. (nationaljewish.org)
Excluded from this definition are in vitro studies that utilize human tissues that cannot be linked to a living individual. (nih.gov)

In this thesis, a compact solid-state eye cooler is proposed to address the significant need for a portable, field-deployable, robust means of achieving and maintaining therapeutic cooling of eye tissues following traumatic injury. (uic.edu)

Indomethacin is a potent inhibitor of prostaglandin synthesis in vitro. (nih.gov)

Taken together, the pharmacologic activity of TSR-033 demonstrates that it is a potent anti-LAG-3 therapeutic antibody and supports its clinical investigation in cancer patients. (aacrjournals.org)
This technology exploits the unique qualities of the BCR to reversibly suppress signaling for therapeutic use in autoimmunity, cancer and transplantation. (nationaljewish.org)

Against gram-negative bacilli, the in vitro activity of BLFX was the same or slightly lower than that of the other drugs. (elsevierpure.com)
A study evaluated the in vitro antifungal activity of apple cider vinegar on Candida spp. (medscape.com)

We identify a unique cell motility regulatory mechanism and synthesize a targeted therapeutic, providing a platform to pursue studies in humans. (nature.com)

However, there might be a delicate balance between oxidative processes that are therapeutic and those that mediate hepatotoxicity. (cdc.gov)

This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. (researchgate.net)

Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro . (aaem.pl)
The presented study investigates the effect of anti-epileptic drugs on the viability and proliferation of synovial fibroblasts in vitro . (aaem.pl)
Effect of glutamate receptor antagonists and antirheumatic drugs on proliferation of synoviocytes in vitro. (aaem.pl)
Parada-Turska J, Mitura A, Brzana W, Jablonski M, Majdan M, Rzeski W. Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro. (aaem.pl)
It is hard to preserve the important characteristics such as proliferation capacity and stemness of MSCs the inadequate cultivating microenvironment in vitro . (hindawi.com)

In this study, we tested HCQ against a SARS-CoV-2 Italian clinical isolate, by using different protocols of drug administration corresponding to its possible prophylactic, therapeutic, and prophylactic/therapeutic use in patients. (frontiersin.org)
This in vitro study was published in Molecular Nutrition & Food Research , vol. 55, pp. 1509-1522, in 2011. (sciencedaily.com)

Our previous In Vitro studies demonstrated that simultaneous combination of imatinib with mitoxantrone yielded additive growth inhibition effects against PC-3 cell line. (ingentaconnect.com)

Hyperbaric oxygen treatment has been used as a therapeutic intervention for acute CCl 4 poisoning. (cdc.gov)

By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)

LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. (scielo.br)

These assemblies are being used to build in vitro models of multidrug resistance for high-throughput screening and drug discovery. (aiche.org)

In order to support its plan to initiate multiple IND-track programs, the Company is providing access to its ExVive™ in vitro tissue disease modeling platform to facilitate high value drug discovery and development collaborations. (globenewswire.com)

Its main focus is the manufacture and / or marketing of specialty/products for diseases of low incidence/prevalence in the therapeutic areas of CNS, Rheumatology, Nephrology, Urology, Gynecology and Oncology-Radiotherapy. (asebio.com)

This suggests that only a combined prophylactic and therapeutic use of hydroxychloroquine may be effective in limiting viral replication in patients. (frontiersin.org)
thus representing a possible therapeutic alternative for patients with denture stomatitis. (medscape.com)

Hereby, we summarized recent research findings of MSCs-derived conditioned medium in in vitro development of immature oocytes . (bvsalud.org)

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Information Science1

Vivo12

Efficacy5

Growth In Vitro1

Cytotoxicity1

Characterization1

Induce4

Narrow therapeutic index1

Diagnostic2

Diagnostics1

Clinical trials4

Toxicology1

Targets3

Hypothermia2

Methods2

Tumor1

Cells10

Quinolones1

Potential5

Evaluation1

Human7

Robust1

Inhibitor1

Cancer2

Activity2

Humans1

Oxidative1

Hydrogen1

Proliferation5

Study2

Studies1

Acute1

Inhibits1

Model1

Models1

Facilitate1

Diseases1

Patients2

Development1