Molecular Targeted TherapyCell Line, TumorSignal TransductionCell ProliferationGene Expression Regulation, NeoplasticRNA, Small InterferingApoptosisDisease Models, AnimalGene Expression ProfilingMice, Inbred C57BLRNA InterferenceGene Knockdown TechniquesMice, KnockoutBlotting, WesternDrug Delivery SystemsAntineoplastic AgentsReverse Transcriptase Polymerase Chain ReactionImmunohistochemistryNeoplasmsTumor Markers, BiologicalUp-RegulationMice, NudeRNA, MessengerCell MovementXenograft Model Antitumor AssaysCells, CulturedMicroRNAsProtein Kinase InhibitorsOligonucleotide Array Sequence AnalysisNeoplasm InvasivenessMice, TransgenicInflammationCell SurvivalEnzyme InhibitorsDrug DesignDisease ProgressionPhosphorylationModels, BiologicalGene Expression RegulationDown-RegulationMice, SCIDBreast NeoplasmsDrug Resistance, NeoplasmMutationGene SilencingGene ExpressionCell Growth ProcessesCell Transformation, NeoplasticProto-Oncogene Proteins c-aktNeoplasm MetastasisTissue Array AnalysisNeoplasm ProteinsReal-Time Polymerase Chain ReactionPrognosisNeoplastic Stem CellsCell LineNeovascularization, PathologicDrug DiscoveryTransfectionPyrimidinesNF-kappa BProtein BindingTOR Serine-Threonine KinasesHEK293 CellsProstatic NeoplasmsDrug Evaluation, PreclinicalSmall Molecule LibrariesPiperazinesTumor Cells, CulturedEnzyme ActivationProtein-Serine-Threonine KinasesCytokinesTransplantation, HeterologousLung NeoplasmsFlow CytometryMice, Inbred BALB CReceptors, G-Protein-CoupledPhosphatidylinositol 3-KinasesCell CycleGlioblastomaIntercellular Signaling Peptides and ProteinsTranscription FactorsMembrane ProteinsPancreatic NeoplasmsEndothelial CellsNeurodegenerative DiseasesBenzamidesBrain NeoplasmsFibrosisAntibodies, MonoclonalCell DeathProto-Oncogene ProteinsNeoplasm TransplantationPhenotypeLigandsRats, Sprague-DawleySTAT3 Transcription FactorOxidative StressTime FactorsAlzheimer Disease