• One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • In addition, morroniside could protect ischemia/reperfusion-induced brain injury by decreased the caspase-3 activity, reduced the infarction volume and minimized oxidative stress [ 7 ]. (ijpsonline.com)
  • Intravenous adipose mesenchymal stem cells (ADSCs) attenuate renal ischemia/reperfusion (IR) injury but with major drawbacks, including the lack of a specific homing effect after systemic infusion, cell trapping in the lung, and early cell death in the damaged microenvironment. (ntnu.edu.tw)
  • We examined whether intrarenal arterial transplantation of dexmedetomidine (DEX) preconditioning ADSC-derived microvesicles (DEX-MVs) could promote further therapeutic potential to reduce renal IR injury. (ntnu.edu.tw)
  • Consistently, DEX-MVs were better than MV in increasing CD44 expression, improving IR-depressed renal hemodynamics and renal erythropoietin expression, inhibiting IR-enhanced renal ROS level, tubular injury score, miR-122-5p expression, pNF-κB expression, Bax/caspase 3/poly(ADP-ribose) polymerase (PARP)-mediated apoptosis, blood urea nitrogen, and creatinine levels. (ntnu.edu.tw)
  • In summary, intrarenal arterial DEX-MV conferred further therapeutic potential to reduce renal IR injury through the miR-122-5p/erythropoietin/apoptosis axis. (ntnu.edu.tw)
  • Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
  • Partial kidney ischemia-reperfusion (IR) injury is the principal cause of acute kidney injury. (hindawi.com)
  • The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. (hindawi.com)
  • Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)
  • Furthermore, APC reduces the ischemia / reperfusion-induced renal injury and the stress-induced gastric mucosal injury in rats. (eurekaselect.com)
  • Furthermore, APC reduced the spinal cord injury induced by compression-trauma or ischemia / reperfusion by inhibiting TNF-α production in rats, suggesting that APC may be a potential therapeutic agent for spinal cord injury in which only limited therapeutic measures are currently available. (eurekaselect.com)
  • The objective of present study was to assess the effects of MK-886 and DITPA on renal I/R injury. (biomedcentral.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
  • Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
  • has been demonstrated to attenuate renal ischemia‑reperfusion (I/R) injury. (spandidos-publications.com)
  • However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
  • SA also attenuated renal I/R injury ( 11 ). (spandidos-publications.com)
  • We aimed to determine the ameliorative impact of diacerein on renal ischemia/reperfusion injury (I/R) condition, exploring the underlying mechanisms. (bvsalud.org)
  • Here we discuss evidence for the role of lectin pathway activation in endothelial injury-associated complications of HSCT and how targeting complement activity may provide therapeutic benefit for patients with HSCT-TMA. (biomedcentral.com)
  • We measured the expression of elements associated with kidney injury, inflammation, macrophage polarization, mesenchymal transition, and nephrogenic genes by qRT-PCR in the renal cortex and medulla. (uandes.cl)
  • Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. (unicatt.it)
  • In conclusion, these data indicate that PTX3 might be a potential therapeutic target to prevent Complement-induced I/R injury. (unicatt.it)
  • Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
  • In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
  • The extrinsic pathway are directly induced upon renal ischemic injury, while intrinsic pathways are dependent on mitochondrial signaling pathways. (wikipedia.org)
  • In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
  • Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
  • The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
  • Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
  • Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization, however therapeutic methods for CIN have made little progress. (asn-online.org)
  • One week later, the left renal artery was clamped for 30 min to cause ischemia-reperfusion injury, and mice were injected with iohexol using a retro-orbital injection method. (asn-online.org)
  • We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. (jci.org)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
  • Moreover, preliminary data identified a novel inhibitory effect of PKG on tubular cell necrosis and apoptosis following renal ischemia reperfusion (IR) induced acute kidney injury in young mice and an inhibitory effect of PKG on macrophage migration, suggesting a therapeutic potential of PKG for renal IR injury. (uky.edu)
  • We will determine whether genetically or pharmacologically increased PKG activity reduces the susceptibility of old animals to ischemia mediated acute kidney injury in Aim 1. (uky.edu)
  • Hopefully, these proposed studies will lead to new therapeutic strategy for acute kidney injury in aging population. (uky.edu)
  • Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)
  • Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. (eurekaselect.com)
  • Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. (eurekaselect.com)
  • For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively. (jci.org)
  • Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury. (rug.nl)
  • Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
  • N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
  • This paradox, known as the pH paradox, is the driving mechanism behind reperfusion injury following cardiac, renal or cerebral ischemia . (tocris.com)
  • Ischemia reperfusion injury (IRI) is pivotal for renal fibrosis development via peritubular capillaries injury. (micrornasynthesis.com)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
  • We evaluated the effect of DEX-MVs on NRK-52E cells migration, hypoxia/reoxygenation (H/R)-induced cell death, and reactive oxygen species (ROS) amount and renal IR model in rats. (ntnu.edu.tw)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • 8. Dehghani A, Saberi S, Nematbakhsh M. Role of Mas receptor antagonist A799 in renal blood flow response to Ang 1-7 after bradykinin administration in ovariectomized estradiol-treated rats. (phypha.ir)
  • In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1+ CD4 T cells and IL-17 expression was restricted to Orai1+ cells. (jci.org)
  • Rats treated with high-salt diet (5-9 weeks after I/R) manifested progressive disease indicated by enhanced inflammation, fibrosis, and impaired renal function. (jci.org)
  • 14. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract ( Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. (ac.ir)
  • This study suggested that WSJPR could effectively relieve renal damage and improve renal function of DN rats by ameliorating metabolism disorder and increasing the gene expression of nephrin and podocin, which might be a useful approach for the treatment of DN. (biomedcentral.com)
  • In our earlier investigation, the therapeutic effects of four kinds of TCM on streptozotocin (STZ) induced DN rats were observed and WSJPR has shown significant effect on decreasing proteinuria. (biomedcentral.com)
  • In previous work, we reported that the pharmacological inhibitions of iNOS before ischemia/reperfusion (I/R) attenuate the I/R-induced AKI in mice. (uandes.cl)
  • Various pharmacologic studies have indicated that morroniside has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption [ 1 - 4 ]. (ijpsonline.com)
  • This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)
  • however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)
  • Wijeysundera et al sought to determine whether N-acetylcysteine is associated with increased blood loss and blood product transfusion in 89 patients with preexisting moderate renal insufficiency undergoing cardiac surgery. (medscape.com)
  • In support of the integral involvement of NHE activity during organ ischemia, NHE1 inhibition has been shown to exert a protective effect during cardiac ischemia . (tocris.com)
  • The trial had to exhibit at least one of the following results: major adverse cardiovascular events (MACE), cardiovascular death or hospitalization for heart failure, cardiovascular death, hospitalization for heart failure, renal or cardiovascular adverse events, or non-cardiovascular death. (bvsalud.org)
  • In addition to ischaemic tissue damage, seen for example in renal failure, stroke or cardiovascular diseases, the mechanism may also play a central role in neurodegenerative diseases and in comorbidities of diabetes mellitus. (sciencedaily.com)
  • These components especially crocin, have significant effects including antidepressant and anticonvulsant, analgesic, anti-cancer and other therapeutic effects on different parts of our body namely cardiovascular, immune, respiratory, genital-urinary and central nervous system. (ac.ir)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
  • The flow cytometry analysis demonstrated an elevated expression of innate and mature dendritic cells in I/R renal tissues. (bvsalud.org)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg −1 .min −1 ) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. (hindawi.com)
  • No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. (hindawi.com)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • Interestingly, PTX3 deposits co-localized with activation of the terminal Complement complex (C5b-9) on endothelial cells, indicating that PTX3-mediated Complement activation occurred mainly at the renal vascular level. (unicatt.it)
  • In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. (eurekaselect.com)
  • These therapeutic effects could not be attributed to its anticoagulant effects, but to inhibition of TNF-α production. (eurekaselect.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • We are studying the effects of apelin on systemic and renal haemodynamics and endothelial function in healthy volunteers and in patients with CKD. (ed.ac.uk)
  • This review will provide insights into the roles of exRNA in pathogenesis, diagnosis and therapy of renal diseases. (biomedcentral.com)
  • citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
  • Taken together, the current findings indicate that BACH1 is critical for immunomodulation of macrophages and may serve as a target for therapeutic approaches in inflammatory disorders. (stanford.edu)
  • Ischemia/ reperfusion was found to affect renal function and induce histopathological alterations. (bvsalud.org)
  • Grupo I/R + diacereína, inyectado por vía intraperitoneal con 50 mg de diacereína/kg i.m. 30 min antes de la operación I/R. Se encontró que la isquemia/ reperfusión afecta la función renal e induce alteraciones histopatológicas. (bvsalud.org)
  • Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells. (unicyte.ch)
  • Although pharmacological therapy, modern dialysis techniques, and intermittent or continuous renal replacement therapies exist, the therapeutic approaches for AKI remain very limited. (biomedcentral.com)
  • Over the past three decades, clinical and pharmacological studies have accumulated a body of evidence that not only demonstrated these therapeutic effects, but also provided significant insights into the pharmacokinetic behavior, therapeutic profile, and mode of action of scutellarin in humans and animal models. (cdc.gov)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. (jci.org)
  • Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. (eurekaselect.com)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)
  • As a consequence, ferroptosis inhibitors open up novel therapeutic opportunities to mitigate diseases previously thought to be untreatable. (sciencedaily.com)
  • Novel therapeutic targets for the treatment of tubulointerstitial fibrosis. (rug.nl)
  • A better understanding of these critical periods of brain development is a concern for public health and may provide new insights into prevention strategies and into novel therapeutic approaches in neuropsychiatry. (micrornasynthesis.com)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
  • More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
  • Diseases such as sepsis can cause kidney ischemia too. (wikipedia.org)
  • In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. (nature.com)
  • Activating or blocking the ferroptosis pathway to alleviate the progression of the disease, which provides a promising therapeutic strategy for many diseases. (nature.com)
  • Thanks to the evolving techniques, exRNAs, particularly those detected from urine have gained great interest in renal diseases. (biomedcentral.com)
  • However, most current studies on exRNA in renal diseases were derived from limited numbers of patients or in vitro data. (biomedcentral.com)
  • In this review, we will overview of the characterization of exRNA, summarize the current cognition about the role of exRNAs in renal diseases and compare the isolation and detection techniques. (biomedcentral.com)
  • In addition to their integral involvement in the control of intracellular pH and volume, the NHE family has also been implicated in diseases including hypertension and organ ischemia. (tocris.com)
  • Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. (rug.nl)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • In this review, we deliver an overview of the pre-conditioning methods that are considered a strategy for improving the therapeutic efficacy of MSCs in organ failures, in particular, renal, heart, lung, and liver. (biomedcentral.com)
  • Solid-organ transplantations have become the therapeutic option of choice for end-stage organ failure. (medscape.com)
  • The involvement of NHE activity during organ ischemia is complex: H + efflux driven by the NHE corrects the drop in intracellular pH, yet the concurrent influx of Na + ions leads to Ca 2+ overload through the actions of the NCX. (tocris.com)
  • Diabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD) in many developed countries [ 1 ]. (biomedcentral.com)
  • What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)
  • In this study, we investigated the therapeutic effects of human adipose-derived MSCs cultured in serum-free medium (SF-MSCs) on a mouse model of CIN. (asn-online.org)
  • In this study we analysed the participation of renal CSC-derived EVs in the interaction between tumor and MSCs. (unicyte.ch)
  • In vivo, EV-stimulated MSCs supported tumor development and vascularization, when co-injected with renal tumor cells. (unicyte.ch)
  • Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumor cells. (sciencedaily.com)
  • We hope to understand the biobehavioral mechanisms by which these substances produce their therapeutic effects in clinical populations. (uams.edu)
  • The outcome of the above mentioned mechanisms shows potential therapeutic properties of saffron against liver cancer, hepatotoxicity, fatty liver, hyperlipidemia, stomach cancer, peptic ulcer, colon cancer, ulcerative colitis, diabetes and pancreas cancer and ileum contractions. (ac.ir)
  • However, the therapeutic mechanisms of this herbal combination are not clear. (biomedcentral.com)
  • In the current investigation, the STZ induced DN rat model was used to evaluate the effects of WSJPR on renal function and renal pathological changes and the potential causal mechanisms. (biomedcentral.com)
  • Unlike the other NHE isoforms, NHE3 is recycled between apical membranes and the endosomal compartment of epithelial cells where it has a significant involvement in renal and intestinal Na + absorption. (tocris.com)
  • These data suggest that Orai1 SOCE is a potential therapeutic target in AKI and CKD progression. (jci.org)
  • Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets. (tocris.com)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Nevertheless, there are limited protective and therapeutic approaches for this problem. (bvsalud.org)
  • In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. (cdc.gov)
  • The biological effects of Ang1-7 are mainly mediated by specific receptor of MasR, and it is known clearly that Ang 1-7 and Ang II perform different actions in the renal vasculature [ 14 ]. (hindawi.com)
  • RESULTS: Remarkably, we found that 1400W affects the renal cortex and medulla in different ways. (uandes.cl)
  • Thus, in the renal cortex, 1400W prevented the I/R-upregulation of 1. (uandes.cl)
  • Microcirculatory blood flow in the renal cortex and hemorheology index were also measured. (biomedcentral.com)
  • To investigate the therapeutic efficacy, pharmacokinetics, and toxicity profile of novel drug treatments using the Experimental Autoimmune Encephalomyelitis (EAE) mouse model, Cuprizone mouse model, and in-vitro models. (edu.au)
  • Considering the available findings, the present study aims to introduce saffron as a prophylactic and therapeutic agent against gastrointestinal tract disorders. (ac.ir)
  • Preliminary studies demonstrated that nitric oxide (NO) and its downstream signaling pathway cGMP and cGMP-dependent protein kinase (PKG) was down-regulated in aging kidney, which was associated with aging-related renal functional changes. (uky.edu)