Therapeutic potent inhibitory activity. Medical search. Frequent questions

Neuraminidase inhibitors inhibit enzymatic activity of the enzyme neuraminidase (sialidase). (wikipedia.org)
Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. (nih.gov)
These compounds are among the most potent sEH inhibitors derived from natural sources. (nih.gov)
Although existing sEH inhibitors are potent and specific, low solubility and relatively fast metabolism decrease their therapeutic efficiency, stating the requirement for novel sEH inhibitors. (nih.gov)
In sum, our study unveils the pivotal biological role of PRMT6-mediated STAT3 R729me2a in breast cancer metastasis and underscores the prospective utility of PRMT6 inhibitors as effective therapeutic strategies against STAT3-driven metastatic breast cancer. (bvsalud.org)
This study identified novel thiazole-containing inhibitors of the deacetylase sirtuin-2 (SIRT2) with neuroprotective activity in ex vivo brain slice and Drosophila models of HD. (johnshopkins.edu)
LY2811376 (the positive control), one of the most potent clinical BACE1 inhibitors, has shown an IC50 value of 260 nM. (nih.gov)
Potent serotonin (5-HT) reuptake inhibitors are the only drugs that consistently exert a therapeutic action in obsessive-compulsive disorder (OCD). (erowid.org)
While expressing weak cytotoxicity on its own, ZW-1288 potentiates the clinical TOP2 inhibitors etoposide (ETP) and mitoxantrone in human prostate DU145 and CCRF-CEM leukemia and chicken lymphoma DT40 cells while not impacting the activity of the topoisomerase I (TOP1) inhibitor camptothecin or the PARP inhibitor olaparib. (omicsdi.org)
Discovery of potent pyruvate dehydrogenase kinase inhibitors and evaluation of their anti-lung cancer activity under hypoxia. (qxmd.com)
We here report on a comparative study of the antipoliovirus activity of a selection of molecules that have previously been reported to be inhibitors of picornavirus replication and discuss their potential use, alone or in combination, for the treatment or prophylaxis of poliovirus infection. (cdc.gov)
A substantial number of small molecule compounds have been reported as potent inhibitors of the replication of picornaviruses in vitro ( 8 ). (cdc.gov)
These compounds could serve as scaffolds for the development of more potent and selective inhibitors of PV. (cdc.gov)
Selective neuronal nitric oxide synthase (nNOS) inhibitors have therapeutic applications in the treatment of numerous neurodegenerative diseases. (embl-heidelberg.de)
Given the well-studied properties of FDA-approved drugs, identification of SARS-CoV-2 3CLpro inhibitors in an FDA-approved drug library would be of great therapeutic value. (nycu.edu.tw)
Here, we screened a library consisting of 774 FDA-approved drugs for potent SARS-CoV-2 3CLpro inhibitors, using an intramolecularly quenched fluorescence (IQF) peptide substrate. (nycu.edu.tw)
Metabolism studies in vivo together with an inflammatory pain evaluation suggest that A34 may be a viable lead compound for the development of highly potent sEH inhibitors. (inra.fr)

The potent compounds were evaluated in a panel of in vitro ADME assays and in vivo pharmacokinetic studies. (nih.gov)
In terms of therapeutic intervention, we demonstrated the significant capability of the PRMT6 inhibitor, EPZ020411, to curtail breast cancer metastasis both in vivo and in vitro. (bvsalud.org)
Nine derivatives (9a-e, 10b,c, and 15a,b) exhibited apparent XO inhibitory activity in vitro (IC50 values varied from. (researchgate.net)
We have investigated its inhibitory effects in vitro on sebum production in hamster sebocytes and in Propionibacterium acnes lipase activity. (carbon60facts.com)
Disruption of the MFF-VDAC1 complex in vitro resulted in killing of cancer cells, pointing us in the direction of a potential therapeutic target," said Altieri, who is the senior author on the study. (medicalxpress.com)
In the current study, we isolated secondary metabolites from acetone leaf and bud extracts of Artemisia pallens Wall ex DC (Family: Asteraceae) and tested them for their porcine pancreatic α-amylase (PPA) inhibitory activity in vitro and in silico. (mdpi.com)
Therapeutic concentrations were incorporated re-taining the potent in vitro growth inhibitory effect of the selected chalcone. (sciforum.net)
Nb15-NbH-Nb15, with a novel heterotrimeric bispecific configuration, exhibited potent and broad neutralization potency against SARS-CoV-2 in vitro and provided in vivo protection against SARS-CoV-2 infection in hACE2 transgenic mice via intranasal delivery. (news-medical.net)
However, rifabutin is preferred over rifampin for disseminated MAC infections because of its superior activity in vitro and reduced drug interaction potential. (msdmanuals.com)

It acts as a potent co-inhibitor of several activated coagulation factors, especially Factors Xa and IIa (thrombin). (nih.gov)
The primary inhibitory activity is mediated through the plasma protease inhibitor, antithrombin. (nih.gov)
Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
Previously, we found nordihydroguaiaretic acid (NDGA) as a potent GLO1 inhibitor. (elsevierpure.com)
Conclusion: NDGA was found to be a novel and potent inhibitor of GLO1. (elsevierpure.com)
In addition, elimination of the PI3K/AKT axis via the use of a pharmacological inhibitor inhibited the OGD/R‑inhibitory effects induced by the overexpression of RP105. (spandidos-publications.com)
Theophylline can actually be three to five times more potent than caffeine as an inhibitor of both adenosine A1 and A2A receptors. (brainblogger.com)
Emixustat, a retinoid-mimetic RPE65 inhibitor, was developed as a therapeutic visual cycle modulator and used for the treatment of retinopathies. (cornell.edu)
Intensive structural modifications led to the identification of compound B15 as a potent sEH inhibitor with an IC(50) value of 0.03 +/- 0.01 nM. (inra.fr)
Intensive structural modifications led to the identification of compound A34 as a potent sEH inhibitor with good physicochemical properties. (inra.fr)

LSD attenuated the firing activity of OFC neurons, and enhanced the inhibitory effect of 5-HT when concomitantly ejected on the same neurons. (erowid.org)

Our research features rational design and synthesis of a series of novel compounds having potent soluble epoxide hydrolase inhibitory activity with enhanced solubility. (nih.gov)

Moreover, inhibition of sEH by these compounds may mechanistically explain some of the therapeutic effects of P. brazzeana. (nih.gov)
We experimentally found these compounds synergistically inhibit sEH & iNOS (inducible Nitric Oxide Synthase), accounting for higher therapeutic efficacy. (nih.gov)
These drug-like thiazole-containing compounds represent an exciting opportunity for development of multi-targeted agents with potentially synergistic therapeutic benefits in HD and related disorders. (johnshopkins.edu)
Glyoxalase I (GLO1) is a key enzyme for eliminating MGO in mammalian cells, therefore, compounds affecting GLO1 activity are potential therapeutic agents for MGO-induced disorders. (elsevierpure.com)
Since RSK has recently been identified as a TNBC-specific target, we focused on screening for compounds that have the ability to block RSK activity. (allfiberarts.com)
Therefore, this review is aimed at discussing natural compounds with both antioxidant and antiviral activities, specifically against coronavirus infection, in an attempt to contribute to global researches for discovering effective therapeutic agents in the treatment of coronavirus infection and its severe clinical complications. (hindawi.com)
These compounds were synthesized and evaluated for their TNF-alpha inhibitory activity. (nih.gov)
This invention was extended from the inventors' prior work to develop potent compounds to reduce neuroinflammation as a treatment strategy for neurodegenerative disorders. (nih.gov)
The current studies focus the compounds activity in classical models of neurodegeneration as well as cancer. (nih.gov)
Antipicornavirus compounds that reached clinical trials are scarce, and despite the fact that some of these drugs have demonstrated activity against certain picornavirus-associated conditions in humans, no specific antipicornavirus agent has yet been approved by the US Food and Drug Administration (FDA) ( 8 ). (cdc.gov)
Another possible activity of these compounds is the reduction of nervous impairment. (thctotalhealthcare.com)
These biologically active compounds have positive impact on the progression of human pathology including non-communicable diseases, which indicating that administration of diet may have potential as therapeutic agents in modulating the risk of chronic diseases. (intechopen.com)
Therefore, this knowledge may be applied of natural bioactive compounds in preventive or therapeutic approaches. (intechopen.com)

The growth inhibitory activity was quantified by MIC determination. (phcogcommn.org)
The lack of toxicity of the S. formosa leaf extracts and their growth inhibitory bioactivity against a panel of pathogenic bacteria indicate their potential in the development of antiseptic agents. (phcogcommn.org)

The most potent compound, MMU, showed an IC50 of 92 nM via fluorescent assay and a Ki of 54 nM via radioactivity-based assay on human sEH. (nih.gov)
Chrysoeriol (CHE) is a natural flavone with potent XO inhibitory activity (IC50 = 2.487 ± 0.213 μM), however, the mechanism of interaction is still unclear. (researchgate.net)
In cell-based tests, asperterpenes A and B, as natural products, exhibited promising inhibitory activities against BACE1, with IC50 values of 78 and 59 nM, respectively. (nih.gov)

Thus, in this work, chalcone derivatives were tested regarding their inhibitory activity and specificity toward GBM cell lines. (sciforum.net)
We sought to address these issues by more broadly defining the structure-activity relationships of the RPE65 recognition motif via the synthesis of a family of novel derivatives, which were tested and for RPE65 inhibition. (cornell.edu)

We are currently facing a strong limitation on pharmacological interventions for infection control, which has become increasingly complex due to the lack of effective therapeutic options. (frontiersin.org)

Then it was found that the synthetic compound 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en or DANA) which is an analogue of N-acetylneuraminic acid (Neu5Ac), inhibits the release of virus progeny in tissue culture but no antiviral activity in animals was detected. (wikipedia.org)
A systems biology approach revealed an additional SIRT2-independent property of the lead-compound, MIND4, as an inducer of cytoprotective NRF2 (nuclear factor-erythroid 2 p45-derived factor 2) activity. (johnshopkins.edu)
In vivo, compound 1 exhibited activity similar to that of LY2811376 against Alzheimer's disease (AD) in 3xTg AD mice. (nih.gov)
Based on these proof-of-concept studies, researchers then generated a cell-permeable peptidomimetic molecule, or a compound that mimics the inhibitory peptide, to target the complex in vivo for targeted cancer therapy . (medicalxpress.com)
In carrageenan-induced inflammatory pain rat model, compound B15 exhibited a better therapeutic effect compared to t-AUCB and Celecoxib, which demonstrated the proof of potential as anti-inflammatory agents for pain relief. (inra.fr)
Compound A34 exhibited outstanding inhibitory activity against human sEH, with an IC(50) value of 0.04 +/- 0.01 nM and a K(i) value of 0.2 +/- 0.1 nM. (inra.fr)
In carrageenan-induced inflammatory pain rat model, compound A34 exhibited a better therapeutic effect compared to t-AUCB and Celecoxib. (inra.fr)

Potency is determined by means of a biological assay and interpreted by the first International Low Molecular Weight Heparin Standard as units of anti-factor Xa (anti-Xa) activity per milligram. (nih.gov)
The research also explanains why CsA so often induces undesired hair growth in patients as it removes an inbuilt and potent molecular brake on human hair growth. (manchester.ac.uk)
Because of the low yield of 1, a comprehensive characterization of the BACE1 inhibitory activities of 1 was completed via molecular biological, cell and animal studies guided by in silico target confirmation (ISTC). (nih.gov)
The molecular mechanism underlying the antioxidant activity of Triphala against H 2 O 2 was investigated dose dependently by Western blotting. (hindawi.com)
Keratosis Pilaris and its Subtypes: Associations, New Molecular and Pharmacologic Etiologies, and Therapeutic Options. (medscape.com)

Structure-activity relationship studies further identified a potent NRF2 activator (MIND4-17) lacking SIRT2 inhibitory activity. (johnshopkins.edu)
Inflammatory processes associated with the over-production of tumor necrosis-alpha (TNF-alpha), a potent activator of the immune system accompany numerous neurodegenerative diseases. (nih.gov)
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. (bvsalud.org)

however, a Phase I trial has demonstrated evidence of inhibition of CD200-dependent immunosuppression and some antitumor activity. (medscape.com)
3. Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of pim -1 kinase activity. (nih.gov)
Results: NDGA showed significant inhibition of GLO1 enzymatic activity in a dose-dependent manner. (elsevierpure.com)
Substantial evidence has indicated that the activity of the PI3K/AKT pathway exerts neuroprotective effects against I/R injury, which is reinforced by the inhibition of PI3K/AKT driving the progression of I/R ( 13 ). (spandidos-publications.com)
These activities include prevention or restoration of the integrity and permeability of EC, counteraction versus chemical, toxic or metabolic EC injury, regulation of EC-blood cell interactions, inhibition of microvascular inflammatory and proliferative changes, and other similar effects, thus allowing oral SDX to be considered as an endothelial-protecting agent. (dovepress.com)
Results clearly demonstrated a robust antitumor activity of MK-4101, achieved through the inhibition of proliferation and induction of extensive apoptosis in tumor cells. (uniroma1.it)
The antibacterial activity of the methanolic and aqueous S. formosa leaf extracts was further investigated by growth time course assays which showed significant growth inhibition in cultures of all bacterial species within 1 h of exposure. (phcogcommn.org)

Celastrol has been demonstrated to exert potent inhibitory action on tumorigenesis. (spandidos-publications.com)
These mediators exert their biologic activities on three target organs: the kidneys, intestines, and bone matrix. (dvm360.com)

We report here the discovery and characterization of IK-175, a novel, potent and selective AHR antagonist with favorable ADME and pharmacokinetic profiles in preclinical species. (aacrjournals.org)
A novel anticancer molecule created by researchers at The Wistar Institute showed therapeutic activity in preclinical models of various cancer types. (medicalxpress.com)
The next step was to create a molecule that could disrupt the protein-protein interaction between MFF and VDAC1 and deliver preclinical anticancer activity without harming normal cells, and we are excited for the clinical potential of this new agent. (medicalxpress.com)
Altogether, the results of this preclinical study support a therapeutic opportunity for MK-4101 in the treatment of Hh-driven cancers, also providing useful information for combination therapy with drugs targeting pathways cooperating with Hh oncogenic activity. (uniroma1.it)

The inhibitory mechanism is completely unrelated to CsA's immunosuppressive activities, making SFRP1 a new and highly promising therapeutic target for anti-hair loss strategies. (manchester.ac.uk)

The inhibitory activity of these repurposing drugs against SARS-CoV-2 3CLpro highlights their therapeutic potential for treating COVID-19 and other Betacoronavirus infections. (nycu.edu.tw)
Nanobodies are a potential therapeutic strategy for treating COVID-19. (news-medical.net)

Current antibiotic susceptibility testing guiding patient management is performed in a standardized manner, identifying minimum inhibitory concentrations (MIC) in bacteriologic media, but ignoring host immune factors. (nih.gov)
ZW-1288 exhibits potent inhibitory activity at low nanomolar concentrations against recombinant and cellular human TDP2 with profile similar to that of the parent analog SV-5-153 based on high resistance against murine TDP2 and human TDP2 mutated at residue L313H. (omicsdi.org)

They discovered that N-substituted oxamic acids had enzyme inhibitory properties. (wikipedia.org)
The relative expression of 5-LOX gene was monitored in MNCs after treatment with these three molecules and all down-regulated the enzyme activity. (simulations-plus.com)
Our study shows, that certain phase I genes and their enzyme activities are increased by epigenetic modification in HepG2 cells with a concomitant reduction of EMT marker gene SNAIL. (cancerindex.org)
We evaluated behavioral biomarkers of the novel tank test (NTT) and social preference test (SPT), and biochemical markers: the activity of the enzyme acetylcholinesterase (AChE) and the antioxidant enzymes-catalase, superoxide dismutase, and glutathione-S-transferase. (thctotalhealthcare.com)

In this work we characterize two representative analogues from two new deazaflavin subtypes based on their biochemical TDP2 inhibitory potency and drug-likeness. (omicsdi.org)

We will highlight their antibacterial and antibiofilm activities, mechanism of action, and modulation of the innate immune response. (frontiersin.org)
Top2cc are the therapeutic mechanism for killing cancer cells. (omicsdi.org)
The information available on their structure-activity relationship and their mechanism of action could be exploited as a solid base for developing a specific anti-PV therapy. (cdc.gov)
In the t(12;21) ETV6-RUNX1 ALL, it has been reported that the aberrant RAG recombination activity mediates off-target deletions and is the driver mutagenic mechanism [ 8 ]. (nature.com)

The chalcone derivative with the most potent and selective cytotoxic effects on GBM cells was further investigated regarding its ability to reduce critical hallmark features of GBM. (sciforum.net)
After this early example of infection control through microbial pathogens causing infection are killed by antimicro- antisepsis, the next step was inevitable: when chemicals with bial therapy, rather than inhibited, mutations that might antibacterial activity were discovered, they were soon used in already exist or occur under the selective pressure of the anti- the treatment of infected patients. (cdc.gov)

As the main cytotoxic mechanisms of action of the chemotherapeutic agents rely on functional apoptotic pathways, there is potential for synergy with agents that restore such activity. (medscape.com)
Thus, delving deeper into comprehending the intricate mechanisms underlying breast cancer metastasis becomes imperative, offering potential avenues for pioneering therapeutic approaches. (bvsalud.org)
this suggests that oxygen-radical scavengers could be potential therapeutic agents. (carbon60facts.com)
Oxidative stress plays a major role in acne formation, suggesting that oxygen radical scavengers are potential therapeutic agents. (carbon60facts.com)
Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide. (frontiersin.org)
Targeting pyruvate dehydrogenase kinases (PDKs) reverses the Warburg effect, which could be a potential therapeutic target for anti-cancer drug discovery. (qxmd.com)
Thus, modulation of Aβ might be a potential therapeutic strategy for modifying disease progression. (techscience.com)
Our results suggest that the EtOAc extract of Cs fungal mycelium has strong anti-tumor activity and is a potential source of natural anti-tumor products. (nih.gov)

IK-175 dose dependently blocks ligand-stimulated AHR activation of Cyp1a1 transcription in mouse liver and spleen, demonstrating on-target in vivo activity. (aacrjournals.org)

The phosphoinositide 3-kinase (PI3K) and serine/threonine kinase, protein kinase B (AKT) signaling pathways have been suggested as potent downstream effectors of RP105 under I/R stimulation and the immune response ( 10 , 12 ). (spandidos-publications.com)

All of the ureas were chemically synthesized, and their inhibitory activity toward recombinant human and recombinant rat sEH was measured. (nih.gov)
Methods: The inhibitory characteristics of NDGA were determined spectrophotometrically with recombinant GLO1. (elsevierpure.com)

17. T-18, a stemonamide synthetic intermediate inhibits pim kinase activity and induces cell apoptosis, acting as a potent anti cancer drug. (nih.gov)
18. Clinical and therapeutic relevance of pim 1 kinase in gastric cancer . (nih.gov)
19. Identification of a phenanthrene derivative as a potent anti cancer drug with pim kinase inhibitory activity. (nih.gov)
Furthermore, Triphala pretreatment suppressed the phosphorylation of the mitogen-activated protein kinase (MARK) signal pathway (p-Erk1/2, p-JNK1/2, and p-p38), whereas it restored the activities of antioxidant enzymes (superoxide dismutase 1 (SOD1) and catalase) in the H 2 O 2 -treated SH-SY5Y cells. (hindawi.com)

Here we report a potent bactericidal action of AZM against MDR carbapenem-resistant isolates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. (nih.gov)
Bactericidal activity is achieved with specific classes of antimicrobial agents as well as by com- pneumoniae isolates were resistant to penicillin and 16.5% bination therapy. (cdc.gov)
A more recent lincosamine/streptogramin class have increased bactericidal susceptibility study conducted in 2000-2001 showed that activity compared with traditional agents. (cdc.gov)
Accordingly, he examined the inhibitory effect of comprehensive strategy that includes, whenever possible, the various chemicals on the growth and viability of bacteria and selection of antibacterial agents in dosages sufficient to be directly applied the results to the practice of medicine by bactericidal (13). (cdc.gov)

MK-4101 targets the Hh pathway in tumor cells, showing the maximum inhibitory effect on Gli1. (uniroma1.it)

therefore, the RP105‑PI3K‑AKT axis may provide a novel therapeutic target for the prevention of cerebral ischemia/reperfusion injury. (spandidos-publications.com)
For this reason, novel therapeutic strategies that are safer and more effective are sought. (allfiberarts.com)

We demonstrate that the ZW-1288 derivative represents a promising direction for the development of deazaflavins as therapeutic agents. (omicsdi.org)
We identified a potent secondary amine derivative with resistance to deamination and preserved RPE65 inhibitory activity. (cornell.edu)

The outbreaks of viruses with wide spread and mortality in the world population have motivated the research for new therapeutic approaches. (hindawi.com)

In general, adenosine has an inhibitory effect in the CNS, increasing drowsiness and sleep. (brainblogger.com)
Annona montana -mediated inhibitory effect on both human and murine adipogenesis was shown to be exerted via a significant decrease in the accumulation of lipid content by both a dramatic reduction of size and number of lipid droplets. (techscience.com)
All solvent extracts except hot water extract showed a significant and dose-dependent inhibitory effect on the proliferation of four cancer cell lines, MCF-7 breast cancer, B16 mouse melanoma, HL-60 human premyelocytic leukemia and HepG2 human hepatocellular carcinoma, with IC(50) values below 132 microg/ml. (nih.gov)
The EtOAc extract, in particular, had the most potent effect against all four cancer cell lines, with IC(50) between 12 microg/ml (on B16) and 45 microg/ml (on MCF-7). (nih.gov)

We included articles in English describing the latest findings regarding the endocannabinoid system, the pharmacology of cannabinoids, and their therapeutic purpose in MS. (thctotalhealthcare.com)

As a monotherapy and combined with an anti-PD-1 antibody, IK-175 demonstrates antitumor activity in syngeneic mouse models of colorectal cancer and melanoma. (aacrjournals.org)
IK-175 also demonstrates antitumor activity combined with liposomal doxorubicin in syngeneic mouse tumors. (aacrjournals.org)
Of note, beside antitumor activity on transplanted tumors, MK-4101 was highly efficacious against primary medulloblastoma and BCC developing in the cerebellum and skin of Ptch1+/- mice. (uniroma1.it)

Fluticasone has extremely potent vasoconstrictive and anti-inflammatory activities. (medscape.com)

In all conditions, the peptidomimetic molecule effectively delivered potent anticancer activity. (medicalxpress.com)

Here, we illustrate the biology of Ab-based therapeutics and highlight new technologies that could reinvigorate drug discovery for a number of brain diseases for which current therapeutic options are limited. (medscape.com)

Fullerenol C60(OH)44, a recently developed polyhydroxylated fullerene, is a spherical carbon molecule that has many hydroxyl groups capable of potent radical-scavenging activity. (carbon60facts.com)
Our data provide insights into activity-preserving modifications of the emixustat molecule that can be employed to tune its pharmacological properties. (cornell.edu)

CBD- and THC-based oils were able to increase the AChE activity helping the cholinergic nervous system actuate against Al toxicity which was reflected by the behavioral biomarkers changes. (thctotalhealthcare.com)

Finally, AZM monotherapy exerts clear therapeutic effects in murine models of MDR GNR infection. (nih.gov)

Aryl hydrocarbon receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to numerous endogenous and exogenous ligands. (aacrjournals.org)
Shark cartilage can increase the activity of the immune system. (medlineplus.gov)
Some medications, such as those used after a transplant, decrease the activity of the immune system. (medlineplus.gov)

This pharmaceutical activity is associated with enhanced AZM cell penetration in eukaryotic tissue culture media and striking multi-log-fold synergies with host cathelicidin antimicrobial peptide LL-37 or the last line antibiotic colistin. (nih.gov)
Therefore, antimicrobial peptides (AMPs) represent potent and efficient candidates for the development of a new drug generation ( Singh and Abraham, 2014 ). (frontiersin.org)
The antimicrobial activity of S. formosa leaf extracts was investigated by disc diffusion and growth time course assays against a panel of pathogenic bacteria. (phcogcommn.org)
Antimicrobial Activity of Acacia disparrima Benth. (phcogcommn.org)

Activated partial thromboplastin time (aPTT) is prolonged by therapeutic doses of tinzaparin sodium used in the treatment of deep vein thrombosis (DVT). (nih.gov)

Three conditions are involved: (1) population of pathologically excitable neurons, (2) an increase in excitatory glutaminergic activity, and (3) reduction of inhibitory GABAergic projections. (medscape.com)

To the best of our knowledge, relatively few clinical trials inquired about the therapeutic effects of cannabinoids on patients with MS, with variable results. (thctotalhealthcare.com)

Then, mRNA expression of Epithelial-mesenchymal transition (EMT) marker SNAIL and CYP enzymes were measured by PCR and determinate specific drug metabolites, associated with CYP enzymes by LC/MS. Our results demonstrated an epigenetic shift in HepG2 cells towards PHH after exposure to 5-AZA and Vitamin C which resulted in a higher expression and activity of specific drug metabolizing CYP enzymes. (cancerindex.org)
In summary, Triphala is a promising neuroprotective agent against oxidative stress in SH-SY5Y cells and zebrafishes with significant antiapoptosis and antioxidant activities. (hindawi.com)
Retinoic acid decreases cohesiveness of follicular epithelial cells, stimulates mitotic activity, and increases turnover of follicular epithelial cells. (medscape.com)

IK-175 inhibits AHR activity in experimental systems derived from multiple species including mouse, rat, monkey, and humans. (aacrjournals.org)

The substrate-specific hydrolase activity of sEH transforms epoxyeicosatrienoic acids (EETs) to the corresponding dihydroxyeicosatrienoic acids (DHETs) purported to have inflammatory effects. (nih.gov)
This is reflected on the wide range of effects that caffeine has on the CNS that include increased motor activity, cortical activation, information processing rate, and cerebral energy metabolism rate. (brainblogger.com)

Among these peptides, snake venom cathelicidins are being widely exploited, because the variation in the composition of the venom reflects a range of biological activities that may be of biotechnological interest. (frontiersin.org)
The design and clinical implementation of therapeutic antibodies are principally based on the biological functions of IgG molecules that confer protection against infectious diseases. (medscape.com)

However, if the antiviral agent interferes with the replication and/or assembly of the CoVs, there is a higher probability of obtaining similar antiviral activity results in human CoV tests [ 1 , 2 , 10 , 11 ]. (hindawi.com)

RSK2 is an emerging therapeutic target for developing treatments for TNBC, for which there are currently no targeted therapies available [11]. (allfiberarts.com)
MFF regulation of mitochondrial cell death is a therapeutic target in cancer, Cancer Research (2019). (medicalxpress.com)
Their simplest mode of action is to bind to target molecules and thereby interfere with their activity and interaction with binding partners. (medscape.com)

However, we failed to correlate the observed inhibitory activity against PDKs with cellular activity under normal conditions. (qxmd.com)
The activities of these enzymes are consistent with degradation of the mucosal layer of the human gastrointestinal tract, glycosaminoglycans and other cellular glycans found throughout the body. (embl-heidelberg.de)
The activity of GST was also well modulated indicating that the oils played a crucial role in cellular damage avoidance. (thctotalhealthcare.com)

METHODS: Studies were included if they reported Lp-PLA2 mass and/or activity levels and adjusted risk estimates of stroke. (inra.fr)

Some metabolites of caffeine also have marked pharmacological activity. (brainblogger.com)

Although several therapeutic strategies for the treatment of GO have been developed, the effectiveness and the safety profile of these therapies remain to be fully elucidated. (spandidos-publications.com)
Technologies that improve bioavailability of antibody-based treatment platforms within the CNS parenchyma are being developed and could invigorate drug discovery for a number of brain diseases for which current therapeutic options are limited. (medscape.com)

The aim of the present study was to modify liver cancer cell lines in order to improve their drug-metabolizing activities towards PHH. (cancerindex.org)
Therefore, we screened the epigenetic status of four different liver cancer cell lines (Huh7, HLE, HepG2 and AKN-1) which were reported to have metabolizing drug activities. (cancerindex.org)
The ideal drug would be safe, inexpensive, easy to use, stable, and manifest broad activity toward PV strains. (cdc.gov)

Anatomy14

Organisms56

Diseases1

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes32

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care1

Inhibitors17

Vitro9

Inhibitor10

Enhanced the inhibitory effect1

Soluble epoxide h1

Compounds13

Growth inhibitory2

IC503

Derivatives2

Effective therapeutic1

Compound7

Molecular5

Activator3

Inhibition7

Exert2

Preclinical4

Promising therapeutic target1

Treating COVID-192

Concentrations2

Enzyme4

Potency1

Mechanism4

Selective2

Potential8

Vivo1

Signaling pathways1

Recombinant2

Kinase4

Bactericidal4

Tumor1

Novel therapeutic2

Derivative2

Approaches1

Effect4

Pharmacology1

Antitumor activity3

Anti-inflammatory1

Anticancer1

Therapeutics1

Molecule2

Toxicity1

Murine1

Immune3

Antimicrobial4

Doses1

Neurons1

Cannabinoids1

Cells3

Humans1

Effects2

Biological2

Antiviral activity1

Target3

Cellular3

Methods1

Pharmacological1

Treatment2

Drug3