• Newco Breye Therapeutics ApS is poised to repurpose an intravenously administered drug that failed in ischemia reperfusion injury as an orally available treatment for diabetic retinopathy, after closing a €4 million (US$4.1 million) seed round. (bioworld.com)
  • Carleton Hsia, NanoBlood: NanoBlood LLC has developed VitalHemeTM (nanoRBC), an innovative multifunctional neurovascular protective agent for the prevention and treatment of ischemia, reperfusion injury and damaging inflammatory reactions caused by superoxide generation. (invivosciences.com)
  • nanoRBC in small quantities has been shown in preclinical studies to be superior over fresh blood in preventing ischemic damage and reperfusion injury in critical care situations. (invivosciences.com)
  • Furthermore, we reviewed the current treatments available for neonates who have undergone intrapartum asphyxia, and highlight the emergence of maternal dietary creatine supplementation as a preventative therapy, which has been shown to provide multi-organ protection from birth asphyxia-induced injury in our preclinical studies. (frontiersin.org)
  • Aminolevulinic acid hydrochloride (5-ALA) is under development for the treatment of ischemia reperfusion injury, sideroblastic anemia, amnestic mild cognitive impairment. (globaldata.com)
  • Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
  • This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery, using a ''bench-to-bedside'' approach. (123dok.net)
  • Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
  • Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
  • Revive's cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the Company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. (biospace.com)
  • Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning? (southampton.ac.uk)
  • SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion, tMCAo). (nih.gov)
  • SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent models of transient middle cerebral artery occlusion (tMCAo), with clinically relevant long-term outcomes and in models with common stroke comorbidities (i.e., aging, hypertension, diabetes, hyperlipidemia, obesity, etc. (nih.gov)
  • PURPOSE: Reperfusion therapy enables effective treatment of ischemic stroke presenting within 4-6 hours. (harvard.edu)
  • CONCLUSIONS: Diffusion time dependence predicted tissue outcome in ischemic stroke more accurately than the ADC, and may be useful for predicting reperfusion benefit. (harvard.edu)
  • The aim of this review is to summarize the current knowledge of the multi-organ effects of intrapartum asphyxia, with particular reference to the findings from our laboratory using the precocial spiny mouse to model birth asphyxia. (frontiersin.org)
  • Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
  • If successful, this network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between small businesses, preclinical testing laboratories, and a pipeline to clinical testing, in a cost-and time-effective fashion. (nih.gov)
  • Metablok (renamed "LSALT peptide" in Arch communications with the U.S. FDA) is a novel peptide drug candidate in the Arch development pipeline and a potential treatment for the following highly problematic indications: (i) inflammation, (ii) sepsis and (iii) cancer metastasis. (archbiopartners.com)
  • The therapeutic potential of ketamine for treating Rett syndrome was first demonstrated by Dr. David M. Katz, Professor Emeritus, Department of Neurosciences, School of Medicine at CWRU, and colleagues, who found that treatment of heterozygous female Mecp2 mutant mice with a subanesthetic dose of ketamine (8 mg/kg) acutely reversed abnormalities in Fos expression and sensorimotor function [ 1 ]. (pharmather.com)
  • Our findings suggest that oleuropein and oleocanthal have potential therapeutic benefits for TNBC and can be further investigated as alternative treatment options. (bvsalud.org)
  • However, tissue progression from ischemia to infarction is variable, and some patients benefit from treatment up until 24 hours. (harvard.edu)
  • This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed. (biomedcentral.com)
  • In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
  • Our unique combination of tissue engineering technology with assay automation and sample miniaturization offers a rapid and cost effective platform for unprecedented therapeutic discovery. (invivosciences.com)
  • In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
  • Each of the companies has been rigorously vetted through the SBIR/STTR review process prior to receiving the non-dilutive funding to engage in R&D that has the potential for commercialization. (invivosciences.com)
  • We are focused on unlocking ketamine's potential for rare disorders, and the addition of the Rett syndrome program to our FDA-approved orphan drug designation pipeline strengthens our position in leading the potential use of ketamine for unmet medical needs in mental health, neurological and pain disorders," said Fabio Chianelli, CEO of PharmaTher. (pharmather.com)
  • This article delves into the extensive, up-to-date research on BHT's health benefits and its potential as a therapeutic agent. (earthclinic.com)
  • The draft application was accepted for registration on December 10, 2018 and will be followed by the full submission and review in early January 2019. (archbiopartners.com)
  • La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clínicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
  • In conclusion, pre-existing diabetes can lead to more severe lung damage upon SARS-CoV-2 infection, and LMWH may be a valuable therapeutic approach for managing COVID-19 patients with diabetes. (zoores.ac.cn)
  • Many organisms in nature have evolved mechanisms to tolerate severe hypoxia or ischemia, including the hibernation-capable Arctic ground squirrel (AGS). (elifesciences.org)
  • Although hypoxic or ischemia tolerance in AGS involves physiological adaptations, little is known about the critical cellular mechanisms underlying intrinsic AGS cell resilience to metabolic stress. (elifesciences.org)
  • Due to its mechanism of action, it may also be of interest to pharmaceutical companies for improving outcomes in treating disease using their own commercialized or pipeline drugs or therapeutic intervention. (invivosciences.com)
  • Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis. (ucla.edu)
  • This review aims to assimilate the latest developments in CSP and its application in children and CHD patients. (stanfordchildrens.org)
  • Metablok is a novel therapeutic agent that may protect the kidneys and prevent AKI in patients undergoing cardiac surgery. (archbiopartners.com)
  • In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. (unicyte.ch)
  • Revive seeks to develop and commercialize its own pharmaceutical-grade psilocybin with this biosynthesis technology at scale to support the Company's current psilocybin-based product pipeline that includes an oral thin film product currently being developed in collaboration with the University of Wisconsin-Madison and the intellectual property and research with psilocybin being developed by PharmaTher Inc. (CSE: PHRM, OTCQB: PHRRF). (biospace.com)
  • Ocuphire plans to schedule an end-of-phase II meeting with the U.S. FDA to review the results. (bioworld.com)
  • Several other environmental factors including oxy- gen concentration and mechanical, metabolic, and bio- chemical conditions have been shown relevant in cell differentiation and have been reviewed extensively (Fig. 1) [3]. (unicyte.ch)
  • If successful, this network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between small businesses, preclinical testing laboratories, and a pipeline to clinical testing, in a cost-and time-effective fashion. (nih.gov)
  • By supporting world class talent with distinct expertise in early discovery and clinical use the Company will be optimally positioned to identify novel applications for DMT and unlock its full therapeutic potential. (psychedelicalpha.com)
  • Meanwhile, an unprecedented number of new drugs aimed at both the treatment and prevention of end-organ damage are now in the pipeline, outcomes from potentially curative treatments such as allogeneic hematopoietic stem cell transplantation are improving, and great strides are being made in gene therapy, where methods employing both antisickling β-globin lentiviral vectors and gene editing are now entering clinical trials. (nih.gov)
  • This review focuses on current clinical and research initiatives aimed at addressing the greatest challenges in liver transplantation today. (medscape.com)
  • In recent decades the quality of human clinical trials and hence the robustness of their results -- not only in stroke but in many other therapeutic areas -- has improved. (nih.gov)
  • In this review, we systematically summarize the advances in EV (especially exosomes) engineering for clinical application, focusing on strategies toward high yield, facile isolation, efficient cargo loading, improved delivery, and optimized manufacturing, which might unleash the infinite power of EVs in clinical translation. (thno.org)
  • While there are initiatives aimed at speeding up therapeutic development for rare diseases, traditional small molecule drug discovery takes several years to complete, can cost billions of dollars, and identified therapeutic candidates have a low probability of clinical success [ 17 ]. (biomedcentral.com)
  • A comprehensive understanding of basic and clinical research pipelines as well as the current status of thrombolytic therapy will help facilitate the development of new thrombolytics. (j-stroke.org)
  • 10 6 Since pain is a manifestation of complex sickle pathobiology including inflammation, vascular dysfunction and ischemia/reperfusion injury, we investigated cannabinoid receptor-specific modulation of vascular function, inflammation and hyperalgesia. (haematologica.org)
  • A systematic search of PubMed, Cochrane Central Register of Controlled Trials MEDLINE, EMBASE, and the Web of Science electronic data bases was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. (ajnr.org)
  • Nanomedicine-based theranostics has significantly impacted conventional therapeutic modalities. (thno.org)
  • Development of novel and more effective strategies to prevent stroke, protect the brain during ischemia and reperfusion, and facilitate its recovery after stroke hinges on basic and translational preclinical research. (nih.gov)
  • This is a research programme of fundamental and potentially therapeutic importance. (elifesciences.org)
  • In Phase 1, the NINDS asked the Stroke Progress Review Group (SPRG) to conduct a final review of the stroke research landscape, ten years after the first SPRG established research priorities for the field. (nih.gov)
  • The primary aim of this review is to provide a roadmap for therapy development for rare, ultra-rare, and difficult to diagnose diseases, as well as increase awareness of the genetic component of SSMD. (biomedcentral.com)
  • A more detailed understanding of the switch from fetal to adult hemoglobin and the identification of regulators such as BCL11A provide hope that these findings will be translated into genomic-based approaches to the therapeutic reactivation of hemoglobin F production in patients with SCA. (nih.gov)
  • In conclusion, pre-existing diabetes can lead to more severe lung damage upon SARS-CoV-2 infection, and LMWH may be a valuable therapeutic approach for managing COVID-19 patients with diabetes. (zoores.ac.cn)
  • Our aim was to systematically review all available literature investigating the mechanism of action of flow diverters in both human patients and preclinical models. (ajnr.org)
  • This review summarizes a fraction of the existing data to provide some guidance in future research efforts. (karger.com)
  • Here, we review the currently available thrombolytics, strategies for the development of new clot-dissolving substances, and the assessment of thrombolytic efficacies in vitro and in vivo . (j-stroke.org)
  • This review focuses on three major challenges facing liver transplantation in the United States and discusses new areas of investigation that address each issue: (1) the need for an expanded number of useable donor organs, (2) the need for improved therapies to treat recurrent hepatitis C after transplantation and (3) the need for improved detection, risk stratification based upon tumor biology and molecular inhibitors to combat hepatocellular carcinoma. (medscape.com)
  • DDFPe alleviates hypoxia in areas of ischemia. (nuvoxpharma.com)
  • The current review study will be extremely important and beneficial as a desk review as a result of the growing human population and rapid development in the area. (degruyter.com)
  • Stem cells have evoked considerable excitement in vet- erinary medicine because of the promise that stem cell technology could deliver tissue regeneration for injuries for which natural repair mechanisms do not deliver func- tional recovery and for which current therapeutic strate- gies have minimal effectiveness. (unicyte.ch)
  • Beyond the inconvenience associated to the use of radioactivity, these traditional phosphorylation analysis methods can be time-consuming and are not well suited for the high throughput pipelines required for phosphoproteome analysis. (biomedcentral.com)
  • A 1995 article briefly reviewed the historical past of Bendectin in the United States and in contrast it with an identical Canadian product, Diclectin (fifty five). (ehd.org)
  • We will discuss the hypothesis that also soluble factors and ex- tracellular vesicles, also called microvesicles (MVs), re- leased by MSCs may have a relevant regenerative poten- tial and may open new therapeutic perspectives. (unicyte.ch)
  • For this project, we conducted a rigorous two-level screening of around 11,000 articles, based on the eligibility criteria drafted by the client and and identified the records that contained the most relevant information pertaining to the objectives of the review. (marksmanhealthcare.com)
  • Ten articles were eligible for inclusion in this review. (ajnr.org)
  • Although our focus remains on building our ketamine-based product pipeline, we will continue to partner with specialty pharmaceutical companies seeking a delivery solution for psychedelics and proprietary drugs to unlock significant value and return on investment for PharmaTher," said Fabio Chianelli, CEO of PharmaTher. (pharmather.com)
  • The focus of this review is on exosomes, a major subgroup of EVs. (thno.org)