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  • targets
  • Indeed, the mechanisms used by cancer cells to adapt to these conditions are starting to be elucidated and may represent potential therapeutic targets. (aacrjournals.org)
  • We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer. (hindawi.com)
  • The purpose of this paper is to examine the newfound roles of the transient receptor potential (TRP) ion channels, in particular the melastatin subfamily members TRPM7 and TRPM8, in pancreatic cancer and discuss their potential as clinical biomarkers and therapeutic targets. (hindawi.com)
  • Despite the identification of these diverse RAS targets, it is still difficult to precisely determine which downstream signaling components represent the best therapeutic targets for blocking RAS-mediated neoplastic transformation/tumorigenesis. (aacrjournals.org)
  • Sawicki identified therapeutic targets and evaluated the efficacy of many nanoparticle formulations in various cancer mouse models, including for pancreatic cancer, as well as for highly aggressive forms of ovarian cancer for which no effective long-term treatment currently exists. (wikipedia.org)
  • Clinical
  • In this paper, we review the current status of preclinical and clinical gene therapy for malignant mesothelioma and discuss potential clinical directions of gene medicine in terms of a combinatory use with anticancer agents and with immunotherapy. (hindawi.com)
  • pleural
  • 4 Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Barcelona, Spain and 5 Department of Biochemistry and Molecular Biology, UNMC/Eppley Cancer Center, University of Nebraska Medical Center, NE, USA The distinction between pleural malignant mesothelioma and pleural infiltration by adenocarcinomas has complex therapeutic and medicolegal implications. (docplayer.net)
  • Blood MPF and mesothelin levels were correlated, with modest accuracy for malignant pleural mesothelioma and lung cancer (sensitivity 74% and 59%, specificity 90% and 86%, respectively for MPF and mesothelin assays). (wikipedia.org)
  • benign
  • None of the 41 malignant mesotheliomas nor the 32 cases of benign mesothelial cells expressed MUC4 at the protein and mrna levels. (docplayer.net)
  • Most of these markers, such as BerEP4, CD15, the thyroid transcription factor (TTF-1) and carcinoembryonic antigen (CEA) stain adenocarcinomas whereas calretinin and CK5/6 are positive in both benign Correspondence: Professor M-C Copin, Service d Anatomie et Cytologie Pathologiques, Hôpital Calmette, CHRU, Bd J. Leclercq, Lille Cedex, France. (docplayer.net)
  • tumours
  • As the best characterised cancer/testis antigen family members, melanoma-associated antigens (MAGE) have been reported to be expressed in various malignant tumours. (ovid.com)
  • The constitutive overexpression of matrix metalloproteinases (MMPs) is frequently observed in malignant tumours. (springer.com)
  • Growth
  • Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas. (nih.gov)
  • Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung. (wikipedia.org)
  • Florid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-Trélat may be highlighted as part of a continuum, with each having a common or similar pathogenic pathway due to an underlying malignancy that produces a factor epidermal growth factor-like activity. (wikipedia.org)
  • markers
  • Although the panel of adenocarcinoma-associated antibodies and one or two mesothelioma markers is useful in this purpose, most of these antibodies are not totally specific. (docplayer.net)
  • 1,2 Various immunohistochemical markers that can help to the differential diagnosis of mesothelioma or adenocarcinoma have become available. (docplayer.net)
  • Among markers of adenocarcinomas whatever their origin (CEA, BerEP4, CD15), BerEP4 is the most sensitive (80%) but at the same time is the least specific. (docplayer.net)
  • tissue
  • MUC4 protein was expressed in 32 of 35 (91.4%) lung adenocarcinomas on paraffin-embedded tissue. (docplayer.net)
  • Combined small cell lung carcinoma (or c-SCLC, and rarely rendered as "small-cell lung carcinoma") is a form of multiphasic lung cancer that is diagnosed by a pathologist when a malignant tumor arising from transformed cells originating in lung tissue contains a component of small cell lung carcinoma (SCLC) admixed with one (or more) components of non-small cell lung carcinoma (NSCLC). (wikipedia.org)
  • invasion
  • In particular, MMP-2 and MMP-9 have been reported to be closely associated with invasion and angiogenesis in malignant gliomas. (springer.com)
  • These results suggest that MMI-166 may have potentially suppressive effects on the invasion and angiogenesis of malignant gliomas. (springer.com)
  • The control of tumour invasion and angiogenesis are the key problems for the improvement of treatment results of malignant gliomas. (springer.com)
  • adenomas
  • The therapeutic techniques used to treat duodenal adenomas encompass several endoscopic modalities, including polypectomy, endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and ablation (e.g. argon plasma coagulation). (springer.com)
  • closely
  • Malignant mesothelioma, closely linked with occupational asbestos exposure, is relatively rare in the frequency, but the patient numbers are going to increase in the next few decades all over the world. (hindawi.com)
  • effect
  • Several related randomized controlled trials (RCTs) have been published, but opinions vary among clinicians as to the therapeutic effect of the new method. (redorbit.com)