Therapeutic ischemic ischemia time. Medical search. Frequent questions

Tissue plasminogen activator (tPA) thrombolysis, remains to be the only United States Food and Drug Administration (FDA) approved treatment for acute ischemia stroke. (nih.gov)
Of note, ischemia-induced BBB damage in the early stroke stages is increasingly appreciated to negatively affect the safety and efficacy profiles of thrombolytic therapy for ischemic stroke. (nih.gov)
The increased understanding of early ischemic BBB damage and its close link to tPA-associated HT is of particular importance for developing new preventive and therapeutic strategies to reduce the hemorrhagic complications in stroke thrombolysis. (nih.gov)
This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. (wikipedia.org)
Other effects that may result from brain ischemia are stroke, cardiorespiratory arrest, and irreversible brain damage. (wikipedia.org)
citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Ischemic stroke is attributed to a high disability rate with limited or no therapeutic options for functional recovery [ 1 - 3 ]. (hindawi.com)
Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)
Besides, systemic hypoperfusion is another major factor in the occurrence of ischemic stroke [ 4 ]. (hindawi.com)
According to the World Health Organization (WHO), ischemic stroke is the most ubiquitous subclass of stroke that affects almost 15 million people globally [ 5 ]. (hindawi.com)
Therefore, an effective therapeutic strategy is required to prevent the onset of acute stroke and manage the chronic symptoms associated with neural ischemia, i.e., long-term neuroinflammation and localized necrosis [ 8 , 9 ]. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
According to previously established studies [ 8 ], the ischemic avalanche followed by a stroke is comprised of three phases, i.e., (i) acute phase, (ii) the subacute phase, and (iii) the chronic phase (Figure 1 ). (hindawi.com)
Graphical presentation of the various stages of cerebral ischemia stroke, i.e., acute phase, subacute phase, and chronic phase and their contributing factors. (hindawi.com)
Intra-arterial prourokinase for acute ischemic stroke. (nih.gov)
A total of 180 patients with acute ischemic stroke of less than 6 hours' duration caused by angiographically proven occlusion of the MCA and without hemorrhage or major early infarction signs on computed tomographic scan. (nih.gov)
Despite an increased frequency of early symptomatic intracranial hemorrhage, treatment with IA r-proUK within 6 hours of the onset of acute ischemic stroke caused by MCA occlusion significantly improved clinical outcome at 90 days. (nih.gov)
BACKGROUND: To examine serum vitamin B12 concentrations in relation to the risk of ischemic stroke among hospitalized patients in the Department of Neurology. (bvsalud.org)
Logistic regression analysis was used to investigate the association between serum vitamin B12 concentrations and ischemic stroke, with adjustment for a number of relevant demographic and lifestyle factors and comorbidities. (bvsalud.org)
RESULTS: A total of 961 (43.4%) patients had an ischemic stroke. (bvsalud.org)
Ischemic stroke is one of the main causes of mortality and disability worldwide. (bvsalud.org)
Silent mating type information regulation 2 homolog 1 (Sirt1), a nicotine adenine dinucleotide-dependent enzyme, has emerged as a potential therapeutic target for ischemic stroke due to its ability to maintain brain homeostasis and possess neuroprotective properties in a variety of pathological conditions for the central nervous system. (bvsalud.org)
Animal and clinical studies have shown that activation of Sirt1 can lessen neurological deficits and reduce the infarcted volume, offering promise for the treatment of ischemic stroke. (bvsalud.org)
In this review, we summarized the direct evidence and related mechanisms of Sirt1 providing neuroprotection against cerebral ischemic stroke. (bvsalud.org)
Finally, we reviewed the neuroprotective effects of Sirt1 in ischemic stroke and discussed the specific mechanisms, including reducing neurological deficits by inhibiting various programmed cell death such as pyroptosis, necroptosis, ferroptosis, and cuproptosis in the acute phase, as well as enhancing neurological repair by promoting angiogenesis and neurogenesis in the later stage. (bvsalud.org)
Our review aims to contribute to a deeper understanding of the critical role of Sirt1 in cerebral ischemic stroke and to offer novel therapeutic strategies for this condition. (bvsalud.org)
70% of patients have ischemic stroke and the recurrence rate is as high as 17.7% ( 1 , 2 ). (spandidos-publications.com)
An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
The overall goal of the CTP to predict Response to recanalization in Ischemic Stroke Project (CRISP) is to develop a practical tool to identify acute stroke patients who are likely to benefit from endovascular therapy. (stanford.edu)
Following the acute stroke, the majority of which are ischemic, there is secondary neuroinflammation that both promotes further injury, resulting in cell death, but conversely plays a beneficial role, by promoting recovery. (uaeu.ac.ae)
Understanding the time-dependent role of inflammatory factors could help in developing new diagnostic, prognostic, and therapeutic neuroprotective strategies for post-stroke inflammation. (uaeu.ac.ae)
A number of classification systems for ischemic stroke have been proposed in humans. (vin.com)
The most commonly used clinical systems divide ischemic stroke into three major stroke subtypes: large artery or atherosclerotic infarctions, cardioembolic infarctions and small vessel or lacunar infarctions. (vin.com)
Guidelines for the early management of adults with ischemic stroke. (jamanetwork.com)
Recombinant tissue plasminogen activator for acute ischaemic stroke. (jamanetwork.com)
Time to treatment with intravenous alteplase and outcome in stroke. (jamanetwork.com)
Saver JL, Levine SR. Alteplase for ischaemic stroke-much sooner is much better. (jamanetwork.com)
Ultraearly thrombolysis in acute ischemic stroke is associated with better outcome and lower mortality. (jamanetwork.com)
Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke Stem Cell Reviews and Reports. (nottingham.ac.uk)
MicroRNA: an emerging predictive, diagnostic, prognostic and therapeutic strategy in ischaemic stroke Cellular and Molecular Neurobiology. (nottingham.ac.uk)
Prognostic, Diagnostic and Therapeutic Potential of Endothelial Progenitor Cells for Patients with Ischaemic Stroke: hype or hope BIOCELL. (nottingham.ac.uk)
2012 ). Immunity and inflammation plays an integral part in the pathophysiology of stroke and is involved in all stages of ischemic cascade. (biomedcentral.com)
2018 ). But the detailed underlying mechanism to regulate inflammation after ischemic stroke remains unclear (Goldman et al. (biomedcentral.com)
Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage has been extensively explored for treating ischemic stroke. (springer.com)
We demonstrated that treatment with NPD1, RvD1, and combination therapy provides high-grade neurobehavioral recovery and decreases ischemic core and penumbra volumes even when administered up to 6 h after stroke. (springer.com)
The treatment of ischemic stroke is to administer tissue plasminogen activator (t-PA) within 4.5 h of stroke onset, and only 5-8% of patients qualify for this therapy (Liaw and Liebeskind 2020 ). (springer.com)
A recently completed EXTEND trial showed that this could be extended up to 9 h after stroke onset guided by CT or MRI perfusion images, thus allowing more patients eligible to receive tPA beyond the 4.5-h time window (Ma et al. (springer.com)
Mathematical modelling of intravenous thrombolysis in acute ischaemic stroke: effects of dose regimens on levels of fibrinolytic proteins and clot lysis time. (imperial.ac.uk)
Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
Excessive glutamate release resulting in excessive Ca +2 entry into cells is the excitotoxicity which initiates the brain ischemic damage seen in stroke and cardiac arrest. (benbest.com)
Thrombolysis has been a standard treatment for ischemic stroke. (johnshopkins.edu)
Diffusion tensor imaging indicated the highest efficiency of EDV-AM in accelerating axonal remodeling in the ipsilesional white matter and improving functional behaviors of ischemic stroke models. (johnshopkins.edu)
The agonistic micelle holds promise to improve the therapeutic efficiency of ischemic stroke patients who miss the thrombolytic treatment. (johnshopkins.edu)
Ischemic stroke results from arterial occlusion and can cause irreversible brain injury. (en-journal.org)
We evaluated hand motor function in a cynomolgus monkey model of ischemic stroke. (en-journal.org)
Pikija S, Sztriha LK, Sebastian Mutzenbach J, Golaszewski SM, Sellner J. Idarucizumab in Dabigatran-Treated Patients with Acute Ischemic Stroke Receiving Alteplase: A Systematic Review of the Available Evidence. (salk.at)
Mutzenbach JS, Pikija S, Otto F, Halwachs U, Weymayr F, Sellner J. Intravenous thrombolysis in acute ischemic stroke after dabigatran reversal with idarucizumab - a case report. (salk.at)
Pikija S, Magdic J, Trkulja V, Unterkreuter P, Mutzenbach JS, Novak HF, Weymayr F, Hauer L, Sellner J. Intracranial Thrombus Morphology and Composition Undergoes Time-Dependent Changes in Acute Ischemic Stroke: A CT Densitometry Study. (salk.at)
Pikija S, Magdic J, Liebeskind DS, Karamyan A, Bubel N, McCoy MR, Sellner J. Sigmoid Sinus Characteristics Correlate with Early Clinical and Imaging Surrogates in Anterior Circulation Ischemic Stroke. (salk.at)
Pikija S, Trkulja V, Mutzenbach JS, McCoy MR, Ganger P, Sellner J. Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study. (salk.at)
Zepper P, Wunderlich S, Förschler A, Nadas K, Hemmer B, Sellner J. Pearls & Oy-sters: cerebral HSV-2 vasculitis presenting as hemorrhagic stroke followed by multifocal ischemia. (salk.at)
Anthraquinone glycosides extracted from rhubarb have been proven to have significant therapeutic effects on ischaemic stroke. (biomedcentral.com)
According to the theory of TCM, cerebral ischaemia, which is also called stroke, can be induced by hyperactivity of liver Yang, disordered diet, stagnation of blood, etc. (biomedcentral.com)
Program of BIP for experimental types of non-neurological disorders Ischemia and perfusion (I/R)-induced cell loss of life may be the main reason behind poor outcomes following the treatment of cardiac arrest and stroke. (biotech2012.org)
Onwuekwe IO, Ezeala-Adikaibe B. Ischemic stroke and neuroprotection. (amhsr.org)
Greater understanding of the pathophysiology of neuronal damage in ischemic stroke has generated interest in neuroprotection as a management strategy. (amhsr.org)
This paper aims to review the current concept and place of neuroprotection in ischemic stroke. (amhsr.org)
Neuroprotection is an increasingly recognized management strategy in ischemic stroke that promises to assist clinicians in reducing stroke mortality rates and improving the quality of life of survivors. (amhsr.org)
Stroke is classified as being either hemorrhagic or ischemic in nature depending on the underlying pathological process responsible. (amhsr.org)
Several studies have documented that the ischemic subtype accounts for the greater number of stroke cases. (amhsr.org)
5 ‑ 8 ] An ischemic stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. (amhsr.org)
Key words used in the search include stroke ischemia, neuroprotection. (amhsr.org)

Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
The abundance and diversity of the intestinal flora in rats decreased after cerebral ischaemia - reperfusion injury (CIRI). (biomedcentral.com)
but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
The preclinical work focuses on animal models of myocardial ischemia-reperfusion injury, which is an experimental model for STEMI, as well as ex-vivo models of myocardial ischemia. (gu.se)

Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
Additionally, BIP protects retinal cells from hypoxic-ischemic damage, which is normally implicated in the introduction of glaucoma.45 Hypoxia induced retinal cell death seems to occur through apoptotic pathways primarily, and rat RGCs put through hypoxia demonstrated increased viability when treated with BIP.45 Altogether, these studies show that BIP as well as the inhibition of Bax possess potential as therapeutic agents in retinal disorders. (biotech2012.org)
Hypoxic-ischemic brain injury results in cerebral palsy (CP), mental retardation, or learning disabilities in surviving children ( Robertson and Finer, 1985 ). (jneurosci.org)

During the first part, the investigators propose to develop a fully automated system (RAPID) for processing of CT Perfusion (CTP) images that will generate brain maps of the ischemic core and penumbra. (stanford.edu)

There is a therapeutic window in which to deliver the cells, to avoid extensive tissue damage, fibrosis and necrosis. (biomedcentral.com)
Severe ischemia, which in the CNS would produce necrosis of the neurons and glial elements, results in an area of dead tissue termed an infarct. (vin.com)
The specific weight of Bupicain® 2.5 mg/mL and 5 mg/mL with or without a vasoconstrictor is 1.006 at 20°C and 0.997 at 37°C. If infiltrations are administered for local anaesthesia in areas that lack the possibility of collateral circulation (fingers, root of penis, etc.), it is a good precaution to use the anaesthetic without a vasoconstrictor to avoid ischaemic necrosis. (janusinfo.se)
Wong best defines it, in 1997 as a slow-healing radiation-induced ischemic necrosis of variable extent occurring in the absence of local primary tumor necrosis, recurrence, or metastatic disease 2 . (bvsalud.org)

Early ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis? (nih.gov)
In this review, we discussed the recent findings of spatio-temporal evolution of BBB injury in the early stages of cerebral ischemia and its association with intracerebral hemorrhage following tPA thrombolysis. (nih.gov)

In adult male Sprague-Dawley rats, the focal cerebral ischemic injury was induced by middle cerebral artery occlusion (MCAO) models for 1.5 h. (biomedcentral.com)
Cerebral ischaemia is caused by middle cerebral artery occlusion, which leads to some brain tissue damage, accompanied by inflammation and immune response [ 2 ]. (biomedcentral.com)

Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)

2012 ). Our team has proposed a new approach of electroacupuncture (EA) neuroprotection for the prevention of cerebral ischemia injury. (biomedcentral.com)
Although various preventative and therapeutic interventions have been explored for potential neuroprotection following SAH, a considerable percentage of patients still experience serious neurologic and/or cognitive impairments as a result of the primary hemorrhage and/or secondary brain damage that occurs. (alexbotsaris.com.br)

Patients with critical limb ischemia (CLI) require urgent initiation of interventional or surgical treatment, as restoration of the blood flow is the only way to ensure limb salvage in these critical cases. (jce.ro)

Note that cardiac markers are not necessary for the diagnosis of patients who present with ischemic chest pain and diagnostic ECGs with ST-segment elevation. (medscape.com)
Thus, MSCs were suggested as a promising candidate for ischemic brain injury patients[ 11 ]. (hindawi.com)
The program is organized to provide training and experience in the evaluation and management of a wide variety of patients with acute and chronic cardiovascular conditions, including coronary heart disease, congestive heart failure, acute myocardial infarction and other acute coronary ischemic syndromes, valvular heart disease, and peripheral vascular disease. (osu.edu)
Therapeutic angiogenesis has been proposed to serve as an effective and promising alternative therapy for patients with severe limb ischemia who do not have any other option for revascularization. (jce.ro)
This review aims to present the current status in therapeutic angiogenesis and the role of different approaches (gene or cell therapy, intra-arterial vs. intramuscular injections, different sources of cells) in increasing the rates of limb salvage in patients with severe ischemia of the lower limbs. (jce.ro)
Delayed cerebral ischemia can manifest after a successful operation for securing the aneurysm and patients at risk require monitoring for this complication in the post-operative period. (snacc.org)
There were 5404 patients in the 0- to 90-minute time window, 45 029 in the 91- to 180-minute segment, and 7920 in the 181- to 270-minute time window. (jamanetwork.com)
Although r-tPA is considered to be an effective treatment strategy, only 3-5% of patients may benefit from it due to a relatively narrow therapeutic time window (Roger et al. (biomedcentral.com)
13 Patients with type 1 and type 2 diabetes are at risk of developing the condition, and the risk increases with time since diagnosis. (novartis.be)
Background: The healing of foot wounds in patients with diabetes mellitus is frequently complicated by critical limb threatening ischemia (neuro-ischemic diabetic foot syndrome, DFS). (mdpi.com)
In the absence of contraindications, fibrinolytic therapy should be administered to patients with STEMI at non-PCI-capable hospitals when the anticipated first medical contact to device time at a PCI-capable hospital exceeds 120 minutes. (aafp.org)
We have built a unique human tissue sample bank of over 230 patients experiencing myocardial ischemia while undergoing cardiac surgery with cardiopulmonary bypass (CPB). (grantome.com)
Therefore, we will characterize the ncRNA transcriptome in the human and mouse heart, examine exRNA at various non-ischemic and ischemic time points in humans and mice, test for expressed quantitative trait loci (eQTL), and validate in a large population of cardiac surgical patients. (grantome.com)
Absence of coronary artery disease: Cardiac ischaemia with angina pectoris can exist in the absence of significant coronary artery disease, possibly due to microcoronary dysfunction (up to 10% of patients of which a majority of women). (escardio.org)
Patients treated with ranolazine had significantly better exercise duration - an ncrease by 115 seconds from baseline versus 91 seconds in placebo group - time to onset of angina, and fewer angina attacks. (escardio.org)
3,162) Metabolic efficiency with ranolazine for less ischemia in Non-ST elevation acute coronary syndromes compared long-term treatment with extended-release ranolazine with placebo, on top of standard therapy, for acute and long-term treatment of patients with non-ST-elevation ACS. (escardio.org)
Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches, hepatic I/R is still a leading cause of organ dysfunction, morbidity, and resource utilization, especially in those patients with underlying parenchymal abnormali-ties. (123dok.net)
We have suggested that CMD contributes to signs and symptoms of ischaemia in patients both with and without evidence of obstructive CAD, and to HFpEF, both of which share common pathophysiological pathways involving primary or secondary changes in the coronary microcirculation. (medscape.com)

CPB is an applied human model of ischemia, as it is associated with obligatory ischemic myocardial injury evidenced by cardiac biomarker release, and therefore shares commonality with ambulatory myocardial infarction. (grantome.com)
Although cardiovascular death, myocardial infarction or severe recurrent ischaemia were not proven better with ronalazine, the individual component of recurrent ischaemia was significantly reduced by ranolazine - demonstrated as safe. (escardio.org)
However, about 1 h of focal ischemia causes cerebral infarction characterized by the death of neurons, glial, and other supportive cells within the affected vascular bed. (amhsr.org)
When ischemia lasts more than 1 h, this zone of infarction beginning in the central zone of lowest blood flow progressively enlarges in a circumferential fashion towards its maximum volume over 6-7 h in primates and an undetermined time in humans. (amhsr.org)
[ 3 ] While termed ischaemia with no obstructive CAD (INOCA) and myocardial infarction with no obstructive CAD (MINOCA), [ 3 ] it is also sometimes called 'female-pattern' cardiovascular disease along with heart failure with preserved ejection fraction (HFpEF) because these occur more commonly in women, and the relative paucity of studies of women has resulted in therapeutic deserts for these conditions. (medscape.com)

In this review, we discuss how neuroinflammation has both beneficial as well as detrimental roles and recent therapeutic strategies to combat pathological responses. (uaeu.ac.ae)

A variety of observations suggest that coronary microvascular dysfunction (CMD) is related to the pathogenesis of cardiovascular disease, including myocardial ischaemia and heart failure. (medscape.com)

Recognizing that cardiac troponin measurements may be elevated in disease states not primarily related to myocardial ischemia, a fourth universal definition of acute MI was developed by the American College of Cardiology (ACC), European Society of Cardiology (ESC), American Hospital Association (AHA), and World Health Federation (WHF) in 2018. (medscape.com)
Regarding the mechanisms of ranolazine, reduced diastolic myofilament activation is one mechanism of ranolazine which has been demonstrated - this action is achieved at therapeutic levels which have been determined at 375-750 mg twice a day, through inhibition of the cardiac late Na+ current (INa+) and reduction of the Ca2+ overload. (escardio.org)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
Thalamic circuitry and normalization of its function may represent a distinct therapeutic target after cardiac arrest. (cdc.gov)

Dual-energy CT allowed accurate differentiation and illustrated diffuse contrast material extravasation, allowing patient to continue on dual antiplatelets and therapeutic anticoagulation to reduce the risk of ischemic injury post endovascular stent. (surgicalneurologyint.com)

At the same time, in acute limb ischemia, a dramatic form of sudden arterial occlusion of the lower limbs, the integrity of the limb is also seriously threatened in the absence of urgent revascularization. (jce.ro)
Killer-Oberpfalzer M. Therapeutic challenges after successful thrombectomy in a patient with an antiphospholipid syndrome associated M1-occlusion: A case report. (salk.at)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Treating such diseases remains difficult and several strategies have been used to stimulate the growth of blood vessels and promote regeneration of ischaemic tissues, such as the use of recombinant proteins and gene therapy. (biomedcentral.com)
In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
Ischaemia is characterised by a reduction in oxygen supply to tissues and organs, usually as a result of blood vessel constriction or obstruction. (biomedcentral.com)
The evaluation of the most suitable timing of cell delivery as well as the number of cells needed to integrate into resident vasculature and promote revascularisation of specific tissues requires careful optimisation and evaluation. (biomedcentral.com)
Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
As the only clinically approved neuroprotective drug, edaravone (EDV) rescues ischemic brain tissues by eradicating over-produced reactive oxygen species (ROS) without the limitation of therapeutic time-window. (johnshopkins.edu)
Coadministration may result in vasospasm and ischemia of the extremities and other tissues including the CNS. (medscape.com)

Ischemia causes loss of membrane potentials (anoxic depolarisation) and in its mildest form (brief focal ischemia) kills uniquely vulnerable neurones such as the pyramidal neurons in the CA1 and CA4 zones of the hippocampus while sparing other neurons and all glial cells. (amhsr.org)

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)
Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. (jneurosci.org)
Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. (jneurosci.org)
These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
Hypoxia-ischemia (H-I) is also associated with subsequent cerebral injury in a disproportionately high percentage of the survivors of premature birth ( Volpe, 2001 ). (jneurosci.org)
Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)
In the present study, a new neurobehavioral battery of tests was used to characterize the motor performance of newborn pups after sustained hypoxia-ischemia to the preterm rabbit fetus at 67-70% gestation. (jneurosci.org)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
Severe limb ischemia represents a critical condition, being associated with high morbidity and mortality rates. (jce.ro)
While a severe ischemic injury may cause irreversible death within the affected core, administration of a Bax inhibitor near the time of injury may be able to limit the damage caused by the event by avoiding apoptosis in neighboring cell populations. (biotech2012.org)

Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia. (jamanetwork.com)
Our previous studies have reported that EA could relieve neurological disorders, reduce infarct volumes after focal cerebral ischemia (Wang et al. (biomedcentral.com)

Clinical presentations include silent ischemia, angina pectoris, acute. (msdmanuals.com)

Ischemic brain injury is associated with a high rate of mortality and disability with no effective therapeutic strategy. (hindawi.com)
Here, we also focus on time-dependent entry of immune cells to the ischemic area and the impact of other pathological mediators, including oxidative stress, excitotoxicity, matrix metalloproteinases (MMPs), high-mobility group box 1 (HMGB1), arachidonic acid metabolites, mitogen-activated protein kinase (MAPK), and post-translational modifications that could potentially perpetuate ischemic brain damage after the acute injury. (uaeu.ac.ae)
Treatment with Outgrowth Endothelial Cells Protects Cerebral Barrier against Ischaemic Injury Cytotherapy. (nottingham.ac.uk)
Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition of high-mobility group box 1 release mechanism. (biomedcentral.com)
2013 ). In addition, we demonstrated that EA could attenuate cerebral ischemic injury via regulation of α7nAChR-mediated inhibition of HMGB1 release in rats (Wang et al. (biomedcentral.com)
Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure. (elsevierpure.com)
Administration of perioperative hydrogen gas may be a potent and clinically applicable therapeutic strategy for intestinal I/R injury. (elsevierpure.com)
Z-Ligustilide (LIG), the primary lipophilic component of the Chinese traditional medicine Radix Angelica Sinensis, has been shown to reduce ischemic brain injury via anti-apoptotic pathways. (alexbotsaris.com.br)
Using this resource and as part of our NHLBI award, in the past four years we examined mRNA differential expression, lncRNAs, and microRNAs in ischemic human left ventricular myocardium, putting us in an ideal position to study the significance of exRNA in myocardial ischemic injury. (grantome.com)
The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Uterine ischemia in the dams resulted in a distinct neurobehavioral phenotype in the newborn pups, which was characterized by an increase in forelimb tone that was significantly correlated with histological evidence of persistent injury to subcortical motor pathways involving the basal ganglia and anterior thalamus. (jneurosci.org)
Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)

Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. (wikipedia.org)
Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
and global ischemia, which encompasses wide areas of brain tissue. (wikipedia.org)
The main symptoms of brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
The causes of brain ischemia vary from sickle cell anemia to congenital heart defects. (wikipedia.org)
Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
Accordingly, this discovery raised the possibility of intervening after brain ischemia before the damage becomes irreversible. (wikipedia.org)
The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population. (wikipedia.org)
Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. (wikipedia.org)
citation needed] Compression of blood vessels may also lead to brain ischemia, by blocking the arteries that carry oxygen to the brain. (wikipedia.org)
citation needed] A heart attack can also cause brain ischemia due to the correlation that exists between heart attack and low blood pressure. (wikipedia.org)
Therefore, brain ischemia can result from events other than heart attacks. (wikipedia.org)
citation needed] Congenital heart defects may also cause brain ischemia due to the lack of appropriate artery formation and connection. (wikipedia.org)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
These excitotoxic effects play important roles in neuronal and blood-brain barrier damage after cerebral ischemia ( 5 , 6 ). (spandidos-publications.com)
The proinflammatory signals from immune mediators rapidly activate resident cells and influence infiltration of a wide range of inflammatory cells (neutrophils, monocytes/macrophages, different subtypes of T cells, and other inflammatory cells) into the ischemic region exacerbating brain damage. (uaeu.ac.ae)
Time is brain-quantified. (jamanetwork.com)
Here we developed an EDV-encapsulated agonistic micelle (EDV-AM) to specifically deliver EDV into brain ischemia by actively tuning blood-brain barrier (BBB) permeability. (johnshopkins.edu)
HPLC studies showed that EDV-AM delivered more EDV into brain ischemia than free EDV after intravenous injection. (johnshopkins.edu)
BIP administration in postnatal time 9 mice that acquired undergone still left carotid ligation reduced brain damage by 41.2% five times following the hypoxemic ischemic damage.37 Additionally, BIP-treated mice experienced improved sensorimotor and motor function seven weeks after the ischemic event. (biotech2012.org)
Deprivation of oxygen supply to the brain tissue leads to activation of the ischemic cascade with a series of molecular mechanisms being activated. (amhsr.org)

Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
However, effective dose and appropriate time of MSCs delivery are the main challenges in the clinical translation of stem cell therapy. (hindawi.com)
This association with the Davis Heart and Lung Research Institute will enable the catheterization laboratories to begin investigations into novel diagnostic techniques and therapeutic strategies of ischemic heart disease including intravascular brachytherapy, direct myocardial revascularization, left ventricular endocardial mapping for the detection of ischemia and myocardial viability, and clinical trials of gene therapy. (osu.edu)
This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
Over the past three decades, clinical and pharmacological studies have accumulated a body of evidence that not only demonstrated these therapeutic effects, but also provided significant insights into the pharmacokinetic behavior, therapeutic profile, and mode of action of scutellarin in humans and animal models. (cdc.gov)

hence, the importance of time for thrombolytic therapy. (medscape.com)

In its mildest form, impaired regional cerebral blood flow causes a transient ischemic attack (TIA). (vin.com)

The contents of inflammasome proteins were gradually increased after cerebral ischemia/reperfusion (I/R). EA stimulus attenuated NLRP3 inflammasome mediated inflammatory reaction and regulated the balance between proinflammatory factors and anti-inflammatory cytokines. (biomedcentral.com)

Within two minutes of ischemia, extracellular pH can drop from about 7.3 to about 6.7. (benbest.com)
Another ATP-driven pump helps keep extracellular calcium ions (Ca 2+ ) 10,000 times more concentrated than within the cytoplasm. (benbest.com)

However, the use of tPA has been profoundly constrained due to its narrow therapeutic time window and the increased risk of potentially deadly hemorrhagic complications. (nih.gov)

Due to its direct contribution to edema and HT, reperfusion-associated BBB damage has been extensively studied, while BBB damage that occurs within the thrombolytic time window is largely neglected. (nih.gov)
BRVO occurs between 2 and 6 times more frequently than CRVO. (novartis.be)
Unfortunately, this therapeutic strategy is vulnerable by the occurrence of chronic rejection, which occurs when the recipient's immune response impairs the transplanted organ through microvascular disruption. (biomedcentral.com)

However, EDV's short circulation half-life and inadequate cerebral uptake attenuate its therapeutic efficacy. (johnshopkins.edu)

As an integrated platform for triggering inflammation, inflammasome contributes to the pathogenesis of initiating innate immune response after cerebral ischemia/reperfusion (I/R)(Ismael et al. (biomedcentral.com)

A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
Would therapeutic hypothermia be indicated during clipping of this aneurysm? (snacc.org)

Retinal ischaemia results in increased production of VEGF, which promotes new vessel formation in the iris and/or the retina. (novartis.be)

Ischemia initiates specific biological processes that are highly dependent on genetic, transcriptional, and translational variation. (grantome.com)

Dobutamine stress echocardiography ischemia as a predictor of the placebo-controlled efficacy of percutaneous coronary intervention in stable coronary artery disease: the stress echocardiography-stratified analysis of ORBITA. (imperial.ac.uk)

If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
Outgrowth Endothelial Progenitor Cells Restore Cerebral Barrier Function Following Ischaemic Damage: the impact of nox2 inhibition European Journal of Neuroscience. (nottingham.ac.uk)
Hyperglycaemia caused by uncontrolled diabetes can, over time, lead to serious damage to body systems, particularly nerves and blood vessels. (novartis.be)
For a more quantitative approach less concerned with molecular biology, see Quantifying Ischemic Damage for Cryonics Rescue . (benbest.com)
This increased success was further improved when the intravitreal shot of BIP was repeated on time 3 pursuing transection.44 This shows that BIP may have tool in treating disorders of optic nerve damage. (biotech2012.org)
After as little as 10-20 minutes permanent damage may accumulate, summarized by the phrase "time is muscle. (medscape.com)
In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)

Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
Magnetic resonance imaging also demonstrated that EDV-AM more rapidly salvaged ischemic tissue than free EDV. (johnshopkins.edu)

Many important diseases are characterised by acute or chronic ischaemia, which affect millions of people each year and represent a considerable morbidity, mortality and economic cost to healthcare systems worldwide [ 2 ]. (biomedcentral.com)
Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)

Ischaemia-related diseases such as peripheral artery disease and coronary heart disease constitute a major issue in medicine as they affect millions of individuals each year and represent a considerable economic burden to healthcare systems. (biomedcentral.com)
Ischaemic heart disease (IHD) - reduced blood supply to the heart usually caused by coronary artery disease - is the leading cause of death and morbidity in America and Europe and is expected to be so by the year 2020 in emerging countries as well (1-3). (escardio.org)

Anatomy38

Organisms11

Diseases47

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment72

Phenomena and Processes36

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science2

Named Groups2

Health Care20

Stroke77

Reperfusion injury10

Hypoxic ischemic6

Core and penumbra1

Necrosis4

Thrombolysis2

Middle Cerebr2

Abstract1

Neuroprotection2

Critical limb ischemia1

Patients18

Infarction5

Neuroinflammation1

Myocardial ischaemia1

Cardiac4

Endovascular1

Occlusion2

Tissues8

Neurons1

Hypoxia-ischemia10

Severe4

Focal2

Angina pectoris1

Injury14

Brain24

Clinical5

Thrombolytic therapy1

Transient1

Increased after cerebral1

Extracellular2

Narrow therapeutic time window1

Occurs3

Attenuate1

Pathogenesis1

Hypothermia3

Retinal1

Initiates1

Efficacy1

Damage7

Tissue3

Chronic2

Coronary2