2018 ). It occurs due to irregular intestinal absorptive and secretory activities of fluid and electrolytes caused by infectious agents, toxicants, diet, allergic substances and GIT disorders including inflammatory bowel syndrome, dysmotility and drugs (Ezeja et al. (springeropen.com)
Antioxidant4
Some of medicinal plants are thought to be responsible for observed antisickling action for their high contain of phenolic compounds and antioxidant nutrients. (researchsquare.com)
Antioxidants (scavengers of free radicals) are thought to be major components of these antisickling action thus different antisickling agents have different degrees of effect according to amount of antioxidant. (researchsquare.com)
3] So that the higher antioxidant property of an antisickling agent enables it to reduce oxidative stress that contributes to sickle cell crisis. (researchsquare.com)
Hplc profiling, in vitro antisickling and antioxidant activities of amino acids from black bean seeds (phaseolus vulgarus l. (journalcra.com)
Sickle cell di1
DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. (sbir.gov)
Medicinal plants2
Due to the high mortality rate of sickle cell patients, previous studies have been indicated that some medicinal plants have shown an anti-sickling activity, which indicates a new therapeutic way to manage people who are affected by these disorders. (researchsquare.com)
In addition, increase scientific research has been focused on identifying and isolating bioactive agents in medicinal plants [5]. (austinpublishinggroup.com)
Hypertension1
The extracts of Hyphaene thebaica was used in treatment of hypertension, bilharzias and as a haematinic agent. (researchsquare.com)
Anaemia3
This could possibly mean that the phytomolecules present in Millettia aboensis possess stimulatory effect on red blood cell production and could probably be used as a therapeutic agent in the treatment of anaemia. (soapboxscience.org)
The study concluded that these plant extracts may be used for the therapeutic management of sickle cell anaemia. (soapboxscience.org)
Hollingsworth K, Romney MC, Crawford A, McAna J. Risk evaluation mitigation strategy: impact of application of the Food and Drug Adminstration's strategy on use of erythropoiesis-stimulating agents and transfusion in patients with chemotherapy-induced anaemia. (jefferson.edu)
Drugs2
It undertakes commercial studies on behalf of the international pharmaceutical industry, generally in the areas of pain and anaesthesia with drugs that often have a narrow therapeutic index, so intense medical and nursing care are needed. (wikipedia.org)
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (nih.gov)
Gene2
Several new therapeutic options are in development, including gene therapy and gene editing. (nih.gov)
These findings add mechanistic insight to globin gene regulation and offer a new therapeutic avenue to treat ß-hemoglobinopathies. (bvsalud.org)
Activities1
These plants have also been reported to possess antisickling, antiparasitic and antiseptic activities and have been known to be used to treat other ailments including toothache, sexual impotence, gonorrhoea, malaria, dysmenorrhoea, urinary and venereal diseases and abdominal pain. (islamicteachings.org)
Effects1
Previous studies have shown that Carica papaya has antisickling effects (Sofoworaet al. (researchwap.com)
Diabetes1
Also, phytomolecules extracted from Annona muricata, and Delonix regia have been reported as hypoglycaemic and hypolipidaemic agents which can be used in the management of diabetes and cardiovascular diseases. (soapboxscience.org)
Treatment1
Generally, treatment depends on causative agent and course of disease accordingly, because that tonsillitis may occur in the form of chronic or acute condition. (microbiologyjournal.org)
Control1
With an increase in tooth decay and gum diseases all over the world, there is need to produce oral cleaning agents that will better control caries-causing bacteria. (islamicteachings.org)
Management1
This research was planned to explore if any plant product under our study could prove being an effective anti-sickling agent for therapeutic use in SCD management. (jrmds.in)
Effect1
Hess G, Nordyke RJ, Hill J, Hulnick S. Effect of reimbursement changes on erythropoiesis-stimulating agent utilization and transfusions. (jefferson.edu)
Patients1
Therapeutic trials targeting this population of patients are indicated. (nih.gov)
Research1
the chewing stick aspect was researched for being an anti-gingivitis agent, and it appears to increase testosterone and libido in research animals. (islamicteachings.org)
Blood2
Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. (jefferson.edu)
Current management strategies include prophylactic penicillin and immunizations to decrease the occurrence of pneumococcal infections, hydroxyurea (a disease-modifying agent), blood transfusions (for symptomatic acute anemia, stroke management, preoperative optimization), and bone marrow transplant. (ccjm.org)
Compounds4
Not only will the compounds provide further insight on the sickling mechanisms, but those that show therapeutically significant effects at concentrations known to be non-toxic can be very rapidly approved for clinical trials as these agents are either already FDA-approved or under clinical development for other diseases. (nih.gov)
This may be explained by the lack of a suitable high-throughput technique that allows rapid screening of thousands of compounds for their antisickling effect. (umn.edu)
The purpose of this RFA is to fund the development and adaptation of biological assays for automated, high throughput screening of compounds that can potentially be used to improve the understanding of the biology of Sickle Cell Disease (SCD) and provide inroads toward new agents for SCD treatments. (nih.gov)
The screening of medicinal plants used locally for the treatment of infectious diseases, can provide a reliable option in the discovery of potent therapeutic compounds. (biomedcentral.com)
Potent1
Our research has demonstrated that Macaranga barteri extracts has potent antiviral activity against echoviruses E7 and E19, and our findings suggest that this extract may have potential as a therapeutic agent in the treatment of enteroviral infections. (biomedcentral.com)
Clinical development1
The finding has led to genetic strategies targeting BCL11A regulation for therapeutic reactivation in SCD and beta thalassemia under clinical development with promising results. (nih.gov)
Sickle-Cell Di1
The Thein group conducts research on the pathophysiology of sickle cell disease (SCD) applying insights from genotype-phenotype observations to accelerate translation of basic discovery to therapeutic applications. (nih.gov)
Development1
Several new therapeutic options are in development, including gene therapy and gene editing. (nih.gov)
Suggest1
it will provide us the ability to predict disease severity based on a genetic SCD "panel", and dissecting the role of new genetic modifiers might suggest new therapeutic targets for investigation. (nih.gov)
Identify1
While we apply insights from the basic research to identify new therapeutic targets, the Thein lab is also involved in a project with Dr Bill Eaton (Laboratory of Chemical Physics, NIDDK/NIH) to discover newer anti-sickling agents using high throughput screening of drug libraries. (nih.gov)
Test1
Results can be obtained by optical scanning: The size of the red dot is proportional to the antisickling effect of the test molecule. (umn.edu)
Anti-sickli1
New developments in anti-sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo? (nih.gov)
Prevent1
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions. (bvsalud.org)