• In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. (wikipedia.org)
  • In human SCNT experiments, these eggs are obtained through consenting donors, utilizing ovarian stimulation. (wikipedia.org)
  • Controversy surrounds human ESC work due to the destruction of viable human embryos, leading scientists to seek alternative methods of obtaining pluripotent stem cells, SCNT is one such method. (wikipedia.org)
  • For example, if a person with Parkinson's disease donated their somatic cells, the stem cells resulting from SCNT would have genes that contribute to Parkinson's disease. (wikipedia.org)
  • Another application of SCNT stem cell research is using the patient specific stem cell lines to generate tissues or even organs for transplant into the specific patient. (wikipedia.org)
  • Only a handful of the labs in the world are currently using SCNT techniques in human stem cell research. (wikipedia.org)
  • The primary cloning technique is called "somatic cell nuclear transfer" (SCNT). (cbc-network.org)
  • If the authors of this bill really meant what they appear to have written, their legislation would ban all human cloning, since as we have seen, biologically, a new human organism, that is, a new human being, comes into existence with the completion of SCNT. (cbc-network.org)
  • This is junk biology since implanting isn't the act of asexual reproduction: SCNT cloning is. (cbc-network.org)
  • Cloning, or somatic cell nuclear transfer (SCNT), is the technique used to produce Dolly the sheep, the first animal to be produced as a genetic copy of another adult. (eurostemcell.org)
  • Indeed, if passed, Hatch/Feinstein/Kerry would explicitly legalize doing in humans the very cloning procedure -- somatic cell nuclear transfer (SCNT) -- that was used to make Dolly the sheep . (lifeissues.net)
  • Comment: Indeed, if passed, "total cloning bans" H.R. 534, H.R. 234, H.R. 916, and S. 245 would not ban anything either - not even the SCNT cloning technique that was used to make Dolly the sheep. (lifeissues.net)
  • Somatic cell nuclear transfer (SCNT) is a type of cloning that has to be done in a lab. (bartleby.com)
  • In SCNT they take the nucleolus out of an egg cell, replace it with the nucleolus of a somatic cell (body cell with two complete sets of chromosomes), and make the egg cell divide into a blastocyst ("What Is Cloning? (bartleby.com)
  • Again, Saunders is referring to SCNT as "THE" cloning procedure, when there are many other ways to clone a human being as well, and he is scientifically mis-defining the product of SCNT (i.e., the cloned human embryo). (lifeissues.net)
  • Successful somatic-cell nuclear transfer (SCNT) depends on the quality, availability and maturation of the animal's unfertilized oocytes. (nature.com)
  • For SCNT, the chromosomes of the unfertilized canine oocytes were removed by micromanipulation, and a single donor cell was transferred into each enucleated oocyte. (nature.com)
  • Dolly was the first mammal cloned from specialized adult (somatic) cells with the technique of somatic cell nuclear transfer (SCNT). (asu.edu)
  • The egg is now viable and capable of producing an adult organism containing all necessary genetic information from just one parent. (wikipedia.org)
  • Development will ensue normally and after many mitotic divisions, the single cell forms a blastocyst (an early stage embryo with about 100 cells) with an identical genome to the original organism (i.e. a clone). (wikipedia.org)
  • These cells genetically matched the donor organism from which they came. (wikipedia.org)
  • These cells are deemed to have a pluripotent potential because they have the ability to give rise to all of the tissues found in an adult organism. (wikipedia.org)
  • At that point - and this is important to understand - there is no more cloning to be done since a new human organism now exists. (cbc-network.org)
  • If the cloned human organism is to be experimented upon and destroyed, the process is often called "therapeutic cloning. (cbc-network.org)
  • Or to put it the other way around, cloning, not implantation, is what produces a new and distinct human organism. (cbc-network.org)
  • These stem cells are genetically matched to the donor organism, holding promise for studying genetic disease. (eurostemcell.org)
  • A clone is an organism that is a genetic copy of an existing one. (who.int)
  • Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
  • This is cloning, a process in which the body cell that donated the replacement nucleus supplies the chromosomes of the new human organism. (actionlife.org)
  • Whether the new organism is produced by fertilization or by cloning, each new human organism is a distinct entity. (actionlife.org)
  • A new organism is created by asexual reproduction using a duplicate of a single cell from the parent organism. (geminigenetics.com)
  • This is the most known form of cloning and involves creating a genetically identical replica of a whole organism. (geminigenetics.com)
  • The process of reproductive cloning involves the nucleus of a somatic (body) cell from a donor organism to be cloned being transferred into an egg cell whose nucleus (genetic material) has been removed. (geminigenetics.com)
  • XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
  • … "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
  • Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
  • The blastocyst stage is developed by the egg to help create embryonic stem cells from the inner cell mass of the blastocyst. (wikipedia.org)
  • After many divisions in culture, this single cell forms a blastocyst (an early stage embryo with about 100 cells) with almost identical DNA to the original donor who provided the adult cell - a genetic clone. (eurostemcell.org)
  • To produce Dolly, the cloned blastocyst was transferred into the womb of a recipient ewe, where it developed and when born quickly became the world's most famous lamb. (eurostemcell.org)
  • In therapeutic cloning, the blastocyst is not transferred to a womb. (eurostemcell.org)
  • Instead, embryonic stem cells are isolated from the cloned blastocyst. (eurostemcell.org)
  • A blastocyst (cloned or not), because it lacks any trace of a nervous system, has no capacity for suffering or conscious experience in any form - the special properties that, in our view, spell the difference between biological tissue and a human life worthy of respect and rights. (wikiquote.org)
  • Therapeutic cloning involves the creation of an early-stage embryo (blastocyst) and the removal of stem cells from the developing embryo. (geminigenetics.com)
  • Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)
  • The stem cells derived from the inner mass of a blastocyst lack the ability to form a fetus when implanted into a woman, but are self-renewing and can be maintained for long periods of time in the laboratory as undifferentiated stem cells. (jcpa.org)
  • That is what New Jersey legislators did when they passed and then Governor James McGreevey signed S-1909 last year, a law that was sold to the public as outlawing human cloning but which actually permits the creation of cloned human life, and its implantation and gestation up to and including the very moment prior to the emergence of the cloned baby from the birth canal. (cbc-network.org)
  • Some prohibit only cloning for reproductive purposes and allow the creation of cloned human embryos for research, whereas others prohibit the creation of cloned embryos for any purpose. (who.int)
  • In the United States, scientists at the Harvard Stem Cell Institute, the University of California San Francisco, the Oregon Health & Science University, Stemagen (La Jolla, CA) and possibly Advanced Cell Technology are currently researching a technique to use somatic cell nuclear transfer to produce embryonic stem cells. (wikipedia.org)
  • Stem cells can then be obtained by the destruction of this clone embryo for use in therapeutic cloning or in the case of reproductive cloning the clone embryo is implanted into a host mother for further development and brought to term. (wikipedia.org)
  • The aim of carrying out this procedure is to obtain pluripotent cells from a cloned embryo. (wikipedia.org)
  • Embryonic stem cells are undifferentiated cells of an embryo. (wikipedia.org)
  • A little shot of electricity comes next, and if all goes well, a new human cloned embryo comes into being and begins to develop in the same way as a sexually created embryo. (cbc-network.org)
  • Cloning of a human being" means asexual reproduction by implanting or attempting to implant the product of nuclear transplantation [e.g., an embryo] into a uterus or substitute for a uterus with the purpose of producing a human being. (cbc-network.org)
  • The egg is artificially stimulated to divide and behave in a similar way to an embryo fertilised by sperm. (eurostemcell.org)
  • It is also our view that there are no sound reasons for treating the early-stage human embryo or cloned human embryo as anything special, or as having moral status greater than human somatic cells in tissue culture. (wikiquote.org)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
  • But it is perhaps not auspicious to quote him for purposes of the scientific debates on human cloning, because Ramsey agreed with and supported the scientific myth of the "pre-embryo" 47 made famous by Jesuit Richard McCormick and frog embryologist Clifford Grobstein. (lifeissues.net)
  • Perhaps Ramsey would give other extraordinarily powerful arguments as to why human cloning is unethical, but he obviously would not be able to base it on his unscientific "pre-embryo" position. (lifeissues.net)
  • Otherwise, such a treaty would not recognize the inherent human nature of the early human embryo or fetus until after birth , and thus cloning them and using them for research - both "therapeutic" and "reproductive" -- would not be banned, and women undergoing "infertility treatments" could surely be put in danger. (lifeissues.net)
  • Pregnancy was established only after embryo transfer of very-early-stage nuclear-transfer constructs (that is, less than 4 hours after oocyte activation). (nature.com)
  • Normally, the embryo comes into being through sexual conception, in which the female egg cell is fertilized by a male sperm cell. (actionlife.org)
  • Assisted reproductive technology (ART) and embryo research have posed many challenges to the different timeframes of science, ethics and law. (edu.au)
  • The resulting embryo is then implanted into a surrogate mother, resulting in the birth of an animal genetically identical to the body cell donor. (geminigenetics.com)
  • An electrical impulse is then applied to the egg cell to stimulate it to become an embryo. (geminigenetics.com)
  • Though pet cloning may be considered a relatively new technology, the process of cloning as defined above is first documented in 1885, where Hans Adolf Eduard Driesch demonstrated artificial embryo twinning on a sea-urchin. (geminigenetics.com)
  • … "human clone" means an embryo that, as a result of the manipulation of human reproductive material or an in vitro embryo, contains a diploid set of chromosomes obtained from a single - living or deceased - human being, fetus, or embryo. (hinxtongroup.org)
  • The fusion ultimately gives rise to a microscopic embryo, from which embryonic stem cells can theoretically be derived. (the-scientist.com)
  • In the best case, an early embryo consisting of a few cells may form, but these are not capable of giving rise to human life, nor hESCs for therapeutic purposes. (the-scientist.com)
  • The resulting clone developed into a microscopic embryo, which survived long enough for pluripotent stem cell lines to be derived. (the-scientist.com)
  • Keith Henry Stockman Campbell studied embryo growth and cell differentiation during the twentieth and twenty-first centuries in the UK. (asu.edu)
  • The predominant bioethical concern arising from this technology is that the blastocyt-stage embryo must be destroyed in the process of isolating and separating the embryonic stem cells from the inner mass region of the pre-embryo. (jcpa.org)
  • The destruction of the pre-embryo has been the critical issue in the U.S. behind imposing limits on federal government-sponsored research in embryonic stem cells. (jcpa.org)
  • Many politicians, religious leaders, and bioethicists believe that any destruction of the pre-implanted embryo or fertilized egg is akin to murder. (jcpa.org)
  • If biotech scientists have the ability to manipulate the genes of an embryo or gamete cell for non-therapeutic purposes, it could be argued that these genetically modified cells are in fact patentable "inventions," given that the material was not, in that particular sequence, naturally occurring. (nyu.edu)
  • In 1996, Dolly the sheep became famous for being the first successful case of the reproductive cloning of a mammal. (wikipedia.org)
  • Although many species produce clonal offspring in this fashion, Dolly, the lamb born in 1996 at a research institute in Scotland, was the first asexually produced mammalian clone. (who.int)
  • Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
  • The cloning of 'Dolly The Sheep' in 1996 by the Rosalind Institute in Scotland, UK, is the most recognised example of reproductive cloning. (geminigenetics.com)
  • is a British developmental biologist who was the first to use nuclear transfer of differentiated adult cells to generate a mammalian clone, a Finn Dorset sheep named Dolly, born in 1996. (mathisfunforum.com)
  • Campbell and his team also cloned a sheep from adult cells in 1996, which they named Dolly. (asu.edu)
  • Somatic cell nuclear transplantation has become a focus of study in stem cell research. (wikipedia.org)
  • It is the policy of Washington state that research involving the derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation , is permitted upon full consideration of the ethical and medical implications of this research. (cbc-network.org)
  • This could allow us to create cells that are useful for transplantation for a variety of diseases without the problem of immunological rejection," said Noggle in a press briefing. (the-scientist.com)
  • Transplantation of cells, tissues, or organs from another member of the same species. (nationalacademies.org)
  • Sir John Bertrand Gurdon further developed nuclear transplantation, the technique used to clone organisms and to create stem cells, while working in Britain in the second half of the twentieth century. (asu.edu)
  • In this procedure, the nucleus of an egg cell is removed and replaced by the nucleus of a cell from another adult. (eurostemcell.org)
  • In Dolly's case, the cell came from the mammary gland of an adult ewe. (eurostemcell.org)
  • After being inserted into the egg, the adult cell nucleus is reprogrammed by the host cell. (eurostemcell.org)
  • For example, stem cells could be generated using the nuclear transfer process described above, with the donor adult cell coming from a patient with diabetes or Alzheimer's. (eurostemcell.org)
  • Here we describe the cloning of two Afghan hounds by nuclear transfer from adult skin cells into oocytes that had matured in vivo . (nature.com)
  • The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
  • if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
  • The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
  • Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
  • and from mature adult tissue cells reprogrammed to behave like stem cells. (cmq.org.uk)
  • Contrary to popular belief, stem cells are present in the human body throughout life and are found in many adult organs. (jcpa.org)
  • In most countries, it is illegal to attempt reproductive cloning in humans. (eurostemcell.org)
  • The Ethical Debate Concerning Cloning In the year that has elapsed since the announcement of Dolly's birth, there has been much discussion of the ethical implications of cloning humans. (bartleby.com)
  • However, the idea of cloning humans is a highly charged topic. (bartleby.com)
  • Stem cell technology in humans derives from earlier and complementary work in animal studies. (edu.au)
  • Humans and other mammals may produce natural clones, commonly referred to as identical twins. (geminigenetics.com)
  • In humans, somatic transfer has been less fruitful-the egg cell quits dividing and often dies after nuclear transfer. (the-scientist.com)
  • The bill purports to promote stem-cell research, while outlawing the cloning of a human being. (cbc-network.org)
  • While stem-cell research holds enormous potential for treating or even curing some diseases, the cloning of a human being is morally and ethically unacceptable…Any attempt to clone a human being is in direct conflict with the public policies of this state. (cbc-network.org)
  • What is cloning, and what does it have to do with stem cell research? (eurostemcell.org)
  • This form of cloning is unrelated to stem cell research. (eurostemcell.org)
  • It's given name is the "Human Cloning Ban and Stem Cell Research Protection Act of 2003," the stated purpose of which, supposedly, is to "prohibit human cloning and to protect important areas of medical research, including stem cell research. (lifeissues.net)
  • Experts from around the world are assessing the difficult issue of the extent to which embryonic stem cell research should be allowed to proceed, and to date there is little international consensus on this matter. (edu.au)
  • How, then, should embryonic stem cell research be regulated in Australia? (edu.au)
  • This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)
  • In this article we examine embryonic stem cell research and explore the current regulatory framework associated with this research in Australia, with particular reference to the Andrews Report . (edu.au)
  • In order to better appreciate the role of stem cell research in reproductive medicine, there is a need to understand the critical biological principles of stem cell research and its potential applications to medicine. (jcpa.org)
  • While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
  • In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
  • The second way to reproduce is a strictly human invention - known as "asexual" reproduction - or more commonly, cloning. (cbc-network.org)
  • Asexual reproduction is a natural method used by certain plants, bacteria, and single-celled creatures to create genetically identical offspring, i.e. clones. (geminigenetics.com)
  • The resulting cells would be genetically identical to the somatic cell donor, thus avoiding any complications from immune system rejection. (wikipedia.org)
  • Another long-term hope for therapeutic cloning is that it could be used to generate cells that are genetically identical to a patient. (eurostemcell.org)
  • In biology , cloning is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria , insects or plants reproduce asexually . (wikiquote.org)
  • A type of cloning that occurs naturally is when identical twins are born ("What Is Cloning? (bartleby.com)
  • Snuppy is genetically identical to the donor Afghan hound. (nature.com)
  • We tested whether the cloned dogs were genetically identical by microsatellite analysis of genomic DNA from the donor Afghan, the cloned dogs and the surrogates (see supplementary information ). (nature.com)
  • Analysis of eight canine-specific microsatellite loci confirmed that the cloned dogs were genetically identical to their donor dog. (nature.com)
  • The term "clone", from the Greek word for twig, denotes a group of identical entities. (who.int)
  • In sexual reproduction, clones are created when a fertilized egg splits to produce identical (monozygous) twins with identical genomes. (who.int)
  • Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)
  • Beyond this scientific interest, the commercial concern in animal cloning focuses on replicating large numbers of genetically identical animals, especially those derived from a progenitor that has been modified genetically. (who.int)
  • The word "cloning" refers to a variety of procedures that may be used to create biological copies that are genetically identical to the original. (geminigenetics.com)
  • When a fertilised egg separates into two or more embryos with almost identical DNA, these twins are created. (geminigenetics.com)
  • Pet cloning is the process where a genetically identical twin is created of your original animal companion. (geminigenetics.com)
  • The surrogate mum carries the cloned pet for the gestation period and once ready, gives birth to the clone who will be an identical genetic twin to the original pet whose skin sample was used to make the nucleus of the donor egg cell. (geminigenetics.com)
  • As the fertilized egg divides from one cell into two, physicians can separate these two cells and implant each one of them into a woman's uterus to generate two genetically identical children. (jcpa.org)
  • A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
  • The genetically modified egg now has 46 chromosomes, the full human compliment. (cbc-network.org)
  • 7. "[footnote 16]: The cloning procedure supplies the oocyte with a complete set of chromosomes, all of which are contained in the nucleus which is transferred into the denucleated oocyte. (lifeissues.net)
  • In sexual reproduction the new individual gets half of its chromosomes from the nucleus of the sperm cell and half from the nucleus of the egg cell. (actionlife.org)
  • In the end, the egg cell contained three sets of chromosomes-two from the diploid somatic cell, and one from the haploid egg. (the-scientist.com)
  • The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. (lookformedical.com)
  • Recommendation 2: In licensing any research using embryos created by cell nuclear replacement, the Human Fertilisation and Embryology Authority should satisfy itself that there are no other means of meeting the objectives of the research. (cmq.org.uk)
  • The technique consists of taking an denucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. (wikipedia.org)
  • The first being a female gamete, known as the ovum (egg/oocyte). (wikipedia.org)
  • In the case of asexually creating a human, the biotechnologist removes the nucleus from a mature human egg (an oocyte). (cbc-network.org)
  • Moreover, most early-stage embryos that are produced naturally (that is, through the union of egg and sperm resulting from sexual intercourse) fail to implant and are therefore wasted or destroyed. (wikiquote.org)
  • There are also naturally occurring clones among animal populations. (geminigenetics.com)
  • As well as their distinctive white markings and long curved horns, these cattle are special because they are now considered a herd of naturally occurring clones. (geminigenetics.com)
  • The advance here is the proof that somatic cell nuclear transfer can work [in human cells] and can fully reset the donor cell genome to a pluripotent state," said Harvard Medical School's George Daley , who was not affiliated with the study. (the-scientist.com)
  • Instead of removing the egg genome prior to nuclear transfer, he and his colleagues added the somatic cell nucleus directly to the intact egg. (the-scientist.com)
  • The triploid cells aren't suitable for therapeutic purposes, and future efforts will be focused on trying to eliminate the [egg cell] genome," said Daley, who wrote an accompanying News & Views in Nature . (the-scientist.com)
  • For the first time researchers can now compare iPSC differentiation to the same process an egg goes through after the transfer of a somatic cell genome. (the-scientist.com)
  • Advances in the biotechnology industry have increased scientists' understanding of the human genome and enhanced their ability to genetically modify eggs, sperm, and human embryos. (nyu.edu)
  • The Supreme Court's decision in Association for Molecular Pathology v. Myriad Genetics , Inc. [2] could be interpreted as paving the way for patenting genetically altered genome or gamete cells. (nyu.edu)
  • A potential use of stem cells genetically matched to a patient would be to create cell lines that have genes linked to a patient's particular disease. (wikipedia.org)
  • Numerous biological components, including genes, cells, tissues, and even complete creatures like sheep, have been cloned by researchers, and now cat, dog and equine cloning is widely and reliably available via international companies such as our partner, ViaGen Pets & Equine. (geminigenetics.com)
  • A breakthrough in somatic cell nuclear transfer opens the possibility of producing human embryonic stem cells with a patient's own genes. (the-scientist.com)
  • While iPSCs avoid the ethical issues surrounding embryonic stem cells, the methods used to derive them sometimes induce mutations in cancer causing genes, making them unsuitable for therapeutic purposes. (the-scientist.com)
  • King showed that mutated BRCA1 and BRCA2 genes cause two types of reproductive cancer, breast and ovarian cancer. (asu.edu)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • As part of the study, Noggle and his colleagues developed new protocols that allow women to choose between giving their eggs to research or in vitro fertilization programs. (the-scientist.com)
  • While women have always been paid for donating their eggs for in vitro fertilization, ethical guidelines have prevented researchers from paying women for their eggs. (the-scientist.com)
  • As most women will not donate altruistically, this has left researchers working with the poor-quality eggs rejected from in vitro fertilization. (the-scientist.com)
  • According to the researcher's new protocols, women are paid to donate, but only later choose whether their eggs should go to research or in vitro fertilization. (the-scientist.com)
  • Research using human embryos (whether created by in vitro fertilisation or by cell nuclear replacement) to increase understanding about human disease and disorders and their cell based treatments should be permitted, subject to the controls in Human Fertilisation and Embryology Act 1990. (cmq.org.uk)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • The genetic material of the donor egg cell is removed and discarded, leaving it 'deprogrammed. (wikipedia.org)
  • Most natural cloning occurs in those species that produce their descendants asexually, that is, without combining the male and female genetic material. (who.int)
  • The DNA within the skin sample is cultured and inserted into a donor egg cell whose nucleus (genetic material) has been removed. (geminigenetics.com)
  • The findings validate this controversial method, and may one day allow therapeutic stem cells to be created from a patient's own genetic material. (the-scientist.com)
  • If there are intact cells in this tissue they have been 'stored' frozen. (wikiquote.org)
  • Therapeutic cloning refers to the production of embryonic stem cells for medicinal reasons, for example regenerative medicine and tissue replacement. (geminigenetics.com)
  • These three sources of stem cells do not create the same serious ethical concerns as those derived from embryonic and foetal tissue. (cmq.org.uk)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Somatic cell nuclear transfer is a technique for cloning in which the nucleus of a somatic cell is transferred to the cytoplasm of an enucleated egg. (wikipedia.org)
  • The process of somatic cell nuclear transfer involves two different cells. (wikipedia.org)
  • More than 100 nuclear transfer procedures could be required to produce one viable clone. (wikiquote.org)
  • The use of the technique of nuclear transfer for reproduction of human beings is surrounded by strong ethical concerns and controversies and is considered a threat to human dignity. (who.int)
  • 3. Media reports on nuclear transfer are usually about one form, reproductive nuclear transfer, also known as reproductive cloning of human beings . (who.int)
  • This transfer of early-stage embryos is a crucial factor in successful assisted reproductive technology for dogs. (nature.com)
  • Figure 1: Dog cloned by somatic-cell nuclear transfer. (nature.com)
  • The first pluripotent human embryonic stem cells (hESCs) have been generated from somatic cell nuclear transfer, according to a study published today (October 5) in Nature . (the-scientist.com)
  • Somatic cell nuclear transfer typically involves the transfer of genomic information from a somatic cell into an unfertilized egg cell whose nucleus has been removed. (the-scientist.com)
  • Somatic cell nuclear transfer has shown limited success in animal studies, which have successfully isolated pluripotent cells. (the-scientist.com)
  • Often, but inaccurately, used to refer to the propagation of animals by nuclear transfer. (nationalacademies.org)
  • Gurdon's research built on the work of Thomas King and Robert Briggs in the United States, who in 1952 published findings that indicated that scientists could take a nucleus from an early embryonic cell and successfully transfer it into an unfertilized and enucleated egg cell. (asu.edu)
  • from nationalreview.com Let's call it "stealth human-cloning legalization. (cbc-network.org)
  • article: Now, he's done it again by signing up as a co-sponsor (along with Senators Orin Hatch and Dianne Feinstein) of what could be called the Human Cloning Legalization and Legitimization Act of 2003 (S. 303) . (lifeissues.net)
  • The cloning "bans" being supported in his article could likewise be called "the Human Cloning Legalization and Legitimazation Acts of 2003" (e.g. (lifeissues.net)
  • In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. (wikipedia.org)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • WHA50.37 of 1997 argues that human cloning is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • WHA50.37, which states "the use of cloning for the replication of human individuals is ethically unacceptable and contrary to human integrity and morality. (who.int)
  • The scientific community should be concentrating its efforts in working on ethically non-controversial stem cells. (cmq.org.uk)
  • Cloning in biotechnology refers to processes used to create copies of DNA fragments ( molecular cloning ), cells (cell cloning), or organisms . (wikiquote.org)
  • Molecular cloning refers to the production of multiple copies of a DNA fragment or gene. (geminigenetics.com)
  • Defines both molecular clones and whole-animal clones. (nationalacademies.org)
  • your supposed cloning ban actually authorizes human cloning, implantation, and gestation through the ninth month. (cbc-network.org)
  • And now Washington joins the infamous list with Senate Bill 5594, a thoroughly disingenuous piece of legislation that purports to outlaw the cloning of human beings, but by manipulating language and redefining terms, actually permits human cloning and gestation of the resulting cloned embryos through the ninth month. (cbc-network.org)
  • When the cloning process is used in this way, to produce a living duplicate of an existing animal, it is commonly called reproductive cloning. (eurostemcell.org)
  • General Assembly the adoption of a declaration on human cloning by which Member States were called upon to prohibit all forms of human cloning inasmuch as they are incompatible with human dignity and the protection of human life. (who.int)
  • Several authors have attempted to outline some of the ethical objections to cloning while at the same time minimizing the role religion plays in this debate. (bartleby.com)
  • The ethical and legal controversies that were aroused in the ART debates during the 1980s have been re-ignited with the development of stem cell technology. (edu.au)
  • The report arose out of a recommendation for the Committee to review the report of the Australian Health Ethics Committee (AHEC) of the NHMRC entitled Scientific, Ethical and Regulatory Considerations Relevant to Cloning of Human Beings (hereafter the AHEC Report ). (edu.au)
  • These are then fused by inserting the somatic cell into the 'empty' ovum. (wikipedia.org)
  • The ovum, now containing the somatic cell's nucleus, is stimulated with a shock and will begin to divide. (wikipedia.org)
  • The term applies not only to entire organisms but also to copies of molecules (such as DNA) and cells. (who.int)
  • The stem cells could be studied in the laboratory to help researchers understand what goes wrong in diseases like these. (eurostemcell.org)
  • Claims that you could clone individual treatments of human beings to treat common diseases like diabetes, suggests you need a huge supply of human eggs. (wikiquote.org)
  • The recovered stem cells can then be used in the treatment of diseases and to aid the recovery of injuries. (geminigenetics.com)
  • Gene cloning refers to the identification and duplication of a single gene or a DNA segment, for the intention of investigating its function or creating a particular protein. (geminigenetics.com)
  • The first is that great old standard, "sexual" reproduction, in which sperm meets egg. (cbc-network.org)
  • One of these techniques stages the encounter of sperm with egg in a laboratory dish rather than in a woman's body. (actionlife.org)
  • It is true that the company was not attempting to patent actual sperm or egg cells, but merely facilitate a "preview" of unborn children. (nyu.edu)
  • It defines the term "cloning of a human being" inaccurately. (cbc-network.org)
  • Developments in biotechnology have raised new concerns about animal welfare, as farm animals now have their genomes modified (genetically engineered) or copied (cloned) to propagate certain traits useful to agribusiness, such as meat yield or feed conversion. (wikiquote.org)
  • In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1). (lookformedical.com)
  • In 1995, Campbell and his scientific team used cells grown and differentiated in a laboratory to clone sheep for the first time. (asu.edu)
  • Before the technique will ever make it to the clinic, however, researchers must find a way to remove genomic material from the egg cell. (the-scientist.com)
  • However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
  • If it is to be brought to birth, the process is usually called "reproductive cloning. (cbc-network.org)
  • This process allows people to clone living things of any sort. (bartleby.com)
  • To achieve this success, Scott Noggle at the New York Stem Cell Foundation Laboratory took a unique approach to the process. (the-scientist.com)
  • His embryological work consisted of experiments in understanding the process of generation, and led him to adopt the model of preformationism called ovism (the idea that the new individual exists within the maternal egg prior to conception). (asu.edu)
  • This gives them the ability to create patient specific pluripotent cells, which could then be used in therapies or disease research. (wikipedia.org)
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
  • In the ongoing debate about cloning human embryos for research, and about destroying them in order to harvest their stem cells, it is important to keep some basic facts in mind. (actionlife.org)
  • Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
  • This document has been produced for the benefit of Members of Parliament and others involved in the proposed legislation to permit cloning research on human embryos. (cmq.org.uk)
  • The Donaldson committee 1 examined the issue of research into 'therapeutic' cloning and reported in June 2000. (cmq.org.uk)
  • In 1966, his final year at Nottingham, he received a scholarship to conduct research for a summer under English biologist Ernest John Christopher Polge in the Unit of Reproductive Physiology and Biochemistry, then a division of the Agricultural Research Council at the University of Cambridge. (mathisfunforum.com)
  • From his research on immunology, Good was able to perform the first successful allogeneic (donor and recipient are unrelated) bone marrow transplant. (asu.edu)
  • Maurice Ralph Hilleman developed vaccines at the Merck Institute of Therapeutic Research in West Point, Pennsylvania, during the twentieth century. (asu.edu)
  • Israeli policy is based on the belief that such a pre-embyro does not confer personhood and that many therapeutic applications can be derived from such research. (jcpa.org)
  • In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
  • Noggle said the findings may also pave the way for better induced pluripotent stem cells (iPSCs), which form when somatic cells are regressed to a pluripotent state through the use of genetic factors. (the-scientist.com)
  • Cell lines derived from early embryos that have the potential to differentiate into all types of somatic cells as well as to form germ line cells, and hence whole animals, when injected into early embryos. (nationalacademies.org)
  • Similarly, when the fertilized egg divides from two cells into four cells, each of these four cells has the potential to individually form a human fetus. (jcpa.org)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Given that we have an efficiency of 1% cloning for livestock species and if only one in a thousand cells are viable then around 100,000 cells would need to be transferred. (wikiquote.org)
  • Although the simple use of the word 'clone' may have negative connotations, many people have resigned themselves to the idea of cloning cows that produce more milk or using a cloned mouse for use in controlled experimentation. (bartleby.com)
  • After the somatic cell transfers, the cytoplasmic factors affect the nucleus to become a zygote. (wikipedia.org)
  • Every human being begins as a single-cell zygote, grows through the embryonic stage, then the fetal stage, is born and develops through infancy, through childhood, and through adulthood, until death. (actionlife.org)
  • The egg is then stimulated by an electrical charge, creating a living human zygote. (actionlife.org)
  • This could help researchers identify abnormalities in iPSC differentiation, correct them, and develop pluripotent stem cells that don't harbor tumorigenic qualities and do not require the use of human embryos. (the-scientist.com)
  • On e of the wardens protecting these animals in Chillingham Cattle Park, Denene Crossley, states how "being isolated, they've managed to essentially purify their gene pool, to the point where they're natural clones of each other. (geminigenetics.com)
  • However, by the time the fertilized egg divides into 8 or 16 cells something changes and each respective cell, if separated, no longer has the potential to create a fetus. (jcpa.org)
  • The present report gives an overview of the terms and methods used in cloning and summarizes the debates in the General Assembly. (who.int)
  • Understanding human [eggs'] ability to reprogram could shed light on improved methods for reprograming," said Noggle. (the-scientist.com)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)