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  • effect of thalidomide
  • Drowsiness is a common side effect of thalidomide and people should not operate heavy machinery or drive while using this medication. (news-medical.net)
  • A 24-week trial of the effect of thalidomide and placebo on CSF and plasma biomarkers including BACE1 in patients with mild to moderate Alzheimer's disease is ongoing at Banner Sun Health Research Institute in Sun City, Arizona. (alzforum.org)
  • Specifically, Sawamura's research group used cerebral ischemia model rats of the cerebral artery occlusion/reperfusion (MCAO/R) to examine the effect of thalidomide on infarct lesions caused by cerebral ischemia and related intracellular signals. (eurekalert.org)
  • Moreover, to determine the molecular mechanisms of the effect of thalidomide on neuronal death, they used oxidative stress-induced neuronal cells, which were induced by administration of H2O2, as cerebral ischemia model cells. (eurekalert.org)
  • 2001
  • Stevens, T., & Brynner, R. (2001), Dark remedy: The impact of thalidomide and its revival as a vital medicine. (wikipedia.org)
  • The Insider, Australian Story, 22 February 2001, accessed 26 July 2010 Thalidomide hero found guilty of scientific fraud - Article published in "New Scientist" on 27 February 1991 ] Dr. William McBride Case - Parliament of New South Wales "Time Magazine" Archived 3 September 2009 at the Wayback Machine. (wikipedia.org)
  • fetal
  • To make this discovery, the scientists developed a new animal model for fetal thalidomide exposure by extracting rabbit embryos from pregnant mothers during the first trimester of pregnancy, when the limbs and other structures are developing. (redorbit.com)
  • mothers
  • So far as is known, close to 8,000 babies have been born deformed because their mothers used a sleeping-pill-tranquilizer called thalidomide (TIME, Feb. 23). (time.com)
  • 1997
  • Data from a double-blind, randomized, placebo-controlled trial in HIV-infected patients with oral aphthous ulcers supports the use of thalidomide for this condition [Jacobson . (drugs.com)
  • mechanism
  • There's a new report in the literature on the mechanism of thalidomide , so I thought I'd spend some time talking about the compound. (sciencemag.org)
  • After performing qualitative analysis and assessments on the rats' physical movements, they found that thalidomide treatment significantly decreased the infarct volume and neurological deficits in MCAO/R model rats, and that AMPK was the key signaling protein in the mechanism through additional experiments. (eurekalert.org)
  • pregnant
  • Lynette Rowe, 50, was born without arms and legs after her mother Wendy took Thalidomide for a month while pregnant. (freerepublic.com)
  • Thalidomide is well known for its damaging effects on the unborn baby when taken by a pregnant mother. (news-medical.net)
  • No pregnant woman should take thalidomide in any form. (news-medical.net)
  • Administering thalidomide to pregnant women remains was of the biggest mistakes made in modern medicine," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "Yet we now use thalidomide and related products as effective therapies for serious diseases. (redorbit.com)
  • treatment
  • After 3 cycles of ruxolitinib treatment, either prior to study enrollment or through the ruxolitinib run-in phase, patients who meet eligibility criteria will be treated with ruxolitinib and thalidomide orally on days 1-28 of a 28 day cycle. (clinicaltrials.gov)
  • Data from a trial evaluating the use thalidomide in patients with advanced systemic light chain amyloidosis suggests that thalidomide may be beneficial for the treatment of this condition [Wechalekar . (drugs.com)
  • Data regarding thalidomide, a recognized teratogen, in the treatment of pruritus are limited. (drugs.com)
  • In these cells, we found that the AMPK-CRBN interaction weakened and phosphorylation of AMPK enhanced, but thalidomide treatment restored the AMPK-CRBN interaction and suppressed phosphorylation of AMPK," explains Sawamura. (eurekalert.org)
  • safer
  • This research not only explains what caused all that misery years ago, but promises to help us find safer alternatives to thalidomide in the future. (redorbit.com)
  • CRBN
  • What this implies is that thalidomide regulates AMPK-CRBN interactions in cells under ischemic conditions, meaning, it can suppress nerve cell death. (eurekalert.org)