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  • imbalance
  • An imbalance of Th2 over Th1 immunity is associated with allergic disease and hypersensitivity and mood changes including depression. (health.mil)
  • Our data showed that neferine significantly restored the significant reductions in body weights, the increased levels of lung index and hydroxyproline, the abnormal histological findings, the serum SP-D increase, the Th1/Th2 imbalance by decreasing IL-4 and increasing IFN-γ levels and the increases in the population of CD4+CD25+ Tregs associated with amiodarone instillation in mice. (nih.gov)
  • In conclusion, these results indicated that neferine possessed a significant inhibitory effect on amiodarone-induced pulmonary fibrosis, probably due to its properties of anti-inflammation, SP-D inhibition and restoring increased CD4+CD25+ Tregs which may modulate Th1/Th2 imbalance by suppressing Th2 response (from Th2 polarity toward a Th1 dominant response). (nih.gov)
  • macrophages
  • Interestingly, an immature dendritic cell (iDC) phenotype with a Th2-driving ability and huge populations of alternatively activated macrophages (AAMs) with the ability to suppress lymphocyte proliferation can also be found within this response [ 3 , 5 , 6 ]. (hindawi.com)
  • Several cellular mechanisms have been implicated in T1D development in the NOD mouse, including IL-12-dependent Th1 cells ( 4 ), cytotoxic CD8 + lymphocytes and macrophages ( 5 ), and defective immunoregulation ( 6 ). (jimmunol.org)
  • inhibits
  • Here, we demonstrate that treatment of adult nonobese diabetic (NOD) mice with an analog of 1α,25-dihydroxyvitamin D 3 , an immunomodulatory agent preventing dendritic cell maturation, decreases lipopolysaccharide-induced IL-12 and γ-interferon production, arrests Th1 cell infiltration and progression of insulitis, and inhibits diabetes development at nonhypercalcemic doses. (diabetesjournals.org)
  • response
  • Furthermore, another characteristic of Th2 responses is the suppression of the immune response to bystander antigens, which may compromise the effectiveness of vaccination [ 7 ] and alter the immune response to several other antigens, even autoantigens. (hindawi.com)
  • Clinical
  • Using clinical balance tests to assess fall risk among established unilateral lower limb prosthesis users: cutoff scores and associated validity indices. (bioportfolio.com)
  • These decisions can be guided by standardized clinical balance tests, but require population. (bioportfolio.com)