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Transforming Growth Factor beta1Transforming Growth Factor beta3Transforming Growth Factor beta2Loeys-Dietz SyndromeTransforming Growth Factor betaCamurati-Engelmann SyndromeReceptors, Transforming Growth Factor betaPalateCleft PalateInhibin-beta SubunitsSmad2 ProteinPolymorphism, Single NucleotideGenetic Predisposition to DiseaseGenotypeHaploinsufficiencySmad3 ProteinFollicle Stimulating Hormone, beta SubunitAllelesMarfan SyndromeParacrine CommunicationMitogen-Activated Protein Kinase 14Polymorphism, GeneticTrophoblastsSignal TransductionCleft LipActivinsGene Expression ProfilingHaplotypesMice, KnockoutGenetic Association StudiesGene FrequencyGene Expression RegulationIntegrin beta ChainsHomozygotePhenotypeRadiation InjuriesLinkage DisequilibriumMyofibroblastsCell ProliferationFibrosisIntegrasesSmad ProteinsCase-Control StudiesAutocrine CommunicationGranulosa CellsCorpus LuteumMice, Mutant StrainsHeterozygoteGenetic VariationMice, Inbred C57BLGenetic MarkersOligonucleotide Array Sequence AnalysisRNA, MessengerSpondylitis, AnkylosingPlacentaReverse Transcriptase Polymerase Chain ReactionEmbryo ImplantationPregnancyGene Expression Regulation, DevelopmentalCrosses, GeneticMice, TransgenicGenetic TechniquesExtracellular Matrix ProteinsMutationCells, CulturedProtein-Serine-Threonine KinasesIn Situ Nick-End LabelingIntegrinsGene Regulatory NetworksFollicle Stimulating HormoneUterusBreast NeoplasmsPolymorphism, Single-Stranded ConformationalGenome-Wide Association StudyImmunohistochemistryLod ScoreApoptosisProtein IsoformsRiskEpitheliumGene Expression Regulation, NeoplasticGene ExpressionPolymerase Chain ReactionChromosome MappingCell MovementMice, SCIDCell Line, TumorDisease Models, AnimalCattleInflammationEmbryo, MammalianPromoter Regions, GeneticEndothelial CellsTime FactorsCell DifferentiationMice, Inbred BALB CSwineCohort StudiesBlotting, WesternCell Line
GeneTransforming growPolymorphismsPrognosticProteinGenesCytokinesIdiopathicPromoterLevels
Gene10
  • The TGFB1 gene provides instructions for producing a protein called transforming growth factor beta-1 (TGFβ-1). (medlineplus.gov)
  • At least 12 mutations in the TGFB1 gene have been found to cause Camurati-Engelmann disease. (medlineplus.gov)
  • Most of the TGFB1 gene mutations change single protein building blocks (amino acids) in the TGFβ-1 protein. (medlineplus.gov)
  • All TGFB1 gene mutations that cause Camurati-Engelmann disease result in the production of an overly active TGFβ-1 protein. (medlineplus.gov)
  • Changes in the TGFB1 gene have been reported to be associated with certain cancers. (medlineplus.gov)
  • Studies have shown that TGFB1 gene variants are associated with breast , colorectal, lung , liver, and prostate cancer . (medlineplus.gov)
  • The aim of this study was to analyze common TGFB1 gene promoter polymorphisms C-509T and G-800A in Serbian asthmatics and to investigate their association with exacerbations. (nih.gov)
  • Camurati-Engelmann disease is caused by a genetic change in the TGFB1 gene and inheritance is autosomal dominant. (nih.gov)
  • 533 disease terms (MeSH) has been reported with TGFB1 gene. (cdc.gov)
  • is caused by mutations in the TGFB1 gene. (msdmanuals.com)
Transforming grow3
  • The transforming growth factor beta 1 (TGFB1) is a regulatory cytokine with both tumor suppressor and tumor-promoting effects in breast cancer (BC) cell lines and tissue. (nih.gov)
  • Transforming growth factor beta 1 (TGFB1) is a multifunctional cytokine that plays an important role in airway remodeling in asthma. (nih.gov)
  • Here we will focus on HMG AT-hook 2 protein (HMGA2), a member of the HMGA family that mediates transforming growth factor beta 1 (TGFB1, commonly known as TGFβ1) signaling 16 . (nature.com)
Polymorphisms1
  • Although within B9D2 , these two SNPs are believed to be promoter polymorphisms of TGFB1 . (cdc.gov)
Prognostic3
  • Data about level of circulating TGFB1 and its prognostic significance in BC patients is conflicting. (nih.gov)
  • Serum TGFB1 level is elevated in BC patients and has a favorable prognostic value. (nih.gov)
  • 8. Prognostic value of tgfb1 protein in endometrioid adenocarcinoma. (nih.gov)
Protein3
  • B9D2 is a protein that lies partially within the TGFB1 promoter. (cdc.gov)
  • Many cells synthesize TGFB1 and essentially all of th have specific receptors for this protein. (joplink.net)
  • Haplotype Structures and Protein Levels of TGFB1 in HPV Infection and Cervical Lesion: A Case-Control Study. (nih.gov)
Genes1
  • NPI-110 reduced both visible measures of fibrosis (dermal thickness, collagen density, and fibril bundling) and mRNA expression of pro-fibrotic genes (Tgfb1, c-Myc, Col1a1, Col3a1 ). (uwo.ca)
Cytokines1
  • With that aim, we armored allogeneic CAR T-cells with specific attributes to locally release immune inflammatory cytokines and protect from inhibitory effects of the TGFB1 and PD1 pathways. (cellectis.com)
Idiopathic1
  • The relevance of these findings is demonstrated within the context of TGFB1 signaling and idiopathic pulmonary fibrosis, suggesting therapies against this lethal disease. (nature.com)
Promoter2
  • An analysis of the TGFB1 promoter was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). (nih.gov)
  • These findings should be confirmed in a larger study group, and since the TGFB1 promoter is highly complex and very responsive to environmental factors, future studies should also take other genetic and non-genetic factors into consideration. (nih.gov)
Levels2
  • The objective of this study is to determine the clinical significance of the serum TGFB1 levels in BC patients. (nih.gov)
  • Serum TGFB1 levels were measured by ELISA method and compared with 30 healthy controls. (nih.gov)