The JS-81 monoclonal antibody specifically binds to CD81, which is also known as, Target of the antiproliferative antibody 1 (TAPA1, TAPA-1), or Tetraspanin-28 (Tspan-28/TSPAN28). (bdbiosciences.com)
CD81 is an ~26 kDa transmembrane protein that belongs to the tetraspanin (TM4SF) family. (bdbiosciences.com)
The antibody M38 reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells. (exbio.cz)
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. (exbio.cz)
CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells, e.g. in muscles CD81 promotes cell fusion and myotube maintenance. (exbio.cz)
Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
Mouse monoclonal to CD81.COB81 reacts with the CD81, a target for anti-proliferative antigen (TAPA-1) with 26 kDa MW, which ia a member of the TM4SF tetraspanin family. (woofahs.com)
Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcγ-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. (johnshopkins.edu)
The Tetraspanin Exo-Flow Capture Kit has all the reagents you need to purify exosomes using FACS: streptavidin magnetic beads, CD9, CD63, and CD81 biotin capture antibodies, wash and elution buffers, and reversible Exo-FITC staining (not EXOFLOW800A-1): You supply the FACS and optional magnetic holder (Cat. (histochem.org)
Our well-validated tetraspanin-biotin antibodies (CD9, CD63, and CD81) and high-quality kit components ensure reliable and reproducible exosome purification based on the presence of three general exosome markers (CD9, CD63, and CD81). (histochem.org)
This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. (platcovid.com)
MAbs specific for E2 amino acid (aa) regions 396-407, 412-423 and 528-535 blocked binding to CD81 of all antigens tested. (ox.ac.uk)
Lipopolysaccharide, in addition, induced co-clustering with Toll-like receptor 4, Fcgamma-RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated. (unideb.hu)
TM4SF2
CD63, also known as LIMP, LAMP-3, gp55, and melanoma-associated antigen (ME491), is a member of the tetraspanin superfamily (TM4SF) that constitutes a main component of the lysosomal membrane. (biolegend.com)
TSPAN8 Belongs to the tetraspanin (TM4SF) family. (affbiotech.com)
CD631
The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. (neobiotechnologies.com)
Exosomes contain mRNA and small functional RNA, the microRNA (miRNA), and multivesicular bodies (MVB) associated proteins e.g. heat shock proteins, signal transduction intermediates and metabolic enzymes, and transmembrane proteins such as the integrins, tetraspanins, cytoskeletal proteins, MHC class I and II. (australianprostatecentre.org)
The anti-CD37 (clone3D24) TF car in this product is approximately 58 kD and consists of anti-CD37 (clone3D24) scFv (single-chain variable fragment) linked to a second-generation CAR (chimeric antigen receptor) containing the CD8 hinge and transmembrane domain and 4-1BB and CD3ζ signaling domains. (promab.com)
This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. (platcovid.com)
Antibodies4
Imai T, Yoshie O: C33 antigen and M38 antigen recognized by monoclonal antibodies inhibitory to syncytium formation by human T cell leukemia virus type 1 are both members of the transmembrane 4 superfamily and associate with each other and with CD4 or CD8 in T cells. (exbio.cz)
Fukudome K, Furuse M, Imai T, Nishimura M, Takagi S, Hinuma Y, Yoshie O: Identification of membrane antigen C33 recognized by monoclonal antibodies inhibitory to human T-cell leukemia virus type 1 (HTLV-1)-induced syncytium formation: altered glycosylation of C33 antigen in HTLV-1-positive T cells. (exbio.cz)
The technique includes immuno-capturing of EVs with 15-nm magnetic nanoparticles, staining captured EVs with antibodies against their antigens, and separating them from unbound EVs and free of charge antibodies within a magnetic field, accompanied by stream analysis. (e-core.org)
P1a, tetraspanin protein CD151, BPAG1e, or bullous pemphigoid antigen isoform e, and BPAG2 (also known as BP180 or type 17 collagen). (wikipedia.org)
CD151, a protein of the tetraspanin superfamily, resides on the cell surface of keratinocytes and vascular endothelium. (wikipedia.org)
Integrin4
Type 2 hemidesmosomes contain integrin α6β4 and plectin without the BP antigens. (wikipedia.org)
BPAG2, or (bullous pemphigoid antigen 2), is a transmembrane protein that exists adjacent to integrins, BPAG2 has domains that bind to plectin, integrin β4 subunit in the cytoplasm and integrin α6 and laminin-332 in the extracellular space. (wikipedia.org)
BPAG1e is an antigen with multiple isoforms that binds to integrin α6β4, BPAG2 and keratin 5 and 14. (wikipedia.org)
Berditchevski F, Odintsova E. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. (bdbiosciences.com)
Receptor2
Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. (platcovid.com)
B7 antigens are ligands for specific cell surface receptor subtypes found on T-CELLS. (jefferson.edu)
Cells7
Violin plots show distribution of expression levels for Tetraspanin (SMED30018665) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Tetraspanin (SMED30018665) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for Tetraspanin (SMED30018665) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
A tetraspanin protein found at high levels in cells of the lymphoid-myeloid lineage. (nih.gov)
Since several cells providing EVs exhibit different antigens, EVs made by these cells will vary antigenically. (e-core.org)
Antigen-presenting cells (APCs) produce and release a broad spectrum of EVs involved in the pathogenesis of atherosclerosis. (bmrat.org)
They are secreted by a wide array of cells, including cardiac myocytes, mature and progenitor endothelial cells, mesenchymal stem cells, immune cells like antigen-presenting cells (APCs), and malignant cells 5 , 6 . (bmrat.org)
Antibody4
The CD9 antibody recognizes a 24-kilodalton (kDa) cell surface glycoprotein belonging to the tetraspanin family. (bdbiosciences.com)
CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. (platcovid.com)
Sera from ladies with and without histories of UTI have been tested for antibody levels to vaccine antigens. (morainetownshipdems.org)
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
MIC31
The CD9 antigen is also known as p24, tetraspanin-29 (Tspan-29), motility-related protein-1 (MRP-1), and leucocyte antigen MIC3. (bdbiosciences.com)
Leukocyte1
The leukocyte antigen CD37, encoded by the CD37 gene, is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (promab.com)
Schistosoma2
2006) Tetraspanins on the plane superficially zestril canada buy of Schistosoma mansoni are heedful antigens against schistosomiasis. (upb.ro)
High levels of polymorphism in DNA sequences of tetraspanin-23 (TSP-23) were revealed within and between nine different species of Schistosoma from Africa including Schistosoma mansoni, Schistosoma rodhaini, Schistosoma margrebowiei, Schistosoma mattheei, Schistosoma intercalatum, Schistosoma haematobium, Schistosoma guineensis, Schistosoma curassoni and Schistosoma bovis. (sruc.ac.uk)
Retrieval1
Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). (ptglab.com)
Serum2
We shown for all four vaccine antigens that antigen-specific serum IgG represents a strong correlate of safety in vaccinated mice. (morainetownshipdems.org)
Among these, 25-40% of cases develop castrate resistance prostate cancer (CRPC) with a rise in serum levels of prostate specific antigen (PSA), used as a marker of tumour growth, and continue to progress with metastatic disease. (australianprostatecentre.org)
Vaccine2
This could be indicative of host-specific evolution of antigens in different species of schistosomes, a factor that should be considered carefully when developing vaccine targets. (sruc.ac.uk)
To advance the vaccine for energy in humans, we will group the individual antigens, all associated with iron acquisition (IreA, Hma, IutA, FyuA), into an effective combination to establish a multi-subunit vaccine. (morainetownshipdems.org)
Presentation1
Using GSEA analysis, we found that the antigen processing and presentation pathway were related to the five tumor coexpressed genes mentioned above. (hindawi.com)
Mesh1
B7 Antigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Insulin2
Other outcomes are: (1) Any persistent confirmed beta-cell autoantibody (glutamic acid decarboxylase (GADA), IA-2A, autoantibodies to insulin (IAA) and zinc transporter 8 or tetraspanin 7), or diabetes, (2) Persistent confirmed IAA, (3) Persistent confirmed GADA and (4) Abnormal glucose tolerance or diabetes.Ethics and disseminationThe study is approved by the ethical committees of all participating clinical sites. (ox.ac.uk)
Our research is focused on the role of HLA and non-HLA genes in the etiology and pathogenesis with particular emphasis to uncover the importance of beta cell autoantigens such as GAD65, insulin, IA-2, ZnT8, INS-IGF2 and tetraspanin 7. (lu.se)
Analysis1
Strikingly, immunofluorescence analysis revealed that BST-2/tetherin was excluded from HIV containing tetraspanin-enriched microdomains (TEMs) in both immature DC and IFN-α-matured DC. (biomedcentral.com)