The cholesterol transfer activity of SCARB1 allows E2 exposure and binding of E2 to SCARB1 and the tetraspanin CD81 (PubMed:22767607, PubMed:12913001). (proteopedia.org)
The antibody M38 reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family, expressed on majority of cells. (exbio.cz)
CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. (exbio.cz)
CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells, e.g. in muscles CD81 promotes cell fusion and myotube maintenance. (exbio.cz)
Distribution of CD9, CD81 tetraspanins, and αV integrin within the bull testis. (sav.sk)
Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
Antigen2
CD63, also known as LIMP, LAMP-3, gp55, and melanoma-associated antigen (ME491), is a member of the tetraspanin superfamily (TM4SF) that constitutes a main component of the lysosomal membrane. (biolegend.com)
Among these, 25-40% of cases develop castrate resistance prostate cancer (CRPC) with a rise in serum levels of prostate specific antigen (PSA), used as a marker of tumour growth, and continue to progress with metastatic disease. (australianprostatecentre.org)
Proteins2
Proteins of the tetraspanin family modulate Aβ production by interacting to γ-secretase. (url.edu)
Exosomes contain mRNA and small functional RNA, the microRNA (miRNA), and multivesicular bodies (MVB) associated proteins e.g. heat shock proteins, signal transduction intermediates and metabolic enzymes, and transmembrane proteins such as the integrins, tetraspanins, cytoskeletal proteins, MHC class I and II. (australianprostatecentre.org)
Extracellular vesicles1
Tetraspanins are unevenly distributed across single extracellular vesicles and bias sensitivity to multiplexed cancer biomarkers. (ucdavis.edu)
Metastasis1
Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers. (gitam.edu)
Protein4
Tetraspanin 9 is a protein that in humans is encoded by the TSPAN9 gene. (wikipedia.org)
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (wikipedia.org)
Results: Tetraspanin-6 (TSPAN6) is increased in AD brains and overexpression in cells exerts paradoxical effects on Amyloid Precursor Protein (APP) metabolism, increasing APP-C-terminal fragments (APP-CTF) and Aβ levels at the same time. (url.edu)
A tetraspanin protein found at high levels in cells of the lymphoid-myeloid lineage. (nih.gov)
Available at: h ttps://pubmed.ncbi.nlm.nih.gov/30753992-exosomal-transmission-of-microrna-from-hcv-replicating-cells-stimulates-transdifferentiation-in-hepatic-stellate-cells/ [Accessed 25 Feb. 2020]. (bioscience.co.uk)
Colo-320 cells possess the distinctive feature of lacking endogenous expression of tetraspanin CD9 while they abundantly express integrin α5β1 but not many other members of the β1 integrin subfamily. (encyclopedia.pub)
Examples of EV subpopulation analysis and cargo quantification will be presented, including measurements of a new standard material expressing both endogenous GFP and tetraspanin surface markers. (selectbiosciences.com)
Liblice : Biotechnologický ústav AV ČR, 2023, p. 25. (sav.sk)
Vitro1
The function of the selected tetraspanin was studied in vitro and the physiological relevance of our findings was confirmed in vivo. (url.edu)
Ligand1
To identify biomarkers, nasopharyngeal gene expression was profiled by microarray studies, resulting in the selection of five genes: ubiquitin D, tetraspanin 8, mucin 13, beta-microseminoprotein and chemokine ligand 7. (ru.nl)
Expression4
Methods: We searched for tetraspanins with altered expression in AD brains. (url.edu)
Violin plots show distribution of expression levels for Tetraspanin (SMED30018665) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Tetraspanin (SMED30018665) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for Tetraspanin (SMED30018665) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
Species2
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Tetraspanin 30 (TSPAN30) in samples from Plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
High levels of polymorphism in DNA sequences of tetraspanin-23 (TSP-23) were revealed within and between nine different species of Schistosoma from Africa including Schistosoma mansoni, Schistosoma rodhaini, Schistosoma margrebowiei, Schistosoma mattheei, Schistosoma intercalatum, Schistosoma haematobium, Schistosoma guineensis, Schistosoma curassoni and Schistosoma bovis. (sruc.ac.uk)
Mouse1
Description: A sandwich ELISA kit for detection of Tetraspanin 30 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
Human1
Description: A sandwich quantitative ELISA assay kit for detection of Human Tetraspanin 30 (TSPAN30) in samples from plasma, tissue homogenates, cell lysates or other biological fluids. (kits-elisa.com)
Distribution1
Distribution of tetraspanins in bovine ovarian tissue and fresh/vitrified oocytes. (sav.sk)
Description1
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Tetraspanin 30 (TSPAN30) in Plasma, tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Superfamily3
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. (wikipedia.org)
Tetraspanins CD151, a known transmembrane 4 superfamily protein, contains several different structure domains. (oncotarget.com)
CD81 is a 26 kD non-glycosylated member of the tetraspanin superfamily (TM4SF), also known as TAPA-1 (target of an antiproliferative antibody). (biolegend.com)
The results were published on April 25, 2022 in the open access scientific journal Molecular Systems Biology. (bmedia.nl)
CD1513
Tetraspanin CD151, also known as PETA-3 or SFA-1, has been reported to predict prognosis in various solid tumors. (oncotarget.com)
CD151 and other tetraspanins participate in a variety of key cellular functions [ 1 - 3 ]. (oncotarget.com)
CD151 is the first characterized member of the tetraspanin family. (oncotarget.com)
TSPAN82
4. A Positive Tetraspanin 8 (TSPAN8)/β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells. (nih.gov)
Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. (unibas.ch)
TSPAN303
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Tetraspanin 30 (TSPAN30) in Plasma, tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Tetraspanin 30 (TSPAN30) in samples from Plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (lipidx.org)
Description: A sandwich quantitative ELISA assay kit for detection of Human Tetraspanin 30 (TSPAN30) in samples from plasma, tissue homogenates, cell lysates or other biological fluids. (lipidx.org)
Glycoproteins2
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. (nih.gov)
The 693 amino acid (aa) human GPR56 contains a 25 aa signal sequence, a 377 aa N-terminal extracellular domain (ECD) and seven TM regions separated by short intracellular and extracellular regions. (rndsystems.com)
Gene2
Tetraspanin 9 is a protein that in humans is encoded by the TSPAN9 gene. (wikipedia.org)
The regulation of tetraspanin 8 gene expression-A potential new mechanism in the pathogenesis of bipolar disorder. (cdc.gov)
Regulate1
Tetraspanins might regulate the intrusive procedure for cancers cells by managing the appearance, discharge, and activity of MMP and tissues inhibitors of metalloproteinases (TIMPs). (iassist2012.org)
Member1
26 kD, type III transmembrane protein, member of the TM4SF tetraspanin family. (biolegend.com)
Cell2
Description: A sandwich ELISA kit for detection of Tetraspanin 30 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. (unibas.ch)
Role1
Although ubiquitous, understanding the precise role of some of these tetraspanins in the complement system is the challenge in this combined project in Utrecht and Leiden. (bmedia.nl)
Cells2
A tetraspanin protein found at high levels in cells of the lymphoid-myeloid lineage. (nih.gov)
Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells. (nih.gov)