Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, anti-proliferatives and antimycobacterials. (ac.rs)
TY - JOUR AU - Opsenica, Dejan M. AU - Kyle, DE AU - Milhous, WK AU - Šolaja, Bogdan A. PY - 2003 UR - https://cherry.chem.bg.ac.rs/handle/123456789/555 AB - Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, anti-proliferatives and antimycobacterials. (ac.rs)
article{ author = "Opsenica, Dejan M. and Kyle, DE and Milhous, WK and Šolaja, Bogdan A.", year = "2003", abstract = "Mixed tetraoxanes of the 4"-phenyl-substituted cyclohexyl-spirotetraoxacyclohexyl-spirocholate series have been prepared and evaluated as possible antimalarials, anti-proliferatives and antimycobacterials. (ac.rs)
We present methodology for the synthesis of nonlinear analogues of second-generation tetraoxane antimalarials E209 and N205 to investigate reduced molecular symmetry on in vitro antimalarial activity and physicochemical properties. (bvsalud.org)
Vitro2
Very promising in vitro results of the said tetraoxanes were obtained against solid tumours and, in some instances. (ac.rs)
Results: The addition of a pyrimidinyl residue to an artemisinin or, preferably, a tetraoxane peroxidic structure results in antitubercular activity in vitro. (edu.au)
Synthesis1
This study reports the synthesis and structure of trioxolane-pyrazole ( OZ1 , OZ2 ) and tetraoxane-pyrazole ( T1 , T2 ) hybrids obtained from the reaction of 3(5)-aminopyrazole with endoperoxide-containing building blocks. (nih.gov)
Activity1
In a search for effective compounds against both the blood- and liver-stages of infection by malaria parasites with the ability to block the transmission of the disease to mosquito vectors, a series of hybrid compounds combining either a 1,2,4-trioxane or 1,2,4,5-tetraoxane and 8-aminoquinoline moieties were synthesized and screened for their antimalarial activity. (unl.pt)