Tetrahydrouridine and decitabine were rapidly absorbed into the systemic circulation after a single combination oral dose , with relative bioavailability of decitabine ≥74% in fasted males compared with separate oral administration of THU followed by decitabine 1 h later. (bvsalud.org)
EpiDestiny's therapy, known as EPI01, is an oral, fixed-dose combination of two drugs, decitabine, which inhibits the enzyme that turns off the production of fetal hemoglobin after infancy, and tetrahydrouridine, which turns off an enzyme in the body that destroys decitabine. (nih.gov)
Cytidine deaminase1
1. Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies. (nih.gov)
Inhibits1
Tetrahydrouridine is a synthetic pyrimidine analogue that inhibits deoxycytidine monophosphate (dCMP) deaminase, which in turn inhibits cell proliferation ( PMID: 22616006 , PMID: 32314030 ). (jax.org)
Enzyme1
The drug tetrahydrouridine (THU) blocks an enzyme that breaks down Dec. This increases the time cells are exposed to Dec. The drug nivolumab blocks a signal that prevents white blood cells from attacking cancer. (nih.gov)
Tumors2
7. Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors. (nih.gov)
12. Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro. (nih.gov)
Mice2
3. Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755. (nih.gov)
4. Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma. (nih.gov)
Interaction1
10. Effect of tetrahydrouridine and deoxytetrahydrouridine on the interaction between 2'-deoxycytidine and 1-beta-D-arabinofuranosylcytosine in human leukemia cells. (nih.gov)
Human1
16. Reversal of deamination-related cytotoxicity of 5-methyl-2'-deoxycytidine by tetrahydrouridine in human leukemia cells. (nih.gov)