• protein
  • This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism. (uniprot.org)
  • The phosphoribosylaminoimidazolecarboxamide formyltransferase activity of cytosolic ATIC (bifunctional purine biosynthesis protein PURH) catalyzes the reaction of 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and 10-formyltetrahydrofolate to form 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) and tetrahydrofolate. (reactome.org)
  • gene
  • Moreover, the T allele of the MTHFR gene has been associated with an accumulation of formylated tetrahydrofolate in red blood cells, which is not the normal form of RCF (12). (thefreedictionary.com)
  • The tetrahydrofolate (THF) riboswitch is a conserved RNA element proposed to regulate gene expression based on the presence of THF, while discriminating against closely related analogs. (colorado.edu)
  • units
  • Enzymes that participate in the transfer of one-carbon units require the coenzyme tetrahydrofolate (THF). (ebi.ac.uk)
  • Purines are enzymatically assembled on a 5-phosphoribosyl pyrophosphate (PRPP) molecule derived from the pentose phosphate pathway, with carbon and nitrogen moieties donated by nonessential amino acids and one-carbon formyl units from the tetrahydrofolate (THF) cycle ( Fig. 1A ). (sciencemag.org)