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  • efflux
  • Resistance to these agents is most commonly due to a single base pair deletion in the regulatory region of the mtrCDE locus that results in increased expression of the energy-dependent Mtr efflux pump. (asm.org)
  • tetB
  • All eight classes of genes encoding this mechanism of resistance [tet(O), tet(Q), tet(W), tet(M), tetB(P), tet(S), tet(T), and otrA] were found in total DNA extracted from water of two lagoons. (usgs.gov)
  • Antimicrobials
  • Staphylococcus aureus is a remarkable pathogenic organism that has acquired resistance to all classes of antimicrobials and thus is a continuing threat in both the hospital and community health care settings ( 1 , 21 ). (asm.org)
  • protection proteins
  • In S. pneumoniae , this resistance results from the acquisition of one of two genes, tet (M) or, sporadically, tet (O), both of which encode ribosome protection proteins ( 50 ). (asm.org)
  • strain
  • We therefore characterized the resistance phenotypes of this strain and its close relatives to determine whether they were of recent origin, and therefore likely to be transmissible. (frontiersin.org)
  • Site-saturation and site-directed mutagenesis of Gly-120 and Ala-121 revealed that both a single mutation, G120K, and the double mutations G120R A121H and G120P A121P also conferred antibiotic resistance to the recipient strain. (asm.org)
  • nucleotide
  • Instead, Pro509 at the tip of loop III is located directly within the tetracycline binding site where it interacts with nucleotide C1054 of the 16S rRNA, such that RPP action uses Pro509, rather than Y506/Y507, to directly dislodge and release tetracycline from the ribosome. (pnas.org)