[ 3 ] Larger doses of lidocaine are generally tolerated during tumescent anesthesia for liposuction, probably due to coadministration of epinephrine, the low concentration of lidocaine in tumescent solution, and poor systemic absorption from subcutaneous fat. (medscape.com)
Information derived from diverse formulations, concentrations and usages reveals that lidocaine HCl is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. (nih.gov)
The plasma binding of lidocaine HCl is dependent on drug concentration, and the fraction bound decreases with increasing concentration. (nih.gov)
At concentrations of 1 to 4 mcg of free base per mL 60 to 80 percent of lidocaine HCl is protein bound. (nih.gov)
The morphine analog dibucaine (Rectacaine, Nupercainal) Tetracaine is one type of anaesthetic (Pontocaine, Ametop gel, Viractin). (sportsmoto.co.uk)
Procaine2
Similar effects are observed for local anesthetics such as tetracaine and procaine (functional IC50 values of approximately 5 and approximately 50 microM, respectively), although TMB-8 is the most potent of these agents. (aspetjournals.org)
For information on calculating appropriate amounts of local anesthetic/epinephrine, please refer to the Calculating Concentrations and Dilutions section below. (medscape.com)
Also, as only lower concentrations of topical anesthetics are currently marketed in the United States, physicians often use compounded materials containing higher concentrations of anesthetic. (justia.com)
Tetracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. (hbgymaterial.com)
Tetracaine is a local anesthetic (numbing medicine). (qualitypowders.com)
Tetracaine topical (for the skin) is used to numb different parts of the body before a medical test or procedure. (qualitypowders.com)
Tetracaine topical may also be used for purposes not listed in this medication guide. (qualitypowders.com)
Dibucaine4
The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. (asahq.org)
Higher concentrations of dibucaine and tetracaine were needed to suppress the activation of MAP kinase induced by ionomycin (the IC50 values of dibucaine and tetracaine were 62.5+/-2.2 and 330.5+/-32.8 microM, respectively) compared with potassium chloride (the IC50 values of dibucaine and tetracaine were 17.7+/-1.0 and 70.2+/-1.2 microM, respectively). (asahq.org)
Dibucaine and tetracaine at clinical concentrations were found to inhibit the activation of MAP kinase and the expression of c-Fos mediated by L-type Ca2+ channels in PC12 cells. (asahq.org)
The suppression of MAP kinase pathway may thus be a potential target site for the actions of dibucaine and tetracaine, including the modification of the synaptic functions. (asahq.org)
Intracellular1
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. (qualitypowders.com)
Agonist4
Moreover, functional inhibition by TMB-8 of muscle-type nAChR is due to a reduction in agonist efficacy, but not potency, and is proportionately stronger with increasing agonist concentration, thereby suggesting that TMB-8 acts as a noncompetitive inhibitor. (aspetjournals.org)
To further assess the differences in agonist accessibility to the quinacrine binding site, we calculated the agonist concentration in the lipid membrane (C M ) at an external agonist concentration high enough to inhibit 50% of quinacrine binding (IC 50 ), which in turn was obtained by agonist back titration of AChR-bound quinacrine. (okstate.edu)
initial experiments established that high agonist concentrations do not affect either transmembrane proton concentration equilibria (pH) of AChR membrane suspension or AChR-bound quinacrine fluorescence spectra. (okstate.edu)
The agonist membrane partitioning experiments indicated relatively small (≤20) K p values relative to tetracaine. (okstate.edu)
Creams6
These creams generally have a lower concentration of active ingredients compared to prescription creams. (foxybeauty.co.za)
These creams contain higher concentrations of active ingredients, resulting in longer-lasting effects. (foxybeauty.co.za)
Tetracaine-based creams are often used by healthcare professionals for numbing prior to medical procedures. (foxybeauty.co.za)
The numbing effects of tetracaine-based creams can last for up to two hours. (foxybeauty.co.za)
Some numbing creams come in maximum strength formulations, which contain higher concentrations of active ingredients. (foxybeauty.co.za)
However, some compounding pharmacies offer creams with higher concentrations. (acconciaturevenus.com)
Plasma2
A formulation of bupivacaine that provides prolonged release of the active ingredient after a single administration would simplify pain management in the postoperative period and eliminate the undesired peak plasma concentrations as a result of excessively high concentrations and reduce the risk of local and systemic reactions [ 7 ]. (hindawi.com)
Binding is also dependent on the plasma concentration of the alpha-1-acid glycoprotein. (nih.gov)
High2
At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. (qualitypowders.com)
It was previously demonstrated that high concentrations of cholinergic agonists such as acetylcholine (ACh), carbamylcholine (CCh), suberyldicholine (SubCh) and spin-labelled acetylcholine (SL-ACh) displaced quinacrine from its high-affinity binding site located at the lipid-protein interface of the nicotinic acetylcholine receptor (AChR) (Arias, H. R. and Johnson, D. A. (1995) Biochemistry, 34, 1589-1595). (okstate.edu)
Numbing cream2
The larger the concentration of the active ingredient, the greater important the numbing cream is going to be. (procurementcupboard.org)
The strength of a skin numbing cream depends on its active ingredients and their concentration. (msnho.com)
Peak1
Cyanosis is a time to maximum peak concentration of 90-140 mg/ dl, but constant monitoring of signs and symptoms are involuntary generalized muscular contractions known as erythema of the irreversible inhibition of the. (revivemedicalny.com)
Anaesthetic1
Tetracaine, also known as amethocaine, is the most potent and lipidsoluble ester local anaesthetic and has significant potential for toxicity if used systemically. (hbgymaterial.com)
Reactions1
Rates of positive reactions to those concentrations were 75, 67 and 50 percent, respectively. (dermatologytimes.com)
Effects1
Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes. (hbgymaterial.com)
Lower1
We injected 0.01-0.05 ml of lower concentration (25 mg/g) HA in these particular areas of the upper lip, from the vermillion border into the vermillion. (lww.com)
A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations. (qualitypowders.com)