• Found that choline improves digestion powerful Poses Improve vascular endothelial cells. (cydiablog.com)
  • NO is reactive oxygen radical that is produced in testicular vascular endothelial cells and leydig cells, and by affecting the hypothalamicpituitarygonadal axis causes a reduction in testosterone production and inhibits steroidogenesis [ 5 , 6 ]. (biomedres.info)
  • In the growth of vascular endothelial cells and leuko- addition, we have previously reported the advantage cytes (Hirata et al. (sagepub.com)
  • Adenomatoid tumors represent 30% of the tumors of the testicular adnexa and 60% of benign tumors of these structures. (medscape.com)
  • on rare occasions, it may extend to the testicular parenchyma (most often tumors of the upper pole). (medscape.com)
  • In contrast, tumors arising in the retroperitoneum are virtually always associated with premalignant lesions in one of the testes and behave clinically similar to metastatic testicular seminomas. (medscape.com)
  • The mean age at presentation of patients with seminoma is 40 years, which is 5-10 years older than in patients with nonseminomatous testicular tumors. (medscape.com)
  • In a study of human and rat prostate cancer cells, the expression of GHRHR significantly increases in prostate tumors. (usapeptides.info)
  • In human and rat prostate cancer cells, GHRH causes an increase in the release of growth hormone, and binding of the hormone to the GHRH receptor is increased in prostate tumors. (usapeptides.info)
  • Tumors contain a sub-population of self-renewing and expanding cells known as cancer stem cells (CSCs). (oncotarget.com)
  • Several studies have demonstrated that tumors contain a small subset of cells that share many characteristics with CSCs [ 4 ]. (oncotarget.com)
  • Mast cells can be found in all tissues of the body but typically form tumors on the skin in close to 20 percent of the canine population. (clearcaninecancer.com)
  • Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)
  • Within the adult testis, Germ cells (GC) do not express androgen receptor (AR) suggesting androgen-mediated promotion of spermatogenesis must act via AR-expressing somatic cell-types. (biomedcentral.com)
  • Several recent studies have exploited the Cre/lox system of conditional gene-targeting to ablate AR function from key somatic cell-types in order to establish the cell-specific role of AR in promotion of male fertility. (biomedcentral.com)
  • In the adult testis, Germ cells (GC), do not express AR, and GCs lacking a functional AR mature normally [ 4 ], consequently, androgens are believed to regulate spermatogenesis via androgen-AR signalling in AR-expressing testicular somatic cells. (biomedcentral.com)
  • The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. (novusbio.com)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
  • We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
  • Renal cell apoptosis and plasma creatinine were significantly increased in wild-type versus OLFM4-null pups. (bvsalud.org)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • Administration of troxerutin improves testicular function and structure in type-1 diabetic adult rats by reduction of apoptosis. (journalsmededu.pl)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • Protects retinal pigment epithelium (RPE) cells against oxidative stress-induced and endoplasmic reticulum (ER) stress-induced apoptosis (PubMed:26990160, PubMed:27783653). (cansar.ai)
  • Reduces testicular hormone deprivation-induced apoptosis of germ cells at the nonandrogen-sensitive stages of the seminiferous epithelium cycle (PubMed:19952275). (cansar.ai)
  • Etoposide does not influence phenotype of this sub-population of melanoma cells, while a combined treatment with Etoposide and Bevacizumab significantly abolished P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells. (oncotarget.com)
  • Hypoxic melanoma cells sorted for VEGF-R2/CD133 positivity also undergo apoptosis when exposed to Etoposide and Bevacizumab. (oncotarget.com)
  • In men, testosterone is produced in the testes, where what's called leydig cells work to convert cholesterol into testosterone. (hims.com)
  • The predominant cell population expressing transcripts of the PDGFs and PDGFRs genes during prenatal and early postnatal periods were Sertoli cells and peritubular myoid cells (PMC) or their precursors, respectively, while in adult animals PDGFs and PDGFRs were confined in Leydig cells. (rupress.org)
  • Opposing effects of retinoic acid and FGF9 on Nanos2 expression and meiotic entry of mouse germ cells. (ac.ir)
  • Sodium nitrite causes the irritation of evolving male germ cells by disrupting hormonal balance and tissue anoxia, and by deforming the sperms, causes the reduction of their fertility. (biomedres.info)
  • However, GCTs, including seminomas, can occur in extragonadal sites along the midline of the body, following the embryologic migration route of its precursor cells -- the primordial germ cells. (medscape.com)
  • Researchers have k nown that the production of sperm could be restored in mice that were sterilized after treatment with the chemotherapeutic agent busulfan by injecting immature sperm cells from a donor into their seminiferous tubules-located in the testes. (pennmedicine.org)
  • This intermediate (I)-ProSG subset translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in its periphery soon after birth. (biologists.com)
  • At high doses (5 mg/kg cadmium chloride or higher), testicular damage in mice, rats, and other rodents includes interstitial edema, hemorrhage, and changes in the seminiferous tubules affecting spermatogenesis. (cdc.gov)
  • An inhibitor of CN, the immunosuppressant, FK506, prevented cadmium-induced testicular damage in five pathological categories, including vascular endothelial and seminiferous epithelial endpoints. (cdc.gov)
  • It replaces most of the testicular parenchyma but is organ confined. (medscape.com)
  • Immunofluorescent detection revealed expression of YFP (and therefore Cre Recombinase function) limited to VE cells and an interstitial population of cells, believed to be macrophages, that did not express AR. (biomedcentral.com)
  • The IHC tests showed that the ECM of the mice testicular interstitial tissue showed reaction to anti-laminin-α5 antibody. (biomedres.info)
  • High concentration of sodium nitrate did not change the laminin α5 expression in the ECM of the testicular interstitial tissue. (biomedres.info)
  • Transplanting testicular endothelial cells (but not lung endothelial cells) into the testes of mice after destruction of sperm due to treatment with the chemotherapy drug busulfan restores developing sperm. (pennmedicine.org)
  • Mouse cells in long-term culture restored the ability of mice after chemotherapy-induced infertility to produce sperm. (pennmedicine.org)
  • Mating of Tie2-Cre males to females carrying a floxed AR gene produced Vascular Endothelial Androgen Receptor Knockout (VEARKO) mice and littermate controls. (biomedcentral.com)
  • This study aims to investigate the effects of oral administration of sodium nitrite on expression of laminin α5 in extracellular matrix of mice testicular interestitium using an Immunohistochemical (IHC) assessment. (biomedres.info)
  • GHRH also appears to be necessary for normal testicular function, as evidenced by the fact that mice with knockout of GHRH are infertile and show testicular atrophy. (usapeptides.info)
  • When Etoposide and Bevacizumab-treated hypoxic cells were injected intravenously into immunodeficient mice revealed a reduced capacity to induce lung colonies, which also appear with a longer latency period. (oncotarget.com)
  • FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. (cdc.gov)
  • Ppp3ca-/- mice were investigated but were found to exhibit endogenous testicular abnormalities, making them an inappropriate model for determining whether the inactivation of the Ppp3ca gene would afford protection from cadmium-induced testicular toxicity. (cdc.gov)
  • Dr. Jonasch is Vice-Chair of the NCCN Guidelines Panels for Kidney and Testicular Cancers. (jnccn.org)
  • Squamous cell carcinoma is one of the most common cancers found in dogs. (clearcaninecancer.com)
  • Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)
  • During his presentation at the NCCN 20th Annual Conference, Dr. Jonasch focused on the host of systemic therapies now available for metastatic renal cell carcinoma (RCC) that have category 1 evidence in the most recent version of the NCCN Guidelines. (jnccn.org)
  • They constitute a pool of self-renewing cells with the ability of sustaining tumor growth and promoting metastatic dissemination. (oncotarget.com)
  • Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
  • For years researchers have been trying to find ways to grow and expand these cells from testicular biopsies donated by young patients prior to their cancer treatment, but until now, there has not been a consistently successful approach," said Ryeom. (pennmedicine.org)
  • We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
  • PHILADELPHIA - Researchers have discovered a way to grow human stem cells destined to become mature sperm in an effort to provide fertility options later in life to males who are diagnosed with cancer and undergo chemotherapy and radiation as children. (pennmedicine.org)
  • Cancer treatments leave a majority of boys infertile, as chemotherapy and radiation often kill sperm-producing stem cells (SSCs). (pennmedicine.org)
  • Home to a proud history of "firsts" in medicine, Penn Medicine teams have pioneered discoveries and innovations that have shaped modern medicine, including recent breakthroughs such as CAR T cell therapy for cancer and the mRNA technology used in COVID-19 vaccines. (pennmedicine.org)
  • Steroid users (Parssinen and Seppala in addition, such a positive effect as the gynecomastia include: Cancer (testicular, adrenal, liver, carcinoid) Family history of hormone imbalance. (cydiablog.com)
  • It has been an exciting 15 years for renal cell carcinoma," noted Eric Jonasch, MD, Associate Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, and Director of the Von Hippel-Lindau Clinical Center at The University of Texas MD Anderson Cancer Center. (jnccn.org)
  • Testicular cancer strikes nearly 8,000 men a year, mostly young men between the ages of 15 and 40. (mh.co.za)
  • When caught early enough, testicular cancer can be cured more than 95 percent of the time. (mh.co.za)
  • In comparison to straight men, gay men are more likely to report a cancer diagnosis including testicular cancer, the most common. (hrb.ie)
  • Whilst the body's immune system is designed to detect and destroy cancer cells, tumours are known to produce proteins that suppress the immune response. (hrb.ie)
  • 1976). Serum that is rich in testosterone testicular, breast and prostate cancer, endometriosis, enhances the myoblast formation of satellite and polycystic ovarian syndrome and decreased semen C3H10T1/2 cells (Sinha-Hikim et al. (sagepub.com)
  • Therefore, recycling bovine and estrone enhance growth of breast cancer cells blood in the preparation of serum for cell culture (Lee et al. (sagepub.com)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
  • ROS-modulation in normal vs. cancer cell. (degruyter.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Hence, our study indicates that a combined exposure to Etoposide and Bevacizumab targets melanoma cells endowed with stem-like properties and might be considered a novel approach to treat cancer-initiating cells. (oncotarget.com)
  • Indeed, a 5-year survival rate of advanced stage malignant melanoma is less than 10% and resistance to chemotherapy, most likely due to the presence of cancer stem cells (CSCs), is the major cause of treatment failure [ 1 - 3 ]. (oncotarget.com)
  • Cancer is caused by the uncontrolled growth of cells in the body. (newportharborvets.com)
  • This form of dog cancer is an incurable tumor of cells that line blood vessels, called endothelial cells. (newportharborvets.com)
  • This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. (biomedcentral.com)
  • Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
  • Загальні відомості про терапію злоякісних новоутворень Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)
  • The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
  • Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
  • In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)
  • NO is located in Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), which is essential for the reproductive behaviour, and if their levels exceed the natural amounts, it cause testicular dysfunction, reduction in the production of gonadotropins, and abnormality in the sperm parameters, and ultimately unsuccessful childbearing [ 2 ]. (biomedres.info)
  • Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
  • Protects against high glucose-induced endothelial cell dysfunction by mediating activation of ERK5 which leads to increased expression of transcription factor KLF2 and prevents monocyte adhesion to endothelial cells (PubMed:30029058). (cansar.ai)
  • Khazaei M, Roshankhah S, Ghorbani R, Chobsaz F. Sildenafil effect on nitric oxide secretion by normal human endometrial epithelial cells cultured in vitro . (ac.ir)
  • In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
  • One of the side effects of prolonged exposure to sodium nitrite is testicular toxicity [ 8 ]. (biomedres.info)
  • The goal of this study was to fine map and identify the cdm gene, a gene that when mutated prevents cadmium-induced testicular toxicity in mouse strains with a mutation in this gene. (cdc.gov)
  • It regulates vascular endothelial cell growth, regulates the development of colon and lung epithelium, influences insulin secretion, stimulates gastrin release, and alters pancreatic hormones' secretion. (usapeptides.info)
  • Increases the expression of PPARGC1A/PGC1A in pancreatic beta cells which promotes mitochondrial biogenesis (PubMed:29432738). (cansar.ai)
  • Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (lookformedical.com)
  • A common malignant tumor in dogs is the mast cell tumor . (clearcaninecancer.com)
  • However, the testes of prepubescent boys contain such a small number of SSCs that, in order for this approach to be successful, the cells would need to be grown and multiplied in the lab prior to subsequent reinjection. (pennmedicine.org)
  • For example, human non-small cell lung carcinomas have more GHRH receptors than normal tissue. (usapeptides.info)
  • This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. (lookformedical.com)
  • There is a proliferation of cells ranging from cuboidal to flattened, which form solid cords with an epithelial appearance alternating with tubular and angiomatoid spaces (see the following images). (medscape.com)
  • The growth factors activate specific receptors on the surface of the cells, and the growth signal is transmitted into the cell to produce the proliferation of the cell. (usapeptides.info)
  • Platelet-derived growth factors (PDGFs) are growth-regulatory molecules that stimulate chemotaxis, proliferation and metabolism primarily of cells of mesenchymal origin. (rupress.org)
  • The expression of PDGFRs by PMC and of PDGFs by Sertoli cells corresponds in temporal sequence to the developmental period of PMC proliferation and migration from the interstitium to the peritubulum. (rupress.org)
  • Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. (biomedcentral.com)
  • Given the wide-ranging impact of VE function on both the vascular system and peripheral organs, expression of AR within VE cells of the testicular blood vessels would raise the possibility that androgen-mediated modulation of endothelial cell function within the testis contributes to the regulation of spermatogenesis. (biomedcentral.com)
  • Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
  • Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. (medscape.com)
  • As a supplement in RPMI 1640 medium used to culture human umbilical vein endothelial cells (HUVEC) and in M199 complete medium for ex-vivo treatment of testicular tissue. (sigmaaldrich.com)
  • An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
  • Tissue infiltration by activated innate immune cells, including monocytes, macrophages, and neutrophils, if untreated, leads to rapidly progressive organ injury, that can involve many organ systems. (nature.com)
  • Peptide growth factors regulate the development of normal tissue cells and tumor cells. (usapeptides.info)
  • Human prostatic carcinoma cell lines, with higher GHRH receptors, release more growth hormone than normal prostatic tissue or benign hyperplasia. (usapeptides.info)
  • The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)
  • Antiangiogenic therapies remain the standard of care in the front-line setting for renal cell carcinoma, although vascular endothelial growth factor (VEGF) blockade is not sufficient, and many patients do not respond to such treatment. (jnccn.org)
  • See Renal Cell Carcinoma: Recognition and Follow-up , a Critical Images slideshow, to help evaluate renal masses and determine when and what type of follow-up is necessary. (medscape.com)
  • Renal cell carcinoma may remain clinically occult for most of its course. (medscape.com)
  • Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)
  • Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)
  • Less frequently, a tubular morphology can be seen (see the images below), posing a differential diagnosis with Sertoli cell tumor. (medscape.com)
  • We also found that early postnatal Sertoli cells produce PDGF-like substances and that this production is inhibited dose dependently by follicle-stimulating hormone (FSH). (rupress.org)
  • Moreover, we observed that all the PDGF isoforms and the medium conditioned by early postnatal Sertoli cells show a strong chemotactic activity for PMC which is inhibited by anti-PDGF antibodies. (rupress.org)
  • VE cells line the interior wall ( Tunica Intima ) of all vessels of the circulatory system. (biomedcentral.com)
  • Hypogammaglobulinaemia in patients pre‑ and post‑allogeneic hematopoietic stem cell transplantation. (wikipedia.org)
  • Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
  • Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
  • Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)
  • Cords of adenomatoid tumor cells with focal lymphoid infiltrate. (medscape.com)
  • Methods: Data-mining approaches, cell lines, and patient-derived xenograft models were used to study the levels of 14 members of the SLC2A family (encoding GLUT proteins), 4 members of the hexokinase family (genes HK1-HK3 and GCK), and PSMA (FOLH1 gene) after AR inhibition and in correlation with neuroendocrine hallmarks. (bvsalud.org)
  • Functional studies revealed increased expression of ICAM-1 on induced patient-derived endothelial cells (iECs) and of β2-integrins on patient neutrophils that increase neutrophil adhesion and vascular transendothelial migration (TEM). (nature.com)
  • In this study, we have used a similar approach to specifically ablate AR-signalling from Vascular Endothelial (VE) cells, with a view to defining the significance of androgen signalling within this cell-type on spermatogenesis. (biomedcentral.com)
  • We demonstrate the successful generation and empirical validation of a cell-specific knockout of AR from VE cells, and conclude that AR expression in VE cells is not essential for spermatogenesis or male fertility. (biomedcentral.com)
  • We then exploited a conditional gene targeting approach to specifically ablate AR from endothelial cells of the vascular system to examine the impact of perturbed endothelial AR-signalling on spermatogenesis and male fertility. (biomedcentral.com)
  • Testicular development involves the spatiotemporal control of PDGFs and PDGF receptors gene expression and action. (rupress.org)
  • These data indicate that, through the spatiotemporal pattern of PDGF ligands and receptors expression, PDGF may play a role in testicular development and homeostasis. (rupress.org)
  • Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. (lookformedical.com)
  • Also reduces CASP4 levels in RPE cells, suppresses ER stress-induced mitochondrial superoxide production and plays a role in up-regulation of mitochondrial glutathione (PubMed:27783653). (cansar.ai)
  • At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
  • The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. (lookformedical.com)
  • This study identifies Rasip1 as a unique, endothelial-specific regulator of Rho GTPase signaling, which is essential for blood vessel morphogenesis. (xenbase.org)
  • A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. (biomedcentral.com)
  • Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. (biomedcentral.com)
  • This decrease in testosterone production can lead to problems with sex drive, sperm production, muscle mass levels, fat distribution, bone density and even red blood cell production. (hims.com)
  • 2009). Thus, gender-specific sera with high pressure and electrolytes that play critical roles in or low contents of testosterone and estrogen can cell growth and morphology (Pilili et al. (sagepub.com)
  • AR expression in VE cells of the testicular vasculature was confirmed using an antibody against AR. (biomedcentral.com)
  • Well-defined associations of seminoma are: cryptorchidism, familial history or a previous testicular GCT, certain intersex syndromes, and oligospermic infertility. (medscape.com)
  • Putative CSCs were isolated from human melanoma cells of a different aggressiveness, Hs294T and A375 cell lines, grown under hypoxia using "sphere-forming assay", CD133 surface expression and migration ability. (oncotarget.com)
  • Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12860203, PubMed:19386761, PubMed:12787071, PubMed:12154011). (cansar.ai)
  • VE cells possess an anti-thrombotic surface which facilitates laminar blood flow, whilst permitting nutrients and macromolecules to flow out of the bloodstream through intercellular spaces, the result of endothelial cell contraction or active transport through the cells themselves by transcytosis. (biomedcentral.com)
  • Cardiovascular function depends on patent blood vessel formation by endothelial cells (ECs). (xenbase.org)
  • When you exercise, blood flow increases-blood rushes through the endothelial cells (the lining of the blood vessels) and stimulates them to make more nitric oxide, a key chemical involved in producing erections. (mh.co.za)
  • antioxidant (Francis 2010), and vitronectin/fibronec- In Korea, up to 650,000 cattle are slaughtered every tin aids in cell spreading and heparin and collagen year and around 25 million liters of blood waste is binding activity (Hayman et al. (sagepub.com)
  • However, substitution of serum in cell culture blood from slaughter-houses is used currently for the media has not been successful due to the presence of production of plasma proteins (Belhocine et al. (sagepub.com)
  • An incurable tumor of cells that line blood vessels (endothelial cells). (clearcaninecancer.com)
  • In the intima from normal aorta fibronectin was present in the subendothelial basal layer, along the internal and external elastic laminae, around and between the smooth muscle cells of the media and along the collagen and elastic fibres in the adventitia. (zib.de)
  • Fibronectin, in increased amounts, was found between and around the endothelial cells and in the subendothelial thickenings between the proliferating smooth muscle cells in relation to the fine, thin elastic and argyrophilic fibres. (zib.de)
  • GHRHR is in many tumor cells. (usapeptides.info)
  • These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. (biomedcentral.com)
  • We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
  • At the same time, we already provide customers with high quality gene-editing tools for cell or animal research worldwide. (ubigene.us)
  • 4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
  • Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)
  • These cells have weakly acidophil and markedly vacuolated cytoplasm, without prominent nucleoli and little to no mitotic activity. (medscape.com)
  • Medium magnification showing cords of bland cells with abundant pink cytoplasm and focal vacuolization. (medscape.com)
  • GHRH stimulates somatotroph cells, and the GHRH receptor is expressed in many organs, particularly the brain, pancreas, and gut, suggesting that GHRH is involved in these organs in various functions. (usapeptides.info)
  • Differences in behavior and clinical outcome suggest that mediastinal seminomas are biologically different from gonadal seminomas and can develop de novo without a testicular primary focus. (medscape.com)
  • Recently suggested associations include high estrogen levels, previous radiotherapy or chemotherapy, exposure to organochlorine,[11] abusive use of marijuana,[12] testicular microlithiasis, and nutrition status during infancy, but these reports lack confirmation. (medscape.com)
  • Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
  • cell culture Introduction using charcoal-dextran has been used to study the cellular effect of steroids. (sagepub.com)
  • Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. (biomedcentral.com)
  • pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. (nature.com)