• They are broadly divided in two classes: The germinomatous or seminomatous germ-cell tumors (GGCT, SGCT) include only germinoma and its synonyms dysgerminoma and seminoma. (wikipedia.org)
  • The nongerminomatous or nonseminomatous germ-cell tumors (NGGCT, NSGCT) include all other germ-cell tumors, pure and mixed. (wikipedia.org)
  • The accepted pathogenetic model is a complex network including SOX2, SOX17, OCT3/4 and PRAME, which modulates the epigenetic transcription of numerous downstream genes and drives a divergent gene expression profile resulting in the transition from pure S (P-S) to S component (S-C) of mixed germ cell tumors of the testis (M-GCTT), and finally to embryonal carcinoma (EC). (bvsalud.org)
  • However, clinical significance and prognostic value of MAGE-A2 in different histological subtypes of testicular germ cell tumors (TGCTs) have not been explored. (bvsalud.org)
  • Compared with germinomatous tumors, nongerminomatous tumors tend to grow faster, have an earlier mean age at time of diagnosis (around 25 years versus 35 years, in the case of testicular cancers), and have a lower five-year survival rate. (wikipedia.org)
  • They are found in:[citation needed]} head inside the cranium - pineal and suprasellar locations are most commonly reported inside the mouth - a fairly common location for teratoma neck mediastinum - account for 1% to 5% of all germ cell neoplasms pelvis, particularly sacrococcygeal teratoma In females, GCTs account for 30% of ovarian tumors, but only 1 to 3% of ovarian cancers in North America. (wikipedia.org)
  • In younger women, they are more common, thus in patients under the age of 21, 60% of ovarian tumors are of the germ-cell type, and up to one-third are malignant. (wikipedia.org)
  • The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
  • The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
  • Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
  • Patients with germ-cell cancer often need to be treated with combination chemotherapy for at least three cycles, but female patients with early-stage disease may not require this treatment. (wikipedia.org)
  • Interest in targeting polyamine metabolism as a potential strategy for cancer chemotherapy was stimulated in the early 1970s. (justia.com)
  • Human Cripto-1, also known as teratocarcinoma-derived growth factor-1 (TDGF-1), is a member of the Epidermal growth factor-cripto FRL1 cryptic (EGF-CFC) family (Cripto in humans, FRL1 in Xenopus, and Cryptic in mice), which is indispensable for early embryonic development[ 4 ]. (biomedcentral.com)
  • ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
  • It is one of the most common cancers in Southeast Asia and Southern China. (biomedcentral.com)
  • In general, all patients with malignant GCTs have the same staging surgery that is done for epithelial ovarian cancer. (wikipedia.org)
  • Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
  • INTRODUCTION: Melanoma-associated antigen A2 (MAGE-A2) is a member of the cancer-testis antigen family differentially overexpressed in a variety of malignancies and is associated with tumor development. (bvsalud.org)
  • Nasopharyngeal carcinoma (NPC) is a distinctive type of head and neck cancer with special racial and geographic distributions. (biomedcentral.com)
  • Plain chest radiographs are routinely obtained in patients who are suspected of having cancer and are also used in the staging of cancer, but plain abdominal radiography has a limited role in the investigation of liver metastases. (medscape.com)
  • In younger women, they are more common, thus in patients under the age of 21, 60% of ovarian tumors are of the germ-cell type, and up to one-third are malignant. (wikipedia.org)
  • In general, all patients with malignant GCTs have the same staging surgery that is done for epithelial ovarian cancer. (wikipedia.org)
  • Patients with germ-cell cancer often need to be treated with combination chemotherapy for at least three cycles, but female patients with early-stage disease may not require this treatment. (wikipedia.org)