• NF-E2- related factor-2(Nrf-2), as well as mitogen-activated protein kinase (MAPK), is regulated by SFN. (nih.gov)
  • Genes within the Mitogen Activated Protein Kinase (MAPK) pathway are frequently mutated driver oncogenes in cancer. (ladydavis.ca)
  • Subsequently, the phosphatidylinositol-3-kinase and mitogen-activated protein kinase pathways can be activated, resulting in proliferation and inhibition of apoptosis ( 13 , 14 ). (snmjournals.org)
  • The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability. (wikipedia.org)
  • The normal reference value for the activated protein C resistance (APCR) ratio is greater than 2.1. (medscape.com)
  • APC resistance (APCR) is a hypercoagulability disorder in which factor V cannot be inactivated by APC. (medscape.com)
  • The APCR assay uses snake venoms to activate factor V and prothrombin, thus triggering the lower portion of the clotting pathway and eliminating interference by factor VIII and by lupus anticoagulants (in the absence of phospholipid complexes). (medscape.com)
  • Although the APCR assay is no longer based directly on the activated partial thromboplastin time (aPTT), it is expressed as a ratio of aPTT with APC:aPTT without APC. (medscape.com)
  • Patients with abnormal APCR ratios should have genetic testing to confirm factor V Leiden mutation status. (medscape.com)
  • His reports says: APCR ratio (Activated protein C resistance) is 0.95 L and a normal person should have anywhere between 1.67- 3.75. (ndtv.com)
  • The most common cause of APC resistance (APCR) is a genetic mutation referred to as factor V Leiden. (ndtv.com)
  • Thrombosis may also result if factor V is normal but there is deficiency of Protein C or Protein S or there is abnormal Protein C. The APCR assay is not completely specific for factor V Leiden as it may be positive in any condition that affects the activity of APC. (ndtv.com)
  • In other words, factor V Leiden is characterised by APC resistance but not all APCR is caused by factor V Leiden. (ndtv.com)
  • A: The most unexpected and promising finding is that activation of AMP-activated protein kinase (AMPK), major bioenergetic sensor and metabolic regulator, effectively reversed the maladaptive phenotype of lung fibroblasts. (uab.edu)
  • AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome. (medscape.com)
  • IFN-α and IFN-γ work by binding their receptors and activating downstream antiviral pathways involving the dsRNA-dependent protein kinase (PKR), the 2´, 5´ oligoadenylate synthetase/RNase L, or the MxA protein. (cdc.gov)
  • Agents that activate cAMP-dependent protein kinase (PKA) enhance wound repair while agents that activate protein kinase C (PKC) inhibit wound repair. (cdc.gov)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. (lu.se)
  • We observed greater variation in lower thermal limits, with CT min ranging from 1.81 to 8.60°C, while CT max ranged from 38.74 to 40.64°C. We identified 151 and 99 distinct genes associated with CT min and CT max , respectively, and there was strong support that these genes are involved in both dynamic responses to thermal stress and preparatory processes that increase thermal resistance. (frontiersin.org)
  • Ptr1 was identified by cloning of candidate NLR-encoding genes located in the Ptr1 region and testing using Agrobacterium-mediated transient expression in Nicotiana glutinosa identified one gene for the ability to activate the plant immune system in response to AvrRpt2 in the presence of tomato Rin4. (cornell.edu)
  • This, explains Zhang, drives expression of not only traditional estrogen receptor-positive cancer target genes, but also HER2 and those estrogen receptor target genes abnormally activated by HER2. (uc.edu)
  • An amino acid polymorphism at the binding interface between NRC2 and the inhibitor is sufficient for this helper NLR to evade immune suppression, thereby restoring the activity of multiple disease resistance genes. (bvsalud.org)
  • Based on new findings, UC Cancer Institute scientists believe that tamoxifen resistance may be driven by a novel molecular 'crosstalk point between the estrogen and HER2 (human epidermal growth factor receptor 2) signaling pathways. (uc.edu)
  • Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
  • The mutations associated with resistance to many of the antituberculosis drugs have been identified, though much work remains to be done to identify the molecular basis of resistance for some of the drugs and to determine the predictive value of finding a particular mutation in a strain of M. tuberculosis (1,2). (cdc.gov)
  • For example, approximately 95% of rifampin-resistant M. tuberculosis strains carry mutations within the rifampin-resistance determining region (RRDR), an 81-bp region encoding codons 507 through 533 of the rpoB gene. (cdc.gov)
  • Molecular genetic tests for detecting drug-resistance are, in general, just a variation of nucleic acid amplification (NAA) tests and can reliably provide information on the presence of mutations associated with drug resistance in 1 to 2 days. (cdc.gov)
  • Kits for detecting mutations associated with rifampin resistance that are commercially available in Europe and elsewhere include line-probe assays (INNO-LiPA® Rif.TB, Innogenetics and GenoType® MTBDR( plus ), Hain LifeScience GmbH) and microarray assays (CombiChip Mycobacteria DR, GENE IN). (cdc.gov)
  • Some also detect mutations associated with isoniazid resistance. (cdc.gov)
  • For example, a single-well assay has been developed that uses five molecular beacons to detect mutations associated with rifampin resistance in M. tuberculosis bacteria and appears to perform similarly as the line-probe assays. (cdc.gov)
  • While pursuing medical oncology residency at the University of Toronto and fellowship at the Princess Margaret Cancer Centre, Dr. Rose and her colleagues developed the BEAVER trial (NCT03839342) which is an investigator initiated clinical trial testing the efficacy of specific BRAF + MEK inhibitors in cancer patients with non-V600 BRAF mutations. (ladydavis.ca)
  • Testing for specific mutations in these patients helps to determine the decision on the duration of anticoagulant therapy, risk stratification for primary or secondary prophylaxis. (intechopen.com)
  • Feng's team have discovered that some prostate cancers become resistant to PARP-inhibitors by gaining mutations that overwrite the original BRCA2 mutation and restore the activity of the BRCA2 protein. (pcf.org)
  • In this project, the team will study patients being treated with PARP-inhibitors in clinical trials to comprehensively characterize mutations that cause tumors to be sensitive to PARP-inhibitors, and the mutations that lead to acquired PARP-inhibitor resistance. (pcf.org)
  • However, 25% to 30% of patients with EGFR -activating mutations show intrinsic resistance, and the responders invariably acquire resistance to gefitinib. (aacrjournals.org)
  • The ETP-based APC resistance test involves the addition of APC to a thrombin generation assay (TGA). (wikipedia.org)
  • Whereas the aPTT-based APC resistance test only measures the initiation phase of coagulation, the ETP-based test is a global assay and measures the initiation, propagation, and termination phases of coagulation. (wikipedia.org)
  • The aPTT-based assay is more sensitive to levels of prothrombin and factor VIII, whereas the ETP-based test is more sensitive to levels of tissue factor pathway inhibitor (TFPI) and protein S. The ETP-based test has traditionally been performed using methods such as the calibrated automated thrombogram (CAT) and has been limitedly available due to its technical difficulty. (wikipedia.org)
  • The activated protein C resistance assay is a screening test for the presence of factor V Leiden. (msdmanuals.com)
  • Typically, PCR is used to amplify a target sequence followed by a second assay to determine if the sequence contains a mutation associated with resistance. (cdc.gov)
  • For the INNO-LiPA Rif.TB assay, the pooled sensitivity was 0.97 (95%CI 0.95-0.98) and the pooled specificity was 0.99 (95%CI 0.98-1.00) for detecting rifampin resistance in M. tuberculosis isolates. (cdc.gov)
  • Factor V Leiden (FVLeiden ) is a common hereditary thrombophilia that causes activated protein C (APC) resistance . (nih.gov)
  • Thrombophilia testing results in patients with a first venous thromboembolic event: should the selection criteria for testing be revisited? (cdc.gov)
  • APC resistance can be measured using either an activated partial thromboplastin time (aPTT)-based test or an endogenous thrombin potential (ETP)-based test. (wikipedia.org)
  • This patient's clinical presentation is consistent with heparin resistance, which occurs when the activated partial thromboplastin time (aPTT) does not increase into the therapeutic range despite increasing doses of heparin or when unusually high doses of heparin are required to achieve a therapeutic aPTT. (acponline.org)
  • Diagnose antithrombin deficiency as a cause of heparin resistance. (acponline.org)
  • There may also be coexistent Protein C deficiency along with factor V Leiden. (ndtv.com)
  • Now scientists, reporting in ACS Central Science , have found that insights into a rare genetic disease known as NGLY1 deficiency could help scientists understand how that resistance works-and potentially how drugs can outsmart it. (medicalxpress.com)
  • 100 U/kg/24 hours of activated prothrombin complex concentrate was administered for 24 hours or more to patients receiving HEMLIBRA prophylaxis . (rxlist.com)
  • The initiation phase accounts for less than 5% of total thrombin generation, making aPTT-based tests poorly indicative of hypercoagulability in general. (wikipedia.org)
  • Activated protein C (APC) is the enzymatically active form of protein C after proteolytic cleavage by thrombomodulin-bound thrombin. (medscape.com)
  • The heparin-antithrombin complex then inactivates thrombin, activated factor X (fXa), and other activated clotting factors. (acponline.org)
  • Protein C inhibits thrombin generation by changing into its active form, activated protein C (APC). (ndtv.com)
  • Tests include APTT, PT, mixing studies, hexagonal phase phospholipid test, dilute Russell viper venom time, thrombin time, anticardiolipin IgG and IgM antibodies and anti-beta-2-glycoprotein I IgG and IgM antibodies. (clinlabnavigator.com)
  • Genetic variants analyzed for association with PCOS and subclinical coronary heart disease (CHD) risk measures were the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) single nucleotide polymorphism (SNP) P12A, insulin receptor substrate-1 (IRS-1) SNP G972R, one novel SNP of lipoprotein lipase (LPL), and three novel SNPs from acetyl-CoA carboxylase-beta (ACC-beta). (pitt.edu)
  • It is presently unknown whether peroxisome proliferator-activated receptor (PPAR) β/δ activation prevents inflammation in adipocytes. (diabetesjournals.org)
  • The F5 gene provides instructions for making a protein called coagulation factor V. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury. (medlineplus.gov)
  • For the hybridization assays, the region of the target gene associated with resistance is PCR amplified, and the labeled PCR products hybridized to oligonucleotide probes immobilized on a nitrocellulose strip or in a microarray. (cdc.gov)
  • The culprit in the colon cancer treatment examined in the Nature paper is the KRAS gene, which is responsible for producing a protein to regulate cell division. (sciencedaily.com)
  • When activated, the gene helps cancer cells develop resistance to targeted-therapy drugs, effectively making the treatment useless. (sciencedaily.com)
  • To better understand what role the KRAS gene plays in drug resistance, a team of researchers led by Bert Vogelstein, the Clayton Professor of Oncology and Pathology at the Johns Hopkins Kimmel Cancer Center, launched a study that began by testing patients to determine if the KRAS gene was activated in their tumors. (sciencedaily.com)
  • Patients without an activated KRAS gene underwent a normal round of targeted therapy treatment, and the initial results -- as expected -- were successful. (sciencedaily.com)
  • Tests performed after the treatment broke down, however, showed a surprising result: The KRAS gene had been activated. (sciencedaily.com)
  • Resistance is associated with the nonstructural gene of H5N1 and may be 1 mechanism for H5N1's extraordinary virulence. (cdc.gov)
  • Testing in both pre-clinical models and human breast cancer tissue samples showed that MED1 co-amplifies and co-expresses with HER2, a gene that has an increased presence in 20-30 percent of invasive human breast cancer and plays a major role in tamoxifen resistance. (uc.edu)
  • All tests include full gene sequencing of the coding exons and exon / intron boundaries unless otherwise specified. (cincinnatichildrens.org)
  • BACKGROUND: A trio exome sequencing study identified a previously unreported NLRP1 gene variant resulting in a p.Leu813Pro substitution of the LRR (leucine-rich repeats) domain of the NLRP1 protein (NACHT, LRR and PYD domains-containing protein 1). (bvsalud.org)
  • Certain VKORC1 gene polymorphisms decrease the amount of functional VKORC1 enzyme available to help activate clotting proteins. (medlineplus.gov)
  • Intriguingly, strong evidence has showed the dark side of Nrf-2: stable upregulation of Nrf-2-mediated survival pathway would protect cancer cells from a subset of chemotherapeutic agents tested. (nih.gov)
  • The VKORC1 enzyme helps turn on (activate) clotting proteins in the pathway that forms blood clots . (medlineplus.gov)
  • Ironically, not ordering a test that could provide an accurate diagnosis quickly also could mean greater inconvenience and risk for the patient, not to mention prolonged and exacerbated illness. (clpmag.com)
  • Antiphospholipid I panel includes only coagulation tests for diagnosis of lupus anticoagulant. (clinlabnavigator.com)
  • This revision has been made primarily to update the information on tuberculin skin testing and laboratory services for the diagnosis of tuberculosis, and to remove material pertaining to nontuberculous mycobacterial diseases, which will henceforth be dealt with separately. (cdc.gov)
  • Confirmation of factor V Leiden is then done by DNA-based testing for the mutation. (msdmanuals.com)
  • The condition can be confirmed by a genetic (DNA) test for factor V Leiden, which will pick up the mutation. (ndtv.com)
  • Analyzing the clinical results, Allen and Bozic were able to mathematically describe the exponential growth of the cancer and determine whether the mutation that led to drug resistance was pre-existing, or whether it occurred after treatment began. (sciencedaily.com)
  • The aPTT-based APC resistance test involves a modified aPTT test performed in the presence and absence of activated protein C (APC). (wikipedia.org)
  • Opposite to the case of the APCsr with the aPTT-based APC resistance test, higher nAPCsr values indicate greater APC resistance. (wikipedia.org)
  • However, the aPTT-based APC resistance test is much less sensitive to the procoagulatory effects of estrogens than is the ETP-based test. (wikipedia.org)
  • Pregnancy and ethinylestradiol (EE)-containing combined birth control pills increase APC resistance as measured by either the aPTT- or ETP-based test. (wikipedia.org)
  • In contrast to EE-containing birth control pills, studies have not found increased APC resistance with menopausal hormone therapy or with estetrol- or estradiol-containing birth control pills using the aPTT-based test, though increased APC resistance has been shown with the ETP-based test. (wikipedia.org)
  • Increased APC resistance with both the aPTT-based and ETP-based tests has been observed with feminizing hormone therapy in transgender women, which involves higher doses of estradiol than are used in other contexts. (wikipedia.org)
  • The aPTT-based APC resistance test was developed in 1993, while the ETP-based test was developed in 1997. (wikipedia.org)
  • It was discovered that a locus in Solanum lycopersicoides, termed Pseudomonas tomato race 1 (Ptr1), confers resistance to race 1 Pst strains by recognizing the type III effector AvrRpt2. (cornell.edu)
  • Here, we show that a cyst nematode virulence effector binds and inhibits oligomerization of the helper NLR protein NRC2 by physically preventing intramolecular rearrangements required for activation. (bvsalud.org)
  • Allergy is caused by adverse immune responses to otherwise innocuous proteins, the allergens. (ispub.com)
  • The immune system has the ability to identify and eliminate cancer cells, if properly activated. (pcf.org)
  • The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
  • Treatment strategies that effectively activate the immune system to target cancer will provide a promising new therapeutic opportunity for men with prostate cancer. (pcf.org)
  • To enhance this immune effect, we developed Delta-24-RGDOX, a new generation of Delta-24-RGD virus, that is capable to activate immune cells within a treated tumor, generating an in-situ cancer-vaccine effect. (thecurestartsnow.org)
  • Parasites counteract host immunity by suppressing helper nucleotide binding and leucine-rich repeat (NLR) proteins that function as central nodes in immune receptor networks. (bvsalud.org)
  • which measures resistance to APC and is computed using the ETP), when derived through a validated and standardized methodology, is appropriately sensitive no matter which laboratory is employing it. (medscape.com)
  • They have recently tested a combination of two drugs that directly inhibit these proteins and discovered this therapy, at the right dose, is effective in inhibiting breast cancer growth in the laboratory. (cancercouncil.com.au)
  • Laboratory test results are dependent on the quality of the specimens submitted. (mmchs.org)
  • Like an "if then" statement that leads to different actions based on differences in conditions in a computer program, the coagulation algorithms use reflex tests to guide laboratory technologists in selecting the next test and the next algorithm depending on the results of the previous test. (clpmag.com)
  • The Molecular Genetics Laboratory at Cincinnati Children's performs a variety of tests for patients of all ages. (cincinnatichildrens.org)
  • When a laboratory updates a registered test, a new version number is assigned. (beds.ac.uk)
  • This may be a general statement for the laboratory and not specific to this test. (beds.ac.uk)
  • Does laboratory systematically re-evaluate prior interpretations and generate new reports, or does the person ordering the test need to periodically recontact the labortory to inquire about changes in test interpretation? (beds.ac.uk)
  • Expression of Lcn2 is elevated by agents that promote insulin resistance and is reduced by thiazolidinediones. (diabetesjournals.org)
  • Exogenous Lcn2 promotes insulin resistance in cultured hepatocytes. (diabetesjournals.org)
  • CONCLUSIONS- Lcn2 is an adipokine with potential importance in insulin resistance associated with obesity. (diabetesjournals.org)
  • Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder characterized by insulin resistance and an increased risk of type 2 diabetes mellitus (T2DM), a disorder with epidemic public health significance. (pitt.edu)
  • Generalized linear modeling was utilized to test for association of genotype with subclinical measures of CHD, including insulin resistance (HOMA-IR) and C-reactive protein (CRP). (pitt.edu)
  • In conclusion, the significant risk of T2DM attributed to women by PCOS was not explained by genetic SNPs analyzed here, however, a significant association of G972R and G972RxPCOS interaction with CRP concentrations was found, further supporting the growing body of evidence of associations between insulin resistance and systemic inflammation. (pitt.edu)
  • OBJECTIVE- Chronic activation of the nuclear factor-κB (NF-κB) in white adipose tissue leads to increased production of pro-inflammatory cytokines, which are involved in the development of insulin resistance. (diabetesjournals.org)
  • On binding of insulinlike growth factors to the receptor, adaptor proteins, such as insulin-receptor substrate-1 (IRS-1) and IRS-2, are recruited to the phosphorylation site of the cytoplasmic domain ( 19 - 21 ). (snmjournals.org)
  • Recent statistics indicate that number of epidemiological studies standing of the role of excessive fat dep- nearly 50% of the total Arab population from each country, we did not set any osition in promoting insulin resistance, are less than 25 years of age. (who.int)
  • The performance of the line-probe assays relative to culture-based DS tests was evaluated in meta-analyses (3-5). (cdc.gov)
  • For the MTBDR and MTBDR( plus ) assays, the pooled sensitivity was 0.98 (95%CI 0.96-0.99) and the pooled specificity was 0.99 (95% CI 0.97-0.99) for detecting rifampin resistance in isolates or directly from clinical specimens. (cdc.gov)
  • Recently however, a fully automated commercial test system called the ST Genesia has been introduced, and it has been said that this should allow for adoption of TGAs and ETP-based APC resistance tests in routine clinical settings. (wikipedia.org)
  • In-house PCR-based tests using molecular beacons have also been used for diagnostic purposes in a few clinical laboratories. (cdc.gov)
  • In four studies, the INNO-LiPA Rif.TB showed 100% specificity and sensitivity ranging from 80% to 100% for detecting rifampin resistance directly from clinical specimens. (cdc.gov)
  • Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
  • Recent advances in clot waveform analysis now mean PT and PTT tests can provide more valuable clinical information. (clpmag.com)
  • A panel involves a series of tests, some of which may not necessarily be associated with the clinical condition, whereas, reflex-test based algorithms involve only tests associated with the patients clinical condition - for us in coagulation, that means bleeding or clotting," said Laposata. (clpmag.com)
  • We've tried to associate each algorithm with a clinical situation or an abnormal result for a screening test," said Laposata. (clpmag.com)
  • Presently, at least two drugs are in late-stage clinical testing. (nature.com)
  • We use highly robust pre-clinical in vitro and in vivo mouse models of NRAS and nonV600 BRAF mutated cancers to investigate the molecular mechanisms of therapeutic response and resistance. (ladydavis.ca)
  • The goal of this research is to identify and test more effective treatments, which can be translated back into clinical trials for patients. (ladydavis.ca)
  • However, several new targeted agents are currently being tested in clinical trials for their efficacy in patients with triple-negative breast cancer ( 10 ). (snmjournals.org)
  • Currently, several small-molecule inhibitors and antibodies directed against the IGF-1R are being developed and tested in phase I and II clinical trials. (snmjournals.org)
  • When a lab uses the same methods for a test in both clinical and research settings, the test appears as two separate GTR records. (beds.ac.uk)
  • Is test offered to affected individuals and/or presumed obligate carriers to help determine clinical significance of a VUS? (beds.ac.uk)
  • Is research allowed on the sample after clinical testing is complete? (beds.ac.uk)
  • Both vaccines are being tested in phase I and phase II clinical trials. (pcf.org)
  • The team will conduct a randomized phase II clinical trial in prostate cancer patients testing the PAP vaccine + the anti-PD1 checkpoint inhibitor pembrolizumab, versus the PAP vaccine + the AR vaccine + pembrolizumab. (pcf.org)
  • Dr. McNeel and team will conduct a clinical trial testing the combination of two therapeutic prostate cancer vaccines plus the checkpoint immunotherapy anti-PD1, which may result in an effective new therapy for prostate cancer patients. (pcf.org)
  • The second generation of these biological agents, termed Delta-24-RGD has been tested in several phase I and phase II clinical trials in both adults and children with malignant gliomas and DIPG. (thecurestartsnow.org)
  • Antiphospholipid antibodies are acquired autoantibodies against phospholipids and phospholipid-binding proteins, such as cardiolipin and β 2 -glycoprotein I. In vitro, they can prolong clotting tests, but in vivo, they increase the risk of venous and arterial thrombosis. (acponline.org)
  • Effective prophylaxis and treatment for venous thrombosis are available, but are often not administered because testing for hypercoagulable disorders is not routinely performed and risk factors are not fully understood. (clinlabnavigator.com)
  • In patients with homozygous or heterozygous factor V Leiden resistance , the prolongation of the clotting time is significantly reduced because their factor V is resistant to cleavage by activated protein C. (msdmanuals.com)
  • Some tests are bound to be inappropriate and clinically irrelevant and performing them subjects patients to unnecessary risk, anxiety, inconvenience, potential treatment delays and increased costs. (clpmag.com)
  • CINCINNATI A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease. (uc.edu)
  • Despite advances in hormone therapy drugs, cancer surveillance research has shown that 50 percent of patients will develop resistance to the drug and experience a cancer relapse. (uc.edu)
  • Together, these findings suggest this crosstalk could play a central role in mediating tamoxifen resistance in human breast cancer, especially because recent published data also indicated that high MED1 expression levels correlate with poor treatment outcome and disease-free survival of patients who underwent endocrine therapy, explains Zhang, an assistant professor of cancer biology at the UC College of Medicine and breast cancer researcher with the UC Cancer Institute. (uc.edu)
  • Stable disease and objective responses have been reported in patients treated with these new agents, but no relationship with the IGF-1R expression has been tested in a structured way ( 22 ). (snmjournals.org)
  • Potential allergenicity of a protein is a complex issue and various tests can be made for the prediction, includes in silico as well as in vitro digestibility and binding antisera of allergic patients. (ispub.com)
  • Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional. (beds.ac.uk)
  • However, treatment resistance occurs, necessitating studies that will lead to new therapeutic strategies for these patients. (pcf.org)
  • Feng and team are studying the mechanisms of resistance to PARP-inhibitors and are developing strategies to identify and treat these patients. (pcf.org)
  • The choice of fixed dose combination Atazanavir (as sulfate)/Ritonavir 300 mg/100 mg Tablets for use in treatment-experienced patients should be based on treatment history of patients and, if available, also on individual viral resistance testing (see sections 4.4 and 5.1). (who.int)
  • La présente analyse récapitule les facteurs pathologiques majeurs liant l'obésité au diabète, en se concentrant sur les données épidémiologiques actuelles relatives aux patients diabétiques obèses dans le monde arabe, l'étiologie de la maladie et les déterminants génétiques du diabète et de l'obésité. (who.int)
  • But the drugs have been limited by cancer cells ability to development resistance, as well as the inhibitors inability to fight solid tumors effectively. (medicalxpress.com)
  • Accordingly, this therapeutic combination has never been tested in children with malignant brain tumors and has the potential to induce a vertical advance in the field by inducing the complete regression of these deadly tumors. (thecurestartsnow.org)
  • Can We Measure the Individual Prothrombotic or Prohemorrhagic Tendency by Global Coagulation Tests? (wikipedia.org)
  • Take blood tests, for example, currently there are more than 100 coagulation tests available. (clpmag.com)
  • One way, at least in regard to coagulation tests, is to use the many algorithms developed by Michael Laposata, M.D., Ph.D., and colleagues at Massachusetts General Hospital in Boston. (clpmag.com)
  • We evaluated the practices of companies offering DTC genetic tests for risk of thrombosis using criteria from multiple sources and a minimal set of key practices. (karger.com)
  • The condition APC resistance is a resistance to the anticoagulant function of APC, which promotes clotting of blood in the blood vessels (thrombosis). (ndtv.com)
  • Spontaneous central vein thrombosis in a patient with activated protein C resistance and dengue infection: An association or causation? (medscape.com)
  • Unexpectedly, 8-oxoguanine DNA glycosylase1 (Ogg1) knockout mice show enhanced stimuli-driven IFN expression that confers increased resistance to viral and bacterial infections and allergen challenges. (lu.se)
  • The IgE antibodies bind the intruding allergen, or a structurally similar cross-reacting protein, leading to release of mediators, which causes allergic reactions. (ispub.com)
  • Different types of transgenic proteins food allergen proteins sequences were scanned for IgE epitopes. (ispub.com)
  • This ratio is inversely related to the degree of APC resistance. (wikipedia.org)
  • By 2020 however, a validated methodology was developed aiming to propose a standardized and harmonized scale for ETP-based APC resistance, the normalized activated protein C sensitivity ratio (nAPCsr). (wikipedia.org)
  • They found that NGLY1 is responsible for activating Nrf1, the protein that is suspected of weakening proteasome inhibitors' effectiveness against cancer. (medicalxpress.com)
  • Molecular genetic methods were implemented into the screening examinations for thrombophilic disorders in the 1990's along with the first discoveries of coagulation inhibitors (AT, protein C and protein S). The discovery of the molecular cause of activated protein C (APC) resistance by Bertina in 1994 greatly expanded their utilization. (intechopen.com)
  • Warfarin prevents (inhibits) the action of the VKORC1 enzyme and slows the activation of clotting proteins and clot formation. (medlineplus.gov)
  • The discovery of leptin more than a decade ago established a paradigm in which secreted proteins from adipocytes coordinate energy balance and glucose homeostasis ( 2 , 3 ). (diabetesjournals.org)
  • But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. (medicalxpress.com)
  • McNeel and team are developing prostate cancer vaccines and testing them in combination with checkpoint immunotherapy for the treatment of prostate cancer. (pcf.org)
  • These initial results open an exciting possibility to test the effects of metformin, an AMPK activator, in a model of lung fibrosis in mice. (uab.edu)
  • This results in resistance to degradation of the activated factor V, thus promoting clotting. (ndtv.com)
  • IFN resistance also exists for other viral infections. (cdc.gov)
  • It plays a role in proliferation, apoptosis, angiogenesis, and tumor invasion ( 12 - 14 ), and its expression may be related to resistance to cytotoxic-, antiestrogen-, and HER2 / neu -targeted therapy ( 15 - 18 ). (snmjournals.org)
  • In addition to the well-characterized catalytic activity, recent evidence has shown that certain GST isozymes can regulate mitogen-activated protein kinases or can facilitate the addition of glutathione to cysteine residues in target proteins ( S -glutathionylation). (nature.com)
  • Activated protein C is added to a 5-fold dilution of patient plasma, and the coagulation time is measured. (msdmanuals.com)
  • The blood clotting system of the body comprises multiple plasma proteins that interact with platelets (a type of blood cells) to promote physiological coagulation. (ndtv.com)
  • Methods: To test this hypothesis, we cultured primary tracheal epithelial cells in monolayers from both wild type and dimethylarginine dimethylaminohydrolase (DDAH) overexpressing C57Bl/6 mice and measured wound repair using the electric cell impedance sensing (ECIS) system. (cdc.gov)
  • METHODS: We established an in vitro sepsis model using lipopolysaccharide (LPS)-activated macrophages, followed by transfection of a miR-122-3p mimic into RAW264.7 macrophages. (bvsalud.org)
  • This trial is actively enrolling and includes a number of correlative endpoints, which will allow the identification molecular mechanisms of therapeutic resistance. (ladydavis.ca)
  • This is why factor V Leiden is also (erroneously) known as APC resistance. (ndtv.com)
  • Here, we tested the hypothesis that the DNA repair protein OGG1 recognizes 8-oxoguanine (8-oxoGua) in promoters modulating IFN expression. (lu.se)
  • The expression of Lcn2 is induced during 3T3-L1 adipogenesis in a CCAAT/enhancer-binding protein-dependent manner. (diabetesjournals.org)
  • Over the last three decades, data from cancer studies have linked aberrant expression of GST isozymes with the development and expression of resistance to a variety of chemicals, including cancer drugs. (nature.com)
  • We observed that overexpression of miR-122-3p effectively restored cell viability and attenuated the expression of key inflammatory markers promoted by LPS, such as caspase-1, pro-caspase-1, IL-18, IL-1ß, NLRP3, apoptosis-associated speck-like protein containing CARD, and cleaved- gasdermin-D. Our data indicate that miR-122-3p is capable of directly bounding to NLRP1 and inhibiting its expression. (bvsalud.org)
  • For many years, the ETP-based APC resistance test suffered from a lack of standardization which hampered study-to-study comparison. (wikipedia.org)
  • Hormone-sensitive (i.e., positive) breast cancer cells contain specific proteins known as hormone receptors that become activated once hormones bind to them, leading to cancer growth. (uc.edu)
  • In Arabidopsis and apple, strains of Pst and Erwinia amylovora expressing AvrRpt2 degrade the RIN4 protein, thereby activating RPS2 or Mr5-mediated immunity, respectively. (cornell.edu)
  • Others drugs are being tested for aerosolized delivery to modulate mucosal immunity of the respiratory tract. (cdc.gov)
  • Recent years have seen increased concern about direct-to-consumer (DTC) genetic testing (i.e., the sale and use of genetic tests without involving a health care provider). (karger.com)
  • We conducted a systematic search to identify genetic tests that are sold DTC without involving a health care provider. (karger.com)
  • The prediction of an allergenic protein is important presently due to the specific use of modified proteins in edible foods, therapeutics and biopharmaceuticals (Goodman et al 2005). (ispub.com)
  • We also provided new mechanistic insights to myofibroblast maladaptive reprogramming associated with defective autophagy and ECM turnover, as well as mitochondrial dysfunction linked to myofibroblast resistance to apoptosis. (uab.edu)
  • RESULTS: The variant p.Leu813Pro triggered activation of the NLRP1 inflammasome leading to ASC (apoptosis-associated speck-like protein containing a CARD) speck formation and interleukin (IL)-1ß release. (bvsalud.org)
  • This suggested that overexpression of Nrf-2 resulted in enhanced resistance of cancer cells to chemotherapeutic agents. (nih.gov)
  • A protein called Nrf1 (shown in white in these mouse cells) can hamper promising drugs for blood cancers, but now researchers have found a possible workaround to shut Nrf1 down. (medicalxpress.com)
  • Further testing showed that dampening NGLY1 allowed a proteasome inhibitor to continue doing its work killing cancer cells without interference from Nrf1. (medicalxpress.com)
  • Mediators released by activated cells cause the symptoms of allergy, such as sneezing and swelling of the mucosa, characteristic for allergic rhinitis, allergic conjunctivitis, and asthma. (ispub.com)
  • Importantly, a significant enhancement of wound repair (25% increase in resistance) was observed in DDAH cells vs. wild type cells treated with swine CAFO dust for 24 hr. (cdc.gov)
  • When present in high levels, this protein drives cancer growth and contributes to treatment resistance. (cancercouncil.com.au)
  • Triple negative breast cancers are lacking the key proteins that would make them responsive to the traditional breast cancer drugs, Tamoxifen and Herceptin. (cancercouncil.com.au)
  • Professor Baxter's previous work has shown that triple negative breast cancers often have very high levels of a protein called IGFBP-3. (cancercouncil.com.au)
  • A new, multi-drug approach to treatment could make many cancers manageable, if not curable, illnesses by overcoming resistance to certain drug treatments, a new study suggests. (sciencedaily.com)
  • Nowak is one of several co-authors of a paper, published in Nature on June 28, that details how resistance to targeted drug therapy emerges in colorectal cancers and describes a multidrug approach to treatment that could make many cancers manageable, if not curable. (sciencedaily.com)