• All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
  • As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
  • Other uses of cytostatic chemotherapy agents (including the ones mentioned below) are the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and the suppression of transplant rejections (see immunosuppression and DMARDs ). (wikidoc.org)
  • The targeted-therapy revolution has arrived, but the principles and limitations of chemotherapy discovered by the early researchers still apply. (wikidoc.org)
  • experimental condition [Term] id: XCO:0000002 name: resting def: "A state in which the organism is not exhibiting any physical exertion. (mcw.edu)
  • physical activity [Term] id: XCO:0000009 name: controlled atmosphere composition def: "An experimental condition in which the amount of one or more of the gases which make up the air surrounding an organism are controlled, or in which additional components are added to the air surrounding an organism, as part of the experiment on that organism. (mcw.edu)
  • experimental condition [Term] id: XCO:0000010 name: air oxygen content def: "A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment. (mcw.edu)
  • experimental condition [Term] id: XCO:0000014 name: controlled content diet def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled. (mcw.edu)
  • Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
  • It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including chemotherapy. (worldsbest.rehab)
  • It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
  • Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
  • The first drug used for cancer chemotherapy, however, dates back to the early 20th century, though it was not originally intended for that purpose. (wikidoc.org)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
  • As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
  • however, the most prevalent forms of human cancer respond poorly or not at all to chemotherapy. (doctorlib.info)
  • Malignancies with slower growth rates, such as indolent lymphomas, tend to respond to chemotherapy much more modestly. (wikidoc.org)
  • The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (worldsbest.rehab)
  • Besides the toxic effects of chemotherapy, another major problem is chemoresistance [5]. (savedelicious.com)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology . (worldsbest.rehab)
  • physical activity [Term] id: XCO:0000008 name: running def: "Condition in which the major influencing factor is the action of rapid movement of feet that propels the organism forward or is done on an exercise machine so that the organism performs the activity in place. (mcw.edu)
  • Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
  • This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. (chemscene.com)
  • The primary effect is to interfere with the synthesis of deoxyribonucleic acid (DNA) and to a lesser extent inhibit the formation of ribonucleic acid (RNA). (nih.gov)
  • Watch the video to hear how sarcoma survivor Ned Crystal dealt with the side effects of high dose chemotherapy. (cancerquest.org)
  • Whereas cell-cycle phase-specific chemotherapies are generally given more frequently or as continuous infusions, cell-cycle phase-nonspecific chemotherapies are usually given as a single dose. (basicmedicalkey.com)
  • Prospective dose modification of some chemotherapy and targeted therapies are essential in patients with impaired organ function to reduce the risk of severe adverse events. (basicmedicalkey.com)
  • Myelosuppression is the acute dose-limiting toxicity for most nonspecific chemotherapy. (basicmedicalkey.com)
  • pegargiminase) combined with pemetrexed (Pem) and cisplatin (Cis) chemotherapy in a phase 1 dose-expansion study of patients with argininosuccinate synthetase (ASS1)-deficient metastatic UM. (bvsalud.org)
  • Death of the normal cells produces some of the common side-effects of chemotherapy, including hair loss, anemia, immune suppression and stomach/digestive problems. (cancerquest.org)
  • Many chemotherapy drugs kill cancer cells by causing damage to DNA (their genes). (cancerquest.org)
  • Many of the antimetabolites used in the treatment of cancer interfere with the production of the nucleic acids, RNA and DNA. (cancerquest.org)
  • It is recommended that floxuridine be given only by or under the supervision of a qualified physician who is experienced in cancer chemotherapy and intra-arterial drug therapy and is well versed in the use of potent antimetabolites. (nih.gov)
  • Metabolite is a general term for the organic compounds that are synthesized, recycled, or broken down in cells. (cancerquest.org)
  • The presence of the 'decoy' antimetabolites prevents the cells from carrying out vital functions and the cells are unable to grow and survive. (cancerquest.org)
  • Traditional chemotherapy affects rapidly proliferating cells. (basicmedicalkey.com)
  • Chemotherapy can be either "cell-cycle phase specific," targeting one specific phase of the cell cycle, or "cell-cycle phase nonspecific," targeting all proliferating cells regardless of their place in the cell cycle. (basicmedicalkey.com)
  • Any form of therapy which adds to the stress of the patient, interferes with nutrition or depresses bone marrow function will increase the toxicity of floxuridine. (nih.gov)
  • experimental condition [Term] id: XCO:0000010 name: air oxygen content def: "A condition in which the oxygen level of the air surrounding an organism or breathed by the organism is controlled as part of the experiment. (mcw.edu)
  • experimental condition [Term] id: XCO:0000014 name: controlled content diet def: "A regimen of solid food in which the amount of one or more elements of the diet are controlled. (mcw.edu)
  • solid diet [Term] id: XCO:0000015 name: controlled calorie content diet def: "A regimen of solid food in which the number of calories consumed is controlled. (mcw.edu)