Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (thieme-connect.de)
Radiotherapy with procarbazine, lomustine, and vincristine improves overall survival (OS) in patients with 1p19q co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma. (cambridge.org)
À l'instar de la procarbazine, de la lomustine et de la vincristine, les traitements de radiothérapie améliorent le taux de survie général des patients atteints d'oligodendrogliomes/oligoastrocytomes anaplasiques associés à des codélétions 1p/19q. (cambridge.org)
Vincristine is a 15minute IV drip (intravenous drip), Procarbazine is a tablet for 10 consecutive days, and CCNU (Lomustine) is one tablet. (cancercanwait.com)
Ten patients were treated with temozolomide (TMZ), 3 with procarbazine/lomustine/vincristine (PCV), 3 with platinum-based chemotherapy and 1 patient received epirubicin/ifosfamide. (health-atlas.de)
Chemotherapy10
and temozolomide chemotherapy alone. (cochrane.org)
Furthermore, several randomised trials have shown that the addition of alkylating chemotherapy, either temozolomide or nitrosourea-based regimens, to radiotherapy results in prolonged survival. (smw.ch)
3. Temozolomide (TMZ) - Concomitant TMZ chemotherapy during RT and adjuvant (maintenance) TMZ for 6 cycles has been shown to significantly improve survival (HR 0.63)3. (orlandohealth.com)
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy. (mycancergenome.org)
Recent histopathological confirmation of WHO grade 3 AA - Received EBRT and temozolomide chemotherapy prior to first tumor progression or recurrence of WHO Grade 3 AA. (mycancergenome.org)
NOTE: In the 1st line adjuvant setting, combination of temozolomide (TMZ) with an experimental agent, is considered one line of chemotherapy. (dana-farber.org)
Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (ucbraid.org)
The current chemotherapy options include nitrosoureas (e.g., lomustine) and the imidazotetrazine-class monofunctional DNA alkylating agent, temozolomide (TMZ). (oncotarget.com)
Concomitant temozolomide chemotherapy was applied in 16 cases, combined temozolomide/lomustine chemotherapy was applied in one case and concomitant bevacizumab therapy in one case. (biomedcentral.com)
Median time to radiotherapy in 47 patients (44%) was 34.7 months and 41.2 months in 9 patients with co-deleted/incompletely co-deleted anaplastic oligodendroglioma/anaplastic oligoastrocytoma who received upfront temozolomide alone. (cambridge.org)
A phase I/II/IIb clinical trial with Fibromun in combination with radiotherapy and temozolomide in newly diagnosed glioblastoma ( NCT04443010 ). (philogen.com)
Treatment of Glioblastoma Multiforme with Radiotherapy and Concomitant and Adjuvant Temozolomide: Translation of Randomised Controlled Trial Evidence into Routine Clinical Practice. (medscape.com)
Bevacizumab2
Received any prior treatment with lomustine, agents part of any of the experimental arms, and bevacizumab or other vascular endothelial growth factor (VEGF) or VEGF receptor-mediated targeted agent. (dana-farber.org)
The second study [ 11 ] investigated whether patients with progressive glioblastoma benefit from bevacizumab added to lomustine . (medscape.com)
Glioblastoma6
Tumour-treating fields (TTFields) have emerged as an additional treatment option in combination with maintenance temozolomide treatment for patients with newly diagnosed glioblastoma. (smw.ch)
This phase III trial compares the effect of adding lomustine to temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. (uci.edu)
Adding lomustine to usual treatment of temozolomide and radiation therapy may help shrink and stabilize glioblastoma. (uci.edu)
This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide in patients with newly diagnosed glioblastoma. (uci.edu)
It is not yet known whether dose-escalated photon IMRT or proton beam radiation therapy is more effective than standard-dose radiation therapy with temozolomide in treating glioblastoma. (uci.edu)
This phase II/III trial compares the usual treatment with radiation therapy and temozolomide to radiation therapy in combination with immunotherapy with ipilimumab and nivolumab in treating patients with newly diagnosed MGMT unmethylated glioblastoma. (uci.edu)
Glioma4
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide. (thieme-connect.de)
It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma. (ucbraid.org)
A phase I/II clinical trial with Fibromun in combination with lomustine in grade III/IV glioma at first relapse ( NCT04573192 ). (philogen.com)
[ 10 ] This trial showed that patients with 1p/19q non-codeleted anaplastic glioma receive benefit when temozolomide is added to standard therapy. (medscape.com)
Irradiation1
GTR) then external beam irradiation with concomitant temozolomide (TMZ). (nature.com)
Eflornithine1
A total of approximately 340 patients will be randomized in a 1:1 ratio to receive either eflornithine + lomustine or lomustine alone. (mycancergenome.org)
TUMORS1
Temozolomide, may not work as well for the treatment of tumors that have the unmethylated MGMT. (uci.edu)
Radiation3
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. (stanford.edu)
Drugs, such as temozolomide, may make tumor cells more sensitive to radiation therapy. (uci.edu)
Giving radiation therapy with ipilimumab and nivolumab may lengthen the time without brain tumor returning or growing and may extend patients' life compared to usual treatment with radiation therapy and temozolomide. (uci.edu)
Survival2
6. Lomustine-TMZ as maintenance therapy might improve survival in newly diagnosed patients compared to maintenance TMZ alone, as suggested by an open-label phase 3 trial in 141 patients, which demonstrated a HR of 0.6 (95% CI 0.35-1.03, p=0.0492) for the combined treatment9. (orlandohealth.com)
Unfortunately, no survival benefit was seen compared with lomustine alone. (medscape.com)
Gliomas1
Temozolomide and 13-cis reinoic acid patients with anaplastic gliomas: a prospective single-arm monocentric phase-II study (RNOP-05). (neuroonkologische-arbeitsgemeinschaft.de)
Patients1
Patients who are considered to be refractory to EBRT and temozolomide but who have not progressed. (mycancergenome.org)
Treatment1
Other pathways must be activated to escape from temozolomide (TMZ) treatment, however acquired resistance mechanisms to TMZ are not well understood. (nature.com)
Days1
The second option, Temozolomide , is less toxic and consists of 5 tablets a month (every 28 days), on consecutive days. (cancercanwait.com)