Temozolomide. Medical search. Frequent questions

Encouraging experience of concomitant Temozolomide with radiotherapy followed by adjuvant Temozolomide in newly diagnosed glioblastoma multiforme: single institution experience. (nih.gov)
Factors predicting recurrence in patients with grade III glial tumors: impact of adjuvant temozolomide on recurrence. (drugurcoskun.com)

Temozolomide is contraindicated in people with hypersensitivity to it or to the similar drug dacarbazine. (wikipedia.org)
MTIC, the active metabolite AIC (part of the naturally occurring AICA ribonucleotide) The related drug dacarbazine for comparison Temozolomide is an imidazotetrazine derivative. (wikipedia.org)
tell your doctor and pharmacist if you are allergic to temozolomide, dacarbazine (DTIC-Dome) any other medications, or any of the ingredients in temozolomide capsules. (medlineplus.gov)
You should say whether you have an allergy to temozolomide, dacarbazine or any other part of this drug. (medexmd.com)

In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. (nih.gov)
At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with radiotherapy alone. (nih.gov)
The two-year survival rate was 26.5 percent with radiotherapy plus temozolomide and 10.4 percent with radiotherapy alone. (nih.gov)
Concomitant treatment with radiotherapy plus temozolomide resulted in grade 3 or 4 hematologic toxic effects in 7 percent of patients. (nih.gov)
This study also aims to determine whether treatment with SurVaxM plus temozolomide improves the survival of glioblastoma patients like yourself compared to treatment with temozolomide alone. (dana-farber.org)
12. Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. (nih.gov)

Temozolomide, sold under the brand name Temodar among others, is an anticancer medication used to treat brain tumors such as glioblastoma and anaplastic astrocytoma. (wikipedia.org)
Temozolomide is also used to treat aggressive pituitary tumors and pituitary cancer. (wikipedia.org)
In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. (wikipedia.org)
Conversely, the presence of AGT protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide. (wikipedia.org)
Temozolomide is used to treat certain types of brain tumors. (medlineplus.gov)
For some types of brain tumors, temozolomide is taken daily for 42-49 days. (medlineplus.gov)
For treatment of other types of brain tumors, temozolomide is taken once a day for 5 days in a row, followed by a 23-day break before repeating the next dosage cycle. (medlineplus.gov)
Temozolomide is an orally administered alkylating agent used largely in the therapy of malignant brain tumors including glioblastoma and astrocytoma. (nih.gov)
The reception of Temozolomide 100 mg was accompanied by very severe, sometimes fatal, disorders of the bone marrow and the development of secondary tumors. (medexmd.com)
ChemotherapyAdvisor) - Patients with locally advanced or metastatic pancreatic neuroendocrine tumors (NETs) appear to benefit from the combination of temozolomide and bevacizumab, a phase 2 study has shown. (cancertherapyadvisor.com)
Glioblastoma multiforme (GBM) is the most fatal cancer among brain tumors, and the standard treatment of GBM patients is surgical tumor resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. (ntu.edu.tw)
Objectives The combination chemotherapy regimen capecitabine/temozolomide (CAPTEM) is efficacious for metastatic well-differentiated pancreatic neuroendocrine tumors (PNETs), but its role in the neoadjuvant setting has not been established. (elsevierpure.com)

It represents the first randomized clinical trial of temozolomide and capecitabine in advanced pancreatic NETs. (medpagetoday.com)

Temozolomide capsules is administered in combination with focal radiotherapy (concomitant phase) followed by up to 6 cycles of temozolomide (TMZ) monotherapy (monotherapy phase). (tajgenerics.com)
The standard treatment of GB consists of maximal resection followed by radiotherapy and concomitant chemotherapy with the alkylating agent temozolomide (TMZ) [ 3 ]. (biomedcentral.com)

we start with a combined therapy of 13,5 mg cortison/day + 140mg temodal (temozolomide)/day + a unknown starting dose of thalidomide on a family member with several inoperable glioblastoma multiforme's. (science-bbs.com)

To learn the highest dose of selinexor that people with brain cancer can tolerate when given with temozolomide and radiation therapy. (nih.gov)

The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity. (nih.gov)
It is unknown whether the addition of temozolomide (TMZ) to radiotherapy (RT) is associated with improved overall survival (OS) among older glioblastoma patients. (nih.gov)

Temozolomide comes as a capsule to take by mouth. (medlineplus.gov)
Pill with imprint barr 5 mg 1078 is White, Capsule/Oblong and has been identified as Temozolomide 5 mg. (drugs.com)

Temozolomide is approved by the FDA for the treatment of newly diagnosed glioblastoma multiforme (GBM) and refractory anaplastic astrocytoma cancers. (ucsd.edu)

NEW YORK (Reuters Health) Jul 05 - Temozolomide extends survival and improves function and quality of life in severely impaired older patients newly diagnosed with glioblastoma, according to the results of a new phase II trial. (medscape.com)
One-third of patients in the study experienced improvements in functional status, while a quarter became capable of self-care after temozolomide treatment, before disease progression occurred, said Dr. Jaime Gallego Perez-Larraya of the Groupe Hospitalier Pitie-Salpetriere in Paris and colleagues. (medscape.com)
We not only observed that temozolomide did not worsen the patients' quality of life, but also that one third of patients improved their performance status, and most of these improving patients became capable of self-care. (medscape.com)
He concluded: "Treatment with temozolomide alone is feasible in elderly patients with glioblastoma and impaired functional status. (medscape.com)
This is a summary of a preprint research study, " Assessment of clinical effect of long-term administration of maintenance temozolomide therapy in patients with IDH1/2-wildtype glioblastoma ," written by researchers at the National Cancer Center Hospital, Japan on ResearchSquare.com provided to you by Medscape. (medscape.com)
Cite this: Long-Term Temozolomide in Patients With Glioblastoma - Medscape - Apr 12, 2022. (medscape.com)
These results suggest that the combination of capecitabine and temozolomide should be included as a standard treatment option for patients with advanced pancreatic NETs and is a reasonable comparator arm in future randomized studies. (medpagetoday.com)
As the team reported in the Journal of Clinical Oncology , the final analysis of data from the 133 predominantly white, male, non-Hispanic patients enrolled in the ECOG-ACRIN E2211 trial showed that median progression-free survival (PFS) was 23.2 months in the capecitabine-temozolomide arm, and 15.1 months in the temozolomide-only arm. (medpagetoday.com)
There was a statistically significant difference in OS at the planned interim analysis, with a median OS of 38 months for patients treated with single-agent temozolomide and not reached for those in the combination arm. (medpagetoday.com)
This indicates that temozolomide can be considered for some patients who may not be able to tolerate the combination due to other medical comorbidities. (medpagetoday.com)
The main purpose of this study is to determine whether adding SurVaxM to standard-of-care temozolomide chemotherapy is better than temozolomide treatment alone for patients with newly diagnosed glioblastoma. (dana-farber.org)
This study is designed to compare the length of survival in patients with newly diagnosed glioblastoma who receive temozolomide plus SurVaxM to that of patients treated with standard-of-care temozolomide plus placebo. (dana-farber.org)
This phase I/II trial tests the safety, side effects and best dose of selinexor given in combination with the usual chemotherapy (temozolomide) and compares the effect of this combination therapy vs. the usual chemotherapy alone (temozolomide) in treating patients with glioblastoma that has come back (recurrent). (roswellpark.org)
Giving selinexor in combination with usual chemotherapy (temozolomide) may shrink or stabilize the tumor better than the usual chemotherapy with temozolomide alone in patients with recurrent glioblastoma. (roswellpark.org)
A Randomized Phase II Trial of Temozolomide (TMZ) with/without Recentin (AZD2171) in Patients with unresectable Stage IV Malignant Melanoma. (astrazenecaclinicaltrials.com)
Jennifer A. Chan, MD, MPH, of Dana-Farber Cancer Institute, Boston, MA, and colleagues treated 34 patients-56% with carcinoid and 44% with pancreatic NETs-with oral temozolomide 150mg/m 2 /day days 1-7 and days 15-21 with bevacizumab 5mg/kg/day IV days 1 and 15 of each 28-day cycle. (cancertherapyadvisor.com)
We present data from a dose-finding study of the ErbB inhibitor afatinib in combination with radiotherapy (RT), with or without temozolomide (TMZ), in patients with GBM. (liverpool.ac.uk)
It was a retrospective study in the population of patients with diagnosed grade 3 neuroendocrine neoplasms of different origin treated with capecitabine and temozolomide. (viamedica.pl)
The study included 32 patients with grade 3 neuroendocrine tumours treated with capecitabine and temozolomide. (viamedica.pl)
2. Patients must be eligible for definitive external beam radiotherapy and temozolomide. (nih.gov)
Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study. (uib.no)
Comparative effectiveness of radiotherapy with vs. without temozolomide in older patients with glioblastoma. (nih.gov)

medical citation needed] Other metabolites include temozolomide acid and unidentified hydrophilic substances. (wikipedia.org)
Temozolomide 5 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)

Take temozolomide capsules on an empty stomach with a glass of water. (medlineplus.gov)
Temozolomide capsules come in several different strengths. (medlineplus.gov)
Temozolomide capsules should only be prescribed by physicians experienced in the oncological treatment of brain tumours. (tajgenerics.com)

Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. (nih.gov)

Olaparib in combination with temozolomide demonstrated substantial clinical activity in relapsed small cell lung cancer. (wikipedia.org)
The combination is associated with improved PFS compared with temozolomide alone and is associated with the longest PFS and highest RR reported in randomized trials of pancreatic NETs. (medpagetoday.com)
Our findings that the combination of temozolomide and capecitabine is more effective confirmed our hypothesis and reinforced findings from retrospective studies. (medpagetoday.com)
The combination of Temozolomide 100 mg with some medications and diseases can be unfavorable. (medexmd.com)
16. Temozolomide in paediatric high-grade glioma: a key for combination therapy? (nih.gov)

Further studies examining the optimal dose regimen for temozolomide and the relative contributions of temozolomide and bevacizumab to the antitumor activity and PFS are warranted," they concluded. (cancertherapyadvisor.com)
Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnoses, MGMT-nonmethylated glioblastoma. (neuroonkologische-arbeitsgemeinschaft.de)

Now, results from a randomized phase II trial show significantly improved progression-free survival (PFS) and a clinically meaningful improvement in overall survival (OS) with combined capecitabine-temozolomide compared with temozolomide alone. (medpagetoday.com)
However, this trend did not reach statistical significance in the final analysis, which showed a median OS of 53.8 months in the temozolomide arm and 58.7 months in the capecitabine-temozolomide arm. (medpagetoday.com)
The response rate (RR) with capecitabine/temozolomide was 39.7% -- higher than that reported with other available therapies. (medpagetoday.com)
Many retrospective studies have confirmed that capecitabine combined with temozolomide is effective in neuroendocrine neoplasms. (viamedica.pl)
There are limited data regarding the efficacy capecitabine with temozolomide in grade 3 neuroendocrine tumours. (viamedica.pl)

Your doctor may need to delay your treatment or adjust your dose of temozolomide depending on your response to treatment and any side effects that you experience. (medlineplus.gov)
Temozolomide is a medicine that is used for the treatment of brain tumours. (sgh.com.sg)
Temozolomide has been associated with a low rate of serum enzyme elevations during treatment and with rare instances of clinically apparent cholestatic liver injury. (nih.gov)
Temozolomide and treatment of malignant glioma. (nih.gov)
abstract = "Clinical trials have shown temozolomide to be an effective agent for treatment of malignant melanoma. (aston.ac.uk)
These results suggest that temozolomide esters could be an effective alternative to temozolomide in the treatment of skin cancer. (aston.ac.uk)
Even with aggressive treatment, tumor recurrence is almost universal and patient prognosis is poor because many GBM cell subpopulations, especially the mesenchymal and glioma stem cell populations, are resistant to temozolomide (TMZ) the most commonly used chemotherapeutic in GBM. (authorea.com)
Temozolomide is considered experimental because it is not approved by the FDA for the treatment of SDH-Mutant/Deficient Gastrointestinal Stromal Tumor . (ucsd.edu)
Temozolomide dose may be held and/or modified for the management of adverse treatment effects according to pre-specified criteria. (ucsd.edu)
We have treated the LN405 glioblastoma cell line with temozolomide, panobinostat, and combined treatment, in order to test apoptosis, colony formation, and a possible molecular reversion of the mesenchymal phenotype of the cells to an epithelial one. (unav.edu)
Temozolomide (TMZ) is a drug of choice in glioblastoma treatment . (bvsalud.org)
8. The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation. (nih.gov)

1. Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. (nih.gov)
9. Regimen of procarbazine, lomustine, and vincristine versus temozolomide for gliomas. (nih.gov)

In cultured glioma cells, we show that PAM-OBG is converted to O 6 BG, inhibiting MGMT and sensitizing cells to DNA alkylating agents such as BCNU, CCNU, and Temozolomide (TMZ). (oncotarget.com)
3. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. (nih.gov)
10. Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide. (nih.gov)

The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. (wikipedia.org)
medical citation needed] However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein O6-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. (wikipedia.org)
Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions. (bvsalud.org)
The aim of our research was to explore a novel epigenetic mechanism of temozolomide action in therapeutic conditions. (bvsalud.org)

MGMT deficiency may predict a higher likelihood of objective response to this regimen," the researchers said, noting that this is the first randomized trial to examine MGMT as a biomarker for temozolomide-based chemotherapy. (medpagetoday.com)

4. Second-line chemotherapy with temozolomide in recurrent oligodendroglioma after PCV (procarbazine, lomustine and vincristine) chemotherapy: EORTC Brain Tumor Group phase II study 26972. (nih.gov)

Do not take another dose of temozolomide on the same day. (medlineplus.gov)
13. "One week on-one week off": efficacy and side effects of dose-intensified temozolomide chemotherapy: experiences of a single center. (nih.gov)

In vitro assays demonstrated temozolomide, temozolomide acid and the hexyl ester equi-effective against selected cancer cell lines. (aston.ac.uk)
Temozolomide 100 mg is used to treat brain cancer. (medexmd.com)

Nonetheless, the rate of temozolomide penetration from blood to cerebrospinal fluid is only 20-30%, and even smaller into brain intestinum. (bvsalud.org)

7. Treating anaplastic oligodendrogliomas and WHO grade 2 gliomas: PCV or temozolomide? (nih.gov)

2. History of allergic reactions attributed to compounds of similar chemical or biologic composition to selinexor or temozolomide used in study. (nih.gov)

We hereby describe a novel approach for treating GBM by CED of liposomes containing the known chemotherapeutic agent, temozolomide (TMZ). (huji.ac.il)

Like all chemotherapy drugs, temozolomide (TMZ) may cause one or more side-effects. (thebraintumourcharity.org)

While GEPCOT NICs were ablated by temozolomide, pre-GEPCOT cells survived and repopulated the SVZ. (nih.gov)
XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair. (nih.gov)

Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide. (nih.gov)
You can find full, detailed drug information on temozolomide in the electronic Medicines Compendium (eMC). (thebraintumourcharity.org)
The purpose of this study is to investigate SDH-Mutant/Deficient Gastrointestinal Stromal cancer's response to the drug Temozolomide (TMZ) and aim to improve patient outcomes. (ucsd.edu)

Acute temozolomide induced liver injury : Mixed type hepatocellular and cholestatic toxicity. (nih.gov)

PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation. (oncotarget.com)

Mirroring its medicinal use as an alkylating antineoplastic agent, temozolomide has been reported to be a comparatively safe and stable in situ source of diazomethane in organic synthesis. (wikipedia.org)

Anatomy5

Organisms2

Diseases34

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes25

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

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Health Care13

Adjuvant temozolomide2

Dacarbazine4

Plus temozolomide6

Tumors12

Randomized clinical trial of tem1

Concomitant2

Temodal1

Given With Temozolomide1

Addition of temozolomide2

Capsule2

Newly diagnosed glioblastoma multiforme1

Patients22

Substances2

Capsules3

Chemotherapy alone1

Combination5

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Treatment12

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Glioma3

Therapeutic4

Biomarker1

Vincristine1

Dose2

Cancer2

Brain1

Gliomas1

Selinexor1

Chemotherapeutic1

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Drug3

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MGMT1

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