• Telomeres (in white) cap the ends of human chromosomes, protecting the genetic information from damage. (howstuffworks.com)
  • Discovered in 1938 by gen-eticist Hermann J. Müller, telomeres (Greek for 'end part') are essentially protective caps composed of short DNA sequences on the tips of chromosomes. (howstuffworks.com)
  • Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. (sciencedaily.com)
  • Our current understanding of cellular aging rests upon the uncapping of the repetitive, non-protein-coding extremities of our linear chromosomes called telomeres. (genengnews.com)
  • Telomeres specialized structures found at the ends of chromosomes are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. (cshlpress.com)
  • Telomeres are specialized structures that evolved to protect the end of linear chromosomes from the action of the cell DNA damage machinery. (nih.gov)
  • Short telomeres - the protective caps on the ends of chromosomes - have been previously linked to increased risk of death from heart disease. (scienceblog.com)
  • A bit like those plastic tips on the ends of your shoelaces, telomeres prevent the ends of the chromosomes from fraying. (glycemicindex.com)
  • In more scientific terms, telomeres protect the integrity of information carrying throughout each cell cycle by serving as specialized DNA caps on chromosomes. (glycemicindex.com)
  • Shorter telomeres on the ends of white blood cell chromosomes were discovered to be associated with an increased risk of dementia. (nepalnews.com)
  • A telomere, which looks like a shoelace cap, is intended to keep chromosomes from fraying or unravelling during replication. (nepalnews.com)
  • Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. (goodreads.com)
  • Telomeres are the tips at the ends of chromosomes that protect our DNA. (enzymedica.com)
  • A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. (news-medical.net)
  • Our telomeres get shorter with every cell division until they eventually become too small to protect the chromosomes. (antiaging-systems.com)
  • Consider telomeres little helmets for your DNA: These protein structures cap off both sides of our chromosomes to protect them from damage and decay over time. (mindbodygreen.com)
  • Genetic from Mendel to the Era of He had just observed that the ends of the irradiated chromosomes, different from the other genome, did not present alterations such as deletions or inversions, thanks to the presence of a protective cap that he called «terminal gene» and afterwards «telomere», from the Greek terms «telos» (end) and «meros» (part) (Müller HJ. (slideshare.net)
  • It all depends on the length of the telomeres, which are described as "acting like the plastic ends on shoelaces" to protect chromosomes from wear and tear. (bellenews.com)
  • Professor Elizabeth Blackburn won the Nobel Prize in Physiology or Medicine in 2009, jointly with professor Carol Greider and professor Jack Szostak, for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. (frontiersin.org)
  • Linear eukaryotic chromosomes contain specialized protective structures at the chromosome ends, called telomeres, which are essential for maintaining genome stability. (ubc.ca)
  • So, what if it were possible to treat them by acting on the causes of ageing or, more specifically, by acting on the shortening of telomeres, the structures that protect chromosomes? (cnio.es)
  • Telomeres are proteins that protect the ends of chromosomes when a cell divides, something that happens many times during life to -among other things- regenerate tissues. (cnio.es)
  • With each cell division, the telomeres become shorter until they are so short that they can no longer protect the chromosomes. (cnio.es)
  • Telomeres help protect chromosomes from abnormally sticking together or breaking down (degrading). (medlineplus.gov)
  • Telomeres are repetitive DNA sequences located at the ends of chromosomes , playing a vital role in maintaining chromosomal integrity and stability. (bvsalud.org)
  • The telomeres are the DNA-protein structures at the ends of eukaryotic chromosomes, which serve to protect and stabilize the genome. (lu.se)
  • However, previous studies evaluating telomere length in white blood cells called leukocytes as a predictor of mortality have produced inconsistent findings, only sometimes predicting mortality. (scienceblog.com)
  • A 2007 dermatology study conducted at King's College London indicates that people with more moles often have longer telomeres. (howstuffworks.com)
  • In reality, some people are born with longer telomeres than others. (howstuffworks.com)
  • Researchers have correlated higher vitamin D levels with longer telomeres in humans. (mindbodygreen.com)
  • The longer the telomere, the more cell divisions can take place over a lifetime - and more moles were linked to longer telomeres . (stackexchange.com)
  • There are a several different claims in the article: moles are correlated with: skin cells that divide more often, better bone density, and longer telomeres. (stackexchange.com)
  • It is not understood why there are variations of telomere length but if you had a choice, you would want to be born with longer telomeres. (bellenews.com)
  • Each time a cell divides, however, the telomeres become shorter. (howstuffworks.com)
  • Even now, your telomeres may grow shorter with each cell division, burning down ever closer to the point of guttering out. (howstuffworks.com)
  • In other words, the shorter your telomeres, the greater your biological age. (glycemicindex.com)
  • In observational studies conducted in Asia, Europe and North America, people with shorter telomeres are found to have an increased risk of developing type 2 diabetes, independent of other known diabetes risk factors. (glycemicindex.com)
  • In people with existing diabetes, observational studies also indicate that shorter telomeres are associated with common diabetes complications like heart disease and stroke. (glycemicindex.com)
  • Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. (goodreads.com)
  • Telomeres become shorter with age, oxidation and chemical insults. (huffpost.com)
  • We examined whether adverse neighborhood conditions, alone or in conjunction with discrimination, associate with shorter leukocyte telomere length among a predominantly AA cohort. (rand.org)
  • Less walkable neighborhoods were associated with shorter telomeres. (rand.org)
  • Higher air pollution (PM 2.5 ) was associated with shorter telomeres among those experiencing greater discrimination. (rand.org)
  • However, whether patients with schizophrenia also have shorter telomeres remains inconclusive, because the results of previous studies investigating an association between leukocyte telomere length and schizophrenia have been largely inconsistent. (databasefootball.com)
  • As we get older, our telomeres get shorter and can directly impact our body health and how we age. (antiaging-systems.com)
  • As we age, our telomeres naturally get shorter due to cell replication and the natural wear and tear of everyday life. (antiaging-systems.com)
  • as our telomeres get shorter, we experience the effects of aging[ 1 ]. (antiaging-systems.com)
  • Telomere length can also impact overall health, as shorter telomeres can increase our risk for age-related diseases like cancer and heart disease [ 2 ] and even shorten our lifespan. (antiaging-systems.com)
  • As we get older, our telomeres naturally get shorter, increasing the risk of age-related diseases and impacting overall wellness. (antiaging-systems.com)
  • Most Tetrahymena are immortal, Blackburn explained, and they have lots of telemorase, but the mutant had shorter and shorter telomeres over time, so its cells started to die. (lindau-nobel.org)
  • Shorter telomeres were found in older women, Latinas, particularly those who were Mexican-born, and those with higher education. (confex.com)
  • There was a dose-response relationship between higher educational attainment and shorter telomeres (p-trend = 0.006). (confex.com)
  • Women who chose an affirmative or neutral response to the statement, I would move from this neighborhood if I could , had shorter telomeres (p=0.02) than women who disagreed with this statement. (confex.com)
  • on the other hand, it had also been described that patients with renal fibrosis have shorter telomeres. (cnio.es)
  • In most cells, telomeres become progressively shorter as the cell divides. (medlineplus.gov)
  • Our results also demonstrated significantly shorter telomere lengths in NSCLC patients compared to controls (p = 0.0004). (bvsalud.org)
  • Since telomeres shorten with each cell division, it pays to start out ahead. (howstuffworks.com)
  • Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length. (sciencedaily.com)
  • Telomeres naturally shorten with age. (cdc.gov)
  • In somatic cells such as leukocytes, telomeres gradually shorten with each cell division because of low telomerase activity. (databasefootball.com)
  • In the next stage of their research, the Glasgow scientists will look at what causes telomeres to shorten - including inherited and environmental factors - to make it possible to predict life expectancy more accurately. (bellenews.com)
  • Every time a cell divides, the telomeres shorten a bit. (msdmanuals.com)
  • Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2000. (cdc.gov)
  • The researchers measured patients' leukocyte telomere length at the start of the study and again five years later, and then examined whether the difference between these measurements predicted which patients were most likely to die over the next four years. (scienceblog.com)
  • The researchers also measured the length of their leukocyte telomeres. (huffpost.com)
  • Here, we investigate the association of leukocyte telomere length with schizophrenia with the quantitative polymerase chain reaction method in independent Japanese cohorts consisting of 1,241 patients with schizophrenia and 1,042 controls, which we believe is the largest ever as an independent sample set of telomere studies in schizophrenia. (databasefootball.com)
  • Correlations between leukocyte telomere length and age in patients with schizophrenia and healthy controls. (databasefootball.com)
  • The red and blue dashed lines show non-linear relationships between leukocyte telomere length and age in patients with schizophrenia and healthy controls, respectively. (databasefootball.com)
  • Black lines represent the mean leukocyte telomere length in each group. (databasefootball.com)
  • Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? (cdc.gov)
  • Telomere, a complex of guanine-rich repeat sequences and associated proteins, caps and protects every eukaryotic chromosome end against chromosomal fusion, recombination, and terminal DNA degradation ( Blackburn, 2001 ). (nature.com)
  • On one hand, Noah might have been born with rather long telomeres, while Batty drew the proverbial shortest straw. (howstuffworks.com)
  • While short telomeres do lead to health problems, long telomeres lead to health problems of their own. (cdc.gov)
  • Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease. (cdc.gov)
  • However, it turns out that cells lacking functional telomerase have a backup plan to restore telomere length by "alternative lengthening of telomeres" (ALT). (yeastgenome.org)
  • By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)
  • Studies have shown taking telomerase activation supplements can help lengthen telomeres, which can help slow down the aging process and reduce the risk of age-related diseases [ 3 ]. (antiaging-systems.com)
  • Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. (cdc.gov)
  • Recently, another study in the journal PLoS ONE showed that stress from phobic anxieties -- like being afraid of spiders, social situations, or the like -- is linked with shortened telomeres. (huffpost.com)
  • Telomeres Increasingly Develop Aberrant Structures in Aging Humans. (sens.org)
  • Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging. (cshlpress.com)
  • TA65® capsules - plant based compound to help maintain telomere length, or rebuild where necessary. (antiaging-systems.com)
  • Although most cancer cells activate telomerase to maintain telomere length, about 10% of tumors use an alternative telomere lengthening mechanism, the so-called ALT mechanism. (lu.se)
  • Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. (nature.com)
  • In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
  • Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
  • A team of cancer scientists led by Francis Rodier, PhD, a professor at the University of Montréal, has updated the current model of cellular senescence by providing evidence that the aging-related arrest of DNA replication is caused by irreversible damage to the genome rather than simply by an erosion of telomeres. (genengnews.com)
  • It cannot help in determining the cellular threshold for the number of dysfunctional telomeres that causes cells to stop dividing due to persistent DNA damage response signaling. (genengnews.com)
  • Genetically, we were able to reproduce the phenomenon of cellular aging in the laboratory and ensured that all the telomeres of a population of cells became dysfunctional," said PhD student Marc-Alexandre Olivier, co-first author of the study with former colleague Sabrina Ghadaouia, PhD, currently pursuing postdoctoral studies in England. (genengnews.com)
  • During successive cellular divisions, telomeres prevent base pair loss of chromosomal DNA. (glycemicindex.com)
  • On top of that, the ingredients in Telomere Plus-including astragalus root, broccoli seed, rhodiola extract and vitamin D3-give us a whole range of additional benefits, from immune support to enhancing the body's stress tolerance, cellular protection and boosted enzyme activity. (enzymedica.com)
  • The steady shortening of telomeres with each replication in somatic cells is linked to cellular aging, genetic instability, and tumor formation. (news-medical.net)
  • Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. (evmedreview.com)
  • The risk of these phenotypes was mediated by extended cellular longevity and by the capacity to maintain telomeres over time. (evmedreview.com)
  • The shortening of telomeres to a critical length leads to genomic instability and cellular apoptosis. (databasefootball.com)
  • It seems that vitamin D , a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase 4 , the building blocks of telomeres that protect cellular DNA from aging. (mindbodygreen.com)
  • Telomere length is a biomarker of cellular aging and predictor of chronic disease. (confex.com)
  • Telomere associations have been observed during key cellular processes including mitosis, meiosis and carcinogenesis. (ubc.ca)
  • Normal cellular ageing involves the shortening of telomeres in each cell division. (lu.se)
  • When telomeres are not properly controlled, the resulting chromosomal alterations can induce genomic instability and ultimately the development of human diseases, such as cancer. (nih.gov)
  • Telomeres consist of tandem repeats of TTAGGG and DNA binding proteins that form a cap to protect chromosomal termini from the loss of genetic material. (databasefootball.com)
  • The longer a person's telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality. (cdc.gov)
  • Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. (glycemicindex.com)
  • An article in this week's NEJM provides some of the best evidence yet for the role of telomere length in the trade-off between slowing aging and the risk of cancer. (evmedreview.com)
  • Discuss the potential role of telomere biology in maternal and child health outcomes. (confex.com)
  • In the new study, Whooley and colleagues asked whether the rate of telomere change - rather than absolute telomere length - might be a better predictor of health span in heart disease patients. (scienceblog.com)
  • This makes telomeres a telling marker for how a body will age: After studying telomere length across multiple species, a research team out of Spain found that the rate of telomere decay over time could accurately predict the life span of that species. (mindbodygreen.com)
  • Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
  • In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
  • The new multistep model for entry into telomere-mediated senescence presented in the current study reconciles observations of senescence-associated genomic instability with observations that telomere breaks are largely irreparable and that cells can tolerate telomere-induced DNA damage foci (TIF) during an unstable "pre-senescent" state. (genengnews.com)
  • Telomere resolution and genomic instability in mouse. (ubc.ca)
  • Now, research by scientists at UC San Francisco and the Veterans Affairs Medical Center in San Francisco has found that change in telomere length over time is also important: heart disease patients whose telomeres shrank over time had a worse short-term prognosis than those whose telomeres stayed stable, and those whose average telomere length grew over the course of the study had a higher chance of survival. (scienceblog.com)
  • Overall, one quarter of patients had died by the end of the study, but only 12 percent of patients whose telomeres had lengthened during the five-year observation period were among this group. (scienceblog.com)
  • In contrast, 39 percent of patients whose telomeres had shrunk in the five-year observation period died within the next four years. (scienceblog.com)
  • However, those whose telomeres shortened over the course of the study also showed higher abdominal fat, worse kidney function, and lower overall fitness. (scienceblog.com)
  • Controlling for these and other factors, the researchers found that those whose telomeres shortened over five years were 32 percent more likely to die during the next four years than those whose telomeres stayed the same, and those who experienced telomere lengthening were 56 percent less likely to die. (scienceblog.com)
  • The results hold huge implications for humans, whose telomeres work in the same way. (bellenews.com)
  • Participants with the shortest leucocyte telomeres were 14 per cent more likely to be diagnosed with dementia and 28 per cent more likely to be diagnosed with Alzheimer's disease after controlling for gender and age. (nepalnews.com)
  • Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob , referring to research in the Archives of Medical Science 2 and the Journal of Nutrition 3 on the association between telomere length and vitamin D levels. (mindbodygreen.com)
  • The birds with the shortest telomeres did tend to die first - from as early as seven months after the start of the trial. (bellenews.com)
  • Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. (columbia.edu)
  • Furthermore, it was predicted that a specialized DNA polymerase (originally called a tandem-DNA-polymerase) could extend telomeres in immortal tissues such as germ line, cancer cells and stem cells. (slideshare.net)
  • Among the research-vetted ways to protect telomeres, the authors cite avoiding smoking, getting at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week, and maintaining a healthy, low-fat diet. (scienceblog.com)
  • The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)
  • But one bird in the group with the longest telomeres survived to almost nine years old. (bellenews.com)
  • In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)
  • In older people with stable heart disease, longevity can vary widely, but a number of studies have suggested that telomere length appears to be a good predictor of a patient's likely health span - their number of healthy years of life remaining. (scienceblog.com)
  • A new study in the journal PLoS ONE shows the impact job stress has on certain sections of our DNA called telomeres, which have been linked in research with longevity. (huffpost.com)
  • By understanding what telomeres are and how they work, we can take measures to help lengthen our telomeres and promote longevity. (antiaging-systems.com)
  • When combined with a healthy diet and regular exercise , taking a vitamin D supplement can help keep telomeres in tiptop shape and promote longevity from the inside out. (mindbodygreen.com)
  • The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)
  • Genetic from Mendel to the Era of Elizabeth Blackburn and her graduate student Carol Greider then went looking for the mechanism that maintains telomeres, and on Christmas day, 1984, discovered the first evidence for the enzyme telomerase. (slideshare.net)
  • Findings arising from this prolonged collaboration were published in 2017 in a popular science book called The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer . (frontiersin.org)
  • The researchers also point out several limitations: Because telomere length was only assessed once, it was unable to determine whether changes over time increased dementia risk. (nepalnews.com)
  • Nevertheless, the researchers conclude, "We found that leucocyte telomere length acts as an aging biomarker associated with the risk of dementia. (nepalnews.com)
  • In this study, the researchers observed that telomere shortening alone is not enough to cause renal fibrosis, which is to be expected because the disease does not affect 100% of elderly persons. (cnio.es)
  • The telomerase ribonucleoprotein complex is the primary means by which yeast cells maintain telomeres. (yeastgenome.org)
  • We are using the yeast model organism Saccharomyces castellii, which has telomere traits and telomerase activity that are highly similar to human cells. (lu.se)
  • This inconsistency may be partially due to the relatively small sample sizes in each study and heterogeneity caused by various uncontrolled confounders (e.g., duration of illness or hospitalization, lifetime antipsychotic dose, and telomere length assay methods). (databasefootball.com)
  • Indeed, only one study has recruited more than 1,000 patients with schizophrenia (and a sufficient sample of controls), although this was a meta-analysis, including different telomere length assay protocols. (databasefootball.com)
  • A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)
  • And abnormally short telomeres seem to make humans more susceptible to conditions such as bone marrow failure, pulmonary fibrosis, liver disease, and gastrointestinal disease over time. (mindbodygreen.com)
  • A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
  • The study is reported in an article in the journal Nucleic Acids Research, titled, " Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence . (genengnews.com)
  • This updated model offers a new basis for stress- or age-associated genome damage and indicates, cells that escape telomere-mediated senescence harbor irreparable genome damage. (genengnews.com)
  • Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. (sens.org)
  • Telomeres and Cell Senescence - Size Matters Not. (sens.org)
  • Numerous factors localize at telomeres to regulate their length, structure and function, to avert replicative senescence or genome instability and cell death. (cdc.gov)
  • Telomeres don't shrink significantly in healthy humans for decades due to an enzyme called telomerase , which partially repairs and lengthens them after each shortening. (howstuffworks.com)
  • Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
  • Telomeres and the natural lifespan limit in humans. (sens.org)
  • Since this RNA also facilitates the formation of DNA at telomeres-a process that can protect aging cells and destabilize tumor cells-manipulating its expression may be useful in treating cancer and other diseases. (news-medical.net)
  • Many of the diseases of ageing, including cancers, are associated with the shortening of telomeres,' Blackburn said. (lindau-nobel.org)
  • Even the risk factors for these diseases increases with short telomeres. (lindau-nobel.org)
  • Dr. Park's book offers a clear and friendly account of the role of telomeres in causing age-related diseases and the enormous potential of telomerase to prevent and cure age-related diseases by reversing human aging at the genetic level. (rechargebiomedical.com)
  • Blasco's group at CNIO has already shown that short telomeres are at the origin of other age-related diseases, such as pulmonary fibrosis. (cnio.es)
  • To prevent degradation by exonucleases or processing as damaged DNA, the telomere 3′ single-strand overhang folds back into the D-loop of duplex telomeric DNA to form a protective 'T-loop', which is reinforced with TRF2 and other telomeric DNA-binding proteins named Shelterin ( de Lange, 2005 ). (nature.com)
  • Telomeres are a protective nucleoprotein structure at each chromosome end. (cdc.gov)
  • It also shows, rather surprisingly, that a substantial number of people had telomere lengthening, and that this appeared to be protective. (scienceblog.com)
  • At the end of each chromosome is a telomere, which acts as a protective cap. (antiaging-systems.com)
  • In this article, I will tell you about telomeres, which are the protective tips of DNA molecules-the molecules where the organism's genes are stored. (frontiersin.org)
  • The study - which used zebra finches, one of Australia's most common bird species - is the first to measure telomere lengths at regular intervals through an entire life. (bellenews.com)
  • They went on to evaluate potential correlations between leucocyte telomere length and dementia risk, including Alzheimer's disease and vascular dementia, as well as total and regional brain volumes, using data from the UK Biobank. (nepalnews.com)
  • The length of leucocyte telomeres was determined by analysing blood samples collected at the time of enrollment. (nepalnews.com)
  • The data analysis found a substantial link between leucocyte telomere length and the risk of dementia. (nepalnews.com)
  • Furthermore, we also observed linear associations of leucocyte telomere length with total and regional brain structure. (nepalnews.com)
  • Our GWAS confirmed 11 genetic loci previously associated with leucocyte telomere length (LTL) and two novel loci in SCNN1D and PITPNM1. (cdc.gov)
  • Previous human studies of telomere attrition were predominantly conducted on leukocytes. (columbia.edu)
  • Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India. (bvsalud.org)
  • This study highlights the crucial interplay between genetic variation in telomere maintenance genes , telomere attrition, and NSCLC risk in the Jammu and Kashmir population of North India . (bvsalud.org)
  • Telomere lengthening appears to happen in people, and may be a meaningful phenomenon," said co-author Elizabeth Blackburn , PhD, a professor emeritus at UCSF, president of the Salk Institute for Biological Studies in San Diego and 2009 recipient of the Nobel Prize in Physiology or Medicine for her co-discovery of the telomerase enzyme. (scienceblog.com)
  • In cancer cells, the telomerase enzyme elongates telomeres, providing a mechanism for a continued unlimited cell division. (lu.se)
  • Over time, telomere length decreases until the telomere becomes too short for the cell to divide, eventually resulting in the death of the cell. (glycemicindex.com)
  • Finnish scientists found that people affected by the highest levels of job stress were more likely to have short telomeres, NBC News reported. (huffpost.com)
  • Often, when telomeres reach a critically short length, the cell dies in a process called apoptosis. (huffpost.com)
  • Telomerase helps to rebuild our telomeres and keep them from getting too short. (antiaging-systems.com)
  • She found that the telomeres of pond scum are composed of short, repeating patterns of the nucleotides thymine and guanine, in the form of TTGGGG. (frontiersin.org)
  • Now they take a first step towards doing the same with renal fibrosis by demonstrating that short telomeres are at the origin of this disease, which is also associated with ageing. (cnio.es)
  • These results show the important role short telomeres play in its development, and this finding undoubtedly opens new doors for the treatment of renal fibrosis," says the first author of the study, Sarita Saraswati , a researcher with the Telomeres and Telomerase Group at CNIO. (cnio.es)
  • The authors, headed by Maria A. Blasco , also offer a possible link between short telomeres and kidney fibrosis: a phenomenon called epithelial-to-mesenchymal transition (EMT), a basic process that is crucial to the functioning of the body and is involved in regeneration and repair. (cnio.es)
  • Short telomeres exacerbate EMT in the kidneys and thus promote pathological scarring of kidney tissue, i.e. fibrosis. (cnio.es)
  • This is new - it is the first time that short telomeres have been linked to epithelial-to-mesenchymal transition," says Blasco. (cnio.es)
  • So we specifically looked for alterations in the expression of genes involved in the epithelial-to-mesenchymal transition in our mice with short telomeres and renal fibrosis, to see if short telomeres could be the trigger for the changes in expression of these genes," explains Blasco. (cnio.es)
  • To investigate whether the same occurs with renal fibrosis, they worked with an animal model that reproduces what, according to their hypothesis, happens in older people with pulmonary fibrosis: a mouse with short telomeres that is also exposed to low doses of a kidney toxin that mimics the exposure of people to environmental damages throughout their lives. (cnio.es)
  • However, if mice with short telomeres were exposed to low doses of a kidney toxin, they did develop kidney fibrosis. (cnio.es)
  • The toxin administered -folic acid- "is not sufficient to induce fibrosis in healthy mice, but it acts synergistically with short telomeres," the paper explains. (cnio.es)
  • After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). (medlineplus.gov)
  • Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)
  • Eventually, the telomeres become so short that the cell can no longer divide. (msdmanuals.com)
  • Speaking at the 61st Meeting of Nobel Laureates at Lindau, Elisabeth Blackburn compared the caps, called telomeres , to the tips on the end of a shoelace that prevent it from fraying. (lindau-nobel.org)
  • Telomere length has emerged as a leading biomarker of aging, and predicts early onset of cardiovascular disease. (scienceblog.com)
  • These findings highlight telomere length as a potential biomarker of brain health. (nepalnews.com)
  • For this study, we wanted to know if chronic stress was associated with accelerated telomere shortening in cancer patients, and if a psychosocial intervention that modulates the stress response could also modulate telomere length," he said. (sciencedaily.com)
  • We embarked on the first study of telomere length and chronic stress in a cancer population and the first longitudinal analysis in whether changes in quality of life and changes in the stress response would be associated with modulating the telomere length," he said. (sciencedaily.com)
  • Chronic life stress and multiple trauma exposures are implicated in telomere shortness, Blackburn said, as are pessimism and hostility. (lindau-nobel.org)
  • The association between psychosocial stressors and shortened telomere length suggests telomeres may mediate relationships between chronic stress and adverse health outcomes. (confex.com)
  • Our pilot study examined whether conditions of chronic adversity are associated with shortened telomeres among low-income pregnant women. (confex.com)
  • Describe how telomeres may mediate the relationship between socioeconomic status, chronic psychosocial stress, and adverse health outcomes. (confex.com)
  • Together with psychology researcher Elissa Epel, she studied the relationships between telomeres and chronic stress. (frontiersin.org)
  • ATRX-deficient neu-roprogenitors exhibited higher incidence of telomere fusions and increased sensitivity to replication stress-inducing drugs. (bepress.com)
  • Telomere shortening in somatic tissues largely reflects stem cell replication. (columbia.edu)
  • Genetic from Mendel to the Era of According to his theory of telomeres are represented by tandem repeats, which create a buffer that determines the number of divisions that a certain cell clone can undergo. (slideshare.net)
  • Therefore, proper establishment, regulation, and maintenance of the telomere chromatin structure are required for cell homeostasis. (nih.gov)
  • As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
  • We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. (columbia.edu)
  • Our findings suggest that TERT and POT1 gene variants, along with telomere length, may serve as potential biomarkers and therapeutic targets for NSCLC in this population . (bvsalud.org)
  • Systematic analysis of telomere length and somatic alterations in 31 cancer types. (sens.org)
  • The length of telomeric repeats is dynamically regulated and can be affected by changes in the telomere chromatin structure. (nih.gov)
  • TERRA associates with telomeric factors, but its precise function and mechanism of localization at telomeres had been largely unknown. (news-medical.net)
  • Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
  • Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
  • I will also introduce you to an enzyme that we discovered, called telomerase, which is responsible for the addition and maintenance of telomeres. (frontiersin.org)
  • In a small number of individuals with dyskeratosis congenita, mutations in other genes involved with telomere maintenance have been identified. (medlineplus.gov)
  • In these cases, the cause of the disorder is unknown, but other unidentified genes related to telomere maintenance are likely involved. (medlineplus.gov)
  • Genetic variations within telomere maintenance genes may influence the risk of developing NSCLC. (bvsalud.org)
  • The present study aimed to evaluate the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India , and to investigate the relationship between telomere length and NSCLC risk . (bvsalud.org)
  • We employed the cost -effective and high-throughput MassARRAY MALDI -TOF platform to assess the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India . (bvsalud.org)
  • In our research we aim to shed light on the molecular mechanisms for the telomerase elongation and maintenance processes of telomeres. (lu.se)
  • A recent study proposes a key role for telomere maintenance in the development of clonal hematopoiesis. (cdc.gov)
  • We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentro-meric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation. (bepress.com)