Telomere s. Medical search. Frequent questions

However, previous studies evaluating telomere length in white blood cells called leukocytes as a predictor of mortality have produced inconsistent findings, only sometimes predicting mortality. (scienceblog.com)

Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2000. (cdc.gov)
The researchers measured patients' leukocyte telomere length at the start of the study and again five years later, and then examined whether the difference between these measurements predicted which patients were most likely to die over the next four years. (scienceblog.com)
We examined whether adverse neighborhood conditions, alone or in conjunction with discrimination, associate with shorter leukocyte telomere length among a predominantly AA cohort. (rand.org)
Purpose: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. (aacrjournals.org)
We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. (aacrjournals.org)
Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? (cdc.gov)

Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. (goodreads.com)
In other words, the shorter your telomeres, the greater your biological age. (glycemicindex.com)
In observational studies conducted in Asia, Europe and North America, people with shorter telomeres are found to have an increased risk of developing type 2 diabetes, independent of other known diabetes risk factors. (glycemicindex.com)
In people with existing diabetes, observational studies also indicate that shorter telomeres are associated with common diabetes complications like heart disease and stroke. (glycemicindex.com)
Shorter telomeres on the ends of white blood cell chromosomes were discovered to be associated with an increased risk of dementia. (nepalnews.com)
Less walkable neighborhoods were associated with shorter telomeres. (rand.org)
Higher air pollution (PM 2.5 ) was associated with shorter telomeres among those experiencing greater discrimination. (rand.org)
As we get older, our telomeres get shorter and can directly impact our body health and how we age. (antiaging-systems.com)
As we age, our telomeres naturally get shorter due to cell replication and the natural wear and tear of everyday life. (antiaging-systems.com)
Our telomeres get shorter with every cell division until they eventually become too small to protect the chromosomes. (antiaging-systems.com)
as our telomeres get shorter, we experience the effects of aging[ 1 ]. (antiaging-systems.com)
Telomere length can also impact overall health, as shorter telomeres can increase our risk for age-related diseases like cancer and heart disease [ 2 ] and even shorten our lifespan. (antiaging-systems.com)
As we get older, our telomeres naturally get shorter, increasing the risk of age-related diseases and impacting overall wellness. (antiaging-systems.com)
Shorter telomeres were found in older women, Latinas, particularly those who were Mexican-born, and those with higher education. (confex.com)
There was a dose-response relationship between higher educational attainment and shorter telomeres (p-trend = 0.006). (confex.com)
Women who chose an affirmative or neutral response to the statement, I would move from this neighborhood if I could , had shorter telomeres (p=0.02) than women who disagreed with this statement. (confex.com)
Heterogeneity among studies and their publication bias were further assessed by the χ(2)-based Q statistic test and Egger's test, respectively.The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60), compared with longer telomeres. (duke.edu)
on the other hand, it had also been described that patients with renal fibrosis have shorter telomeres. (cnio.es)
With each cell division, the telomeres become shorter until they are so short that they can no longer protect the chromosomes. (cnio.es)
Our results also demonstrated significantly shorter telomere lengths in NSCLC patients compared to controls (p = 0.0004). (bvsalud.org)

The longer the telomere, the more cell divisions can take place over a lifetime - and more moles were linked to longer telomeres . (stackexchange.com)
There are a several different claims in the article: moles are correlated with: skin cells that divide more often, better bone density, and longer telomeres. (stackexchange.com)
Researchers have correlated higher vitamin D levels with longer telomeres in humans. (mindbodygreen.com)
While scientists and researchers have long believed longer telomeres are associated with good health, some recent studies indicate that might not be the case. (ku.edu)
After more than four decades of telomeres research, leading to a belief that longer telomeres are important for good overall health and in protecting cells from senescence, this belief turns out to be only partially true or completely mistaken for certain parts of the body. (ku.edu)

Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length. (sciencedaily.com)
Telomeres naturally shorten with age. (cdc.gov)
Telomeres have been implicated in senescence and mortality because they tend to shorten with stress, growth and age. (datadryad.org)
Greider showed that the telomeres would shorten in mice with only one functional copy of the telomerase gene or had the half the normal amount of telomerase. (animalresearch.info)
Every time a cell divides, the telomeres shorten a bit. (msdmanuals.com)

In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
For this study, we wanted to know if chronic stress was associated with accelerated telomere shortening in cancer patients, and if a psychosocial intervention that modulates the stress response could also modulate telomere length," he said. (sciencedaily.com)
Improved quality of life and reduced stress response was associated with changes in telomere length," Nelson said. (sciencedaily.com)
We embarked on the first study of telomere length and chronic stress in a cancer population and the first longitudinal analysis in whether changes in quality of life and changes in the stress response would be associated with modulating the telomere length," he said. (sciencedaily.com)
After all, making patients feel better should be an outcome that a cancer team should want to have, but whether we can draw conclusions or make recommendations about the capacity of a behavioral intervention to modulate telomere length remains an open question. (sciencedaily.com)
The length of telomeric repeats is dynamically regulated and can be affected by changes in the telomere chromatin structure. (nih.gov)
TeloMean: Mean T/S ratio which is measured telomere length relative to standard reference DNA. (cdc.gov)
It is important to note that there is wide variance in telomere length measures across labs and types of assays. (cdc.gov)
In this case, results from NHANES are comparable to other studies performed in the Blackburn Lab and may be similar to other PCR-derived measures of telomere length if they used the same methods as written here. (cdc.gov)
While comparisons across studies of telomere length in base pairs are commonly done, it is not highly accurate. (cdc.gov)
Now, research by scientists at UC San Francisco and the Veterans Affairs Medical Center in San Francisco has found that change in telomere length over time is also important: heart disease patients whose telomeres shrank over time had a worse short-term prognosis than those whose telomeres stayed stable, and those whose average telomere length grew over the course of the study had a higher chance of survival. (scienceblog.com)
Telomere length has emerged as a leading biomarker of aging, and predicts early onset of cardiovascular disease. (scienceblog.com)
In older people with stable heart disease, longevity can vary widely, but a number of studies have suggested that telomere length appears to be a good predictor of a patient's likely health span - their number of healthy years of life remaining. (scienceblog.com)
In the new study, Whooley and colleagues asked whether the rate of telomere change - rather than absolute telomere length - might be a better predictor of health span in heart disease patients. (scienceblog.com)
Of those whose telomere length had remained stable, 22 percent had died by the end of the study. (scienceblog.com)
This study goes beyond telomere length as a single measure and shows that the rate of change may also be an important predictive factor," Whooley said. (scienceblog.com)
Fortunately there are multiple ways to protect telomere length throughout the lifespan. (scienceblog.com)
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. (sens.org)
Systematic analysis of telomere length and somatic alterations in 31 cancer types. (sens.org)
Nucleus with chromosomes, DNA molecule (double helix), telomere and gene (length of DNA that codes for a specific protein). (istockphoto.com)
Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. (goodreads.com)
Over time, telomere length decreases until the telomere becomes too short for the cell to divide, eventually resulting in the death of the cell. (glycemicindex.com)
Perhaps unsurprisingly, there is an inverse association between the length of telomeres and biological ageing. (glycemicindex.com)
In fact, telomere length is what some scientists have used to assess biological age.1 Therefore, it is critical that if we want to age well, we keep our telomeres as long as possible. (enzymedica.com)
They went on to evaluate potential correlations between leucocyte telomere length and dementia risk, including Alzheimer's disease and vascular dementia, as well as total and regional brain volumes, using data from the UK Biobank. (nepalnews.com)
The length of leucocyte telomeres was determined by analysing blood samples collected at the time of enrollment. (nepalnews.com)
The data analysis found a substantial link between leucocyte telomere length and the risk of dementia. (nepalnews.com)
The researchers also point out several limitations: Because telomere length was only assessed once, it was unable to determine whether changes over time increased dementia risk. (nepalnews.com)
Furthermore, telomere length was only measured in leucocytes. (nepalnews.com)
They believe that measuring telomere length in glial cells (non-neuronal cells in the central nervous system) would have been more revealing, but this information was not available from the UK Biobank. (nepalnews.com)
Nevertheless, the researchers conclude, "We found that leucocyte telomere length acts as an aging biomarker associated with the risk of dementia. (nepalnews.com)
Furthermore, we also observed linear associations of leucocyte telomere length with total and regional brain structure. (nepalnews.com)
These findings highlight telomere length as a potential biomarker of brain health. (nepalnews.com)
An article in this week's NEJM provides some of the best evidence yet for the role of telomere length in the trade-off between slowing aging and the risk of cancer. (evmedreview.com)
However, whether long telomere length is advantageous is poorly understood. (evmedreview.com)
In contrast to noncarrier relatives, who had the typical telomere shortening with age, POT1 mutation carriers maintained telomere length over the course of 2 years. (evmedreview.com)
POT1 mutations associated with long telomere length conferred a predisposition to a familial clonal hematopoiesis syndrome that was associated with a range of benign and malignant solid neoplasms. (evmedreview.com)
Are skin moles linked to telomere length? (stackexchange.com)
This makes telomeres a telling marker for how a body will age: After studying telomere length across multiple species, a research team out of Spain found that the rate of telomere decay over time could accurately predict the life span of that species. (mindbodygreen.com)
Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob , referring to research in the Archives of Medical Science 2 and the Journal of Nutrition 3 on the association between telomere length and vitamin D levels. (mindbodygreen.com)
In this article, we will take a closer look at telomeres and how their length can affect our health. (antiaging-systems.com)
Why Does Telomere Length Impact Aging? (antiaging-systems.com)
TA65® capsules - plant based compound to help maintain telomere length, or rebuild where necessary. (antiaging-systems.com)
TA65® cream - plant based skin cream containing astalagus extract to help support telomere length and rebuild. (antiaging-systems.com)
Telomere length is a biomarker of cellular aging and predictor of chronic disease. (confex.com)
The association between psychosocial stressors and shortened telomere length suggests telomeres may mediate relationships between chronic stress and adverse health outcomes. (confex.com)
A blood sample was collected during labor, and telomere length was measured from DNA by quantitative PCR. (confex.com)
Age, race/ethnicity, country of origin, education, and neighborhood perceptions were independently associated with telomere length in multivariate models. (confex.com)
Objectives Critically shortening of telomere length caused by various factors including environmental pollutants results in genome instability and age-associated diseases. (bmj.com)
However, it is still unclear whether lead exposure affects telomere length. (bmj.com)
This study aims to investigate the association between lead exposure and peripheral white blood cell telomere length (PWBTL) in Chinese battery manufacturing plant workers. (bmj.com)
Univariate and multivariate analyses were performed to examine the associations of telomere length and other variables. (bmj.com)
Is the Subject Area "Telomere length" applicable to this article? (plos.org)
Their first study led to a whole series of studies connecting telomere length to human health in various ways. (frontiersin.org)
Shortened telomere length is associated with increased risk of cancer: a meta-analysis. (duke.edu)
A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting.A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. (duke.edu)
Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. (duke.edu)
We group the hypotheses (i) based on their association with different research questions, and (ii) using a hierarchical approach that builds on the assumptions they make, such as about causality of telomere length/shortening and/or the proposed functional consequences of telomere shortening on organism performance. (lu.se)
We investigated age-specific telomere length in female and male red-sided garter snakes, Thamnophis sirtalis parietalis. (datadryad.org)
We hypothesized that age-specific telomere length would differ between males and females given their divergent reproductive strategies. (datadryad.org)
We investigated this prediction using skeletochronology to determine the ages of individuals and qPCR to determine telomere length in a cross-sectional study. (datadryad.org)
For both sexes, telomere length was positively related to body condition. (datadryad.org)
Telomere length decreased with age in male garter snakes, but remained stable in female snakes. (datadryad.org)
There was no correlation between telomere length and growth in either sex, suggesting that our results are a consequence of divergent selection on life histories of males and females. (datadryad.org)
Overall, survival correlated strongly with telomere length. (ca.gov)
Patients and Methods: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. (aacrjournals.org)
The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio. (aacrjournals.org)
Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19-77 years). (columbia.edu)
We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. (columbia.edu)
The present study aimed to evaluate the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India , and to investigate the relationship between telomere length and NSCLC risk . (bvsalud.org)
Furthermore, we investigated telomere length variation and its relation to NSCLC risk in the same population using dual-labeled fluorescence -based qPCR. (bvsalud.org)
Our findings suggest that TERT and POT1 gene variants, along with telomere length, may serve as potential biomarkers and therapeutic targets for NSCLC in this population . (bvsalud.org)
A possible relationship between telomere length and markers of neurodegeneration in rat brain after welding fume inhalation exposure. (cdc.gov)
Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. (cdc.gov)
Here, we investigated the effect of WF inhalation on telomere length and markers of neurodegeneration in whole brain tissue in rats. (cdc.gov)
Telomere length, DNA-methylation, gene expression of Trf1, Trf2, ATM, and APP, protein expression of p-Tau, a-synuclein, and presenilin 1 and 2 were assessed in whole brain tissue at 12 wk after WF exposure ended. (cdc.gov)
Results suggest that WF inhalation increased telomere length without affecting telomerase in whole brain. (cdc.gov)
Moreover, we observed that components of the shelterin complex, Trf1 and Trf2, play an important role in telomere end protection, and their regulation may be responsible for the increase in telomere length. (cdc.gov)
These findings suggest a possible correlation between epigenetic modifications, telomere length alteration, and neurodegeneration because of the presence of factors in serum after WF exposure that may cause extra-pulmonary effects as well as the translocation of potentially neurotoxic metals associated with WF to the central nervous system (CNS). (cdc.gov)
all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
Early life adversity and telomere length: a meta-analysis. (bvsalud.org)
Using yeast as a model system, we study the molecular mechanisms of telomere length regulation. (lu.se)
Telomere Length and Clonal Hematopoiesis. (cdc.gov)
Our GWAS confirmed 11 genetic loci previously associated with leucocyte telomere length (LTL) and two novel loci in SCNN1D and PITPNM1. (cdc.gov)
Numerous factors localize at telomeres to regulate their length, structure and function, to avert replicative senescence or genome instability and cell death. (cdc.gov)

While short telomeres do lead to health problems, long telomeres lead to health problems of their own. (cdc.gov)
Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease. (cdc.gov)
Mice have long telomeres and senesce just fine. (cdc.gov)

Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. (nature.com)
Telomere, a complex of guanine-rich repeat sequences and associated proteins, caps and protects every eukaryotic chromosome end against chromosomal fusion, recombination, and terminal DNA degradation ( Blackburn, 2001 ). (nature.com)
When telomeres are not properly controlled, the resulting chromosomal alterations can induce genomic instability and ultimately the development of human diseases, such as cancer. (nih.gov)
During successive cellular divisions, telomeres prevent base pair loss of chromosomal DNA. (glycemicindex.com)
Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies. (ca.gov)
Telomeres are repetitive DNA sequences located at the ends of chromosomes , playing a vital role in maintaining chromosomal integrity and stability. (bvsalud.org)
The longer a person's telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality. (cdc.gov)

To prevent degradation by exonucleases or processing as damaged DNA, the telomere 3′ single-strand overhang folds back into the D-loop of duplex telomeric DNA to form a protective 'T-loop', which is reinforced with TRF2 and other telomeric DNA-binding proteins named Shelterin ( de Lange, 2005 ). (nature.com)
In a study published on-line on August 27 in Molecular Cell, the Wistar scientists, led by Lieberman, describe how they discovered the telomere proteins that interact with TERRA and the processes by which they do so. (news-medical.net)
This epigenetic protection of fly telomeres has been essentially studied in somatic cells where capping proteins such as HOAP or HP1 are essential in preventing chromosome end-to-end fusions. (ens-lyon.fr)
We thus propose that the maintenance of capping proteins at Drosophila sperm telomeres is crucial for the transmission of telomere identity to the diploid zygote. (ens-lyon.fr)
Telomere aggregates appeared to resolve upon cleavage of TRF1 proteins, suggesting that telomere associations result primarily from protein interactions mediated by TRF1. (ubc.ca)
Telomeres are proteins that protect the ends of chromosomes when a cell divides, something that happens many times during life to -among other things- regenerate tissues. (cnio.es)
A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. (bvsalud.org)

By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)
Studies have shown taking telomerase activation supplements can help lengthen telomeres, which can help slow down the aging process and reduce the risk of age-related diseases [ 3 ]. (antiaging-systems.com)
Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. (cdc.gov)

Telomere attrition was also accelerated in cell populations from magnesium-deficient cultures. (wellnessresources.com)
Previous human studies of telomere attrition were predominantly conducted on leukocytes. (columbia.edu)
Title : Association of chronic fatigue syndrome with premature telomere attrition Personal Author(s) : Rajeevan, Mangalathu S.;Murray, Janna;Oakley, Lisa;Lin, Jin-Mann S.;Unger, Elizabeth R. (cdc.gov)
Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India. (bvsalud.org)
This study highlights the crucial interplay between genetic variation in telomere maintenance genes , telomere attrition, and NSCLC risk in the Jammu and Kashmir population of North India . (bvsalud.org)

Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
A team of cancer scientists led by Francis Rodier, PhD, a professor at the University of Montréal, has updated the current model of cellular senescence by providing evidence that the aging-related arrest of DNA replication is caused by irreversible damage to the genome rather than simply by an erosion of telomeres. (genengnews.com)
The study is reported in an article in the journal Nucleic Acids Research, titled, " Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence . (genengnews.com)
The new multistep model for entry into telomere-mediated senescence presented in the current study reconciles observations of senescence-associated genomic instability with observations that telomere breaks are largely irreparable and that cells can tolerate telomere-induced DNA damage foci (TIF) during an unstable "pre-senescent" state. (genengnews.com)
This updated model offers a new basis for stress- or age-associated genome damage and indicates, cells that escape telomere-mediated senescence harbor irreparable genome damage. (genengnews.com)
Telomeres and Cell Senescence - Size Matters Not. (sens.org)
Progerin induced senescence, lamin B1 loss, DNA damage, and telomere shortening are prevented by TERT in primary and HGPS fibroblasts, control experiments. (elifesciences.org)

Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
The steady shortening of telomeres with each replication in somatic cells is linked to cellular aging, genetic instability, and tumor formation. (news-medical.net)
While HipHop is involved in telomere capping in somatic cells, K81 hasspecialized in the protection of telomeres in post-meiotic male germ cells. (ens-lyon.fr)

Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. (evmedreview.com)
Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)
In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)

Controlling for these and other factors, the researchers found that those whose telomeres shortened over five years were 32 percent more likely to die during the next four years than those whose telomeres stayed the same, and those who experienced telomere lengthening were 56 percent less likely to die. (scienceblog.com)
Researchers, journalists, and inquiring minds want to know more about telomeres, which seem to hold clues to human aging and age-related diseases. (cdc.gov)
A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. (news-medical.net)
The DNA still seemed to look normal, until the researchers focused on the caps that protect the ends of chromosomes, called telomeres. (labroots.com)
In this study, the researchers observed that telomere shortening alone is not enough to cause renal fibrosis, which is to be expected because the disease does not affect 100% of elderly persons. (cnio.es)

Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging. (cshlpress.com)
Since this RNA also facilitates the formation of DNA at telomeres-a process that can protect aging cells and destabilize tumor cells-manipulating its expression may be useful in treating cancer and other diseases. (news-medical.net)
Dr. Park's book offers a clear and friendly account of the role of telomeres in causing age-related diseases and the enormous potential of telomerase to prevent and cure age-related diseases by reversing human aging at the genetic level. (rechargebiomedical.com)
Blasco's group at CNIO has already shown that short telomeres are at the origin of other age-related diseases, such as pulmonary fibrosis. (cnio.es)
Telomerase is very sensitive to mutations and telomere defects have now been implicated in a number of diseases. (animalresearch.info)
Their findings have now been tested across a range of animals, including mice and frogs, and research into telomere-based therapies for cancer and other diseases often makes use of mouse models. (animalresearch.info)

Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. (sciencedaily.com)
Telomeres are specialized structures that evolved to protect the end of linear chromosomes from the action of the cell DNA damage machinery. (nih.gov)
Telomeres Increasingly Develop Aberrant Structures in Aging Humans. (sens.org)
Telomeres specialized structures found at the ends of chromosomes are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. (cshlpress.com)
To explore the mechanisms of sequence-specific ssDNA recognition, we determined the crystal structures of 10 different non-cognate ssDNAs complexed with the Oxytricha nova telomere end-binding protein (OnTEBP) and evaluated their corresponding binding affinities (PDB ID codes 1PH1-1PH9 and 1PHJ). (rcsb.org)
Consider telomeres little helmets for your DNA: These protein structures cap off both sides of our chromosomes to protect them from damage and decay over time. (mindbodygreen.com)
Linear eukaryotic chromosomes contain specialized protective structures at the chromosome ends, called telomeres, which are essential for maintaining genome stability. (ubc.ca)
So, what if it were possible to treat them by acting on the causes of ageing or, more specifically, by acting on the shortening of telomeres, the structures that protect chromosomes? (cnio.es)

In fact, the cell division caused by telomere dysfunction is so unstable that it ends up creating genetic defects. (genengnews.com)
Without telomeres, our genome would be vulnerable to damage and dysfunction. (antiaging-systems.com)
However, the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown. (ca.gov)

According to his theory of marginotomy DNA sequences at the ends of telomeres are represented by tandem repeats, which create a buffer that determines the number of divisions that a certain cell clone can undergo. (wikipedia.org)
In 1975-1977, Elizabeth Blackburn, working as a postdoctoral fellow at Yale University with Joseph G. Gall, discovered the unusual nature of telomeres, with their simple repeated DNA sequences composing chromosome ends. (wikipedia.org)
Telomeres are non-coding, repetitive sequences located at the termini of linear chromosomes to act as buffers for those coding sequences further behind. (wikipedia.org)
Showcasing a revolutionary new way to think about aging and health, Dr. Ed Park's entertaining and insightful new book introduces readers to Telomeres - repetitive DNA sequences that play a vital role in aging and health. (rechargebiomedical.com)
These sequences, called telomeres, do not code for genes, but Blackburn, Greider and Szostak showed that they have a very important role. (animalresearch.info)
Telomerase is the enzyme synthesizing the specific DNA sequences found at the telomeres and is thus responsible for maintaining their lengths. (lu.se)

These telomere associations need to be resolved prior to cell division to avoid loss of telomere function. (ubc.ca)

A critical function of telomeres is to prevent the ligation of chromosome ends by DNA repair enzymes. (ens-lyon.fr)
We are aiming to clarify the structure and function of telomeres. (lu.se)
This group studies the function of telomeres and the basic molecular mechanisms of telomerase, the enzyme catalyzing the synthesis of telomeric DNA. (lu.se)

Our current understanding of cellular aging rests upon the uncapping of the repetitive, non-protein-coding extremities of our linear chromosomes called telomeres. (genengnews.com)
It cannot help in determining the cellular threshold for the number of dysfunctional telomeres that causes cells to stop dividing due to persistent DNA damage response signaling. (genengnews.com)
Genetically, we were able to reproduce the phenomenon of cellular aging in the laboratory and ensured that all the telomeres of a population of cells became dysfunctional," said PhD student Marc-Alexandre Olivier, co-first author of the study with former colleague Sabrina Ghadaouia, PhD, currently pursuing postdoctoral studies in England. (genengnews.com)
On top of that, the ingredients in Telomere Plus-including astragalus root, broccoli seed, rhodiola extract and vitamin D3-give us a whole range of additional benefits, from immune support to enhancing the body's stress tolerance, cellular protection and boosted enzyme activity. (enzymedica.com)
The risk of these phenotypes was mediated by extended cellular longevity and by the capacity to maintain telomeres over time. (evmedreview.com)
Sequence-specific protein recognition of single-stranded nucleic acids is critical for many fundamental cellular processes, such as DNA replication, DNA repair, transcription, translation, recombination, apoptosis and telomere maintenance. (rcsb.org)
It seems that vitamin D , a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase 4 , the building blocks of telomeres that protect cellular DNA from aging. (mindbodygreen.com)
Telomere associations have been observed during key cellular processes including mitosis, meiosis and carcinogenesis. (ubc.ca)

Participants with the shortest leucocyte telomeres were 14 per cent more likely to be diagnosed with dementia and 28 per cent more likely to be diagnosed with Alzheimer's disease after controlling for gender and age. (nepalnews.com)

A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)
Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. (duke.edu)

Telomeres are a widespread genetic feature most commonly found in eukaryotes. (wikipedia.org)
Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. (goodreads.com)
This is because telomeres eventually 'run out' after a certain number of cell divisions, resulting in the loss of vital genetic information from the cell's chromosome with future divisions. (news-medical.net)
Genetic from Mendel to the Era of According to his theory of telomeres are represented by tandem repeats, which create a buffer that determines the number of divisions that a certain cell clone can undergo. (slideshare.net)
Genetic from Mendel to the Era of Elizabeth Blackburn and her graduate student Carol Greider then went looking for the mechanism that maintains telomeres, and on Christmas day, 1984, discovered the first evidence for the enzyme telomerase. (slideshare.net)
Genetic variations within telomere maintenance genes may influence the risk of developing NSCLC. (bvsalud.org)
We employed the cost -effective and high-throughput MassARRAY MALDI -TOF platform to assess the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India . (bvsalud.org)
Telomeres are used to move the cell's genetic material in preparation for cell division. (msdmanuals.com)

Furthermore, it was predicted that a specialized DNA polymerase (originally called a tandem-DNA-polymerase) could extend telomeres in immortal tissues such as germ line, cancer cells and stem cells. (wikipedia.org)

Among the research-vetted ways to protect telomeres, the authors cite avoiding smoking, getting at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week, and maintaining a healthy, low-fat diet. (scienceblog.com)
The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)

Scientists at the University of California in San Francisco have shown that Telomerase Reverse Transcriptase, an enzyme that maintains telomeres and hence protects cells from aging, also plays a significant role in the development of brain cancer known as gliomas. (ku.edu)

We examined the clinical and molecular features of aging and cancer in persons carrying heterozygous loss-of-function mutations in the telomere-related gene POT1 and noncarrier relatives. (evmedreview.com)

He had just observed that the ends of the irradiated chromosomes, different from the other genome, did not present alterations such as deletions or inversions, thanks to the presence of a protective cap that he called "terminal gene" and afterwards "telomere", from the greek terms "telos" (end) and "meros" (part) (Müller HJ. (wikipedia.org)
TERRA is a major component in helping protect the genome at a very sensitive place, the telomeres,' said senior author Paul M. Lieberman, Ph.D., a professor in Wistar's Gene Expression and Regulation Program. (news-medical.net)
Results PWBTL averaged 1.76 (telomere/single-copy gene of albumin, T/S) in 144 battery plant workers. (bmj.com)
Another gene implicated in DKC, TINF2 , encodes a key component of the protein shelterin, which plays a role in telomere homeostasis. (medscape.com)
A heterozygous mutation was found on the conserved telomere maintenance component 1 gene ( CTC1 ). (medscape.com)

And abnormally short telomeres seem to make humans more susceptible to conditions such as bone marrow failure, pulmonary fibrosis, liver disease, and gastrointestinal disease over time. (mindbodygreen.com)

Blackburn, Carol Greider, and Jack Szostak were awarded the 2009 Nobel Prize in Physiology or Medicine for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. (wikipedia.org)
The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)
Professor Elizabeth Blackburn won the Nobel Prize in Physiology or Medicine in 2009, jointly with professor Carol Greider and professor Jack Szostak, for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. (frontiersin.org)

Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. (goodreads.com)
The botanicals in Telomere Plus have been shown to increase the activity of telomerase, a naturally-occurring enzyme that lengthens telomeres and protects them from shortening. (enzymedica.com)
Blackburn and Szostak found that chromosomes without telomeres are protects them from degradation. (animalresearch.info)

So we specifically looked for alterations in the expression of genes involved in the epithelial-to-mesenchymal transition in our mice with short telomeres and renal fibrosis, to see if short telomeres could be the trigger for the changes in expression of these genes," explains Blasco. (cnio.es)

Therefore, proper establishment, regulation, and maintenance of the telomere chromatin structure are required for cell homeostasis. (nih.gov)

Our pilot study examined whether conditions of chronic adversity are associated with shortened telomeres among low-income pregnant women. (confex.com)
Describe how telomeres may mediate the relationship between socioeconomic status, chronic psychosocial stress, and adverse health outcomes. (confex.com)
Together with psychology researcher Elissa Epel, she studied the relationships between telomeres and chronic stress. (frontiersin.org)

Telomeres are a protective nucleoprotein structure at each chromosome end. (cdc.gov)
Short telomeres - the protective caps on the ends of chromosomes - have been previously linked to increased risk of death from heart disease. (scienceblog.com)
It also shows, rather surprisingly, that a substantial number of people had telomere lengthening, and that this appeared to be protective. (scienceblog.com)
Because some really villainous free radicals have the power to tear away at your telomeres (protective tips of your DNA critical for aging), they ultimately have the power to tear away at your DNA, too. (susansmithjones.com)
At the end of each chromosome is a telomere, which acts as a protective cap. (antiaging-systems.com)
In this article, I will tell you about telomeres, which are the protective tips of DNA molecules-the molecules where the organism's genes are stored. (frontiersin.org)

So far, the mechanism of telomere lengthening is unknown, the authors say. (scienceblog.com)
TERRA associates with telomeric factors, but its precise function and mechanism of localization at telomeres had been largely unknown. (news-medical.net)
The mechanism that limits cell division involves a structure called a telomere. (msdmanuals.com)
We hope to contribute fundamental knowledge about telomere maintenance and the evolution of this mechanism. (lu.se)

A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer. (cdc.gov)
Genetics of human telomere biology disorders. (cdc.gov)

When combined with a healthy diet and regular exercise , taking a vitamin D supplement can help keep telomeres in tiptop shape and promote longevity from the inside out. (mindbodygreen.com)
By understanding what telomeres are and how they work, we can take measures to help lengthen our telomeres and promote longevity. (antiaging-systems.com)

TRF1, a core component of the telomere protein complex shelterin, has been implicated as a mediator of telomere associations. (ubc.ca)

Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride. (ens-lyon.fr)
Home / Teams / Epigenetics and Zygote Formation - B. Loppin / Publications / Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride. (ens-lyon.fr)

Telomere resolution and genomic instability in mouse. (ubc.ca)

However, little is known about regulation of telomere biology during pregnancy. (confex.com)
Taken together, our results demonstrate that precise regulation of TRF1 levels is essential for telomere resolution and mitotic segregation. (ubc.ca)

ATRX-deficient neu-roprogenitors exhibited higher incidence of telomere fusions and increased sensitivity to replication stress-inducing drugs. (bepress.com)
A telomere, which looks like a shoelace cap, is intended to keep chromosomes from fraying or unravelling during replication. (nepalnews.com)
Telomere shortening in somatic tissues largely reflects stem cell replication. (columbia.edu)

Findings arising from this prolonged collaboration were published in 2017 in a popular science book called The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer . (frontiersin.org)
Funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis (P = 0.532).The results of this meta-analysis suggest that the presence of shortened telomeres may be a marker for susceptibility to human cancer, but single larger, well-design prospective studies are warranted to confirm these findings. (duke.edu)

To determine the effect of TRF1 protein levels on telomere associations, we used live-cell fluorescence microscopy to visualize telomeres and chromosome dynamics in cells expressing defined levels of TRF1. (ubc.ca)
We also observed telomere aggregates, mitotic bypass, and TRF1 bridges persisting into the following cell cycle. (ubc.ca)
To examine the role of TRF1 in these telomere associations, we generated a TRF1 protein which can be inducibly cleaved by TEV protease. (ubc.ca)
The essential helicase RTEL1 was observed at the extremities of persistent TRF1 bridges, possibly indicating a function for RTEL1 in the resolution of TRF1-induced telomere associations. (ubc.ca)

Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. (glycemicindex.com)
Telomeres play an essential role in our body's health and aging process. (antiaging-systems.com)
Discuss the potential role of telomere biology in maternal and child health outcomes. (confex.com)
These results show the important role short telomeres play in its development, and this finding undoubtedly opens new doors for the treatment of renal fibrosis," says the first author of the study, Sarita Saraswati , a researcher with the Telomeres and Telomerase Group at CNIO. (cnio.es)
To determine the role telomerase plays when the lung is challenged, B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres and wild-type controls were subjected to partial pneumonectomy. (ca.gov)
Dyskerin is composed of 514 amino acids and has a role in ribosomal RNA processing and telomere maintenance. (medscape.com)
This will help to elucidate the role of telomerase activity in tumorigenesis as well as the role of telomere shortening in aging. (lu.se)
The Role of Telomeres in Human Disease. (cdc.gov)
A recent study proposes a key role for telomere maintenance in the development of clonal hematopoiesis. (cdc.gov)

A bit like those plastic tips on the ends of your shoelaces, telomeres prevent the ends of the chromosomes from fraying. (glycemicindex.com)
Telomeres are the tips at the ends of chromosomes that protect our DNA. (enzymedica.com)
Combining both protein and RNA components, telomerase is a reverse transcriptase which adds telomere DNA to the ends of molecules using an RNA template. (slideshare.net)
Telomeres are tandem nucleotide repeats that protect the ends of chromosomes from erosion during cell division. (datadryad.org)
Additionally, recent studies suggest that the Werner protein may be particularly important for maintaining DNA at the ends of chromosomes (telomeres). (medlineplus.gov)

An up to date survey of the current exciting state of telomere biology. (cshlpress.com)
The second edition of Telomeres is an outstanding summary of what has become an area of biology with substantial range and depth. (cshlpress.com)
In 1978, Blackburn became an assistant professor of molecular biology at the University of California Berkeley, where she continued investigating the telomeres of pond scum. (frontiersin.org)

Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)

The model also suggests that strategies targeted at repairing telomeres in pre-senescent cells could eradicate telomere-induced DNA damage foci and low-level DNA damage response while preventing further irreversible damage to the genome. (genengnews.com)
We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentro-meric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation. (bepress.com)
So between DNA getting attacked by free radicals (which can be produced by harmful UV exposure) and decreasing NADs unable to adequately, efficiently repair the DNA damage caused by destroyed telomeres. (susansmithjones.com)
In B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres, response to pneumonectomy was characterized by decreased survival, diminished compensatory lung growth, attenuated distal lung progenitor cell response, persistent DNA damage, and cell growth arrest. (ca.gov)

I will also introduce you to an enzyme that we discovered, called telomerase, which is responsible for the addition and maintenance of telomeres. (frontiersin.org)
As male investment in reproduction involves a yearly bout of physiologically stressful activities, while females prioritize self-maintenance, we predicted male snakes would experience more age-specific telomere loss than females. (datadryad.org)

Oxidative stress plays an important part in telomere shortening in people with diabetes. (glycemicindex.com)
This increased oxidative stress level speeds up telomere shortening. (glycemicindex.com)
The good news is that healthy eating guidelines for preventing and managing type 2 diabetes that help people to optimise their blood glucose levels, like consuming a moderate amount of low GI carbohydrate at main meals, and eating plenty of non-starchy vegetables and low GI fruit, will also help slow the shortening of telomeres, in-part by reducing oxidative stress. (glycemicindex.com)
[ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)

Anatomy5

Organisms3

Diseases5

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes18

Information Science2

Evaluating telomere length1

Leukocyte telomere length7

Shorter20

Longer telomeres5

Shorten5

Length89

Long telomeres3

Chromosomal7

Proteins7

Lengthen telomeres3

Attrition5

Senescence7

Somatic cells3

Short telomere syndromes3

Researchers5

Diseases6

Structures8

Dysfunction3

Sequences6

Loss of telomere1

Function of telomeres3

Cellular8

Leucocyte1

Stability2

Genetic9

Extend telomeres1

Protect telomeres2

Maintains telomeres1

Mutations1

Gene5

Abnormally short1

Enzyme telomerase3

Protects3

Alterations1

Homeostasis1

Chronic3

Protective6

Mechanism4

Genetics2

Longevity2

Shelterin1

Epigenetic2

Genomic instability1

Regulation2

Replication3

Findings2

TRF14

Role10

Ends5

Biology3

Telomerase activity2

Damage4

Maintenance2

Oxidative4