Loading...
  • telomeric
  • I am seeking additional qualified postdoctoral researchers to study one of two ongoing projects: a) the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. (bio.net)
  • We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) The mechanisms of nucleation and inheritance of telomeric silencing (e.g. (bio.net)
  • However, there is some debate on the topic, since telomeric length does not seem to affect lifespan in mice and birds with both long and short life-spans have been shown to have mega-telomeres. (wikipedia.org)
  • In birds, whose cells contain microchromosomes, it has been suggested that there was a correlation between the presence of mega-telomeres and the number of microchromosomes present in a species, such that bird genomes with large numbers of microchromosomes also possessed larger amounts of telomeric DNA sequence. (wikipedia.org)
  • Since TRF1 bends the telomeric site, it may be a critical step in properly functioning telomeres to maintain its length. (wikipedia.org)
  • POT1 (Protection of Telomere 1): POT1 contains OB-folds (oligonucleotide/oligosaccharide binding) that bind POT1 to single-stranded DNA, which increase its affinity for single-stranded TTAGGG region of telomeric DNA. (wikipedia.org)
  • Pot1
  • Baumann P, Cech T (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. (springer.com)
  • telomerase activity
  • Here we provide evidence that psychological stress- both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. (pnas.org)
  • structures
  • The telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structures" (PDF). (wikipedia.org)
  • lengths
  • Overall, the individuals with the shortest and the longest telomere lengths were at an increased risk for colorectal cancer, Boardman said. (mdtmag.com)
  • leukocyte
  • The researchers measured peripheral blood leukocyte DNA telomere length in 772 patients diagnosed with microsatellite stable colorectal cancer. (mdtmag.com)
  • In a longitudinal study, both leukocyte telomere length and carotid atherosclerosis were quantified in 154 subjects at baseline and after a 9.5-year follow-up, and their interrelation was evaluated. (ahajournals.org)
  • lengthens
  • Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potentially immortal, as is often the case with cancerous cells. (wikipedia.org)
  • strongly correlated
  • Since telomere shortening is strongly correlated with an increased risk of cancer during aging and chronic disease, the scientific literature suggests that the loss of telomere capping function contributes to the induction of chromosomal instability and cancer initiation process. (news-medical.net)
  • senescence
  • In vitro , when telomeres shorten sufficiently, the cell is arrested into senescence. (pnas.org)
  • The discovery that critical telomere shortening initiates replicative senescence triggered a vast body of epidemiological studies exploring its implications for human aging. (ahajournals.org)
  • The absence of shelterin causes telomere uncapping and thereby activates damage-signaling pathways that may lead to non-homologous end joining (NHEJ), homology directed repair (HDR), senescence, or apoptosis. (wikipedia.org)
  • Oxidative
  • Most notably, in vitro , oxidative stress can shorten telomeres and antioxidants can decelerate shortening ( 9 , 10 ). (pnas.org)
  • Given these observed links, we hypothesized that chronic psychological stress may lead to telomere shortening and lowered telomerase function in peripheral blood mononuclear cells (PBMCs) and to oxidative stress. (pnas.org)
  • function
  • Postdoctoral position to study telomere structure and function. (bio.net)
  • The specific function of mega-telomeres in vertebrate cells is still unclear. (wikipedia.org)
  • Many studies in model organisms have established the significance of telomere structure and function in regulating genome stability, cellular aging, and oncogenesis. (wikipedia.org)
  • Since telomeres appear at the end of chromatids, and function to prevent their ends from fusing with other chromatids, the lack of a telomere on these two sister chromatids causes them to fuse with one another. (wikipedia.org)
  • cell
  • In humans, telomerase assembles with telomeres during S phase of the cell cycle. (springer.com)
  • This study was the first to evaluate donor cell telomere length and outcomes after HCT in SAA. (cancer.gov)
  • The association between donor cell telomere length and patient survival remained statistically significant after adjusting for donor age and other factors important in SAA-related transplant outcomes. (cancer.gov)
  • The results of this study suggest that donor white blood cell telomere length may have a role in long-term post-transplant survival. (cancer.gov)
  • Thus, telomere length can serve as a biomarker of a cell's biological (versus chronological) "age" or potential for further cell division. (pnas.org)
  • When you examine the cell in culture, you find that well, the telomere shortens when you add a stressor like free radicals, hydrogen peroxide when you buffer that environment with an antioxidant like Vitamin C, you don't get the shortening. (sharecare.com)
  • However, subsequent studies showed that mega-telomeres are not necessarily present in all species with microchromosomes, nor are they found on all microchromosomes within a cell. (wikipedia.org)
  • Each time a cell in the body divides, its telomeres become shorter. (wikipedia.org)