• We anticipated that we would see some people who had young-onset colon cancer and shorter telomeres compared to people of the same age group who did not have cancer," said Boardman. (mdtmag.com)
  • Cancer cells have shorter telomeres compared to healthy cells, but they guard their immortality by maintaining these telomeres' length. (asm.org)
  • However, mega-telomeres are substantially longer than regular telomeres, ranging in size from 50 kilobases to several megabases (for comparison, the normal length of vertebrate telomeres is usually between 10 and 20 kilobases). (wikipedia.org)
  • However, there is some debate on the topic, since telomeric length does not seem to affect lifespan in mice and birds with both long and short life-spans have been shown to have mega-telomeres. (wikipedia.org)
  • A new study suggests that telomere length in adults should be regarded as a static biomarker that does not significantly change during adult life. (news-medical.net)
  • At every age, telomere length displays a normal distribution that is defined by the percentile lines labelled on the right. (nih.gov)
  • Telomere length in individuals with four different clinical presentations across the age range is indicated. (nih.gov)
  • Correct telomere length setting is crucial for long-term survival. (springer.com)
  • The telomere length reserve must be sufficient to avoid premature cellular senescence and the acceleration of age-related disease. (springer.com)
  • In recent years, novel insight into the regulation of telomerase at chromosome ends has increased our understanding on how telomere length homeostasis in telomerase-positive cells is achieved. (springer.com)
  • This suggests a model in which telomeres switch between extendible and nonextendible states in a length-dependent manner. (springer.com)
  • In this review we expand this model to incorporate the finding that telomerase levels also limit telomere length and we propose a second switch between a non-telomerase-associated "extendible" and a telomerase-associated "extending" state. (springer.com)
  • We focused this review on factors whose functions are well integrated into telomere replication and length homeostasis in S . cerevisiae or human cells. (springer.com)
  • 53,54 In the animal kingdom, though, long-lived species often have shorter telomeres than do short-lived species, indicating that telomere length probably does not determine life span. (scientificamerican.com)
  • 55,56,57 Solid scientific evidence has shown that telomere length plays a role in determining cellular life span in normal human fibroblasts and some other normal cell types. (scientificamerican.com)
  • 56 Kakuo S, Asaoka K, Ide T. Human is a unique species among primates in terms of telomere length. (scientificamerican.com)
  • Telomere length decreases with age. (news-medical.net)
  • By contrast, the length of telomeres in a patient's own white blood cells, as measured before transplantation, was not associated with survival. (cancer.gov)
  • Telomere length has been implicated in the development of several cancers, as well as other health conditions. (cancer.gov)
  • This study was the first to evaluate donor cell telomere length and outcomes after HCT in SAA. (cancer.gov)
  • In this study, Shahinaz Gadalla, M.D., Ph.D., of NCI's Division of Cancer Epidemiology and Genetics, and her colleagues evaluated associations between pre-HCT white blood cell telomere length among 330 transplant recipients and their matched unrelated donors and survival after an HCT. (cancer.gov)
  • The association between donor cell telomere length and patient survival remained statistically significant after adjusting for donor age and other factors important in SAA-related transplant outcomes. (cancer.gov)
  • The results of this study suggest that donor white blood cell telomere length may have a role in long-term post-transplant survival. (cancer.gov)
  • Inheritance of telomere length in a bird. (nih.gov)
  • Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. (nih.gov)
  • While telomere length is influenced by environmental factors there is also good evidence for a strong heritable component. (nih.gov)
  • Genetic factors, e.g. sex chromosomal inactivation, and non-genetic factors, e.g. antioxidant properties of oestrogen, have been suggested as possible explanations for these sex-specific telomere inheritance and telomere length differences. (nih.gov)
  • We found that, contrary to findings in humans, telomere length was maternally inherited and also longer in males. (nih.gov)
  • These results argue against an effect of sex hormones on telomere length and suggest that factors associated with heterogamy may play a role in telomere inheritance and sex-specific differences in telomere length. (nih.gov)
  • Telomere length of Kakapo against age. (nih.gov)
  • Parent-offspring correlations of kakapo telomere length corrected for sex. (nih.gov)
  • Here we provide evidence that psychological stress- both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, which are known determinants of cell senescence and longevity, in peripheral blood mononuclear cells from healthy premenopausal women. (pnas.org)
  • Thus, telomere length can serve as a biomarker of a cell's biological (versus chronological) "age" or potential for further cell division. (pnas.org)
  • Cellular environment also plays an important role in regulating telomere length and telomerase activity. (pnas.org)
  • The telomere length is actually not a one way street. (sharecare.com)
  • The researchers measured peripheral blood leukocyte DNA telomere length in 772 patients diagnosed with microsatellite stable colorectal cancer. (mdtmag.com)
  • The researchers compared this group's telomere length with 1,660 nonrelated, age-matched, healthy controls. (mdtmag.com)
  • Patients with the longest telomeres - those patients in the 95th percentile of telomere length - were 30 percent more likely to develop colorectal cancer than those in the 50th percentile, the results showed. (mdtmag.com)
  • In a longitudinal study, both leukocyte telomere length and carotid atherosclerosis were quantified in 154 subjects at baseline and after a 9.5-year follow-up, and their interrelation was evaluated. (ahajournals.org)
  • A distinct pattern in the changing length of blood telomeres, the protective end caps on our DNA strands, can predict cancer many years before actual diagnosis, according to a new study from Northwestern Medicine in collaboration with Harvard University. (medicalxpress.com)
  • Initially, scientists discovered telomeres aged much faster (indicated by a more rapid loss of length) in individuals who were developing but not yet diagnosed with cancer. (medicalxpress.com)
  • The Northwestern and Harvard study is believed to be the first to look at telomere length at more than one time point before diagnosis. (medicalxpress.com)
  • The telomerase enzyme complex is comprised of TERT (the reverse transcriptase) and TR (the essential RNA component that contains a template for telomere repeat addition). (nih.gov)
  • Telomerase (TERT), a reverse transcriptase, forms a complex with an RNA template and cofactors to extend telomeres. (qiagen.com)
  • Telomerase, which is composed of both an enzymatic subunit (TERT) and an RNA component, promotes genomic stability by lengthening telomeres that have become shortened and is particularly important for stem cell renewal and tumor cell survival. (sciencemag.org)
  • The amount of telomerase present in a cell is key to telomere maintenance, and many transcription factors both positively and negatively regulate the transcription of Tert (see the Perspective by Greider). (sciencemag.org)
  • The CST complex has three components - conserved telomere protection component 1 (CTC1), suppressor of cdc thirteen 1 (STN1) and telomeric pathway with STN1 (TEN1) - which are thought to function in part in telomere lagging-strand synthesis. (nih.gov)
  • On the other side, telomere shortening suppresses tumor formation through limiting the replicative potential of cells. (springer.com)
  • The discovery that critical telomere shortening initiates replicative senescence triggered a vast body of epidemiological studies exploring its implications for human aging. (ahajournals.org)
  • In birds, whose cells contain microchromosomes, it has been suggested that there was a correlation between the presence of mega-telomeres and the number of microchromosomes present in a species, such that bird genomes with large numbers of microchromosomes also possessed larger amounts of telomeric DNA sequence. (wikipedia.org)
  • I am seeking additional qualified postdoctoral researchers to study one of two ongoing projects: a) the role of the telomere-binding protein RAP1 in telomere size control and telomeric silencing (see Lustig et al. (bio.net)
  • We have had a long-standing fascination in telomere structure and function and are currently focusing on two broad areas: 1) The mechanisms of nucleation and inheritance of telomeric silencing (e.g. (bio.net)
  • A schematic drawing that illustrates the typical range of telomere lengths by age in, for example, peripheral blood lymphocytes. (nih.gov)
  • Overall, the individuals with the shortest and the longest telomere lengths were at an increased risk for colorectal cancer, Boardman said. (mdtmag.com)
  • In order to determine if these subsets of patients with younger-onset colorectal cancer have tumors that are mechanistically distinct, we are in the process of comparing the telomere lengths in the peripheral blood DNA with that in the tumor. (mdtmag.com)
  • Baumann P, Cech T (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. (springer.com)
  • In vitro evidence has shown that shorter telomeres directly contribute to the swift progression of the earliest stages of certain malignancies. (news-medical.net)
  • We also found that fibroblasts from Hutchinson-Gilford progeria donors had short telomeres, consistent with their reduced division potential in vitro. (pnas.org)
  • In vitro , when telomeres shorten sufficiently, the cell is arrested into senescence. (pnas.org)
  • New and rapid advances in technology have equipped us with a variety of tools and platforms to ask fundamental questions of telomere regulation and have allowed investigators to carry out experiments using diverse model systems. (springer.com)
  • QIAGEN provides a broad range of assay technologies for telomere and telomerase research that enables analysis of gene expression and regulation, epigenetic modification, genotyping, and signal transduction pathway activation. (qiagen.com)
  • Assessing the importance of telomerase for normal cells or demonstrating that its inhibition can in fact destroy telomerase-producing cancers (and supersede telomere-salvaging pathways) are just a couple of examples. (news-medical.net)
  • Inhibition of telomere extension leads to short telomeres and premature aging-related diseases, whereas uncontrolled telomere lengthening promotes carcinogenesis. (qiagen.com)
  • More specifically, 2 competitive hypotheses on the role of telomeres as primary risk factor for ACVD were scrutinized: (1) shorter (inherited) telomeres versus (2) higher telomere attrition rates (Figure). (ahajournals.org)
  • Magnesium plays an important role in many of the processes involved in regulating telomere structure, integrity and function. (mdpi.com)
  • The pervasive role of magnesium in telomere homeostasis is also highlighted. (mdpi.com)
  • Components for which mutations have been identified in telomere syndromes are indicated in bold type and shaded in blue. (nih.gov)
  • When cells divide, the telomere is not fully replicated because of limitations of the DNA polymerases in completing the replication of the ends of the linear molecules, leading to telomere shortening with every replication ( 3 ). (pnas.org)
  • However, subsequent studies showed that mega-telomeres are not necessarily present in all species with microchromosomes, nor are they found on all microchromosomes within a cell. (wikipedia.org)
  • In humans, telomerase assembles with telomeres during S phase of the cell cycle. (springer.com)
  • When you examine the cell in culture, you find that well, the telomere shortens when you add a stressor like free radicals, hydrogen peroxide when you buffer that environment with an antioxidant like Vitamin C, you don't get the shortening. (sharecare.com)
  • Telomeres shorten every time a cell divides. (medicalxpress.com)
  • The older you are, the more times each cell in your body has divided and the shorter your telomeres. (medicalxpress.com)