Telomerase. Medical search. Frequent questions

The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase activity in multiple types of cancer. (wikipedia.org)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
It is true to say that telomeres and telomerase are one of the hottest areas of anti-aging research, but it is also true that the misconceptions and confusion in this area are significant. (antiaging-systems.com)
However, the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown. (ca.gov)
In later work, Blackburn, Greider and Szostak found that telomeres and telomerase play a major part in the ageing process - of cells and of entire organisms. (animalresearch.info)
The flow of weekly news items related to telomeres and telomerase has grown from a trickle to a steady stream. (anti-agingfirewalls.com)

The molecular composition of the human telomerase complex was determined by Scott Cohen and his team at the Children's Medical Research Institute (Sydney Australia) and consists of two molecules each of human telomerase reverse transcriptase (TERT), telomerase RNA (TR or TERC), and dyskerin (DKC1). (wikipedia.org)
Telomerase is a complex of a reverse transcriptase protein encoded by the TERT (telomerase reverse transcriptase) gene and a template RNA TERC (telomerase RNA component). (nature.com)
Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF). (nih.gov)
The TERT mutations compromised telomerase catalytic activity, and mutation carriers had short telomeres. (jci.org)
This is significant because some other telomerase activators may work only indirectly, through reactivation of a gene (the telomerase reverse transcriptase -TERT gene) which then affects telomerase. (antiaging-systems.com)
Five heterozygous, nonsynonymous mutations (which cause an amino acid change in the corresponding protein) were identified in TERT, the gene for the telomerase reverse transcriptase catalytic enzyme, among seven unrelated patients. (nih.gov)
The results of coexpression of wild-type TERT and TERT with aplastic anemia-associated mutations in a telomerase-deficient cell line suggested that haploinsufficiency was the mechanism of telomere shortening due to TERT mutations. (nih.gov)
Heterozygous mutations in the TERT gene impair telomerase activity by haploinsufficiency and may be risk factors for marrow failure. (nih.gov)
Loss of function mutations in TERT , the telomerase reverse transcriptase gene, and TR (also known as TERC ), the telomerase RNA, underlie up to 20% and 3% of familial and sporadic pulmonary fibrosis cases, respectively [ 8 ], [ 9 ]. (ersjournals.com)
Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are independent of this central function. (harvard.edu)
This is therefore the first demonstration of a non-canonical catalytic activity of TERT, which is different from 'authentic'' telomerase activity, is required for during vertebrate hematopoiesis. (harvard.edu)
Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase reverse transcriptase (TERT) and an integral RNA subunit template. (elifesciences.org)
The fundamental question of whether human telomerase catalytic activity requires cooperation across two TERT subunits remains under debate. (elifesciences.org)
Surprisingly, telomerase reconstitutions yielded heterogeneous DNA-bound TERT monomer and dimer complexes in relative amounts that varied with assembly and purification method. (elifesciences.org)
The center of telomerase has a protein called TERT that forms complexes with other proteins. (elifesciences.org)
Both 851884-87-2 manufacture were identified through genetic screens and shown to act in the same pathway as telomerase RNA and TERT and to be subunits of the telomerase complex but dispensable for in vitro activity (10, 32). (bioskinrevive.com)
The minimal elements for catalytic activity reconstitution are the proteins component telomerase invert transcriptase (TERT) and the noncoding telomerase RNA (TR), which bears the template area to synthesize telomeric repeats. (woofahs.com)
This connections is normally mediated by the N-terminal site of TERT, known as the 10 site (telomerase important N-terminal site) (9), and the telomere by the 22232-71-9 IC50 shelterin complicated, a six-member proteins complicated (10). (woofahs.com)
when overexpressed, many TERT substances constitutively localize to most telomeres within a cell, which can be not really noticed in normally telomerase-positive cells (12). (woofahs.com)
Until lately, immediate statement of telomerase actions at telomeres without overexpression offers been substantially hampered by the absence of a dependable antibody finding endogenous amounts of TERT. (woofahs.com)

Family members carrying the mutations also had short telomeres and reduced telomerase activity but no evident hematologic abnormality. (nih.gov)
Upon zTERT knockdown, zebrafish embryos show reduced telomerase activity and are viable, but develop pancytopenia resulting from aberrant hematopoiesis. (harvard.edu)

Mutations in TERC, the gene for the RNA component of telomerase, cause short telomeres in congenital aplastic anemia and in some cases of apparently acquired hematopoietic failure. (nih.gov)
The 5-Fu treatment nearly abolishes transcription of hTERT (the major component of telomerase) mRNA. (biomedcentral.com)

Telomerase RNA TERC and the PI3K-AKT pathway form a positive feedback loop to regulate cell proliferation independent of telomerase activity. (nih.gov)
If you knocked out just the TERC, the key required for telomerase to work ( triangles ) you got high telomere dysfunction (short and damaged) and low ability to reproduce. (rechargebiomedical.com)
We have previously shown that lungs of late generation, telomerase null B6.Cg-Terc(tm1Rdp) mice feature alveolar simplification and chronic stress signaling at baseline, a phenocopy of aged lung. (ca.gov)
To determine the role telomerase plays when the lung is challenged, B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres and wild-type controls were subjected to partial pneumonectomy. (ca.gov)

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. (wikipedia.org)
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. (nih.gov)
The following investigators contribute to the telomerase ribonucleoprotein body of knowledge. (asu.edu)
Telomerase is a ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats. (jhu.edu)
Telomerase is a ribonucleoprotein reverse transcriptase responsible for the maintenance of one strand of telomere terminal repeats. (bioskinrevive.com)
Recent work on the ribonucleoprotein enzyme telomerase has indicated an unanticipated degree of intranuclear dynamics of both its RNA and protein subunits. (rupress.org)

In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
A recent study of centenarian Ashkenazi Jews found that they and their descendents have a mutant gene which results in higher levels of telomerase, longer telomeres, greater health at old age and - well - and ability to live very long healthy lives. (anti-agingfirewalls.com)
This is in contrast to human OSA where 25-40% expression levels of telomerase are reported. (fitzpatrickreferrals.co.uk)

Here, I will assume that you are already familiar with telomeres and the general function of telomerase. (antiaging-systems.com)
In any case, I will discuss the supplements, nutrients and strategies that can help improve the overall function of telomerase and so result in healthy telomeres, and thus, healthy DNA. (antiaging-systems.com)
Telomerase modulators are compounds which regulate the function of telomerase. (antiaging-systems.com)
However, with few exceptions, these noncatalytic components of telomerase do not appear to participate directly in the telomere extension function of telomerase in vivo. (bioskinrevive.com)
Seems to be involved in the function of telomerase. (lu.se)

We investigated whether mutations in genes for other components of telomerase also occur in aplastic anemia. (nih.gov)

100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). (adooq.com)
At the primary sequence level, the two telomerase proteins share only limited homologies with other polymerases and polymerase accessory factors. (jhu.edu)
Telomerase is mechanistically a reverse transcriptase but to the grateful genomes on which it operates it is a chromosome end-specific DNA polymerase. (rupress.org)
Telomerase activity was determined using polymerase chain reaction, which refers to the telomeric repeat amplification protocol. (medicaljournal-ias.org)
Telomerase is RNA dependent DNA polymerase, acts to synthesize DNA repeat fragment of telomeres , which is associated with immortalization of cells. (linguix.com)

Telomerase is active in gametes and most cancer cells, but is normally absent in most somatic cells. (wikipedia.org)
In adults, telomerase is highly expressed only in cells that need to divide regularly, especially in male sperm cells, but also in epidermal cells, in activated T cell and B cell lymphocytes, as well as in certain adult stem cells, but in the great majority of cases somatic cells do not express telomerase. (wikipedia.org)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. (nih.gov)
Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. (nih.gov)
In normal somatic cells, the telomeres shorten with replicative age, and telomerase is not detected. (linguix.com)

We describe the purification of telomerase and the cloning of cDNAs encoding two protein subunits from the ciliate Tetrahymena. (jhu.edu)
This finding is a new twist on the intranuclear location and dynamics of telomerase in mammalian cells, but we still have much to learn about how telomerase and its subunits roam around in the nucleus as related to the enzyme's on- and off-duty work cycles. (rupress.org)
The telomerase inhibitory function of this complex can be enhanced by drugs that block the poly(ADP-ribosyl)ation of its TRF1 and/or TRF2 subunits. (oncotarget.com)

Even though IPF remains defined by its idiopathic adjective, its most frequent identifiable genetic cause is inherited mutations in the telomerase genes [ 8 ]. (ersjournals.com)
Yousin Suh, associate professor of medicine and genetics at Einstein and a lead author on the paper, said: "Our findings suggest that telomere length and variants of telomerase genes combine to help people live very long lives, perhaps by protecting them from the diseases of old age( ref ). (anti-agingfirewalls.com)
Reprinted from Cell 81, Collins, Kathleen, et al, "Purification of Tetrahymena Telomerase and Cloning of Genes Encoding the Two Protein Components of the Enzyme", pg. (jhu.edu)
In this report, we queried the database with telomerase genes and identified three potential protein components of the telomerase complex (named CaTERT, CaEst1p, and CaEst3p). (bioskinrevive.com)

Two proteins of 80 and 95 kDa copurified and coimmunoprecipitated with telomerase activity and the previously identified Tetrahymena telomerase RNA. (jhu.edu)
Particularly, a little area in the shelterin proteins TPP1 known as the TEL spot interacts with the telomerase 10 site (11,C18). (woofahs.com)

Mutations in the telomerase accessory component, DKC1 , the dyskeratosis congenita 1 gene, can also manifest as IPF, underscoring the important role of telomere dysfunction in IPF pathogenesis [ 10 ]. (ersjournals.com)

A subset of pulmonary fibrosis, like dyskeratosis congenita, bone marrow failure, and liver disease, represents a "telomeropathy" caused by germline mutations in telomerase and characterized by short telomere lengths. (nih.gov)
Our findings identify germline mutations in telomerase as a Mendelian risk factor for COPD susceptibility that clusters in autosomal dominant families with telomere-mediated disease including pulmonary fibrosis. (jci.org)

Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
The p95 subunit specifically cross-linked to a radiolabeled telomeric DNA primer, while the p80 subunit specifically bound to radiolabeled telomerase RNA. (jhu.edu)
Telomerase activity, hTERT transcription level and p- p70 S6k was demonstrated by the telomeric repeat amplification protocol and silver staining assay, Dual-Luciferase Reporter Assay and Western blot analysis respectively. (biomedcentral.com)
Since telomerase is recruited to and elongates the single-stranded telomeric 3 ′ overhangs, the generation of 3 ′ overhangs is an essential step in the maintenance process. (lu.se)

Of the evaluable samples, 81% had detectable telomerase activity, 97% had detectable hTERT transcript, and 100% had detectable hTR. (northwestern.edu)
Weak correlations were observed between telomerase activity and hTR level (r = 0.34, P = 0.02) and between telomerase activity and hTERT mRNA level (r = 0.32, P = 0.04). (northwestern.edu)
telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER ov. (targetmol.com)

Telomerase is an enzyme that catalyzes the addition of nucleotides on the ends of chromosomes. (nih.gov)
Jack Szostak , a genetics professor at Harvard Medical School and Harvard-affiliated Massachusetts General Hospital (MGH), has won the 2009 Nobel Prize in physiology or medicine for pioneering work in the discovery of telomerase , an enzyme that protects chromosomes from degrading. (harvard.edu)
The three won the prize for work conducted during the 1980s to discover and understand the operation of telomerase, an enzyme that forms protective caps called telomeres on the ends of chromosomes. (harvard.edu)
Telomerase is an enzyme that is responsible for maintaining the length of our telomeres, which are the protective end caps on our chromosomes that deteriorate as we age. (vermontrepublic.org)
An enzyme called telomerase adds structures called telomeres to the ends of the chromosomes, which protect the DNA from damage. (elifesciences.org)
In 2009, Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak were jointly awarded a Nobel prize for their research into telomeres, which are found at the end of chromosomes, and their discovery of telomerase, the enzyme that maintains them. (animalresearch.info)
Greider and Blackburn identified the enzyme that helps telomeres to protect the chromosomes - telomerase. (animalresearch.info)

Therefore, a future challenge will be to refine the method to allow experiments to use much less protein, which would more closely reflect how telomerase is produced in cells. (elifesciences.org)
Telomerase is unusual because it is made up of RNA as well as protein molecules. (animalresearch.info)
A Rabbit polyclonal to ZNF346 typical telomerase reaction was carried out in a 30-l volume containing the following: 10 mM Tris-HCl (pH 8.0), 2 mM magnesium acetate, 150 mM sodium acetate (contributed by the protein fraction), 1 mM spermidine, 1 mM dithiothreitol, 5% glycerol (contributed by the protein fraction), 851884-87-2 manufacture 5 M primer oligodeoxynucleotides, 5- to. (bioskinrevive.com)
The focus of most research on telomerase in protozoa (gloriously), fungi, and plant and animal metazoa has been on the enzyme's molecular components-once thought to consist of just a subunit of RNA and another one of protein, but now probably several of the latter. (rupress.org)
Telomerase is normally not really generally present at telomeres but is normally definitely hired during the T stage to a subset of telomeres through protein-protein connections that take place between telomerase and the telomere. (woofahs.com)

To further examine the role of telomerase during vertebrate development, the zebrafish telomerase reverse transcriptase (zTERT) was functionally characterized. (harvard.edu)
The acclaimed role of telomerase in the growth properties of some cells has given it tabloid status on both the oncology and biotechnology industry radar screens, but only time will tell if that rush has been warranted. (rupress.org)

The botanicals in Telomere Plus have been shown to increase the activity of telomerase, a naturally-occurring enzyme that lengthens telomeres and protects them from shortening. (enzymedica.com)

Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. (nih.gov)
Many lines of proof suggest that telomerase, especially, the procedure of telomerase recruitment to specific telomeres, must end up being examined in the circumstance of the physical reflection amounts controlled within the endogenous hereditary circumstance. (woofahs.com)

RHPS4 is a potent inhibitor of Telomerase at submicromolar. (adooq.com)
Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. (oncotarget.com)
Braco-19 trihydrochloride is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. (targetmol.com)
Telomerase-IN-2 is an inhibitor of telomerase, and inhibits telomerase activity by decreasing expression of dyskerin(IC50 of 0.89 µM), with anti-cancer activity. (targetmol.com)

Only CaTERT is absolutely required for telomerase activity as measured by a primer extension assay in vitro. (bioskinrevive.com)
Purification of and assay for telomerase. (bioskinrevive.com)
17 (51%) of the 33-bladder carcinoma tested patients revealed positive results for cytology, whereas using TRAP assay presence of the telomerase was positive in all of the tested bladder carcinoma cases. (medicaljournal-ias.org)
360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay). (targetmol.com)
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). (targetmol.com)
BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay). (targetmol.com)

Human cells have an additional barrier to unfettered replication - most lack the chromosome repair enzyme called telomerase that rat cells possess. (linguix.com)

The significance of the genetic diagnosis of telomerase-mediated pulmonary fibrosis to lung transplant management has not been examined. (ersjournals.com)

Whole-cell extracts of and active telomerase fractions were prepared essentially as previously described for (10, 36). (bioskinrevive.com)
The column was washed with TMG-10(400), and active telomerase fractions were obtained by eluting the column with TMG-10(900). (bioskinrevive.com)

Costunolide is an Inhibitor of human telomerase activity (IC50 = 65 μM in MCF-7 breast cancer cells). (adooq.com)
The root keeping track of system that distinguishes telomeres of different measures and communicates the info to telomerase is normally 22232-71-9 IC50 presently not really well 22232-71-9 IC50 known (20, 30). (woofahs.com)
Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). (targetmol.com)
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. (targetmol.com)

however, in telomerase-null mice, short telomeres predispose to emphysema after chronic cigarette smoke exposure. (jci.org)
Leukocytes from these patients had short telomeres and low telomerase enzymatic activity. (nih.gov)

Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.g., with the sequence 3′-CCCAAUCCC-5′ in Trypanosoma brucei) which is used as a template when it elongates telomeres. (wikipedia.org)
In cancer cells, the telomerase enzyme elongates telomeres, providing a mechanism for a continued unlimited cell division. (lu.se)

Telomerase in the ciliate Tetrahymena was discovered by Carol W. Greider and Elizabeth Blackburn in 1984. (wikipedia.org)
Two years later, the first cryo-electron microscopy (cryo-EM) structure of telomerase holoenzyme (Tetrahymena) was determined. (wikipedia.org)

Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
In mice, telomerase gene therapy is quite beneficial, both extending life and reducing cancer risk . (fightaging.org)
Consider that when the bone-making cells of mice were engineered to have a genetic deficiency in telomerase, the viability of those osteoblasts in terms of the ability to keep dividing suffered. (rechargebiomedical.com)
Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. (ca.gov)
Greider showed that the telomeres would shorten in mice with only one functional copy of the telomerase gene or had the half the normal amount of telomerase. (animalresearch.info)

The present study investigated the effects of docosahexaenoic acid (DHA)-enriched fish oil supplement on telomerase activity, mRNA expression of P16INK, IL-6 , and TNF-α considering Pro12Ala polymorphism in the PPARÎ³ gene . (bvsalud.org)
In addition, between-group comparisons showed significant differences in the changes in telomerase activity (p = 0.003) and P16 mRNA expression (p = 0.028) and non-significant differences in TNF-α and IL-6 mRNA expression. (bvsalud.org)
The gene *DHA interaction could not affect changes in P16, IL-6 , or TNF-α mRNA expression or in telomerase activity in PBMC. (bvsalud.org)

Telomerase is a reverse transcriptase that maintains chromosome ends, compensating for the progressive loss of DNA that occurs during replication. (northwestern.edu)
They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. (bvsalud.org)

In 2018, the structure of human telomerase was determined through cryo-EM by UC Berkeley scientists. (wikipedia.org)
Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Here, we tested whether telomerase mutations are a risk factor for human emphysema by examining their frequency in smokers with chronic obstructive pulmonary disease (COPD). (jci.org)
Hu LH, Chen FH, Li YR, Wang L. Real-time determination of human telomerase reverse transcriptase mRNA in gastric cancer. (wjgnet.com)
Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies. (ca.gov)
Overall, this work defines human telomerase DNA binding and synthesis properties at single-molecule level and establishes conserved telomerase subunit architecture from single-celled organisms to humans. (elifesciences.org)
Importantly, our results not only suggest that canine OSA may serve as a good model for aggressive telomerase-positive forms of human OSA but also that antitelomerase therapy strategies for treatment of canine OSA may be more successful than in the treatment of majority of human patients with OSA. (fitzpatrickreferrals.co.uk)
Telomerase is an active gene existing in almost all human cancerous cells. (medicaljournal-ias.org)
Role of zinc as a probably interfering microelement in telomerase gene expression and activity in human bladder cancer is the main subject of this study. (medicaljournal-ias.org)
Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (mcw.edu)
In cultured human coronary artery endothelial cells, ANG 1-7 significantly increased telomerase activity. (mcw.edu)
CONCLUSIONS: ANG 1-7 exerts vasoprotection in the human microvasculature via modulation of telomerase activity. (mcw.edu)
ATCC) were cultured as previously mentioned ( 4 ), as were THF cells (human telomerase life-extended cells) ( 5 ). (cdc.gov)
We are using the yeast model organism Saccharomyces castellii, which has telomere traits and telomerase activity that are highly similar to human cells. (lu.se)

Epitide helps to activate telomerase, which can help to maintain the length of telomeres and promote overall health and well-being. (vermontrepublic.org)
In December 1984, Greider and Blackburn were able to purify the enzyme that can extend the length of telomeres and they named it telomerase. (explorable.com)

One of the most well-known telomerase activators is the compound cycloastragenol. (antiaging-systems.com)
Telomerase activators and nanovesicles are not FDA-approved to prevent or treat any disease and anecdotes are not scientific proof of efficacy. (rechargebiomedical.com)

Further studies implicate Est1p in the recruitment of the telomerase complex to telomere ends in vivo (17, 48). (bioskinrevive.com)

The authors showed that treatment with GRN510 at 10 mg/kg/day can activate telomerase up to 4 fold both ex vivo and in vivo (8). (antiaging-systems.com)
The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)
Epitide is a dietary supplement that is specifically designed to support the functioning of the pineal gland, as well as activate telomerase. (vermontrepublic.org)
Studies have found that Epithalamin can help to regulate cell growth and division, activate telomerase, and improve overall health and well-being. (vermontrepublic.org)
Another key benefit of Epitide is its ability to activate telomerase. (vermontrepublic.org)
You simply take one capsule per day with a meal, and the supplement goes to work to support the functioning of your pineal gland and activate telomerase. (vermontrepublic.org)
Overall, Epitide is a great choice for anyone looking to support the functioning of their pineal gland and activate telomerase. (vermontrepublic.org)
Although most cancer cells activate telomerase to maintain telomere length, about 10% of tumors use an alternative telomere lengthening mechanism, the so-called ALT mechanism. (lu.se)

Surprisingly, only the reverse transcriptase motifs of zTERT are crucial, but the telomerase RNA-binding domain of zTERT is not required, for rescuing complete hematopoiesis. (harvard.edu)
In conclusion our results showed a reverse relationship between zinc deficiency and increasing telomerase activity in our series of bladder cancer. (medicaljournal-ias.org)

Your discoveries have revealed how the conserved function of telomere repeat sequences can maintain chromosomal and genetic stability and how synthesis of telomere DNA is achieved by the enzyme telomerase . (linguix.com)

Teas and extracts of this plant have been used in traditional medicine as health supplements and it is known that cycloastragenol has several other effects apart from the telomerase activities (6). (antiaging-systems.com)
An interesting study has shown that cycloastragenol not only promotes telomerase activity, but it may also be useful in reducing depressive symptoms (7). (antiaging-systems.com)
In another project, it was shown that a direct derivative of cycloastragenol, a compound called GRN510 which is a small proprietary molecule, also has telomerase enhancing activities. (antiaging-systems.com)

TMPyP4 tosylate (TMP 1363) is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines. (adooq.com)

Beyond telomerase recruitment, TPP1, collectively with its shelterin communicating partner Container1, can possess extra triggering and inhibitory tasks in telomerase actions at telomeres, as evaluated in sources 20 and 21. (woofahs.com)

Embryonic stem cells express telomerase, which allows them to divide repeatedly and form the individual. (wikipedia.org)
however, the level of telomerase activity is low or absent in the majority of stem cells regardless of their proliferative capacity. (nature.com)
Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
GRN510, through a mechanism of telomerase activation, also suppressed the accumulation of senescent cells in the lung. (antiaging-systems.com)
Research has also shown that cancer cells have increased telomerase activity, protecting them from death. (harvard.edu)
Like most conditions, poor telomerase activity occurs in cells which are under-performing. (rechargebiomedical.com)
We found that telomerase activity was strongly induced in alveolar epithelial type 2 cells (AEC2) of the remaining lung immediately following surgery. (ca.gov)
In contrast, cancer cells have been shown to have high telomerase activity, which is one of the reasons they can go on dividing indefinitely. (animalresearch.info)
The ability of neoplastic cells to maintain their telomere length, by either telomerase activity or alternate methods, is an important step in tumour development and malignancy. (fitzpatrickreferrals.co.uk)
To complete the 5′ end of the product DNA strand, evolution came up with telomerase (as well as a different, recombination-based mechanism that is very important in many cells and creatures but does not figure in the work we are looking at here). (rupress.org)
Treating SMMC-7721 cells with 5-Fu leads to apoptosis of the cells, and reduction in telomerase activity, as well as a dramatic reduction in the activated form of p70 S6 kinase, a mTOR substrate. (biomedcentral.com)
5-Fu and rapamycin were synergistic in regards to down-regulation of telomerase activity in hepatocarcinoma cells. (biomedcentral.com)
Telomerase actions in telomeres is important for the immortal phenotype of control cells and the extravagant proliferative potential of cancers cells. (woofahs.com)
When active aberrantly, telomerase reflection can offer the immortal phenotype of individual cancer tumor cells (4). (woofahs.com)
Telomerase is expressed in low amounts in control cancer tumor and cells cells. (woofahs.com)
This discussion can be important for telomere maintenance, as cells genetically manufactured to absence an acidic cycle within the TEL spot phenocopy telomerase knockout cells (18). (woofahs.com)
Significantly, overexpression of telomerase in individual cells network marketing leads to the speedy telomere elongation that provides been recommended to end up being uncontrolled, wild and not really subject matter to the regulatory systems that set up telomere homeostasis (31). (woofahs.com)
Results from this work suggest that inhibitors of telomerase and poly(ADP-ribose) polymerases can cooperate to limit the lifespan of pancreatic cancer cells. (oncotarget.com)
If any components of the telomerase are missing, telomeres are gradually shortened and most cells die. (linguix.com)
In eukaryotic cells with telomeres composed of short tandem repeats, this involves the enzyme telomerase . (linguix.com)
Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
Although it is normally inactive in most other cells in the body, telomerase is activated in cancer cells, making them "immortal. (cdc.gov)
Although activating telomerase to immortalize normal cells is a theoretical possibility, its feasibility isn't known. (cdc.gov)

Telomerase mutation carriers with emphysema were predominantly female and had an increased incidence of pneumothorax. (jci.org)
We gathered an international series of telomerase mutation carriers who underwent lung transplant in the USA, Australia and Sweden. (ersjournals.com)

Telomere lengths and the telomerase activity of peripheral-blood leukocytes were evaluated in patients carrying genetic variants. (nih.gov)

Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. (nih.gov)
To broaden knowledge of telomerase components and regulation, we investigated the opportunistic fungal pathogen is an attractive model system for investigating telomere physiology for several reasons. (bioskinrevive.com)
Up-regulation of telomerase activity is thought to be a critical step leading to cell transformation. (biomedcentral.com)

Interestingly, telomerase upregulation to lengthen telomere length may turn out to be a decent match for the capabilities of lipid nanoparticle (LNP) delivery of messenger RNA (mRNA) as an implementation of gene therapy . (fightaging.org)
By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)

This study investigated changes in mTOR pathway and telomerase activity in hepatocarcinoma cell line SMMC-7721 treated with chemotherapeutic agent 5-fluorouracil (5-Fu). (biomedcentral.com)
These results suggest that chemotherapeutic agent 5-Fu may down-regulate telomerase activity at both transcriptional level and PI3K/Akt/mTOR pathway-dependent post-transcriptional level to facilitate hepatocellular carcinoma cell apoptosis. (biomedcentral.com)

Relative telomerase activity, zinc, bladder cancer. (medicaljournal-ias.org)
Telomerase does not cause cancer. (michaelfossel.com)
Since an inhibition of telomerase activity may lead to the activation of ALT survivors, potential combinatorial treatments would be a more efficient strategy for cancer therapy. (lu.se)

Identified mutations were transfected into telomerase-deficient cell lines to examine their effects and their mechanism of action on telomerase function. (nih.gov)

Telomerase restores short bits of DNA known as telomeres, which are otherwise shortened after repeated division of a cell via mitosis. (wikipedia.org)

Telomerase reverses telomere shortening. (wikipedia.org)
A single dose of our telomerase mRNA reverses years of telomere shortening in hours. (fightaging.org)

In normal circumstances, where telomerase is absent, if a cell divides recursively, at some point the progeny reach their Hayflick limit, which is believed to be between 50 and 70 cell divisions. (wikipedia.org)
Under these circumstances, telomerase may end up being in substoichiometric prosperity in relationship to the true amount of telomeres that are present after DNA duplication. (woofahs.com)

Anatomy5

Organisms5

Diseases2

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes13

Information Science2

Telomeres and telomerase6

TERT20

Reduced telomerase activity2

Component of telomerase2

TERC4

Ribonucleoprotein6

Levels of telomerase3

Function of telomerase5

Components of telomerase1

Polymerase5

Somatic cells7

Subunits3

Genes4

Proteins2

Mutations in the telomerase1

Germline mutations in telomerase2

Telomeric4

HTERT3

Chromosomes7

Protein5

Role of telomerase2

Activity of telomerase1

Suggest that telomerase2

Inhibitor of telomerase4

Assay6

Enzyme called1

Pulmonary Fibrosis1

Active telomerase2

IC504

Short telomeres2

Elongates telomeres2

Tetrahymena2

Mice5

MRNA expression3

Chromosome ends2

Human15

Length of telomeres2

Activators2

Telomere ends1

Activate8

Reverse2

Chromosomal1

Cycloastragenol3

Tosylate1

Inhibitory1

Cells23

Mutation2

Variants1

Regulation3

Lengthen2

Pathway2

Cancer3

Mechanism1

Restores1

Reverses2

Circumstances2