UFT plus leucovorin is administered orally with continuous administration over 28 days, with interruptions if moderate or severe toxicity occurs. (cancernetwork.com)
Folinic acid1
Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. (wjgnet.com)
Chemoradiotherapy1
Objectives: To evaluate whether tegafur-uracil maintenance (UFTm) following postoperation adjuvant cisplatin-based concurrent chemoradiotherapy (CCRT) may reduce distant metastasis in patients with resected oral cavity squamous cell carcinoma (OSCC) with pathologic extranodal extension (pENE+). (bvsalud.org)
Oral5
Purpose: The current study assessed the efficacy and safety of biweekly oxaliplatin combining oral tegafur-uracil/leucovorin in treating chemonaive patients with advanced gastric cancer. (tmu.edu.tw)
Oral tegafur-uracil and leucovorin was given at a dose of 300 mg/m2/day and 60 mg/day three times daily from day 1 to 21, respectively, followed by a 1-week rest. (tmu.edu.tw)
Conclusions: Biweekly, oxaliplatin combining oral tegafur-uracil/ leucovorin in treating patients with advanced gastric cancer showed acceptable activity and manageable toxicity. (tmu.edu.tw)
The results of this study could lead to a change to oral therapy as the standard of care for metastatic colorectal cancer, providing the efficacy and toxicity of UFT/leucovorin are at least equivalent due to the ease of administration and patient preference for oral regimens. (cancernetwork.com)
Additional study objectives included evaluation and comparison of the qualitative and quantitative toxicity and reversibility of toxicity of the oral (UFT/leucovorin) and intravenous (IV) (5-FU/leucovorin) regimens. (cancernetwork.com)
Study1
The primary goal of this study was to compare the survival rates of patients with previously untreated metastatic colorectal carcinoma in response to conventional 5-FU/leucovorin therapy vs UFT/leucovorin. (cancernetwork.com)
Colorectal cancer10
2. Comparison of the efficacy, toxicity, and pharmacokinetics of a uracil/tegafur (UFT) plus oral leucovorin (LV) regimen between Japanese and American patients with advanced colorectal cancer: joint United States and Japan study of UFT/LV. (nih.gov)
3. Retrospective study of S-1 versus tegafur/uracil and oral leucovorin in patients with metastatic colorectal cancer. (nih.gov)
4. [Efficacy of uracil/tegafur (UFT) plus oral Leucovorin (LV) therapy for colorectal cancer in elderly patients]. (nih.gov)
6. UFT/leucovorin and mitomycin C as salvage treatment in patients with advanced colorectal cancer - a retrospective analysis. (nih.gov)
9. Oral uracil-tegafur plus leucovorin vs fluorouracil bolus plus leucovorin for advanced colorectal cancer: a meta-analysis of five randomized controlled trials. (nih.gov)
10. Uracil-Tegafur and Oral Leucovorin Combined With Bevacizumab in Elderly Patients (Aged ≥ 75 Years) With Metastatic Colorectal Cancer: A Multicenter, Phase II Trial (Joint Study of Bevacizumab, Oral Leucovorin, and Uracil-Tegafur in Elderly Patients [J-BLUE] Study). (nih.gov)
11. Retrospectively comparative evaluation of the first- and second-line chemotherapy with campto and oxaliplatin combined with oral tegafur/uracil (UFT)/leucovorin (LV) in patients with metastatic colorectal cancer. (nih.gov)
14. Randomised study of tegafur and oral leucovorin versus intravenous 5-fluorouracil and leucovorin in patients with advanced colorectal cancer. (nih.gov)
16. Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients. (nih.gov)
UFT is currently licensed in over 60 countries for use as a first-line treatment, in combination with leucovorin, for metastatic colorectal cancer. (pharmatimes.com)
Locally advanced rectal cancer3
15. Concomitant administration of uracil-tegafur and leucovorin during adjuvant radiotherapy for locally advanced rectal cancer. (nih.gov)
A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis. (cdc.gov)
UFT with leucovorin (folinic acid) and radiotherapy is also proving an effective option for patients with locally advanced rectal cancer, according to Dr Enrique Casado of La Paz University Hospital, Madrid, Spain. (pharmatimes.com)
Rectal Cancer2
The oral fluoropyrimidines UFT (tegafur-uracil) and capecitabine were developed to overcome these difficulties and are widely used instead of 5-FU in rectal cancer treatment regimens. (medscape.com)
Cite this: UFT (tegafur-uracil) in Rectal Cancer - Medscape - Aug 01, 2008. (medscape.com)
Adjuvant1
5. Oral uracil and tegafur plus leucovorin compared with intravenous fluorouracil and leucovorin in stage II and III carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project Protocol C-06. (nih.gov)
Versus intravenous1
Mitoxantrone, 5-fluorouracil, and high dose leucovorin (NFL) versus intravenous cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) in first-line chemotherapy for patients with metastatic breast carcinoma: a randomized phase II trial. (nih.gov)
Radiotherapy1
To evaluate the efficacy and toxicity of a novel combination treatment using concurrent radiotherapy with cisplatin plus UFT, which is comprised of uracil and tegafur, in locally advanced non-small cell lung cancer (NSCLC) patients. (aacrjournals.org)
Fluoropyrimidines2
Oral fluoropyrimidines like UFT (tegafur-uracil) offer a number of advantages over 5-FU. (medscape.com)
1,2] For this reason, our cooperative group has focused on fluoropyrimidines modulated by leucovorin as therapy for advanced gastric cancer. (cancernetwork.com)
Fluorouracil1
To assess the predictive value of polymorphism in nine genes, primarily thymidylate synthase (TS) and orotate phosphoribosyltransferase (OPRT), which relates to 5-fluorouracil (5-FU) metabolism, for toxicity in patients treated with oral uracil/tegafur (UFT) plus leucovorin (LV). (nih.gov)
Resection2
Cholecystectomy with hepatectomy of S4a and S5, lymph node dissection of the hepatoduodenal ligament, resection of the extrahepatic bile duct, and Roux-en-Y choledochojejunostomy were performed in Jul. (springeropen.com)
In a second study presented by Dr. Shimomura's group, called HiSCO-03, 65 patients (33 female) underwent curative resection and received five courses of uracil-tegafur and leucovorin (UFT/LV). (medscape.com)
Cisplatin3
In 1989, Preusser et al[3] reported a 57% response rate with the FLEP regimen-5-FU, leucovorin, etoposide, and cisplatin (Platinol). (cancernetwork.com)
The FLEP regimen we used consisted of leucovorin 300 mg/m 2 /day, followed by etoposide 100 mg/m 2 /day, 5-FU 500 mg/m 2 /day, and cisplatin 30 mg/m 2 /day, all given on days 1 through 3 and repeated every 28 days. (cancernetwork.com)
In this Phase II trial, patients with unresectable stage III NSCLC were treated with the oral administration of UFT (400 mg/m 2 /d tegafur) on days 1-14 and days 29-42 whereas 80 mg/m 2 cisplatin was administered i.v. on days 8 and 36. (aacrjournals.org)
Oral2
7. Phase II trial of oral uracil/tegafur plus leucovorin in patients with hormone-refractory prostate carcinoma. (nih.gov)
Merck KGaA's acquisition from Taiho, Japan, of worldwide rights to the 22-year-old oral 5-FU drug UFT (tegafur-uracil) outside Asia could open up a substantial European market for the product in prostate cancer as well as colorectal disease and other cancers, especially among elderly patients. (pharmatimes.com)
Patients2
13. A multiple-center phase II study of biweekly oxaliplatin and tegafur-uracil/leucovorin for chemonaive patients with advanced gastric cancer. (nih.gov)
In summary, UFT/leucovorin/etoposide is effective and moderately toxic in patients with advanced gastric cancer. (cancernetwork.com)
Trial1
A new trial with UFT/leucovorin/epirubicin is ongoing. (cancernetwork.com)