OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Clustered Regularly Interspaced Short Palindromic RepeatsInverted Repeat SequencesCRISPR-Associated ProteinsCRISPR-Cas SystemsRNA, ArchaealStreptococcus thermophilusRNA CleavageRNA, GuideDNA, IntergenicArchaeal VirusesSulfolobus solfataricusDNA CleavageGenome, BacterialInterspersed Repetitive SequencesRepetitive Sequences, Nucleic AcidBacteriophagesGenome, ArchaealMolecular Sequence DataBase SequenceRNA, BacterialArchaeaPyrococcus furiosusSequence Analysis, DNAArchaeal ProteinsDNA, BacterialEvolution, MolecularDeoxyribonucleasesGenetic EngineeringPlasmidsMultigene FamilyBacteriaBacterial ProteinsPhylogenyGenetic VariationTechnologyRNAEscherichia coliTrinucleotide RepeatsTandem Repeat SequencesBiomedical TechnologyGene Transfer, HorizontalMinisatellite RepeatsTrinucleotide Repeat ExpansionAnkyrin RepeatMicrosatellite RepeatsTechnology Assessment, BiomedicalRepetitive Sequences, Amino AcidTechnology TransferModels, MolecularGenes, Bacterial
CRISPR-Cas9GenomeGenomesReceptorsPrecisionCellsSequencesEmerging TechnologiesAdvancementsInnovationsVitroDevelopmentsAdvancesGene or genesScientists2018DoudnaEthicalGenesTraitsCropsMedicineHumanHereditaryRevolutionizeRefersBiologicalApplicationsSequenceRequireHighImportantOrganismsVisualizePotentialMajorScientificScience and TechnoProteinResearchersDevelopmentArticleImplicationsPotentiallyResultsToolsFind newField
CRISPR-Cas915
  • CRISPR, combined with the Cas9 enzyme, form the basis for the technology known as CRISPR-Cas9. (wikipedia.org)
  • A well-known one is called CRISPR-Cas9, which is short for clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9. (medlineplus.gov)
  • Ethical concerns arise when genome editing, using technologies such as CRISPR-Cas9, is used to alter human genomes. (medlineplus.gov)
  • CRISPR/Cas9 ( C lustered R egularly I nterspaced S hort P alindromic R epeats) is a technology that allows for the editing of genes within organisms. (cbc-network.org)
  • However, the possibilities for genetic modification became much more apparent in 2013 with CRISPR-Cas9 genome-editing technology. (thetablet.org)
  • Doudna , who spoke at Harvard's Science Center, explained the work that led to the development of CRISPR/Cas9 gene-editing technology, which was described in a paper in the journal Science in 2012. (harvard.edu)
  • Using a novel molecular dynamics method capable of capturing the motion of gyrating proteins at time intervals up to one thousand times greater than previous efforts, a team led by UC San Diego researchers has identified, for the first time, the myriad structural changes that activate and drive CRISPR-Cas9, the innovative gene-splicing technology that's transforming the field of genetic engineering. (sdsc.edu)
  • By shedding light on the biophysical details governing the mechanics of CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats) activity, the study provides a fundamental framework for designing a more efficient and accurate genome-splicing technology that doesn't yield "off-target" DNA breaks currently frustrating the potential of the CRISPR-Cas9- system, particularly for clinical uses. (sdsc.edu)
  • CRISPR/Cas9 is a new technology that allows researchers to precisely target and deactivate the genetic information needed to produce a particular protein. (medindia.net)
  • CRISPR/CAS Technology - Potential Cure For All Diseases CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats) technology is a revolutionary gene cutting tool and has innumerable uses in medicine such as removing cancer or disease causing genes and inserting normal genes. (medindia.net)
  • Based on clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) technology, here we devise a homology-independent targeted integration (HITI) strategy, which allows for robust DNA knock-in in both dividing and non-dividing cells in vitro and, more importantly, in vivo (for example, in neurons of postnatal mammals)," wrote the authors of the Nature article. (genengnews.com)
  • Furthermore, the adaptation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-Associated protein 9 (CRISPR/Cas9) technology has dramatically improved gene editing efficiency at the single gene level. (portlandpress.com)
  • Since 2015, more than 3,000 articles were published on studies using crispr /Cas9 genome editing, including more than 900 articles using the technology in mammalian cells (PubMed, accessed June 11, 2017). (brill.com)
  • The genome editing technology proved more stable while producing higher and more uniform levels of fetal hemoglobin in human hematopoietic stem cells compared with CRISPR/Cas9-based editing approaches, according to findings published in Nature Genetics. (cdc.gov)
  • The approach raised the expression of fetal hemoglobin to higher, more stable, and more uniform levels than other genome editing technologies that use CRISPR/Cas9 nuclease in human hematopoietic stem cells. (cdc.gov)
Genome21
  • As whole-genome technologies continue to advance, there will be increased opportunities to discover mutations and variants that are involved in tumour progression, response to therapy, and drug-metabolism. (wikipedia.org)
  • Advancements in the cost and throughput of sequencing technologies is making it possible to perform whole-genome sequencing at higher rates. (wikipedia.org)
  • Genome editing (also called gene editing) is a group of technologies that give scientists the ability to change an organism's DNA. (medlineplus.gov)
  • These technologies allow genetic material to be added, removed, or altered at particular locations in the genome. (medlineplus.gov)
  • Germline cell and embryo genome editing bring up a number of ethical challenges, including whether it would be permissible to use this technology to enhance normal human traits (such as height or intelligence). (medlineplus.gov)
  • Genome editing using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated 9 (Cas-9) technology holds great potential. (ficpi.org)
  • U.S. philanthropic organizations, with the exception of HHMI, tend, by contrast, to specialize in funding CRISPR as a genome editing technology. (mit.edu)
  • This article reviews recent reports of potential contributions from genome editing technologies in terms of increased yield, enhanced nutrition and greater sustainability, highlighting their importance for achieving the leading three SDGs. (frontiersin.org)
  • The most recent transformative innovation, genome editing, is poised to have a relatively short ramp up period, with significant application being reported since its first discovery less than a decade ago ( Doudna and Charpentier 2014 ). (frontiersin.org)
  • Genome editing is the ability to target and control mutagenic breeding technologies to a specific gene or genes, as compared to the insertion of genes utilized by genetic modification (GM) technologies. (frontiersin.org)
  • There are numerous genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR), site directed nuclease and oligonucleotide-directed mutagenesis. (frontiersin.org)
  • These are genome site-directed technologies, capable of up-regulating, down-regulating or silencing a specific gene or genes. (frontiersin.org)
  • CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) represents a profound advancement in genome editing technology. (dystonia-foundation.org)
  • The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system has been broadly adopted for highly efficient genome editing in a variety of model organisms and human cell types. (conferencedequebec.org)
  • Body 1 Nitrarine 2HCl Cas9 RFNs and Csy4-structured gRNA processing Immediately after the introduction of the CRISPR/Cas program as an extremely efficient genome editing and enhancing technology the realization that Cas9 can induce high-frequency off-target mutagenesis provides suggested potential restrictions for make use of for high-fidelity analysis and healing applications (Fu et al. (conferencedequebec.org)
  • Snippets of DNA from invading viruses are cut and stored in the bacterial genome as part of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) array. (harvard.edu)
  • Dr. Cong's group is developing novel genome technology for genome engineering and single-cell genomics, leveraging scalable computational methods. (stanford.edu)
  • We are using genome technology such as gene-editing and data science method/analysis to study immunological and neurological diseases. (stanford.edu)
  • Clustered regularly-interspaced short palindromic repeats (CRISPR) is the latest technology for genome editing. (bvsalud.org)
  • Here, we review the development of CRISPR-based genome-editing tools and their applications in HD research to offer a translational perspective on advancing the genome-editing technology to HD treatment. (bvsalud.org)
  • Scientists at St. Jude Children's Research Hospital and the Broad Institute of MIT and Harvard used a next-generation genome editing technology, adenosine base editing, to restart fetal hemoglobin expression in SCD patient cells. (cdc.gov)
Genomes5
  • The way it works is that bacteria store memories of viral DNA in their own genomes as "clustered regularly interspaced short palindromic repeats"-or CRISPRs. (technologyreview.com)
  • It is part of a wider group of technologies that allows scientists to edit genomes, but CRISPR has become the most prominently known because when used in combination with the Cas9 protein, it gives scientists a kind of precision never before seen. (cbc-network.org)
  • The application of such technologies will require to reliably estimate the effect of loci in plant genomes by avoiding the situation where the number of loci assayed ( p ) surpasses the number of plant genotypes ( n ). (springer.com)
  • The prokaryote-derived CRISPR (clustered regularly interspaced short palindromic repeats) is a genetic engineering technique in molecular biology by which the genomes of living organisms, including humans, may be modified ( Ledford, 2015 ). (sciendo.com)
  • The name refers to the way short, repeated DNA sequences in the genomes microorganisms are organized. (bibalex.org)
Receptors1
  • In particular, chimeric antigen receptor (CAR) - patient T cells genetically engineered to express antigen receptors targeting cancer cells - and organoid technologies (tiny, self-organized three-dimensional tissue cultures derived from stem cells) will continue to disrupt the cell and gene therapy and regenerative medicine fields, translating early successes with liquid cancers to solid tumors and beyond. (corning.com)
Precision2
  • Corning Life Sciences - through its many optimized products for organoid growth and creative tools and technologies for simplifying workflows, such as cell separation and engineering, among other activities - is committed to enabling the accelerated development and commercialization of precision medicines. (corning.com)
  • Key here is that the precision of CRISPR allows it to make cuts in the gene that had previously been impossible by other technologies. (cbc-network.org)
Cells2
  • The new Salk technology is 10 times more efficient than other methods at incorporating new DNA into cultures of dividing cells, making it a promising tool for both research and medicine. (genengnews.com)
  • We now have a technology that allows us to modify the DNA of nondividing cells, to fix broken genes in the brain, heart, and liver," noted Dr. Izpisua Belmonte. (genengnews.com)
Sequences2
  • Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR, technology for reading gene sequences began in 2005. (thetablet.org)
  • The findings have revealed a large number of genetic variations , and these variations appear in large part within these repeated sequences. (drishtiias.com)
Emerging Technologies2
  • The year 2023 brings forth a plethora of emerging technologies that have the potential to revolutionize various industries and reshape the way we live and work. (feri.org)
  • Biotechnology and gene editing is groundbreaking fields within emerging technologies with immense potential for advancing healthcare and addressing various challenges beyond the medical domain. (feri.org)
Advancements3
  • Innovations in other sectors of the agricultural industry have provided additional important technology advancements. (frontiersin.org)
  • Major companies' continued technology advancements and increasing use of analytics are enhancing the user experience and boosting market revenue growth. (tmcnet.com)
  • From advancements in artificial intelligence to breakthroughs in biotechnology, this article explores some of the most exciting technologies expected to gain prominence soon. (feri.org)
Innovations5
  • Although not yet a reality, these innovations and many more could be just around the corner, thanks to a technique called Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR). (springwise.com)
  • The pharma and healthcare sector is rapidly evolving with innovations in technology, increasing healthcare spending, and improving healthcare facilities and systems. (biospace.com)
  • This perspective article considers technologies that have contributed to the evolution of plant breeding and focuses on innovations that will shape its future, amid a growing world population and changing climate. (springer.com)
  • So, as new evolutionary optima have been set by environmental changes (e.g., domestication, management practices, biotic or abiotic pressures) or major shifts in genetic background, plant breeders have selected better-adapted genotypes while pursuing faster genetic gains through technological innovations and scientific breakthroughs. (springer.com)
  • New basic knowledge may lead to a knowledge transfer to technological fields resulting from interactions of citations, and, in this way, promotes innovations in industry and progress in society ( Hu & Rousseau, 2018 ). (sciendo.com)
Vitro2
  • More than ever before, we are able to visualize and analyze human physiological processes, gathering data in vivo, ex vivo, and in vitro using advanced imaging technologies and discovering previously unrealized patterns and connections using artificial intelligence and other computational tools. (corning.com)
  • With further technological developments, these human in vitro cellular models shall be highly useful in the screening of compounds for personalized medicine, allowing optimum therapy with minimum or no adverse effects, and in the study of adverse outcomes in different strata of population. (brill.com)
Developments1
  • The Internet of Things (IoT) and Artificial Intelligence (AI), as well as increased developments in green construction technology by major businesses, and environmental knowledge in this region, are all smart automated solutions that may be accessed by creative facilities. (tmcnet.com)
Advances3
  • Advances in biochemical and gene editing technology, combined with decades of investing in basic science in dystonia, are creating opportunities for novel investigations not previously possible. (dystonia-foundation.org)
  • Inoculation strategies, LAB improvement strategies, their potential to be used as targeted additions, and technological advances involving their use in wine are highlighted along with suggestions for future research. (frontiersin.org)
  • Dubbed Science magazine's "breakthrough of the year" in 2015, researchers are looking to apply the technology to a variety of uses, with hopes of treating diseases through gene therapy or driving advances in areas from crop engineering to the production of biofuels. (sdsc.edu)
Gene or genes1
  • Gene editing technology can be used to almost surgically adjust the gene or genes behind that deleterious trait. (ufl.edu)
Scientists2
  • Jennifer Doudna, the gene-editing pioneer whose breakthrough in CRISPR technology has taken the scientific world by storm, expressed surprise Tuesday evening at how fast the world's scientists have put her findings to work, as well as concern that gene-editing technology could outpace ethical constraints on its use. (harvard.edu)
  • These technologies are important because they allow scientists to modify only specific locations of genes in order to obtain a desired trait. (biofortified.org)
20181
  • The battle ended in September 2018, with a ruling by the U.S. Federal Circuit Court of Appeals that upheld the Broad Institute's patent, paving the way for the widespread licensing of the technology and widespread investment. (springwise.com)
Doudna4
  • The rival teams, led by Jennifer Doudna of the University of California, Berkeley, and Emmanuelle Charpentier at the Helmholtz Centre for Infection Research in Germany, sued, and a four-year legal battle over the ownership of the CRISPR technology followed. (springwise.com)
  • Doudna notes in Technology Networks that, "Mammoth's technology exemplifies some of the most urgent, impactful, and untapped potential in the CRISPR space. (darkdaily.com)
  • Doudna said she was recently asked to write an article reviewing the technology and its scientific use and searched a database of scientific publications. (harvard.edu)
  • Amazingly, this technology operates efficiently in virtually all cell types of organisms in which it's been tested," Doudna said. (harvard.edu)
Ethical2
  • The ethical implications of using gene editing on human beings is the perhaps the greatest concern of this branch of technologies, but it is not the only concern. (cbc-network.org)
  • While this technology provides a lot of answers, its increasing sophistication is raising new questions about how to resolve the ethical controversies it creates. (aacc.org)
Genes3
  • CRISPR is the powerful gene-editing technology already being explored as a way to precisely edit human genes to cure diseases (see "Can CRISPR Save Ben Dupree?" ). (technologyreview.com)
  • Recent technology has been developed to precisely engineer genes for traits of interest. (ufl.edu)
  • By using CRISPR technology, these genes or gene variants can be moved into desirable genetic backgrounds that can be further moved via conventional crossing in later generations. (ufl.edu)
Traits3
Crops1
Medicine3
  • Overall, these technologies will continue to drive the further development of personalized medicine, with all of them ultimately working together to match the right patient with the right treatment at the right time. (corning.com)
  • The study was supported by CityU, Ming Wai Lau Centre for Reparative Medicine, the National Natural Science Foundation of China, The Swedish Research Council, the Innovation and Technology Fund of Hong Kong Government, Hong Kong Health and Medical Research Fund, Hong Kong Research Grants Council, Shenzhen Science and Technology Innovation Fund, and Sanming Project of Medicine in Shenzhen, China. (eurekalert.org)
  • Are you familiar with the key aspects of CRISPR as a technology and its potential for transforming medicine? (medscape.com)
Human3
  • This book also touches on the controversial topic of clustered regularly interspaced short palindromic repeats, an innovative technology that could genetically alter mosquitoes to prevent human diseases. (cdc.gov)
  • Following a decade of meetings by the Royal Commission on New Reproductive Technologies, Canada's Parliament passed the Assisted Human Reproduction Act in 2004. (thetablet.org)
  • Thanks to a new targeted gene modification technology known as CRISPR, genetic modification of human embryos and adults will soon become a reality. (bibalex.org)
Hereditary1
Revolutionize2
Refers1
  • Transgenic technology' refers to the transfer of a genetic material from one species to another. (ufl.edu)
Biological2
  • The results of the content analysis show how the research supported by the main U.S. government agencies focuses both on the study of CRISPR as a biological phenomenon and on its technological development and use as a biomedical research tool. (mit.edu)
  • The term systems toxicology is derived from systems biology and could be defined as the study of biological systems, using omics technologies, with a focus on the mechanisms underlying complex biological processes, their interactions and perturbations in response to a toxin combined with mathematical data integration and modeling. (brill.com)
Applications3
  • The result is "off-target" mutations, severely limiting the technology for clinical applications. (sdsc.edu)
  • AR and VR technologies evolve and find new applications in various industries. (feri.org)
  • CRISPR technology has evolved at a rapid pace since 2012, and there has been speculation about applications ranging from eradication of malaria to designer babies . (medscape.com)
Sequence1
  • They create a small piece of RNA with a short "guide" sequence that attaches (binds) to a specific target sequence in a cell's DNA, much like the RNA segments bacteria produce from the CRISPR array. (medlineplus.gov)
Require3
  • These are ambitious and inspirational goals that require substantial innovation and technology adoption for successful achievement. (frontiersin.org)
  • Reaching that goal will require the government to create a Technology Competitiveness Council akin to the National Security Council, said former Deputy Secretary of Defense Robert Work. (nationaldefensemagazine.org)
  • Modern technologies of omics and high-content imaging are resulting in immense data sets which require large-scale data-processing tools. (brill.com)
High2
  • Toxicology is one of the sciences that have slowly but surely embraced technology and new methods, focusing on high throughput and high content screenings, omics technologies, and mathematical modeling. (brill.com)
  • In the area of crop breeding we believe these technologies will be crucial for improving current lines specially for particular cases like drought-tolerance, high or low temperature tolerance, disease resistance, or even nutrient content. (biofortified.org)
Important2
  • It is important to encourage and continue public dialogue about the use of gene editing technology going forward. (cbc-network.org)
  • Clustered regularly interspaced short palindromic repeats (CRISPR)-technology has emerged as an important tool for gene editing based therapeutics. (microbiologyresearch.org)
Organisms1
  • CRISPR/Cas is a set of versatile technologies aimed to manipulate, analyze, and visualize the biomolecular machinery of living organisms ( Pickar-Oliver & Gersbach, 2019 ). (mit.edu)
Visualize1
  • These technologies provide immersive and interactive experiences, enabling users to visualize data, simulate scenarios, and enhance training processes. (feri.org)
Potential1
Major3
  • In the past, plant breeding has undergone three major transformations and is currently transitioning to a new technological phase, Breeding 4. (springer.com)
  • Within each of these major technological phases, we see a pattern that we would now call a shift from monogenic to polygenic focus. (springer.com)
  • Besides the significant specificity improvement one major advantage of the tru-gRNA technology is usually that it can easily be implemented with any gRNA expression vector. (conferencedequebec.org)
Scientific2
  • In many ways, public conversation and debates about the ethics of biotechnologies like CRISPR lag well behind the realities of scientific and technological progress. (cbc-network.org)
  • The talk, "Rewriting the Code of Life: Biology, Technology, and Ethics," was intended for the general public, while the other two lectures, on Wednesday and Thursday, are aimed at more scientific audiences. (harvard.edu)
Science and Techno3
Protein1
  • The Cas9 protein (short for CRISPR associated protein 9) uses those snippets to recognize future invaders and cuts their genetic material, killing them. (harvard.edu)
Researchers2
Development1
  • In this article, we present a new perspective on observing and understanding the research topics and their development in CRISPR based on the LDA model and try to illustrate the knowledge transfer trends from research topics to technological fields based on paper-patent citations. (sciendo.com)
Article1
Implications1
  • These weighty implications, as well as a charged, ongoing patent battle over who owns the technology, ensure that conversations around CRISPR will continue. (bibalex.org)
Potentially1
  • Any diseases that can be inherited, such Huntington's diseases or inclinations towards certain forms of cancer, could potentially be eliminated thorough gene editing technologies like CRISPR. (cbc-network.org)
Results1
  • Our results raise fundamental questions about the role of the state and the influence of philanthropy over the trajectory of transformative technologies. (mit.edu)
Tools1
  • Therefore, the technologies, bioinformatics tools, systematic engineering approaches for carbon neutrality and circular economy are summarized and leading one step closer to the decarbonization society in this review. (ncku.edu.tw)
Find new1
  • As we work to better understand how these parasites invade and damage our bodies through this new technology, we will find new ideas for treatment and disease control. (medindia.net)
Field1
  • Quantum computing is an emerging field of technology that harnesses the principles of quantum mechanics to perform complex computations at an extraordinary speed. (feri.org)