AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Technetium Tc 99m SestamibiTechnetiumTechnetium Tc 99m Diethyl-iminodiacetic AcidTomography, Emission-Computed, Single-PhotonTechnetium Tc 99m LidofeninTechnetium Tc 99m Sulfur ColloidOrganotechnetium CompoundsTechnetium Tc 99m MedronateTechnetium Tc 99m DisofeninRadiopharmaceuticalsTechnetium Tc 99m PyrophosphateTechnetium Tc 99m Aggregated AlbuminTechnetium Tc 99m PentetateTechnetium CompoundsThallium RadioisotopesTinTechnetium Tc 99m ExametazimeTechnetium Tc 99m Dimercaptosuccinic AcidSodium Pertechnetate Tc 99mDipyridamoleTechnetium Tc 99m MertiatideParathyroidectomyParathyroid NeoplasmsRadionuclide ImagingHeartTissue SurvivalHyperparathyroidism, PrimarySensitivity and SpecificityVentriculography, First-PassGated Blood-Pool ImagingOximesThyroiditis, SubacuteExercise TestCoronary DiseaseOrganophosphorus CompoundsCoronary CirculationChest PainErythrocyte InclusionsTin PolyphosphatesDobutaminePredictive Value of TestsDiphosphatesSoil Pollutants, RadioactiveMyocardial InfarctionTin CompoundsMyocardial Perfusion ImagingRosaniline DyesIsotope LabelingEtidronic AcidHyperparathyroidismElectrocardiographyVasodilator AgentsCoronary AngiographySugar AcidsPhosphinesMyocardial RevascularizationAdenosineProspective StudiesEchocardiographyGamma CamerasRheniumParathyroid GlandsTissue DistributionTomography, Emission-ComputedReproducibility of ResultsVentricular Function, LeftMyocardial IschemiaVentricular Dysfunction, LeftMyocardial ContractionMyocardiumThalliumObserver VariationRadioimmunodetectionCoronary Artery DiseaseIodobenzenesMyocardial StunningNitrilesRadioisotopesSurgical Procedures, Minimally InvasiveDrug Evaluation, PreclinicalPrognosisXenon RadioisotopesOrganometallic CompoundsHemodynamicsClinical ProtocolsSentinel Lymph Node Biopsy
ScintigraphyTomographyMIBIRadiopharmaceuticalsSPECTRadionuclideEmission-ComputedPerfusionIodine 123ScanLipophilic99mTcTetrofosminCationicThallium-201HepatobiliaryLocalizationInjectionMitochondriaNuclear MedicineUptakeAimed to evaluateTumorsAccumulationCardiacAbnormalThyroid glandDiagnosticConclusionSyntheticGammaTissuePatientsStudyCommonHeartTime
Scintigraphy12
  • Numerow LMMorita ETClark OHHiggins CB Persistent/recurrent hyperparathyroidism: a comparison of sestamibi scintigraphy, MRI, and ultrasonography. (jamanetwork.com)
  • Light VLMcHenry CRJarjoura DSodee DBMiron SD Prospective comparison of dual-phase technetium-99m-sestamibi scintigraphy and high resolution ultrasonography in the evaluation of abnormal parathyroid glands. (jamanetwork.com)
  • Noninvasive parathyroid imaging studies include technetium (Tc)-99m sestamibi scintigraphy, ultrasound, computed tomography (CT) scanning, magnetic resonance imaging (MRI), and positron emission tomography (PET) scanning. (medscape.com)
  • Various methodologies for 99m Tc-sestamibi parathyroid scintigraphy are in clinical use. (snmjournals.org)
  • Localization with dual-phase acquisition was more accurate than with single-phase 99m Tc-sestamibi scintigraphy for planar imaging, SPECT, and SPECT/CT. (snmjournals.org)
  • Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported. (netlify.app)
  • Non-invasive imaging modalities for preoperative localization of hyper-functioning parathyroid glands include Tc-99m sestamibi scintigraphy ( sestamibi or MIBI ), single photon emission computed tomography ( SPECT ), positron emission tomography ( PET ). (wikidoc.org)
  • Technetium-99m -methoxyisobutylisonitrile ( 99mTc-sestamibi or MIBI) scintigraphy is the most popular investigation for preoperative localization of hyper-functioning parathyroid glands . (wikidoc.org)
  • The sensitivity of sestamibi scintigraphy can be increased by using it concomitantly with neck ultrasound and/or SPECT . (wikidoc.org)
  • Dual tracer Tc-99m sestamibi scintigraphy - A nuclear medicine parathyroid scan demonstrates a parathyroid adenoma adjacent to the left inferior pole of the thyroid gland. (wikidoc.org)
  • Single photon emission computed tomography may be used along with Tc-99m sestamibi scintigraphy for preoperative evaluation of hyper-functioning parathyroid gland. (wikidoc.org)
  • Imaging of thromboembolism by scintigraphy with the 99m-technetium-labelled synthetic peptide P280]. (unina.it)
Tomography2
  • Single photon emission computed tomography (SPECT) imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays. (wikipedia.org)
  • Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) with technetium-99m ( 99m Tc)-labelled radiotracers. (cadth.ca)
MIBI5
  • The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. (wikipedia.org)
  • A MIBI scan or sestamibi scan is now a common method of cardiac imaging. (wikipedia.org)
  • Preoperative sestamibi (MIBI) and ultrasonography (US) are used to localize parathyroid tumors in patients with primary hyperparathyroidism (pHPT). (nih.gov)
  • Both ultrasonography and 99m Tc-sestamibi (MIBI) SPECT images were obtained from all patients. (snmjournals.org)
  • 99m Tc-Sestamibi (MIBI) has also been approved as an effective diagnostic imaging agent. (snmjournals.org)
Radiopharmaceuticals3
SPECT2
  • Tc-99m sestamibi is considered the most sensitive and specific imaging modality, particularly when used with single-photon emission CT (SPECT). (medscape.com)
  • Sestamibi-SPECT is also called pinhone-SPECT (P-SPECT). (wikidoc.org)
Radionuclide3
  • Wei JPBurke GJMansberger AR Jr Prospective evaluation of the efficacy of technetium 99m-sestamibi and iodine 123 radionuclide imaging of abnormal parathyroid glands. (jamanetwork.com)
  • Table illustrates the biological clearance as well as effective clearance (which includes biological clearance and radionuclide decay) of Tc 99m Sestamibi from the heart and liver. (drugcentral.org)
  • MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. (netlify.app)
Emission-Computed2
  • We developed an automatic quantitative algorithm for the measurement of regional myocardial wall motion and wall thickening from three-dimensional gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomographic images. (nih.gov)
  • Estimation of attenuation maps from scatter and photopeak window single photon-emission computed tomographic images of technetium 99m-labeled sestamibi. (umassmed.edu)
Perfusion3
  • CLINICAL TRIALS:MYOCARDIAL IMAGING: In trial of rest and stress Technetium Tc 99m Sestamibi imaging, the relationship of normal or abnormal perfusion scans and long term cardiac events was evaluated in 521 patients (511 men, 10 women) with stable chest pain. (drugcentral.org)
  • Som noget relativt nyt kan man ved ekg-synkroniseret, såkaldt gated, myokardiescintigrafi samtidigt bestemme venstre hjerteventrikels perfusion og pumpefunktion efter en enkelt i.v. injektion af et radiofarmakon. (ugeskriftet.dk)
  • Det er derfor klinisk relevant ikke alene at vurdere myokardiets perfusion, men også de funktionelle forandringer, som er en tidlig følge af iskæmi. (ugeskriftet.dk)
Iodine 1234
  • Value of technetium 99m sestamibi iodine 123 imaging in reoperative parathyroid surgery. (jamanetwork.com)
  • Subtraction technique uses dual contrast Tc-99m sestamibi along with iodine-123 or 99m-technicium pertechnetate, which are taken by thyroid tissue only. (wikidoc.org)
  • Iodine-123/99m-technicium pertechnetate images of thyroid are later digitally subtracted from Tc-99m sestamibi images leading to visualization of parathyroid tissue only. (wikidoc.org)
  • The above study was performed with Technetium-Sestamibi (1st column) and Iodine-123 (2nd column) simultaneous imaging and the subtraction technique (3rd column). (wikidoc.org)
Scan5
  • Wei JPBurke GJ Analysis of savings in operative time for primary hyperparathyroidism using localization with technetium 99m sestamibi scan. (jamanetwork.com)
  • Borley NRCollins RECO'Doherty MCoakley A Technetium-99m sestamibi parathyroid localization is accurate enough for scan-directed unilateral neck exploration. (jamanetwork.com)
  • All patients had baseline rest and exercise Technetium Tc 99m Sestamibi scan and were followed for 13.2 +- 4.9 months (range: to 24 months). (drugcentral.org)
  • Tc-99m sestamibi scan - Parathyroid adenomas typically retain activity on late scans after wash-out in the thyroid has occurred. (wikidoc.org)
  • A sestamibi or tetrofosmin nuclear scan thus can identify cancer patients in whom certain drugs are unlikely to be effective. (axisimagingnews.com)
Lipophilic2
  • Technetium (99mTc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. (wikipedia.org)
  • Sestamibi is a lipophilic cationic on physioligical pH. (wikidoc.org)
99mTc2
  • More recently, breast radiologists administer lower doses of 99mTc sestamibi (approximately 150-300 MBq or 4-8 mCi) for Molecular Breast Imaging (MBI) scans which results in a high sensitivity (91%) and high specificity (93%) for breast cancer detection. (wikipedia.org)
  • Multiple planar images are obtained, typically one shortly after injection of 99mTc-sestamibi and another after two hours to identify the areas of retained sestamibi showing hyper-functioning parathyroid tissue. (wikidoc.org)
Tetrofosmin1
  • With the help of PET, it is possible to determine the nature of a solitary lung nodule, to stage non-small-cell lung cancer and lymphoma, and to evaluate recurrence of colorectal cancer or lymphoma.2 Technetium Tc 99m sestamibi and technetium Tc 99m tetrofosmin are substrates for the membrane P-glycoprotein transporter that is responsible for multidrug resistance in cancer cells. (axisimagingnews.com)
Cationic1
  • 12.1 Mechanism of Action Technetium Tc 99m Sestamibi is cationic Tc 99m complex which has been found to accumulate in viable myocardial tissue in manner analogous to that of thallous chloride Tl-201. (drugcentral.org)
Thallium-2011
  • Attenuation is more likely with technetium-99m ( 99m Tc) than with radioactive thallium 201 (Tl-201). (msdmanuals.com)
Hepatobiliary2
  • In patients with documented myocardial infarction, imaging revealed the infarct up to four hours post dose.MetabolismThe agent is excreted without any evidence of metabolism.EliminationThe major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. (drugcentral.org)
  • This will promote rapid hepatobiliary clearance of technetium Tc-99m sestamibi resulting in less liver activity in the image. (studylib.net)
Localization3
  • Casas ATBurke GJMansberger AR JrWei JP Impact of technetium-99m-sestamibi localization on operative time and success of operations for primary hyperparathyroidism. (jamanetwork.com)
  • McHenry CRLee KSaadey JNeumann DREsselstyn CB Jr Parathyroid localization with technetium-99m-sestamibi: a prospective evaluation. (jamanetwork.com)
  • Although studies of subcellular fractionation and electron micrographic analysis of heart cell aggregates suggest that Tc 99m Sestamibi cellular retention occurs specifically within the mitochondria as result of electrostatic interactions, the clinical relevance of these findings has not been determined.The mechanism of Tc 99m Sestamibi localization in various types of breast tissue (e.g., benign, inflammatory, malignant, fibrous) has not been established. (drugcentral.org)
Injection1
  • Methods: Twenty patients with untreated breast cancer had 99m Tc-sestamibi imaging 20 and 120 min after tracer injection before and after a 3-d course of toremifene (780 mg/d). (aku.edu)
Mitochondria2
  • Sestamibi is taken up by tissues with large numbers of mitochondria and negative plasma membrane potentials. (wikipedia.org)
  • Most of the sestamibi is retained in mitochondria of thyroid and abnormal parathyroid tissue and is a function of mitochondrial activity. (wikidoc.org)
Nuclear Medicine1
  • One short-lived gamma ray -emitting nuclear isomer , technetium-99m , is used in nuclear medicine for a wide variety of tests, such as bone cancer diagnoses. (knowpia.com)
Uptake2
  • Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and … Supply of Technetium-99m (Tc-99m) is a just-in-time activity requiring continuous production in a complicated and aging supply chain that combines a mix of governmental and commercial entities. (netlify.app)
  • So, the uptake of sestamibi into parathyroid adenoma cells depends on the activity of the P-gp [19] . (wikidoc.org)
Aimed to evaluate1
  • This study aimed to evaluate 99m Tc-sestamibi imaging for predicting overexpression of Pgp in primary breast cancer and to measure the efficacy of toremifene, the MDR modulator, in vivo. (aku.edu)
Tumors1
  • Results: Sixteen of 20 tumors were visualized with sestamibi. (aku.edu)
Accumulation3
  • 99m Tc-Sestamibi accumulation in breast cancer correlates with Pgp expression. (aku.edu)
  • Toremifene has a dual effect on this accumulation, increasing it through an inhibitory effect on Pgp while at the same time reducing it by a direct competition with sestamibi. (aku.edu)
  • P-gp acts as ATP-dependent efflux pump and prevents accumulation of sestamibi in parathyroid tissue. (wikidoc.org)
Cardiac1
Abnormal1
  • The basis of "single-isotope, double-phase technique" is that sestamibi washes out of the thyroid more rapidly than from abnormal parathyroid tissue. (wikidoc.org)
Thyroid gland1
  • described slower washout of 99m Tc-sestamibi from hyperfunctioning parathyroids than from the thyroid gland ( 10 ). (snmjournals.org)
Diagnostic1
  • Technetium-99m is used in over 20 million diagnostic nuclear medical procedures every year, half of which are bone scans, and the other half are roughly divided between kidney, heart and lung scans. (netlify.app)
Conclusion1
  • CONCLUSION: Sestamibi imaging may detect impaired coronary vascular function in response to dipyridamole in patients with untreated mild essential hypertension and normal coronary arteries. (cnr.it)
Synthetic1
Gamma1
  • The ground state of the nuclide technetium-99 is used as a gamma-ray-free source of beta particles . (knowpia.com)
Tissue1
  • As all parathyroid lesions does not retain sestamibi nor all thyroid tissue washes out quickly, subtraction imaging may be beneficial. (wikidoc.org)
Patients3
  • Lee VSWilkinson RH JrLeight GS JrCoogan ACColeman RE Hyperparathyroidism in high-risk surgical patients: evaluation with double-phase technetium-99m sestamibi imaging. (jamanetwork.com)
  • We assessed coronary flow reserve (CFR) by sestamibi imaging in hypertensive patients with normal coronary vessels. (cnr.it)
  • METHODS: Twenty-five patients with untreated mild essential hypertension and normal coronary vessels and 10 control subjects underwent dipyridamole-rest Tc-99m sestamibi imaging. (cnr.it)
Study2
  • Table Biological and Effective ClearanceRESTSTRESSHeart LiverHeart LiverTimeBiologicalEffectiveBiologicalEffectiveBiologicalEffectiveBiologicalEffective5 min.1.21.219.619.41.51.55.95.830 min.1.11.012.211.51.41.34.54.21 hour1.00.95.65.01.41.22.42.12 hours1.00.82.21.71.21.00.90.74 hours0.80.50.70.41.00.60.30.2A study in dog myocardial ischemia model reported that Technetium Tc 99m Sestamibi undergoes myocardial distribution (redistribution), although more slowly and less completely than thallous chloride Tl-201. (drugcentral.org)
  • Due to favorable energy and dosimetric characteristics, MAG3 radiolabeled with technetium has replaced the iodide-131 Hippuran for the study of renal function (tubular secretion physiology) 7. (netlify.app)
Common1
  • Naturally occurring technetium is a spontaneous fission product in uranium ore and thorium ore, the most common source, or the product of neutron capture in molybdenum ores. (knowpia.com)
Heart1
Time1
  • Shen WSabanci UMorita ETSiperstein AEDuh QYClark OH Sestamibi scanning is inadequate for directing unilateral neck exploration for first-time parathyroidectomy. (jamanetwork.com)