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  • neuropathic
  • While the optimal treatment of neuropathic ocular pain is not established, published options include local therapies (e.g., autologous serum tears), adjuvant therapies (e.g., transcutaneous electrical stimulation, botulinum toxin injections) and oral agents (e.g., pregabalin, gabapentin, nortriptyline). (aao.org)
  • The severe ocular discomfort in response to light in these neuropathic patients is referred to as photoallodynia , which has a serious debilitating impact on the quality of life of the patients. (pubmedcentralcanada.ca)
  • Evidence-based Pr
  • For several years, Chris was a senior lecturer and researcher in the School of Optometry & Vision Sciences at Cardiff University where, as Co-Director of the Contact Lens & Anterior Eye Research Unit (CLAER) she established her research interests examining the ocular surface and the tear film, hand hygiene, and evidence-based practice, alongside her clinical work. (plymouth.ac.uk)
  • corneal surface
  • Topical fluorometholone significantly improved corneal surface staining in the BTX-B-injected mice after 1 week of treatment, and increased the tear production within 2 weeks, but without statistical significant difference. (molvis.org)
  • Topical artificial tears, 0.1% nepafenac, and 0.4% ketorolac did not show obvious effects on tear production, corneal surface staining, and levels of IL-1╬▓ and TNF-╬▒ expression in normal, and BTX-B-injected dry eye mice. (molvis.org)
  • Ophthalmology
  • Dr. Shivalingappa (Shiva) Swamynathan is an Assistant Professor in the Department of Ophthalmology, University of Pittsburgh School of Medicine, where he directs the Ocular Surface Development and Gene Expression Laboratory. (pitt.edu)
  • Contact Lenses
  • The invention is especially useful for treatment of individuals wearing ocular prostheses such as contact lenses, as the composition of the invention wets and provides lubrication for both the ocular surface and the surface of the prosthesis in contact with the ocular surfaces. (google.com)
  • abnormalities
  • Dry eye is characterized by qualitative or quantitative abnormalities of the tear film and is estimated to affect and have a negative impact on the quality of life of ~4.88 million people in the United States 8 , 9 , 10 . (pubmedcentralcanada.ca)
  • refractory
  • Despite available therapies, some patients remain refractory to treatment with artificial tears, topical immunomodulators such as cyclosporine, and steroids. (escrs.org)
  • pterygium
  • Anormal tear film function associated with pterygium. (hindawi.com)
  • Several studies have used tear function tests, such as the Schirmer test or tear breakup time (BUT), to investigate the relationship between pterygium and dry eye syndrome (DES), with conflicting results [ 5 , 8 , 9 ]. (hindawi.com)
  • In addition, a very few studies have evaluated the effects of the excision of pterygium on tear function [ 10 , 11 ]. (hindawi.com)
  • inflammatory
  • It would be of added value if, rather than discarding the strips after the assessment, the tear components could be eluted from these strips and used for the measurement of known biomarkers, such as proinflammatory cytokines and other inflammatory mediators. (molvis.org)
  • To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. (molvis.org)
  • Topical fluorometholone caused suppression of inflammatory cytokine expression on the ocular surface in the Botulium toxin B-induced murine dry eye model, while topical NSAIDs demonstrated no clearly beneficial effects. (molvis.org)
  • This current study was designed to investigate whether topical fluorometholone, ketorolac and nepafenac inhibit inflammatory cytokine expression on the ocular surface in the BTX-B-induced murine dry eye model. (molvis.org)
  • Anterior
  • 6 , 10 Thanks to the technological advancements, recently both upper and lower tear menisci were imaged simultaneously by custom anterior segment optical coherence tomography (OCT). 11 , 12 With this development, the correlations between the tear menisci around both eyelids and other conventional tear tests routinely used in clinics for the diagnosis of dry eye can be studied for the first time. (pubmedcentralcanada.ca)
  • The aim of this study was to determine the relationship among tear menisci measured with anterior segment OCT, non-invasive tear break-up time (NITBUT) obtained using a Keeler Tearscope, and Schirmer's test. (pubmedcentralcanada.ca)
  • Optometry
  • Optometry and Vision Science. (vision-research.eu)
  • NovaBay Pharmaceuticals, Inc. announced that NovaBay's i-Lid Cleanser with Neutrox will be added to the Vision Source Independent Optometry Network of more than 3,400 optometrists and clinicians. (clspectrum.com)
  • Her pre-registration training was in hospital optometry, after which a variety of clinical roles followed including private practice, part-time teaching, and specialist contact lens and low vision practice. (plymouth.ac.uk)
  • cytokine
  • Concentrations of cytokines and MMPs in collected tear samples were analyzed by Luminex using both a 10-cytokine and a 5-MMP kit. (molvis.org)
  • This procedure may be used to evaluate the cytokine and MMP content in tear samples in clinical studies, especially for the evaluation of dry eye therapeutics. (molvis.org)
  • defective
  • Dr. Swamynathan discovered that Klf4 conditional null (Klf4CN) and Klf5CN mice display normal viability and fertility, and a defective ocular surface. (pitt.edu)
  • efficacy
  • To evaluate the safety and efficacy of 0.5% GL101 topical gel administered twice daily for 28 days in ameliorating adverse ocular side effects in patients under ongoing treatment with glaucoma medications. (clinicaltrials.gov)
  • evaporative
  • A reduced volume of tear fluid gives rise to aqueous-deficient dry eye (ADDE), whereas impaired tear film stability underlies evaporative dry eye (EDE) 11 . (pubmedcentralcanada.ca)
  • While the critical nociceptive system provides a number of protective functions, it is unique in its central role of monitoring, preserving and restoring the optical tear film in the face of evaporative attrition without which our vision would be non-functional. (bmj.com)