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  • charged molecules
  • Such neurons' nerve ends and cell bodies are known to be studded with mechanically activated ion channel proteins, which essentially spring open-admitting a surge of charged molecules (ions) and triggering an electrical nerve impulse-when the surrounding nerve or cell membrane is distorted sufficiently by a stretching of the local muscle tissue. (healthcanal.com)
  • tumor
  • A nuclear protein of previously unknown function has been shown to regulate the migration of tumor cells in the spread of melanoma, the most deadly form of skin cancer. (riken.jp)
  • They went on to show that TPh A inhibits interaction between pirin and its binding partner, Bcl3, and that it also inhibits the migration of melanoma cells by reducing expression of the tumor mobility protein SNAI2. (riken.jp)
  • H224G11 works by specifically binding to cMet protein and interrupting the signaling pathway, which leads to cancer cell death and the prevention of tumor growth. (bio-medicine.org)
  • In humans, a similar protein complex called CSN and its subunit CSN6 is now believed to be a cancer-causing gene that impacts activity of another gene (Myc) tied to tumor growth. (healthcanal.com)
  • In mouse models, the combined TLR agonists and PD-1 inhibitors injected directly into a tumor incited a tumor-specific response by T cells which prevented metastasis or the spread of the cancer. (eurekalert.org)
  • The Yale team developed a new biodegradable nanoparticle that delivers a combination of two very different therapeutic agents to tumor sites, gradually releasing the agents into the tumor vasculature. (healthcanal.com)
  • novel
  • In parallel, the team developed and characterized a novel protein-based inhibitor of TSLP that can efficiently capture TSLP to prevent its association with its natural receptors on the cell surface. (medicalnewstoday.com)
  • In addition to highlighting a novel anti-cancer pathway, the team found that the same deactivation of the enzyme called EZH2 is necessary for the formation of bone-forming cells from the stem cells that make them and other tissues. (medindia.net)
  • A research team led by David Baker at the University of Washington recently used these antibody-structure data to design novel proteins, smaller than the antibodies, that bind to flu viruses in a similar way and neutralize a broad range of flu strains. (innovations-report.com)
  • As SSB is an essential protein and its binding to interactome partners is required for viability, the goal of these studies is to identify inhibitors that will be further developed into novel antibiotics. (buffalo.edu)
  • Although more work is needed to confirm the exact relationship, the team think that antibodies produced in response to a worm infection could stop the immune system from producing an allergic reaction when faced with a novel substance such as peanut protein. (medicalxpress.com)
  • treatments
  • Characterizing the functions of proteins in the cell, whose role in mediating complex metabolic and signaling networks is central to cellular biochemistry, is essential for developing new medicines and treatments. (riken.jp)
  • We'll now be developing our OGG1 inhibitor and examining whether it can lead to new treatments for inflammatory diseases in order to cure or relieve diseases such as sepsis, COPD and severe asthma. (medicalxpress.com)
  • Stephen G. Emerson, MD, PhD, director of the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center, added that, "Understanding the pathway that allows stem cells to develop into mature cells could eventually lead to more effective, less toxic cancer treatments. (eurekalert.org)
  • Currently NNRTIs, or non-nucleoside reverse transcriptase inhibitors, are the first-line HIV treatments in sub-Saharan Africa. (scienceline.org)
  • The scientists say the findings could be used to develop alternatives to current anti-inflammatory treatments called COX inhibitors which can have lethal side effects. (netdoctor.co.uk)
  • 2017
  • Original publication: Melero-Fernandez de Mera RM1, Li LL1, Popinigis A, Cisek K, Tuittila M, Yadav L, Serva A, Courtney MJ (2017) A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs. (utu.fi)
  • found
  • We found that when a particular protein called 14-3-3 zeta was not present wounds healed a lot quicker in our models of wound healing ," Samuel told ABC News Australia. (advancedtissue.com)
  • However, the team found that delivering a specific frequency of inhibition pulses to JNK in the cytoplasm drove inhibition of gene expression in the nucleus. (utu.fi)
  • It turns out to be a protein called Piezo2, which was found recently to mediate the sense of touch. (healthcanal.com)
  • However, the team found evidence from these initial tests that the main ion-channel protein on proprioceptive neurons is not a selective sodium-channel protein, but in fact has properties consistent with Piezo2s. (healthcanal.com)
  • In a final set of experiments, the team found that leg muscle tissue from these mice lacking Piezo2-tissue with proprioceptive nerves embedded-produced almost no nerve signals in response to muscle stretching, whereas muscle tissue from normal mice produced robust signals. (healthcanal.com)
  • We have found that another protein, CDK1, deactivates EZH2. (medindia.net)
  • The peptides also incorporated amino-acid building blocks that are not found in natural proteins, and this, as well as their cyclic structures, made them relatively resistant to the enzymes that can otherwise quickly clear peptide drugs from the bloodstream. (innovations-report.com)
  • They found that the antibodies responded to several proteins in the peanut, in particular one called Ara h 1, which is known to be a key player in inducing the negative response in people who are allergic to peanuts. (medicalxpress.com)
  • Previous studies have found that there are several proteins in both strawberries and tomatoes, which can cause allergic reactions . (medicalxpress.com)
  • In further experiments with the flies, the research team found that ATP synthase was essential to normal stem cell development, directly controlling the growth and maintenance of the inner membranes inside mitochondria, called cristae, as the cells continue to divide and form the specific cell components that make up an egg, or female germ cell. (medicalxpress.com)
  • Experiments by Lehmann and her colleagues found that when any one of 13 key proteins tied to ATP synthase were blocked, egg development was disrupted or stalled. (medicalxpress.com)
  • We've found a protein that seems to serve as a general switch for photoreceptor cell development," says Seth Blackshaw, Ph.D., an assistant professor in the Solomon H. Snyder Department of Neuroscience at Johns Hopkins. (innovations-report.com)
  • And, since Pias3 also is found in developing rod and cone and no other cells in the eye, the team hypothesized that it might act to help these cells "decide" which type to become. (innovations-report.com)
  • When they reduced the amount of Pias3 in developing mouse eyes, they found that the cells that might otherwise have been rod cells instead developed into conelike cells. (innovations-report.com)
  • They found that eyes containing altered Pias3 did not develop the correct number of rod cells, suggesting that Pias3's SUMOylation activity was the key to its ability to promote rod and suppress cone cell development in the eye. (innovations-report.com)
  • The team also found that Pias3 SUMOylates a protein, Nr2e3, already known to influence rod and cone cell development, and showed that SUMOylation is critical for its ability to repress cone development. (innovations-report.com)
  • neurodegenerative
  • Malfunctions in the cells' protein-disposal machinery can lead to the accumulation of misfolded proteins, which clog up the cell, interfere with its functions, and, over time, precipitate the development of diseases, including neurodegenerative conditions such as amyotrophic lateral sclerosis and Alzheimer's. (harvard.edu)
  • Compounds
  • The primary goal of this project is to determine whether the use of a class of natural product-inspired compounds called macrocycles constitutes a broadly applicable method for developing oral drugs against PPI targets. (bu.edu)
  • The team was able to develop compounds more soluble than existing cytochrome b inhibiting quinolones. (vetscite.org)
  • humans
  • In the coming years, the Aussie team will reate a protein specifically geared toward humans which could be on the market in the next decade or so. (advancedtissue.com)
  • The research team led by Professor Mike Doenhoff from The University of Nottingham, and including Dr Marwa El-Faham from Alexandria University and Dr Susan Liddell set out to discover if the antigens produced by a common species of parasitic worm that infects humans (called Schistosoma mansoni) were cross-reactive to antigens from peanuts, i.e. do the proteins from the worm and from the peanuts trigger the same immune response? (medicalxpress.com)
  • findings
  • We believe our findings set the stage for the development of therapies that harness the cells' natural ability to dispose of proteins and thus enhance the removal of toxic proteins that cause disease," said study's lead investigator, Jordan VerPlank , a postdoctoral research fellow in cell biology at the Blavatnik Institute. (harvard.edu)
  • Lee said that the study findings are important because targeting Myc is a challenging task due to its unique protein structure. (healthcanal.com)
  • The team then compares these findings to brain measurements they take using infrared spectroscopy. (mit.edu)
  • infection
  • As part of their natural defenses against viral infection, human cells have proteins that latch onto dsRNA, setting off a cascade of reactions that prevents the virus from replicating itself. (medicalxpress.com)
  • decades
  • For decades, biologists have been trying to find the crucial sensor protein in nerve endings that translates muscle and tendon stretching into proprioceptive nerve signals. (healthcanal.com)
  • sensitivity
  • In addition, the heat sensitivity of the proteins could be confirmed: If the fruits were exposed to heat during the drying process, their allergy potential was lower. (medicalxpress.com)
  • Offering sensitivity it is designed to allow protein molecules with a hydrodynamic radius down to 0.3 nm to be measured at concentrations of 0.1 mg/ml or less. (technologynetworks.com)
  • antibodies
  • Antibodies are large proteins that are expensive to produce and must be delivered by injection or infusion. (innovations-report.com)
  • The peptides, like the antibodies they are designed to mimic, bind to a site known as the hydrophobic stem groove on the lower part of the flu virus's main envelope protein hemagglutinin. (innovations-report.com)
  • Antibodies are a type of immune protein made by the body to provide a tailored response to any substance deemed to be a threat so the team used antibodies from rabbits that had been exposed to various life stages of the worm. (medicalxpress.com)
  • Consequently
  • Consequently, the proteins investigated in the studies (Sola l 4.02 in tomatoes and Fra a 1 protein in strawberries) may in future serve as markers for the cultivation of hypoallergenic tomato and strawberry varieties. (medicalxpress.com)
  • research
  • Even with several more years of research, the team is optimistic about how this brand new therapy could potentially help millions of chronic wound patients. (advancedtissue.com)
  • The research team is currently conducting more studies to validate these results, and move the drugs further toward studies that are required for consideration of Food and Drug Administration approval. (bio-medicine.org)
  • My research team is also pursuing a new area of research targeted at developing small molecule inhibitors. (buffalo.edu)
  • Other members of the research team are Lincoln Lab staff members Scott Wick, Christina Zook, Tara Boettcher, Jennifer Pancoast and Benjamin Zusman. (medicalxpress.com)
  • In addition to Professor Whitty (quantitative biochemistry and drug discovery), the multidisciplinary research team comprises Professors Sandor Vajda and Dima Kozakov (computational chemistry), John Porco and Aaron Beeler (macrocycle synthesis), Karen Allen (X-ray crystallography), and Tom Gilmore (NF-κB pathway biology). (bu.edu)
  • stem cell
  • They undertook the present study to determine how Id proteins maintain stem cell identity. (eurekalert.org)
  • Another aspect," added Dr. Lasorella, "is to determine whether Id proteins also maintain stem cell properties in cancer stem cells in the brain. (eurekalert.org)
  • laboratory
  • Patapoutian and his laboratory specialize in identifying and characterizing sensory transducer proteins and over the past 15 years have identified transducers of cold, heat and pain. (healthcanal.com)
  • Blackshaw's laboratory is trying to understand the steps necessary for developing light-sensitive eye cells to transition into one of two types: rod or cone cells. (innovations-report.com)
  • crystallography
  • Using X-ray crystallography, the team determined how TPh A binds to pirin at a resolution of 2.35 Å (Figure 2). (riken.jp)
  • Baleja and colleagues used biophysical tools including circular dichroism spectroscopy and x-ray crystallography to test the structure and stability of different inhibitors. (infectioncontroltoday.com)
  • TSRI
  • To the layman it might not seem surprising that touch and proprioception would use the same sensor protein, but within this field there has been a lot of evidence suggesting otherwise-so finding that Piezo2 does both was a surprise," said lead investigator Ardem Patapoutian, a professor at TSRI and investigator with Howard Hughes Medical Institute. (healthcanal.com)
  • another protein
  • Rider had the idea to combine a dsRNA-binding protein with another protein that induces cells to undergo apoptosis (programmed cell suicide) launched, for example, when a cell determines it is en route to becoming cancerous. (medicalxpress.com)
  • drug
  • In fact, a proteasome inhibitor drug Goldberg and his team developed to tamp down protein-disposal activity has been widely used to treat multiple myeloma, a common blood cancer marked by abnormal protein accumulation and overworked proteasomes. (harvard.edu)
  • A new drug which "fine tunes" the immune system is being developed to help prevent asthma and allergies to foods such as peanuts and shellfish. (medicalxpress.com)
  • Viruses are pretty good at developing resistance to things we try against them, but in this case, it s hard to think of a simple pathway to drug resistance, she says. (medicalxpress.com)
  • The drug was developed by Roche's Genentech unit and Plexxikon, which was recently acquired by Daiichi. (reuters.com)
  • Thus, the development of drug-like inhibitors of this pathway is highly relevant to public health. (bu.edu)
  • biologically
  • Our team plans further investigations into precisely how ATP synthase biologically controls cristae development, and whether other developmental roles are influenced by mitochondria," says Lehmann. (medicalxpress.com)
  • drugs
  • Currently, the development of resistance to new drugs is a major problem in cancer, as it cost billions of dollars to develop and approve new drugs, and yet they can rapidly become ineffective as a treatment. (utu.fi)
  • affinity
  • From more than 20,000 molecules screened, the team identified one they named triphenyl compound A (TPh A) that binds to pirin with high affinity. (riken.jp)
  • allergy
  • Of particular note are proteins that resemble the primary allergen in birch pollen and due to this similarity can lead to birch pollen-associated food allergy. (medicalxpress.com)
  • Food allergy sufferers develop symptoms after eating fresh fruit or vegetables, while processed products are often tolerated. (medicalxpress.com)
  • known
  • It involves tagging defective or unneeded proteins with ubiquitin molecules - a process known as the "kiss of death" - marking them for destruction by the cell's protein-disposal unit, known as 26S proteasome. (harvard.edu)
  • Human pirin is a nuclear protein known to play a role in a variety of biological processes, yet one with a function which remains unclear. (riken.jp)
  • Our model organism is the well-characterized bacterium Escherichia coli (E. coli), since the majority of the proteins thought to be involved in fork rescue are known. (buffalo.edu)
  • various
  • Tomatoes ( Solanum lycopersicum ) and strawberries (Fragaria x ananassa) can cause allergic reactions due to the presence of various allergenic proteins. (medicalxpress.com)
  • The aim of the two recently published studies was to quantify an important allergenic protein in the various strawberry and tomato varieties. (medicalxpress.com)
  • In the observation room where she conducts these studies, Greene describes how the team sets up a monitor to record infants' reactions as they sit on their parents' laps and watch various stimuli and animations. (mit.edu)
  • medicines
  • These designed molecules have the potential to be developed into medicines that target influenza, which causes up to 500,000 deaths worldwide each year and costs Americans billions of dollars in sick days and lost productivity. (innovations-report.com)
  • several
  • More specifically we unraveled how it mediates the protein assembly at the cell surface responsible for several atopic diseases, including asthma and atopic dermatitis. (medicalnewstoday.com)
  • Goldberg's lab previously focused on reining in overactive protein breakdown - excessive protein removal that can cause muscle wasting in cancer patients or give rise to several types of muscle atrophy. (harvard.edu)
  • Several breakthroughs have already been reported, which have led, amongst other things, to a new treatment for congenital breast and ovarian cancer using so-called PARP inhibitors, which has been available for some years. (medicalxpress.com)
  • Most of our experimental work is concerned with the function and regulation of the complexes that control fork rescue, with studies focused primarily on the role of the single-strand DNA binding protein (SSB) and several recombination DNA helicases. (buffalo.edu)
  • cancer
  • This important new discovery was made by a team of doctors from the Center for Cancer Biology in Adelaide, Australia. (advancedtissue.com)
  • The team received support from the Turku BioImaging Screening Unit and funding from the National Cancer Institute in the Uniteds States, the EU-Marie Skłodowska Curie programme, and Finnish foundations including the Magnus Ehrnrooth, Alfred Koredelin, Instrumentarium and Orion Foundations. (utu.fi)
  • By understanding how this cancer-causing protein works, we hope to target it much more precisely than before," he said. (xtalks.com)
  • We have developed a protein inhibitor that blocks HPV protein expression in cell culture, a first step toward a topically-applied treatment for this cancer-causing virus," said senior author James Baleja, PhD, associate professor of biochemistry at Tufts University School of Medicine (TUSM) and member of the biochemistry program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts. (infectioncontroltoday.com)
  • immune system
  • However, our work indicates that proteins from these two seemingly very different organisms actually have identical markers on them, meaning the immune system views them in the same way and targets them with the same antibody. (medicalxpress.com)