Loading...
  • Tcf3
  • Four isoforms of TCF/LEF have been identified in humans, namely, TCF1 (TCF7), LEF1, TCF3 (TCF7L1), and TCF4 (TCF7L2) [ 11 - 13 ]. (medsci.org)
  • Promoter
  • The SW480-PKD1-GFP and SW480-GFP cells were transiently transfected with either a TCF-promoter-luciferase construct or a mutant TCF-promoter luciferase construct along with an internal control plasmid expressing Renilla luciferase gene. (nih.gov)
  • The β-catenin transcription activity was measured, normalized to the control Renilla luciferase activity and expressed as a ratio of TCF-promoter-luciferase activity to mutant TCF-promoter luciferase activity. (nih.gov)
  • mutant
  • TCF activity generated by ectopic mutant β-catenin was weak in poorly differentiated SNU449 cell line, suggesting a repressive mechanism. (biomedcentral.com)
  • mechanism
  • Development of novel therapies to normalize bone mass and correct developmental defects requires a good understanding of the specific mechanism of TCF/LEFs. (medsci.org)
  • The relationship between transcription factors and miRNA in different plant species described in this chapter will be of great interest to plant scientists, providing better insights into the mechanism of action and interactions among transcription factors (TFs) and miRNA networks culminating in improving key agronomic traits for crop improvement to meet the future global food demands. (intechopen.com)
  • complex
  • Immune-mediated disorders such as psoriasis and type 1 diabetes result from a complex interplay of genetic and environmental factors. (upenn.edu)