CDDs with toxic properties similar to 2,3,7,8-TCDD are called "dioxin-like" compounds. (cdc.gov)
The registry is a compilation of demographic and occupational history information for all United States production workers who have synthesized products known to be contaminated with 2,3,7,8-tetrachlorodibenzo-p- dioxin (1746016) (TCDD) or hexachlorinated dibenzo-p-dioxins. (cdc.gov)
In the course of purifying the hexachlorophene, still bottom wastes were created with concentrated levels of TCP and dioxin. (wikipedia.org)
The groups with two through eight chlorine atoms are called di-chlorinated dioxin (DCDD), tri-chlorinated dioxin (TrCDD), tetra-chlorinated dioxin (TCDD), penta-chlorinated dioxin (PeCDD), hexa-chlorinated dioxin (HxCDD), hepta-chlorinated dioxin (HpCDD), and octa-chlorinated dioxin (OCDD). (cdc.gov)
Silvex2
Trichlorophenol, the herbicides 2,4,5-trichlorophenoxyacetic-acid and silvex, and hexachlorophene are manufactured products that may be contaminated with TCDD. (cdc.gov)
5 TCP has been utilized primarily as a feedstock for production of the phenoxy herbicides 2,4,5-T and silvex, resulting in the contamination of these products with TCDD. (cdc.gov)
Occupational2
Occupational exposure to TCDD occurred in the United States during the manufacture of Agent Orange, as well as among U.S. Vietnam veterans who were exposed to Agent Orange during Operation Ranch Hand. (nih.gov)
The National Institute for Occupational Safety and Health (NIOSH) recommends that TCDD be regarded as a potential occupational carcinogen, that occupational exposure to TCDD be controlled to the fullest extent feasible, and that decontamination measures be used for TCDD-contaminated work environments. (cdc.gov)
Primarily1
Most of the general population is exposed to low levels of TCDD, primarily through dietary intake of animal fats. (nih.gov)
Humans2
There have been few studies of paternal TCDD exposure and birth weight or preterm delivery in humans, however. (nih.gov)
Studies of humans exposed to TCDD-contaminated materials suggest that TCDD is the cause of observed chloracne, metabolic disorders (porphyria), and other systemic problems and are suggestive of TCDD's ability to cause cancer. (cdc.gov)
Chemical2
We studied pregnancy outcomes among wives of male chemical workers who were highly exposed to chemicals contaminated with TCDD and among wives of nonexposed neighborhood referents. (nih.gov)
The chemical and physical properties are summarized in Table I . TCDD is a colorless crystalline solid at room temperature. (cdc.gov)
Temperature1
Run-away reactions at high temperature, in which excess TCDD was produced, have occurred at TCP production sites in the United States and elsewhere. (cdc.gov)
Products1
The requirement for being included in the registry is a company record of assignment to a department which manufactures products potentially contaminated with TCDD or hexachlorinated dioxins. (cdc.gov)
Studies3
Because the estimated TCDD concentrations in this population were much higher than in other studies, the results indicate that TCDD is unlikely to increase the risk of low birth weight or preterm delivery through a paternal mechanism. (nih.gov)
Because of the compression in this bulletin of the voluminous literature on TCDD, it is suggested that readers wanting to know more of the details of the reported studies consult the appended references. (cdc.gov)
This recommendation is based on a number of reliable studies demonstrating TCDD carcinogenicity in rats and mice. (cdc.gov)
Review1
A recent review of TCDD by the NAS concluded that TCDD is one of the most toxic chemicals known to affect animals, although there is an extreme range of effects among species, and that the most sensitive time of exposure to TCDD is during fetal development ( NAS 2003 ). (nih.gov)