• Based upon application, chemotherapy induced peripheral neuropathy treatment market is classified into Platinum Agents, Taxanes, Vinca Alkaloids, and Others. (medgadget.com)
  • The popular periwinkle plant, which grows along the ground of many front yards, is the source of vinca alkaloids that are effective, for example, against malignant lymphomas. (sciencedaily.com)
  • This paper presents an overview of the investigations on the feasibility and application of flavonoids as P-gp modulators for improved efficacy of anti-cancer drugs like taxanes, anthracyclines, epipodophyllotoxins, camptothecins and vinca alkaloids. (nih.gov)
  • In vitro , overexpression of the mdr-1 gene product, P-glycoprotein (Pgp), in tumor cells can confer high-level resistance to natural product-derived cytotoxics-anthracyclines, vinca alkaloids, epipodophyllotoxins, and taxanes. (cancer.gov)
  • Plant alkaloids are mitotic spindle poisons active in G2 and M phases of cell division (vinca alkaloids, taxanes) or are topoisomerase interactive agents (etoposide and teniposide). (vin.com)
  • Taxol - paclitaxel, Taxotere - docetaxel, and Abraxane - albumin-bound paclitaxel) and vinca alkaloids (e.g. (shu.edu)
  • Vinca alkaloids (vincristine, vinblastine, etc.) bind to microtubule plus ends and the outer surface of microtubules, inhibiting microtubule lengthening (polymerization) as well as shortening (depolymerization) (Figure 2B). (shu.edu)
  • Vinca alkaloids, which also include as ingredients from periwinkle plant to the cytostatics, also referred to as spindle poisons. (drsymptoms.com)
  • Representatives of the vinca alkaloids are vinblastine and vincristine. (drsymptoms.com)
  • Vinca alkaloids used in lymphoma and oxaliplatin used for colon cancer also cause nerve damage. (cancertodaymag.org)
  • This effect is similar to those of cytotoxic anticancer agents that act on microtubules, including vinca alkaloids and taxanes. (srkbusiness.com)
  • The plant contains a group of compounds referred as Vinca alkaloids which are classified as cytotoxics based on their anti-mitotic and anti-microtubule activity. (healthyhabitsliving.com)
  • These resistance mechanisms, when manifested, are a major reason for the failure of clinically used agents such as taxanes and vinca alkaloids. (duq.edu)
  • Its minimal impact on cellular microtubules makes it a viable alternative to other cancer medicines that disrupt these structures, such as taxanes and vinca alkaloids. (firstcontactinc.org)
  • This mechanism of action is similar to that of taxanes (paclitaxel and docetaxel), but epothilones retain activity against multi-drug resistance (MDR) tumours. (knowcancer.com)
  • The use of the newer agents in the taxane class (paclitaxel and docetaxel) is being explored in veterinary medicine as these agents are highly effective in human medicine. (vin.com)
  • Taxanes (paclitaxel and docetaxel) bind to the inner surface of microtubules and promote microtubule lengthening (polymerization), while inhibiting microtubule shortening (depolymerization). (shu.edu)
  • L01CD02 - docetaxel : Belongs to the class of plant alkaloids and other natural products, taxanes. (azurewebsites.net)
  • Microtubule inhibitors such as taxanes (e.g. (shu.edu)
  • Taxine alkaloids, which are often named under the collective title of taxines, are the toxic chemicals that can be isolated from the yew tree. (wikipedia.org)
  • The amount of taxine alkaloids depends on the species of yew, with Taxus baccata and Taxus cuspidata containing the most. (wikipedia.org)
  • The major taxine alkaloids are taxine A and taxine B although there are at least 10 different alkaloids. (wikipedia.org)
  • Until 1956, it was believed that all the taxine alkaloids were one single compound named taxine. (wikipedia.org)
  • The taxine alkaloids are cardiotoxins with taxine B being the most active. (wikipedia.org)
  • Taxine alkaloids have no medical uses but Paclitaxel and other taxanes that can be isolated from yews have been used as chemotherapy drugs. (wikipedia.org)
  • In 1856, H. Lucas, a pharmacist in Arnstadt, prepared a white alkaloid powder from the foliage of Taxus baccata L. which he named taxine. (wikipedia.org)
  • However, in 1956, Graf and Boeddeker discovered that taxine was actually a complex mixture of alkaloids rather than a single alkaloid. (wikipedia.org)
  • Using electrophoresis, they were able to isolate the two major components, taxine A and taxine B. taxine A was the fastest moving band and accounted for 1.3% of the alkaloid mixture, while taxine B was the slowest moving band and accounted for 30% of the mixture. (wikipedia.org)
  • Taxine B, the most common alkaloid in Taxus species, is also the most cardiotoxic taxine, followed by taxine A. Taxine alkaloids are absorbed quickly from the intestine and in high enough quantities can cause death due to general cardiac failure, cardiac arrest or respiratory failure. (wikipedia.org)
  • The estimated lethal dose (LDmin) of taxine alkaloids is approximately 3.0 mg/kg body weight for humans. (wikipedia.org)
  • a major reason is the difficulty of measuring taxine alkaloids. (wikipedia.org)
  • One of the most common hosts for this fungus is the very poisonous Yew tree, and it is often said that the fungus will absorb the toxic alkaloids (Taxine and Taxane) from the tree. (wildfooduk.com)
  • It was previously approved for patients with breast cancer who had undergone at least two prior chemotherapeutic regimens, including an anthracycline and a taxane. (shu.edu)
  • Today, anthracycline and taxane-based treatment strategies are commonly used in clinical routine, since these regimens have been shown to be superior compared to other standard chemotherapies. (justia.com)
  • Several large clinical trials demonstrated that the addition of taxanes to anthracycline-based treatment strategies results in an improved clinical outcome (Martin et al. (justia.com)
  • The leaves, bark and stem contain an alkaloid, camptothecin, which is found to inhibit topoisomerase I, an enzyme needed for DNA replication. (healthyhabitsliving.com)
  • Other chemotherapy drugs, in addition to taxanes, can trigger neuropathy. (webmd.com)
  • Q: Why are taxane-based chemotherapy drugs more likely to cause this problem? (cancertodaymag.org)
  • These drugs are made up of various chemicals such as platinum agents, opioids, alkaloids and others. (medgadget.com)
  • However, the taxanes are extremely anaphylactogenic due to the use of Cremaphor-EL to solubilize the formulation of the drugs, which are not water-soluble compounds. (vin.com)
  • It belongs to a class of drugs known as taxanes, and researchers often refer to it as a plant alkaloid. (chemoeyelawsuit.com)
  • Semisynthetic derivative of camptothecin, an alkaloid extract from the Camptotheca acuminate tree. (medscape.com)
  • L01CB01 - etoposide : Belongs to the class of plant alkaloids and other natural products, podophyllotoxin derivatives. (azurewebsites.net)
  • Taxanes prepared from yew bark and thus belonging to the vegetable and have cytostatic effect in the cells of the so-called microtubules. (drsymptoms.com)
  • Modern researchers continue to discover beneficial compounds based on the taxanes found in this tree. (healthyhabitsliving.com)
  • Plants contain various active compounds like polyphenols, coumarins, alkaloids, terpenoids and peptides that possess antimicrobial activity [ 2 ]. (biomedcentral.com)
  • If you've had taxane-based chemotherapy or other treatments for breast cancer , you may form a condition called peripheral neuropathy . (webmd.com)
  • Peripheral neuropathy is one of the most common side effects of taxane-based treatment. (webmd.com)
  • Another study found that one-fifth of people with breast cancer treated with taxane-based chemotherapy had peripheral neuropathy after treatment. (webmd.com)
  • How Does Taxane-Based Chemotherapy Cause Peripheral Neuropathy? (webmd.com)
  • But researchers think taxanes also affect cells in healthy peripheral nerves. (webmd.com)
  • Isoquinoline alkaloids - Isoquinoline alkaloids 1-Benzyl isoquinoline type: Papaverine: An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. (powershow.com)
  • In one study, just over 40% of participants reported symptoms of neuropathy 2 years after taxane-based chemotherapy to treat breast cancer . (webmd.com)
  • Taxanes alone or in combination with other agents have demonstrated efficacy in the treatment of hormone-refractory prostate cancer. (medscape.com)
  • Although, taxanes are among the most active agents, the absolute benefit of taxane-based treatment is modest (3-5%) and has to be balanced according to serious side-effects. (justia.com)
  • Described herein are methods for predicting a benefit from inclusion of taxane in a chemotherapy regimen in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer. (justia.com)
  • The present invention relates to methods, kits and systems for predicting the benefit from inclusion of taxane in a chemotherapy regimen based on the measurements of gene expression levels in tumor samples of breast cancer patients. (justia.com)
  • But we have a whole generation of women who received taxane-based chemotherapy for breast cancer without any evaluation of its long-term toxicity. (cancertodaymag.org)
  • In any case, the toxic alkaloids found in Yew are very resilient and can be found even on dead wood and fallen needles. (wildfooduk.com)
  • To reduce the number of patients suffering from side effects without a clear benefit of the therapy regimen, there is a great need for novel predictive tests to identify a group of patients that can be safely treated with conventional chemotherapy and a subgroup that has a significant benefit of taxane-based treatment. (justia.com)
  • IXEMPRA, a microtubule inhibitor, in combination with capecitabine is indicated for the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline and a taxane ( 1 ). (nih.gov)
  • This modification Amphotericin B in HIF-1α polysome association happens downstream of microtubule disruption as the current presence of a tubulin mutation in either Mouse monoclonal to CHUK the taxane- or 2-methoxyestradiol (2ME2)-binding site avoided the drug-induced adjustments. (techblessing.com)
  • Unlike the taxanes, which bind poorly to soluble tubulin, vincristine can bind both soluble and microtubule-associated tubulin. (smpdb.ca)
  • The taxanes or taxoids are a closely related group of antineoplastic agents that have a unique mechanism of action as inhibitors of mitosis and which are widely used in the therapy of ovarian, breast, lung, esophageal, prostate, bladder and head and neck cancers. (nih.gov)
  • Vincristine (also named leurocristine) is a natural alkaloid isolated from the leaves of the Catharanthus roseus (commonly known as the Madagascar periwinkle). (smpdb.ca)
  • New drugs such as gemcitabine, taxanes and trabectedin have been explored in several studies, showing promising results. (healthdrugpdf.com)
  • IXEMPRA as monotherapy is indicated for the treatment of metastatic or locally advanced breast cancer in patients after failure of an anthracycline, a taxane, and capecitabine ( 1 ). (nih.gov)
  • IXEMPRA (ixabepilone) is indicated in combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. (nih.gov)
  • We previously demonstrated that different natural products which stabilize MTs by interacting with β-tubulin at the taxane binding site provide significant benefit in transgenic mouse models of tauopathy. (biomedcentral.com)
  • The amount of taxine alkaloids depends on the species of yew, with Taxus baccata and Taxus cuspidata containing the most. (wikipedia.org)
  • In 1856, H. Lucas, a pharmacist in Arnstadt, prepared a white alkaloid powder from the foliage of Taxus baccata L. which he named taxine. (wikipedia.org)
  • Taxine B, the most common alkaloid in Taxus species, is also the most cardiotoxic taxine, followed by taxine A. Taxine alkaloids are absorbed quickly from the intestine and in high enough quantities can cause death due to general cardiac failure, cardiac arrest or respiratory failure. (wikipedia.org)
  • A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. (lookformedical.com)
  • Grupo de CICLODECANOS diterpenoides nombrados por los taxanos que fueron descubiertos en el árbol TAXUS. (bvsalud.org)
  • In contrast, taxanes, agents that stabilize microtubules, are far less effective against the same cancer types. (nih.gov)
  • Taxane resistance is defined as progression while on therapy or within 12 months in the adjuvant setting or 4 months in the metastatic setting. (nih.gov)
  • A nitrogenous secondary metabolite obtained by endophytes originate from various biosynthetic pathways belonging to different structural groups such as alkaloids, amines, peptides, etc. (slideshare.net)
  • Alkaloids liquid in nature, obtained from plant source. (howmed.net)
  • Paclitaxel is a plant alkaloid that was developed from the bark of the Pacific Yew tree. (oncolink.org)
  • Taxanes have many side effects and can be associated with serum enzyme elevations during treatment, and rarely with clinically apparent liver injury. (nih.gov)
  • Grinding or Sanding - Certain woods such as Yew contain highly poisonous taxane alkaloids which can make a person severely ill and even cause death. (blackrockworkwear.com)
  • Taxanes alone or in combination with other agents have demonstrated efficacy in the treatment of hormone-refractory prostate cancer. (medscape.com)