AnatomyChemicals and DrugsPhenomena and Processes
Taurochenodeoxycholic AcidCholagogues and CholereticsTaurodeoxycholic AcidEndoplasmic Reticulum StressUrsodeoxycholic AcidBile Acids and SaltsPhenylbutyratesGlycocholic AcidLithocholic AcidChenodeoxycholic AcidTaurocholic AcidBileEndoplasmic ReticulumCytochrome P-450 Enzyme SystemMicrosomes, LiverApoptosis
Bile acidTaurodeoxycholicTaurocholicSodiumGlycolithocholicTaurineChenodeoxycholic acidUrsodeoxycholicToxicityGlycodeoxycholicGlycohyodeoxycholicGlycochenodeoxycholicSerumLiverProvideDeoxycholic acidTaurolithocholicChenodeoxycholicAminoMetabolismBile acid profilesGlycineMiceBacterialCholesterolPrimaryTreatment
Bile acid8
  • Taurochenodeoxycholic acid is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine. (wikipedia.org)
  • Tauroursodeoxycholic acid (TUDCA) is an amphiphilic bile acid. (fruiterco.com)
  • Sodium ursodeoxycholate is a natural bile acid isolated from bear bile. (fruiterco.com)
  • It is a hydrophilic bile acid and a cholesterol gallstone. (fruiterco.com)
  • The results of metagenomic sequencing and targeted metabolome analysis together revealed that secondary bile acid (SBA) biosynthesis was significantly activated in the cows with excessive lipolysis. (biomedcentral.com)
  • Maintaining bile acid (BA) homeostasis is important and regulated by BA activated receptors and signaling pathways. (aspetjournals.org)
  • The impact of exposures on bile acid (BA) signaling and Farnesoid X receptor-mediated gut-liver crosstalk is emerging. (aspetjournals.org)
  • The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)
Taurodeoxycholic2
Taurocholic1
Sodium1
Glycolithocholic2
  • The use of an integrated analysis showed that the reduction of plasma glycolithocholic acid and taurolithocholic acid could contribute to the immunosuppression of monocytes (CD14 + MON) during excessive lipolysis by decreasing the expression of GPBAR1 . (biomedcentral.com)
  • Glycolithocholic acid NEW! (viochemicals.com)
Taurine2
Chenodeoxycholic acid3
  • HT-29 colon cancer cells and LT97 colorectal micro-adenoma cells derived from a patient with FAP, were exposed to low dose celecoxib and UDCA alone or in combination with tauro-cholic acid (CA) and tauro-chenodeoxycholic acid (CDCA), mimicking bile of FAP patients treated with UDCA. (fapvoice.com)
  • Chenodeoxycholic acid NEW! (viochemicals.com)
  • Subsequent enzymatic reactions catalyzed by sterol 12 α -hydroxylase (CYP8B1) and sterol 27-hyroxylase (CYP27A1), respectively, yield the primary BAs, cholic acid (CA) and chenodeoxycholic acid (CDCA). (aspetjournals.org)
Ursodeoxycholic2
  • Celecoxib and Tauro-Ursodeoxycholic Acid Co-Treatment Inhibits Cell Growth in Familial Adenomatous Polyposis Derived LT97 Colon Adenoma Cells. (fapvoice.com)
  • We investigated the in vitro effects on cell proliferation, apoptosis, and COX-2 expression of the potential chemopreventives celecoxib and tauro-ursodeoxycholic acid (UDCA). (fapvoice.com)
Toxicity1
  • The bile acidity concentrations weren't further elevated with the best dosage, possibly because of saturation of serum bile acids or liver organ toxicity. (bibf1120.com)
Glycodeoxycholic1
Glycohyodeoxycholic1
Glycochenodeoxycholic1
Serum2
  • Fig. 1B illustrates that OA at dosages of 45 mg/kg or more elevated serum concentrations of total bile acids, with 90 mg/kg Crizotinib or more elevated total bilirubin and immediate bilirubin, all indicative of liver organ injury. (bibf1120.com)
  • Twentyfour hr following the last dosage, blood was gathered and serum concentrations of bile acids and their metabolites had been dependant on UPLC-MS/MS and normalized with the inner criteria. (bibf1120.com)
Liver1
  • It can reduce the secretion of cholesterol in the liver, reduce the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, dissolve cholesterol stones or prevent the formation of stones. (fruiterco.com)
Provide1
  • ICE Pharma are able to supply these conjugates to a host of bile acids and we are able to conjugate alternative amino acids to provide custom products as required. (thebileacidsexpert.com)
Deoxycholic acid1
Taurolithocholic1
  • It has been shown that one of the most toxic BAs to acinar cells is the secondary BA, taurolithocholic acid (TLC) that forms from LCA after re-absorption from the intestine. (pancreapedia.org)
Chenodeoxycholic2
Amino2
  • Overall, analysis of transcriptomes and correlation networks indicates both bacterial species-specific responses to BBR, as well as functional commonalities among species, such as up-regulation of Na + /H + antiporter, cell wall synthesis/repair, carbohydrate metabolism and amino acid metabolism. (researchsquare.com)
  • ICE Pharma are able to supply these conjugates to a host of bile acids and we are able to conjugate alternative amino acids to provide custom products as required. (thebileacidsexpert.com)
Metabolism2
  • Altogether, we have demonstrated the therapeutic effects of LcS in DSS-induced colitis, providing new insights into its effect on bile acid metabolism and the related anti-inflammatory mechanisms. (liverpool.ac.uk)
  • Bile acids (BAs) are natural end products of cholesterol metabolism (12). (pancreapedia.org)
Bile acid profiles3
  • Distinguishing indirect effects of BBR on bacteria through altered bile acid profiles is particularly important in understanding how dietary nutraceuticals alter the microbiome. (researchsquare.com)
  • Additionally, LcS treatment modulated circulating bile acid profiles in colitic mice. (liverpool.ac.uk)
  • We further demonstrated that LcS treatment suppressed the expression of pro-inflammatory mediators interferon-gamma (IFN-γ) and nitric oxide (NO), and increased the expression of the anti-inflammatory mediator interleukin-10 (IL-10) in colon tissues, potentially as a result of altered bile acid profiles. (liverpool.ac.uk)
Glycine1
Mice1
  • Glucose-regulated protein 78 is reduced in AT2 cells from old mice and patients with IPF, and ER stress inhibitor tauroursodeoxycholic acid ameliorates ER stress and fibrosis in Grp78 KO mouse and IPF lung slice cultures.Conclusions: These results support a causal role for ER stress and resulting epithelial dysfunction in PF and suggest ER stress as a potential mechanism linking aging to IPF. (nih.gov)
Bacterial1
  • Multi-omics (bile acid metabolomics, 16S rDNA sequencing, cecal metatranscriptomics) were performed in order to provide a simple in vivo model from which to identify network-based correlations between bile acids and bacterial transcripts in the presence and absence of dietary BBR. (researchsquare.com)
Cholesterol2
  • Reduction in lipids, particularly cholesterol, is achieved partly through up-regulation of bile acid synthesis and excretion into the gastrointestinal tract (GI). (researchsquare.com)
  • Additionally, BBR functions to reduce serum cholesterol by up-regulating the conversion of cholesterol into bile acids which are excreted at higher levels in feces [4,5]. (researchsquare.com)
Primary1
  • Moreover, LcS treatment exhibited a suppressive effect on the hydroxylated primary bile acids α-muricholic acid (α-MCA) and β-muricholic acid (β-MCA). (liverpool.ac.uk)
Treatment1
  • Bile acid concentrations in the GI tract increased significantly during BBR treatment and developed extensive correlation networks with expressed genes in the B4PC2 community. (researchsquare.com)