Loading...
  • pathology
  • The most common form of dementia, Alzheimer's disease, and a relatively rare hereditary form of dementia, frontotemporal dementia with parkinsonism-17, share a common pathology: Both are the result of an overaccumulation of tau proteins, which form tangled lesions in the brain's neurons and eventually lead to the collapse of the brain cells responsible for memory. (news-medical.net)
  • Until now, no one has been able to show how tau pathology might lead to navigational difficulties," said co-study leader Karen E. Duff, PhD, professor of pathology & cell biology (in psychiatry and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) at CUMC. (medicalxpress.com)
  • Spatial cognitive tasks revealed that the EC-tau mice performed significantly worse compared to the controls, suggesting that tau alters grid cell function and contributes to spatial learning and memory deficits, according to co-study leader Abid Hussaini, PhD, assistant professor of neurobiology (in Pathology and Cell Biology and the Taub Institute). (medicalxpress.com)
  • It appears that tau pathology spared the inhibitory cells, disturbing the balance between excitatory and inhibitory cells and misaligning the animals' grid fields," said co-first author Hongjun Fu, PhD, associate research scientist in the Taub Institute, who led the immunohistological and behavior studies. (medicalxpress.com)
  • This study clearly shows that tau pathology, beginning in the entorhinal cortex, can lead to deficits in grid cell firing and underlies the deterioration of spatial cognition that we see in human Alzheimer's disease," said Eric Kandel, MD, Nobel laureate, University Professor and Kavli Professor of Brain Science at CUMC. (medicalxpress.com)
  • The team aims to understand how MSUT2 controls tau pathology in living organisms, at a deeper level of biological detail. (washington.edu)
  • Tau pathology is followed by APP dysfunction within hippocampus and entorhinal cortex. (ijpsonline.com)
  • "Mice treated with caffeine developed a less severe pathology from the point of view of memory, tau protein modifications, and neuroinflammation" explains David Blum, a research fellow at Inserm. (healthcanal.com)
  • Pathology dimension, which measures quantity and spread of tangled proteins. (caring.com)
  • serine
  • The brains of Wistar rat pups exposed to 0.2% lead acetate in their drinking water for three weeks after birth were analysed by AAS for the presence of lead and via Western blot for expression of tau, phosphorylated tau and various serine/threonine protein phosphatases (PP1, PP2A, PP2B and PP5). (spectroscopynow.com)
  • These results demonstrate that early postnatal exposure to lead decreases PP2A expression and induces tau hyperphosphorylation at several serine and threonine residues," the team says. (spectroscopynow.com)
  • pathologies
  • Researchers have identified the normal structure of several tau proteins, and they have found examples of improperly folded proteins associated with various neurological pathologies. (wisegeek.com)
  • The Kraemer Lab in the UW Division of Gerontology and Geriatric Medicine and the VA Puget Sound Health Care System focuses on understanding the molecular mechanisms involved in the protein pathologies that lead to symptoms of Alzheimer's disease, frontotemporal lobar degeneration (FTLD), and/or amyotrophic lateral sclerosis (ALS). (washington.edu)
  • buildup
  • The study showed that tau was in fact the driving force behind the disease though initially buildup of amyloid was the only clear indicator of cognitive decline. (medindia.net)
  • Scientists at Washington University are collaborating with the pharmaceutical companies AbbVie, Biogen and Eli Lilly & Co. to investigate the buildup and clearance of tau protein in the brains of patients with Alzheimer's disease. (wustl.edu)
  • The image on the right shows the average amount of tau buildup in the brains of multiple people with mild Alzheimer's symptoms. (wustl.edu)
  • We want to develop ways to make an earlier diagnosis and then design trials to test drugs against amyloid buildup and against tau buildup. (wustl.edu)
  • correlates
  • Neither total Tau nor pTau181 correlates with age or degree of memory impairment, and only a tendency is observed between the concentrations of total Tau and Aβ42 in the CSF. (springer.com)
  • inhibition
  • Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, Maria Medalla, Jennifer Luebke, Tarik Haydar, Benjamin Wolozin, Oleg Butovsky, Sebastian Kügler & Tsuneya Ikezu (2015) Depletion of microglia and inhibition of exosome synthesis halt tau propagation . (rpeptide.com)
  • memory deficits
  • Additionally, tau reduction ameliorated the learning and memory deficits and behavioral abnormalities present in the Dravet mice, which may relate to the cognitive impairments and autism-like behaviors seen in the human condition. (eurekalert.org)
  • role
  • These proteins were first identified in the 1970s, and research on tau protein is continuing in many areas of the world, as researchers are curious about the role of these proteins in healthy individuals and in certain diseases which involve the central nervous system. (wisegeek.com)
  • Understanding the role of tau protein in these diseases may be an important part of treating and preventing them, as researchers learn how and why tau protein occasionally goes awry, and how it might be corrected. (wisegeek.com)
  • Proteins like the so-called heat shock protein Hsp90 play an important role in almost all processes within human cells. (healthcanal.com)
  • Folding proteins also play a role in the development of cancer and cystic fibrosis. (healthcanal.com)
  • His group has received new funding from the National Institute on Aging (NIA) for a project to study the role of the tau protein in Alzheimer's disease, using a variety of model organisms, including mouse, C. elegans worm, and human cell models of tau toxicity. (washington.edu)
  • soluble
  • The aggregate formation is due to the structural refitting of α-helical sheet of normal, soluble amyloid-β-protein to the β-sheets, which lead to oligomeric, fibrillar, insoluble and disease causing amyloid-β 42. (ijpsonline.com)
  • kinases
  • Mounting data suggests that another factor, the tau protein ripens into highly phosphorylated form by several kinases after Aβ-stimulation leads to tangle formation resulting in neuronal bereavement in hippocampus and entorhinal regions as the disease progresses further. (ijpsonline.com)
  • molecular weight
  • This may affect other methylation-dependent pathways involving DNA, proteins, and other small molecular weight compounds, thereby compromising normal cell function ( Cantoni, 1987 ). (jneurosci.org)
  • molecule
  • The sequence suggests that tau is an elongated molecule with no extensive alpha-helical or beta-sheet domains. (sciencemag.org)
  • mice
  • The researchers made electrophysiological recordings of the grid cells of older mice-including mice engineered to express tau in the EC (EC-tau mice) and normal controls-as they navigated different environments. (medicalxpress.com)