tau ProteinsTauopathiesNeurofibrillary TanglesNeuropil ThreadsAlzheimer DiseasePick Disease of the BrainAmyloid beta-PeptidesMice, TransgenicDisease Models, AnimalPlaque, AmyloidAmyloid beta-Protein PrecursorBrainSupranuclear Palsy, ProgressiveAlzheimer VaccinesNerve DegenerationDual Specificity Phosphatase 2ThiohydantoinsPathologyFrontotemporal Lobar DegenerationGlycogen Synthase Kinase 3PhosphorylationCyclin-Dependent Kinase 5Neurodegenerative DiseasesHippocampusGliosisNeuronsPresenilin-1Entorhinal CortexMaze LearningMemory DisordersImmunohistochemistryMutationPathology, ClinicalMice, Inbred C57BLCognition DisordersPathology, SurgicalAgingSolubilityAmyloidMicrogliaAstrocytesGlial Fibrillary Acidic ProteinDisease ProgressionAge FactorsBehavior, AnimalPeptide FragmentsBlotting, WesternEnzyme-Linked Immunosorbent AssayAnalysis of VarianceNerve Tissue ProteinsCognitionTime FactorsNeuropsychological TestsCells, CulturedGene Expression RegulationPathology Department, HospitalCell Line, TumorPathology, OralMicrotubulesPathology, MolecularPathology, VeterinaryNeurofibrils