• The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. (pnas.org)
  • Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box. (pnas.org)
  • These pattern recognition receptors bind conserved motifs found on pathogens, such as LPS (TLR4), dsRNA (TLR3 and RIG-I), and hypomethylated CpG DNA (TLR9). (jimmunol.org)
  • TBP binds with the negatively charged phosphates in the DNA backbone through positively charged lysine and arginine amino acid residues. (wikipedia.org)
  • To receive news and publication updates for Journal of Spectroscopy, enter your email address in the box below. (hindawi.com)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • The blue boxes on this track indicate regions for which coordinates have been observed in PDB. (rcsb.org)
  • Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. (uniprot.org)
  • When TBP binds to a TATA box within the DNA, it distorts the DNA by inserting amino acid side-chains between base pairs, partially unwinding the helix, and doubly kinking it. (wikipedia.org)
  • The temperature stability is probably encoded in the variable α-helices that interact with the highly conserved and DNA binding β -sheets. (hindawi.com)
  • CYP17A1 , CYP21A2 and CYP11A1 were all highly expressed and the proteins localized to the adrenal fetal zone. (springer.com)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • Our findings have broader mechanistic implications for the pathogenesis of diseases involving ER stress and type I IFN, including viral infection, ischemia-reperfusion injury, protein misfolding, and inflammatory diseases. (jimmunol.org)