• Myeloid-derived suppressor cells (MDSCs) play a pivotal role in promoting tumor growth and metastasis and can even decrease the efficacy of immunotherapy. (oncotarget.com)
  • Furthermore, we describe a subset of myeloid cells with immunosuppressive activity (known as myeloid-derived suppressor cells). (hindawi.com)
  • This process is epitomized by myeloid-derived suppressor cells (MDSC). (aacrjournals.org)
  • In the present work, we evaluated the modulatory effect of IL-33 on suppressor cells in an in vivo transplantation model. (uandes.cl)
  • After 10 days of treatment, we analysed draining lymph node cellularity and found in allogeneic animals an increment in myeloid-derived suppressor cells, which co-express MHC-II, and become enriched upon IL-33 treatment. (uandes.cl)
  • Altogether, our work complements previous studies on the immune-modulatory activity of IL-33, showing that this cytokine affects myeloid-derived suppressor cells at the cell number and gene expression levels. (uandes.cl)
  • Myeloid-derived suppressor cells (MDSCs) represent a significant class of immunoregulatory cells that may be turned on to suppress T cell functions. (cell-signaling-pathways.com)
  • Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells). (wikipedia.org)
  • The size of the myeloid suppressor compartment is considered to be an important factor in the success or failure of cancer immunotherapy, highlighting the importance of this cell type for human pathophysiology. (wikipedia.org)
  • In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
  • Immune suppressor cells called MDSCs (myeloid-derived suppressor. (mdanderson.org)
  • Myeloid-derived suppressor cells (MDSC) are pathologically activated neutrophils or monocytes that are absent in healthy individuals, but appear in patients with cancer and conditions associated with chronic inflammation or stress. (beckman.com)
  • 2021) Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity. (beckman.com)
  • 2020) Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer. (beckman.com)
  • Expansion of myeloid derived suppressor cells correlates with number of T regulatory cells and disease progression in myelodysplastic syndrome. (uib.no)
  • We consider possible involvement of oxidative machinery of other professional phagocytes such as microglial cells, myeloid-derived suppressor cells, in the context of biodegradation relevant to targeted drug delivery. (cdc.gov)
  • Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells. (uib.no)
  • Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. (uib.no)
  • This study aimed to evaluate the effects of 15,16-dihydrotanshinone I on FLT3-ITD acute myeloid leukemia cells. (banglajol.info)
  • Based on compelling preclinical data revealing that inhibition of critical myeloid-based programs leads to tumor suppression, novel immune-based therapies and approaches are now entering the clinic for evaluation. (nih.gov)
  • We further describe MDSC-targeted immune therapies for breast cancer, which are classified as: preventing the formation of MDSCs, eliminating MDSDCs, and reducing the products of MDSCs. (oncotarget.com)
  • Importantly, during tumor progression, myeloid cells are implicated in promoting tumor angiogenesis, causing resistance against antiangiogenic therapies in cancer, and suppressing the immune response during cancer [ 3 - 5 ]. (hindawi.com)
  • The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
  • In fact, we shall focus on integrating emerging treatments with therapeutic strategies that include both the older endocrine therapies (the "original targeted therapies") against breast and prostate cancers, and the empirically-derived successful chemotherapies, such as platinums, that are used in gynecologic cancers. (cancernetwork.com)
  • The data underline AKR1C3 as a COX-independent target for NSAID and will provide a structural basis for the future development of new cancer therapies with reduced COX-dependent side effects. (rcsb.org)
  • Generally, it is rapidly lethal, and survival outcomes for adults with AML are very poor despite intensive chemotherapy and/or targeted therapies together with supportive care [ 4 ]. (researchsquare.com)
  • Therefore, imatinib was a paradigm of targeted therapies, which due to that imatinib inhibits the phosphorylation of BCR-ABL then suppress the activation of BCR-ABL tyrosine kinase [ 6 ]. (jcancer.org)
  • Her bench and translational research focuses on improving outcomes for patients after hematopoietic stem cell transplantation and on the development of novel cell therapies for cancer and virus-associated diseases. (lls.org)
  • As we seek to bring the curative power of cell therapies to a greater number of patients suffering from otherwise incurable life-threatening diseases, we are very confident in Prevail InfoWorks' ability to coordinate our Phase I clinical trial in relapsed/refractory AML. (wate.com)
  • at this point, identifying effective, targeted therapies in myeloid disease is the primary goal. (hematology.org)
  • Our work implicates that complement system may be a therapeutic target for developing therapies to prevent or treat cognitive disorders related to neuroinflammation or other disease conditions including neurodegenerative disease per se. (imperial.ac.uk)
  • She shares her excitement about the role of precision medicine, particularly targeted therapies, in impacting chronic disease. (medscape.com)
  • Myeloid cells are a heterogeneous population of bone marrow-derived cells that play a critical role during growth and metastasis of malignant tumors. (hindawi.com)
  • These cells were therefore described as bone marrow derived endothelial progenitor cells (EPCs). (hindawi.com)
  • MDSCs migrate as immature cells from the bone marrow to peripheral tissues (or tumors), where they differentiate into mature macrophages, dendritic cells, and neutrophils without suppressive phenotypes under homeostatic conditions, but become polarized when exposed to pro-inflammatory compounds, chemokines, and cytokines. (wikipedia.org)
  • The myeloid-differentiation cytokine GM-CSF is a key factor in MDSC production from bone marrow,[unreliable medical source? (wikipedia.org)
  • While monocyte and neutrophil differentiation pathways within the bone marrow are antagonistic and dependent on the relative expression of IRF8 and c/EBP transcription factors (and hence there is not a direct precursor-progeny link between these two myeloid cell types), this seems not to be the case for MDSCs. (wikipedia.org)
  • Aberrantly expressed cytokines in the bone marrow (BM) niche are increasingly recognized as critical mediators of survival and expansion of leukemic stem cells. (haematologica.org)
  • 2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
  • Previously, we identified inducible nitric oxide synthase (iNOS) as an essential enzyme for development and reversal of smoke-induced PH and emphysema, and showed that iNOS expression in bone-marrow-derived cells drives pulmonary vascular remodelling, but not parenchymal destruction. (ersjournals.com)
  • We examined the CD45 dim CD34 + CD38 - CD133 + cells on bone marrow samples of hematologic malignancies and healthy controls using four-color flow cytometry experiments. (researchsquare.com)
  • Interestingly, the CD45 dim CD34 + CD38 - CD133 + cells were highly expressed in bone marrow of patients with AML compared to that of healthy controls (HC). (researchsquare.com)
  • In this study, we focused on measuring LSCs easily in the bone marrow cells from AML patients by developing a four-color flow cytometric analysis. (researchsquare.com)
  • Fig. 6: Flow cytometry evaluation of viable cell number and apoptosis induction in primary AML samples and healthy bone marrow cells. (nature.com)
  • Targeted next-generation sequencing of circulating cell-free DNA vs bone marrow in patients with acute myeloid leukemia. (cdc.gov)
  • However, the AML stem cells, which are located in the bone marrow and are responsible for producing cancer cells, are hard to affect. (lu.se)
  • In Menarini's diagnostics division, one thing that our team is working on is to be able to bring for multiple myeloma (a hematologic area), instead of bone marrow biopsy , a blood test that can enable MRD [minimal residual disease]-negative monitoring with circulating tumor cells. (medscape.com)
  • Vasculogenesis is the coalescence of new blood vessels from individual endothelial cells or progenitor cells. (hindawi.com)
  • Moreover, the CD34 + CD38 - progenitor cells expressed variable amounts of the target receptor CD33, CD133 and c-kit (CD117) [ 20 ]. (researchsquare.com)
  • Within the MAD for Cancer Program we aim to clarify the link between kidney cancer and the kidney progenitor cells, and to develop novel biomarkers for kidney cancer based on our understanding of adult kidney progenitor cells. (lu.se)
  • Unlike other forms of blood cancer, acute myeloid leukemia (AML) cannot currently be treated with CAR-T cell immunotherapy. (idw-online.de)
  • Furthermore, MDSC-targeted immunotherapy potentiates the effect of the other immunotherapies. (oncotarget.com)
  • Based on the facts that MSDCs have significant roles in breast cancer malignant behaviors and can be suppressed by various strategies, we do believe MDSC-targeted immunotherapy presents a broad prospect in the future. (oncotarget.com)
  • Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
  • She is currently the Bosworth Chair for Cancer Biology, the Director of the Center for Cancer and Immunology Research, and the Director of the Program for Cell Enhancement and Technologies for Immunotherapy (CETI) at Children's National Health System. (lls.org)
  • High-dimensional Cytometry (ExCYT) and Mass Spectrometry of Myeloid Infiltrate in Clinically Localized Clear Cell Renal Cell Carcinoma Identifies Novel Potential Myeloid Targets for Immunotherapy. (nih.gov)
  • Using both siRNA knockdown and small molecule-based targeting, Rix and his colleagues looked at how inhibition of these kinases affected cell viability, finding that targeting them singly had little effect. (genomeweb.com)
  • Simultaneous inhibition of these targets, however, significantly decreases cell viability, indicating that ceritinib's polypharmacological activity is key to its effectiveness in non-ALK-rearranged cell lines. (genomeweb.com)
  • Recent data demonstrated that M-MDSCs induced through the priming stage of EAE had been powerful suppressors of activated T cells and mediated T cell inhibition through the TG 100801 Hydrochloride production of nitric oxide[18]. (cell-signaling-pathways.com)
  • CDC25 inhibition in acute myeloid leukemia - A study of patient heterogeneity and the effects of different inhibitors. (uib.no)
  • Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
  • Hogan FL, Williams V, Knapper S. FLT3 Inhibition in acute myeloid leukaemia: Current knowledge and future prospects. (banglajol.info)
  • In this review, we discuss the role of myeloid cells in promoting tumor angiogenesis. (hindawi.com)
  • These data provide evidence, for the first time, of an immunosuppressive and pro-tumorigenic role of myeloid cells in early, clinically localized ccRCC. (nih.gov)
  • Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. (hindawi.com)
  • In 1971, Dr. Judah Folkman observed that neovascularization occurs around tumors and proposed that new blood vessel growth is necessary to supply nutrients and oxygen to tumor cells during exponential tumor growth [ 6 ]. (hindawi.com)
  • The observations of the accumulation in spleens and tumors of large numbers of these cells with potent immune-suppressive activity were readily reproducible in most murine tumor models. (aacrjournals.org)
  • Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
  • Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
  • We use systems biology approaches to decipher the molecular T cell states associated with successful immune attack or immune failure in human and mouse tumors. (unil.ch)
  • In collaboration with Hi-TIDe's Tumor microenvironment & biomarkers group and T cell discovery group , we capture tumor-infiltrating lymphocytes in human tumors in action, at the steady state or following adoptive T-cell therapy and other therapeutic perturbations, and interrogate them exhaustively to unveil the underlying T cell intrinsic signaling regulatory networks. (unil.ch)
  • Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors. (unil.ch)
  • Its ELAHERE (Mirvetuximab Soravtansine) is a first-in-class ADC targeting folate receptor alpha (FRa), a cell-surface protein over-expressed in a number of epithelial tumors, including ovarian, endometrial, and non-small-cell lung cancers. (stockhouse.com)
  • The risk is increased 1000-fold for squamous cell carcinoma, basal cell carcinoma, malignant melanoma, and fibrosarcoma and is increased 10-fold to 20-fold for other tumors. (medscape.com)
  • Accumulating data suggests that many human tumors are organized in cellular hierarchies initiated and maintained by a small population of self-renewing so called cancer stem cells. (lu.se)
  • Cells with high expression of HIF-2 α have properties rendering the tumors aggressive behavior potentially being the neuroblastoma tumor stem cells. (lu.se)
  • It is now known that new blood vessels originate from preexisting vessels by activation, proliferation and migration of endothelial cells through a process named "angiogenesis" [ 4 ]. (hindawi.com)
  • Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
  • Cell proliferation analysis was done with BrdU assay. (mjhid.org)
  • DNAJC3-AS1 increased cell proliferation and inhibited the role of miR-140 in suppressing cell proliferation. (mjhid.org)
  • Conclusion:In conclusion, miR-140 may target DNAJC3-AS1 to suppress cell proliferation in AML. (mjhid.org)
  • In the CIA model MDSCs were found to inhibit both T cell proliferation and CD4+ T cell differentiation into Th17 cells[11]. (cell-signaling-pathways.com)
  • In the EAE model G-MDSCs from myelin oligodendrocyte glycoprotein-immunized mice had been found expressing high degrees of designed cell loss of life 1 ligand 1 (PD-L1) a costimulatory molecule that adversely regulates T cell proliferation. (cell-signaling-pathways.com)
  • Oddly enough one report demonstrated that Compact disc11b+Gr-1+ cells isolated from mice with EAE inhibited T cell proliferation in co-culture but advertised Th17 cell differentiation under Th17-polarizing circumstances[33]. (cell-signaling-pathways.com)
  • Nitric oxide production by MDSCs results in the nitrosylation of cysteine residues leading to a significant decrease in mRNA stability and thereby preventing the production of cytokines required for T cell proliferation[28]. (cell-signaling-pathways.com)
  • This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
  • We have demonstrated previously that overexpression of AKR1C3 acts to suppress cell differentiation and promote proliferation in myeloid cells. (rcsb.org)
  • Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
  • We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
  • This study suggests that dihydrotanshinone I inhibits MV4-11 proliferation by apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 path-way, which might provide a novel therapy for acute myeloid leukemia. (banglajol.info)
  • Duan P, Huang Y, Chen K, Cheng C, Wu Z, Wu Y. 15,16-dihydrotanshinone I inhibits EOMA cells proliferation by interfering in posttranscriptional processing of hypoxia-inducible factor 1. (banglajol.info)
  • Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • It is well established that cancer development ensues based on reciprocal interactions between genomically altered neoplastic cells and diverse populations of recruited "host" cells co-opted to support malignant progression. (nih.gov)
  • This review discusses mechanisms underlying protumorigenic programming of myeloid cells and discusses how targeting of these has potential to attenuate solid tumor progression via the induction and of mobilization CD8 cytotoxic T cell immunity. (nih.gov)
  • These cells have emerged as an important contributor to tumor progression. (aacrjournals.org)
  • Reports on the accumulation of immune-suppressive myeloid cells associated with tumor progression were published sporadically beginning in the early 1970s ( 1 ). (aacrjournals.org)
  • Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
  • In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
  • Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
  • Leukemia stem cells (LSCs) in acute myeloid leukemia (AML) played important roles in development of leukemia, chemotherapeutic drug resistance, and disease relapse and progression. (researchsquare.com)
  • CAR-T cell therapy is an innovative therapy. (idw-online.de)
  • During CAR-T cell therapy, T cells are first removed from the patients and then genetically engineered to produce a specific protein (CAR) on their surface. (idw-online.de)
  • This is to take place within the framework of the "Bavarian Cell Therapy Catalyst", which is supported by the Bavarian Research Foundation. (idw-online.de)
  • Finally, we will comment on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as new targets for cancer therapy. (hindawi.com)
  • We also describe the potential of MDSC-based cell therapy for the treating autoimmune illnesses and note a few of hurdles facing the execution of the therapy. (cell-signaling-pathways.com)
  • 2 These characteristics make MDSCs a target for various treatment strategies, for example, a synergistic cancer therapy that is being studied to increase the efficacy of checkpoint inhibitors. (beckman.com)
  • Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
  • Signal Transduction and Targeted Therapy. (uib.no)
  • Targeted therapy" is becoming the centerpiece of current therapeutic strategies, and is often mentioned as the desirable direction for future progress. (cancernetwork.com)
  • JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
  • We employ systems biology approaches to study molecular T cell states associated with deregulation or immune attack either at the steady state or following T cell therapy in the human and in mouse. (unil.ch)
  • We move our novel T cell technologies to the bedside, in collaboration with the other groups in the Hi-TIDe, the Center of Excellence for Cell Therapy , the Center of Experimental Therapeutics and the Service of immuno-oncology . (unil.ch)
  • Identification of genetic targets in acute myeloid leukaemia for designing targeted therapy. (utah.edu)
  • Burchert A. Maintenance therapy for FLT3-ITD-mutated acute myeloid leukemia. (banglajol.info)
  • A study by Tang et al determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
  • LSCs are therefore a critical priority as targets for therapy. (lu.se)
  • Define leukemic stem cell (LSCs) and identify therapy-insensitive cells in chronic myeloid leukemia (CML). (lu.se)
  • These cells are not killed by conventional cancer therapy and thus it is critical to identify those cancer stem cells to be able to improved diagnostics and treatment of cancer. (lu.se)
  • By generating recombinant antibodies against a set of such markers, validating their clinical use, and providing in vivo proof-of-concept data in preclinical models for a targeted antibody-based therapy, novel diagnostic and therapeutic modalities for AML will be designed. (lu.se)
  • More importantly, our research demonstrates for the first time that IL-33 allows for in vivo Foxp3+ Treg cell conversion and favours an anti-inflammatory or tolerogenic state by skewing cytokine production. (uandes.cl)
  • To identify regulators of primitive chronic myeloid leukemia (CML) cells, we performed a high-content cytokine screen using primary CD34 + CD38 low chronic phase CML cells. (haematologica.org)
  • Cytokines are essential for the function and maintenance of cells, and altered cytokine levels influence not only leukemic cells, but also the normal HSC within the BM. (haematologica.org)
  • The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells. (uib.no)
  • Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8+ T cells. (unil.ch)
  • The Mouse Cytokine Array detects multiple analytes in cell culture lysates and supernates. (rndsystems.com)
  • The reason is that specific molecular targets with which certain immune cells could specifically target AML cells are lacking, which would permit the immune system to attack cancer. (idw-online.de)
  • T cells are cells of the immune system. (idw-online.de)
  • In breast cancer, MDSCs are recruited mainly by breast cancer cells to form a tumor-favoring microenvironment to suppress the anti-tumor immune response. (oncotarget.com)
  • The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
  • The main functional characteristic of these cells is their potent ability to suppress various types of immune responses. (aacrjournals.org)
  • During the 1980s and early 1990s, work from the laboratories of Diana Lopez, Jim Talmadge, M. Rita Young, and Hans Schreiber demonstrated that various types of myeloid cells could inhibit immune function in cancer. (aacrjournals.org)
  • MDSCs differ from other myeloid cell types in that they have immunosuppressive activities, as opposed to immune-stimulatory properties. (wikipedia.org)
  • Similar to other myeloid cells, MDSCs interact with immune cell types such as T cells, dendritic cells, macrophages and natural killer cells to regulate their functions. (wikipedia.org)
  • Tumor cell lines overexpress colony-stimulating factors (G-CSF and GM-CSF) and IL6, which promote development of MDSCs that have immune suppressive function in vivo. (wikipedia.org)
  • Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
  • The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
  • Detailed studies on innate immune responses in human myeloid cells with a variety of dengue immune complexes should proceed forthwith. (cdc.gov)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Our group focuses on engineering T cell states that are associated with immune rejection in cancers. (unil.ch)
  • Departing from prior knowledge and the above observations, we design novel synthetic T cell states, aspiring to overcome tumor immune resistance and T cell deregulation in order to defeat difficult cancers. (unil.ch)
  • To investigate the role of the immune system in treatment-naïve clear cell Renal Cell Carcinoma (ccRCC), we interrogated the immune infiltrate in patient-matched ccRCC tumor samples, benign normal adjacent tissue (NAT) and peripheral blood mononuclear cells (PBMCs isolated from whole blood, focusing our attention on the myeloid cell infiltrate. (nih.gov)
  • Once the antibody has become attached to the receptor, it activates the body's natural immune system and attracts killer cells that are part of our immune system. (lu.se)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • There is evidence that DENV neutralization titers differ when the same antibodies are assayed in epithelial and Fc-receptor-bearing cells ( 8 ). (cdc.gov)
  • Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
  • Under the terms of the MSTA, InfoWorks is to provide clinical services and technologies for the Company's upcoming Phase I study of its anti-FLT3 chimeric antigen receptor-redirected T cells ("CAR-T cells") in subjects with relapsed/refractory acute myeloid leukemia (AML). (wate.com)
  • Investigators at the Department of Clinical Genetics have a strong track record in identifying novel cell surface markers on leukemia stem cells and were the first to demonstrate the potential therapeutic use of recombinant antibodies directed against the marker IL1RAP (interleukin-1 receptor accessory protein) on cancer stem cells in chronic myeloid leukemia (CML) and acute myeloid leukemia (AML). (lu.se)
  • The research team has discovered a type of receptor - a protein, located on the surface of the AML stem cells - which sends out signals. (lu.se)
  • This receptor, called (IL1RAP), cannot be found on healthy blood stem cells, which opens up the possibility for a selective attack on the diseased stem cells using antibodies. (lu.se)
  • Studies have shown that by targeting antibodies against IL1RAP, they will attach themselves to the receptor, and thereby inhibit cell growth. (lu.se)
  • The receptor tyrosine kinases KIT and FLT3 are both important regulators of development and maintenance of a number of different cell types. (lu.se)
  • The C-Type Lectin receptor (CRL) is known as the major β-glucan receptor expressed in myeloid cells and is responsible for targeting respiratory fungal pathogens. (lu.se)
  • Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
  • Granulocytic myeloid cells include populations of terminally differentiated polymorphonuclear neutrophils, eosinophils, basophils, and mast cells. (aacrjournals.org)
  • Also, these cell populations directly correlated with poor survival [ 2 , 5 ]. (researchsquare.com)
  • Using flow cytometric, MS, and ExCYT analysis, we discovered unique myeloid populations in PBMCs across patient samples. (nih.gov)
  • Furthermore, normal adjacent tissues and ccRCC tissues contained numerous myeloid populations with a unique signature for both tissues. (nih.gov)
  • Single-cell AbSeq and targeted mRNA-Seq analyses of myeloid cell populations localized in adipose tissue from control and HFD mice. (bdbiosciences.com)
  • The objective of our research is to molecularly dissect known stem cell populations in order to discriminate between normal and malignant stem cells. (lu.se)
  • Delineate the heterogeneity of human hematopietic stem cell (HSC) populations at different ontogenetic stages and identify novel markers for improved HSC isolation. (lu.se)
  • Prospective isolation of human HSCs is in its infancy and current views of the molecular ground state driving HSCs and how it is altered in leukemia is based on studies of heterogeneous populations where HSC and LSC molecular signatures are masked by contaminating cells. (lu.se)
  • Dendritic cells are antigen-presenting cells that act as the link between innate and adaptive immunity. (beckman.com)
  • Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
  • In addition, MDSCs can react directly with breast cancer cells. (oncotarget.com)
  • In this paper, we describe several ways to recruit MDSCs in breast cancer, including breast cancer cell-derived cytokines and chemokines. (oncotarget.com)
  • MDSCs act on T cells and NK cells to suppress the body's immunity, and via IL-6 trans-signaling, promote breast cancer directly. (oncotarget.com)
  • MDSC Subsets In Autoimmunity Early classification of MDSCs was based on cell surface expression of CD11b and Gr-1. (cell-signaling-pathways.com)
  • G-MDSCs frequently inhibit T cell function through arginase-1 enzyme activity. (cell-signaling-pathways.com)
  • M-MDSCs more commonly inhibit T cell functions nitric oxide production. (cell-signaling-pathways.com)
  • The Gr-1 antibody recognizes both Ly6G and Ly6C surface antigens therefore the population of cells used for their studies contained both G-MDSCs and M-MDSCs. (cell-signaling-pathways.com)
  • G-MDSCs had been discovered to inhibit autoantigen-priming of Th1 and Th17 cells inside a PD-L1-reliant manner[12]. (cell-signaling-pathways.com)
  • Furthermore transfer of activated M-MDSCs led to apoptosis of T cells in the central nervous. (cell-signaling-pathways.com)
  • Studies are needed to determine whether MDSCs are a population of immature myeloid cells that have stopped differentiation or a distinct myeloid lineage. (wikipedia.org)
  • PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)
  • Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
  • Targeted antibodies that prevent leukaemia stem cells from multiplying while attracting the natural killer cells of the body, which in turn send a death signal to the diseased stem cell. (lu.se)
  • EF-Tu From Non-typeable Haemophilus influenzae Is an Immunogenic Surface-Exposed Protein Targeted by Bactericidal Antibodies. (lu.se)
  • The Company is advancing PVEK in clinical trials for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myeloid leukemia (AML). (stockhouse.com)
  • Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
  • Ddit3 loss impairs erythroid colony output from multipotent cells, while forcing Ddit3 in granulo-monocytic progenitors (GMPs) enhances self-renewal and impedes differentiation. (lu.se)
  • This study determined that the suppression of T cell responses was due to M-MDSC-mediated nitric oxide production. (cell-signaling-pathways.com)
  • However, in more than half of them, the disease returns within one to two years because the chemotherapy has not destroyed all leukemia cells. (idw-online.de)
  • Open in a separate window Myeloid cell leukemia 1 (Mcl1) is an antiapoptotic protein that plays central role in apoptosis regulation. (cell-signaling-pathways.com)
  • Objectives:MiR-140 and DNAJC3-AS1 have been proven to play critical roles in cancer biology, while their participations in acute myeloid leukemia (AML) are unclear. (mjhid.org)
  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by an acquired 9;22-chromosomal translocation in a hematopoietic stem cell (HSC) resulting in the expression of the BCR-ABL1 fusion protein. (haematologica.org)
  • 7 In CML and acute myeloid leukemia (AML), we and others have shown that IL-1 is a positive regulator of LSC, and blocking IL-1 signaling inhibits the LSC. (haematologica.org)
  • Vacuolar ATPase Is a Possible Therapeutic Target in Acute Myeloid Leukemia: Focus on Patient Heterogeneity and Treatment Toxicity. (uib.no)
  • CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia. (uib.no)
  • The technique has allowed them to uncover new clues about acute myeloid leukemia. (mskcc.org)
  • Therefore, our results suggest that CD45 dim CD34 + CD38 - CD133 + cells in AML might have the potential of leukemia stem cells. (researchsquare.com)
  • Acute myeloid leukemia (AML) is generally regarded as a stem cell disease, and it originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity [ 1 , 2 ]. (researchsquare.com)
  • Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
  • Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins. (chemdiv.com)
  • Acute myeloid leukemia (AML) is a heterogeneous group of aggressive hematological malignancies commonly associated with treatment resistance, high risk of relapse, and mitochondrial dysregulation. (nature.com)
  • The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation. (nature.com)
  • Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. (nature.com)
  • Everyone at our fund is confident in the growth and success of Hemogenyx Pharmaceuticals as they develop CAR-T cells to target acute myeloid leukemia. (wate.com)
  • Till now, the medicines approved for acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) display not ideal efficacy. (banglajol.info)
  • Young children have acute lymphoblastic leukemia of T-cell origin. (medscape.com)
  • Older children have T-cell leukemia. (medscape.com)
  • Is Priapism a Common Presentation of Chronic Myeloid Leukemia in an Adolescent Patient? (eurekaselect.com)
  • A rearrangement (translocation) of genetic material between chromosomes 9 and 22 causes a type of cancer of blood-forming cells called chronic myeloid leukemia. (medlineplus.gov)
  • Ultimately we will use this information to therapeutically target LSCs and thereby improve the treatment of leukemia. (lu.se)
  • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. (medscape.com)
  • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. (medscape.com)
  • The American Cancer Society estimates that in the United States in 2023 there will be about 20,000 new cases of acute myeloid leukemia (AML) and about 11,300 deaths , almost all in adults. (msdmanuals.com)
  • acute myeloid leukemia is caused by a series of acquired genetic aberrations. (msdmanuals.com)
  • This was first demonstrated in acute myeloid leukemia (AML) but during recent years, cancer stem cells have also been demonstrated in other cancer types. (lu.se)
  • The strategy used to identify new therapeutic markers on leukemia stem cells will also be explored in other tumor types studied within the MAD for Cancer Program. (lu.se)
  • Deregulation of these receptors by mutations has been implicated in various human malignancies, including akut myeloid leukemia and melanoma. (lu.se)
  • When you look at acute myeloid leukemia , today we have Flt3 inhibitors, IDH inhibitors. (medscape.com)
  • Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
  • In work performed by Division of Translational Cancer Research it is shows that the hypoxic state pushes neuroblastoma and breast cancer towards an immature, stem cell-like phenotype. (lu.se)
  • Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
  • Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
  • Results: No difference in antigen expression between normal and malignant endothelial cells (ECs) was found for CD54, CD109, CD137, CD141, CD144 and CXCR7. (researchgate.net)
  • Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)
  • As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
  • PDF) Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer SEndothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. (researchgate.net)
  • Of all patients with malignancies, 58% had CD276+ CEC counts above the ULN (8 cell per 4 ml). (researchgate.net)
  • His work also includes the identification of essential genes in hematologic malignancies which have potential for being therapeutic targets through the design and analysis of large shRNA screens. (utah.edu)
  • Debierre-Grockiego F. Anti-apoptotic role of STAT5 in haematopoietic cells and in the pathogenesis of malignancies. (banglajol.info)
  • Expert opinion on therapeutic targets. (uib.no)
  • Investigate the role for super-enhancers in defining LSC heterogeneity and their potential as therapeutic targets for LSCs. (lu.se)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Combining chemical proteomics to identify protein interactors of ceritinib (marketed by Novartis as Zykadia) with phosphoproteomics to assess signaling activity across various protein pathways allowed the researchers to develop an understanding of both the drug's activity and the behavior of the cancer cells more broadly, Rix noted. (genomeweb.com)
  • 1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
  • Fig. 4: PS molecules induce different cell death pathways. (nature.com)
  • The clear cell sarcoma functional genomic landscape. (utah.edu)
  • Under nontumor conditions, these cells provide the first line of protection against pathogens. (hindawi.com)
  • A pro-inflammatory environment is thought to provide a selective advantage for the leukemic stem cells (LSC). (haematologica.org)
  • Mechanistically, all hit compounds reduced ATP and selectively impaired both basal and ATP-linked oxygen consumption in leukemic cells. (nature.com)
  • Pilot in vivo efficacy studies indicate anti-leukemic efficacy in a MOLM14/GFP/LUC xenograft model, including extended survival in mice injected with leukemic cells pre-treated with PS127B or PS127E and in mice treated with PS127E at a dose of 5 mg/kg. (nature.com)
  • Fig. 3: Mitochondrial respiration in leukemic cells is selectively inhibited by PS leads. (nature.com)
  • Similarly to normal hematopoiesis, leukemias are organized in cellular hierarchies where leukemic stem cells (LSCs) drive the tumor growth. (lu.se)
  • 1 From the *Department of Cell, Developmental & Cancer Biology and †Knight Cancer Institute, Oregon Health & Science University, Portland, OR. (nih.gov)
  • Cancer cells evade their "normal" attempts to attack them by using various molecular tricks. (idw-online.de)
  • Thus, T cells no longer recognize their opponents, the cancer cells. (idw-online.de)
  • When these CAR-T cells are injected back into the patient's body, these will only engage their target: CD19, which ensures that they recognize the patient's cancer cells and bind to them in a targeted manner. (idw-online.de)
  • The cancer cells consequently die. (idw-online.de)
  • Rix and his colleagues began the study with a phenotypic screen of 240 compounds against 20 non-small cell lung cancer cell lines harboring a variety of driver mutations. (genomeweb.com)
  • However, in cancer, myeloid cells are largely converted to serve a new master-tumor cells. (aacrjournals.org)
  • The up-regulation of Mcl1 prospects to cancer, while the down-regulation causes apoptosis.9 Thus, Mcl1 is 866405-64-3 a key member of the family and an ideal cancer therapeutic target. (cell-signaling-pathways.com)
  • In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
  • However, prospective identification of targets in the clinic will not only illuminate their clinical significance, but will also further accelerate drug development-witness the way in which the introduction of gefitinib (Iressa) for lung cancer was followed in less than a decade by the identification of driver mutations, new targeted drugs, and the universal adoption of molecular profiling for treatment selection. (cancernetwork.com)
  • A phase 1 trial of adoptive transfer of vaccine-primed autologous circulating T cells in ovarian cancer. (unil.ch)
  • An ADC with the Company's technology comprises an antibody that binds to a target found on tumor cells and is conjugated to one of its potent anti-cancer agents as a payload to kill the tumor cell once. (stockhouse.com)
  • Fig. 2: Mitochondria-related mechanistic effects of PS hit compounds on cancer and normal blood cells. (nature.com)
  • Fig. 5: PS compounds induced synergistic cytotoxicity when combined with other anti-cancer drugs in AML cell lines and primary AML samples. (nature.com)
  • Glutamine addiction: A new therapeutic target in cancer. (nature.com)
  • Inflammation and metabolism in cancer cell-mitochondria key player. (nature.com)
  • Curr Cancer Drug Targets. (banglajol.info)
  • Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply uncontrollably to form a tumor. (medlineplus.gov)
  • These chromosomal changes are seen only in cancer cells. (medlineplus.gov)
  • This slow-growing cancer leads to an overproduction of abnormal white blood cells. (medlineplus.gov)
  • Within the MAD for Cancer Program, a previously unexplored combination of strategies will be used to identify new cell surface markers on AML stem cells. (lu.se)
  • Chronic myeloid leukaemia (CML) is a relatively gentle form of cancer that can be kept in check through medication, but the acute form involves a much bleaker prognosis and a high risk of relapse. (lu.se)
  • Because cancer cells divide faster than normal cells, they are more affected by chemotherapy compared to healthy cells", explains Helena Ågerstam, cancer researchers at Lund University. (lu.se)
  • Compounds derived from PS127 significantly upregulated production of reactive oxygen species (ROS) in AML cells and triggered ferroptotic, necroptotic, and/or apoptotic cell death in AML cell lines and refractory/relapsed AML primary samples. (nature.com)
  • For examples, Rhenen et al showed that a high percentage of CD34 + CD38 - stem cells at diagnosis significantly correlated with a high minimal residual disease frequency and subsequently to relapse especially after the third course of chemotherapy in AML patients. (researchsquare.com)
  • Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
  • Because stem cells multiply slowly, chemotherapy does not have a sufficient impact on them, which explains why two-thirds of these patients relapse. (lu.se)
  • In vitro, ivacaftor does not alter LPS-induced CD80 and tumor necrosis factor alpha mRNA increases in BV2 microglial cells, while augmenting mRNA levels of these markers in mouse macrophages and differentiated human THP-1-derived macrophages. (lu.se)
  • The cells were then tested on different AML models, including AML cells from patients. (idw-online.de)
  • The researchers' next goal: They want to develop GMP (good manufacturing practice)-capable processes to produce CAR-T cells that can then also be used in clinical trials with AML patients. (idw-online.de)
  • Additionally, the high levels of the CD45 dim CD34 + CD38 - CD133 + cells in AML patients were an independently significant poor risk factor for overall survival and event free survivals. (researchsquare.com)
  • Hence, BCR-ABL oncogene has been the target for the treatment of patients with CML. (jcancer.org)
  • As a transfusion medicine physician, numerous cases I see involve patients with transfusion-dependent myeloid diseases or graft-versus-host disease after allogeneic stem cell transplantation for a myeloid disease. (hematology.org)
  • Physical findings of leukostasis and hyperviscosity can occur in some patients, with extraordinary elevation of their WBC counts, exceeding 300,000-600,000 cells/μL. (medscape.com)
  • Structure-activity relationship studies identified six analogs from two original scaffolds that had over an order of magnitude difference between LD50 in AML and healthy peripheral blood mononuclear cells. (nature.com)
  • In the event of a relapse, a stem cell transplant is the only hope for cure for a patient. (idw-online.de)
  • 13 ] isolated mononuclear cells from human peripheral blood that were enriched for expression of the hematopoietic stem cell marker CD34 [ 13 ]. (hindawi.com)
  • Stem Cell Research. (uib.no)
  • LSCs have stem cell characteristics such as self-renewal capacity, quiescence and drug resistance, causing metastasis and relapse. (lu.se)
  • The killer cells are drawn to the antibody because it has indicated that something is wrong inside the body and, in turn, the killer cells send out a death signal to the AML stem cell. (lu.se)
  • fraction and subsequent gene expression analysis revealed a number of myeloid-related genes that were differentially expressed. (nih.gov)
  • Since individual genes display discrete OFF states or a distribution of ON levels, we compute and combine pairwise gene associations from binary and continuous components of gene expression in single cells. (lu.se)
  • The enrichment of Gata2 target genes in Ddit3-dependent transcriptional responses suggests that Ddit3 functions in an erythroid transcriptional network nucleated by Gata2. (lu.se)
  • Research shows that several genes that control cell growth and division are located on chromosome 9. (medlineplus.gov)
  • Many of these genes are tumor suppressors, which means they normally help prevent cells from growing and dividing in an uncontrolled way. (medlineplus.gov)
  • By a broad mass spectrometry based approach on whole cells we are in the process of identifying additional such proteins and their phosphorylation status. (lu.se)
  • The study , which they published last week in Nature Chemical Biology , identified several off-target effects key to ceritinib's activity. (genomeweb.com)
  • Interleukin-33 (IL-33) has been a focus of study because of its variety of functions shaping CD4+ T-cell biology. (uandes.cl)
  • Renal Cell Carcinoma (RCC) is one of the most commonly diagnosed cancers worldwide with research efforts dramatically improving understanding of the biology of the disease. (nih.gov)
  • BD ® AbSeq Antibody-Oligonucleotide Conjugates together with the BD Rhapsody TM mRNA Sequencing Kits enable simultaneous detection of proteins and mRNA expression in a single experiment and help deepen your understanding of protein biology and accelerate your single-cell research. (bdbiosciences.com)
  • American Journal of Respiratory Cell and Molecular Biology. (lu.se)
  • In addition, validation of preliminary findings of solute carrier molecules (usually used for drug-delivery) selectively expressed in tumor cells with the aim to develop imaging-led theranostic approaches of personalized treatment will be performed. (lu.se)
  • The BD ® AbSeq Assay facilitates identification of specific changes in the myeloid cells of high-fat diet (HFD) mice. (bdbiosciences.com)
  • Surprisingly, however, mice with a targeted IKKbeta deletion in myeloid cells are more susceptible to endotoxin-induced shock than control mice. (tum.de)
  • Systemically, ivacaftor leads to higher frequencies of circulating Ly6C + and Ly6C hi cells compared to vehicle-treated MI mice. (lu.se)