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  • HDAC
  • This paper focuses on the role of HDACs in the proliferation and neuronal differentiation of neural stem cells and the application of HDAC inhibitors in reprogramming somatic cells to induced pluripotent stem cells (iPSCs). (hindawi.com)
  • Both valproic acid, a class I HDAC inhibitor, and suberoylanilide hydroxamic acid (vorinostat), an inhibitor of class I, II, and IV HDACs, mitigated the development of and reduced established hypoxia-induced pulmonary hypertension in the rat. (ahajournals.org)
  • The effectiveness of HDAC inhibitors, valproic acid, and suberoylanilide hydroxamic acid, in models of pulmonary arterial hypertension supports a therapeutic strategy based on HDAC inhibition in pulmonary arterial hypertension. (ahajournals.org)
  • 4 , 5 Histone acetylation/deacetylation balance, maintained dynamically by 2 important families of enzymes, histone acetyltransferases and histone deacetylases (HDAC), 6 controls the higher-order structure of chromatin and the resultant accessibility of transcriptional factors to their target genes. (ahajournals.org)
  • 8 , 9 HDACs have emerged as key targets to reverse aberrant epigenetic changes associated with cancer and autoimmune disease, and HDAC inhibitors show promise as anticancer and antiinflammatory agents. (ahajournals.org)
  • 12 Moreover, right ventricular (RV) function was preserved, in contrast to experience with the pan-HDAC inhibitor trichostatin A in rat pulmonary artery banded models. (ahajournals.org)
  • 13 However, neither the involvement of HDACs in human PH nor the ability of HDAC inhibitors to reverse existing PAH has been explored. (ahajournals.org)
  • mRNA
  • Our analysis of both COP1 and p53 at the DNA, mRNA, and protein levels reveals that COP1 is overexpressed in breast and ovarian carcinomas suggesting that it may promote tumorigenesis by inactivating a p53-dependent pathway. (aacrjournals.org)
  • Results showed the redox activation of MAP kinases down regulated the mRNA levels of AP-1 subunits in aqueous areca nut extract treated cells. (springer.com)
  • Radiopharmaceuticals are being designed to target p21WAF-1/CIP-1 at the mRNA or protein levels using antisense based agents or internalizing monoclonal antibodies respectively. (uhnresearch.ca)
  • vivo
  • Precisely how these transcription factors direct such processes is largely unknown due to the lack of bona fide targets in vivo . (jneurosci.org)
  • Chromatin immunoprecipitation-sequencing experiments followed by enhancer reporter analyses identified five direct neuronal subtype-specific targets of Atoh1 in vivo along with their Atoh1-responsive enhancers. (jneurosci.org)
  • cancer
  • Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer. (uhnresearch.ca)
  • genetic
  • In a genetic screen, we identified mutations in cyd-1 cyclin D and cdk-4 Cdk4/6. (biologists.org)
  • Genetic evidence suggests that bHLH factors have shared targets in their common differentiation role, but unique targets with respect to their distinct roles in neuronal subtype specification. (jneurosci.org)
  • distinct
  • Our work establishes on a molecular level that neuronal differentiation bHLH transcription factors have distinct lineage-specific targets. (jneurosci.org)
  • transcription factors
  • These targets, Klf7 , Rab15 , Rassf4 , Selm , and Smad7 , have diverse functions that range from transcription factors to regulators of endocytosis and signaling pathways. (jneurosci.org)
  • development
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abgent.com)
  • specific
  • MicroRNAs (miRNAs) are 22- to 25-nucleotide non-coding RNA molecules that typically prohibit protein production by binding to the 3' untranslated region [UTR] of specific target mRNAs [ 6 ]. (omicsonline.org)
  • However, whether neuronal subtype-specific targets exist remains an unsolved question. (jneurosci.org)
  • Atoh1 was an ideal bHLH to identify neuronal subtype-specific targets. (jneurosci.org)
  • treatments
  • 1 , 2 Currently approved treatments target primarily an imbalance of vasoactive factors in PAH 3 and at best retard the course of the disease. (ahajournals.org)
  • however, current treatments do not target the unique biology of this disease ( 3, 4 ). (aacrjournals.org)