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  • inhibit
  • TSI proteins inhibit secretion for a prolonged period following a single application, making them particularly suited to the treatment of chronic diseases. (mdpi.com)
  • The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. (abcam.com)
  • In contrast to antisense oligonucleotides and small interfering RNAs (siRNAs) that inhibit translation of proteins by Watson-Crick base-pairing to their respective messenger RNAs, aptamers bind to existing proteins (and, less commonly, non-protein targets) with high affinity and specificity, analogous to monoclonal antibodies. (mdpi.com)
  • Novel
  • This prompted us to investigate whether the secretion machinery of membrane proteins but also their orthologues from your important human pathogen is usually rapidly gaining resistance against all available antibiotics and novel antibiotics against this pathogen are urgently needed (7, 17). (onetownmanyvoices.com)
  • Prolonged time to progression and improved overall survival have been recently reported using novel targeted therapies, and it has been argued that this effect is totally or partially mediated by cancer cell cytostasis without direct cytotoxic effects. (aacrjournals.org)
  • This novel method for oral delivery of a targeted protein complement inhibitor will reduce systemic effects, thereby decreasing the risk of opportunistic infection, as well as lowering the required dose and treatment cost and improving patient compliance. (socmucimm.org)
  • Furthermore, the novel delivery system described here may provide similar benefits for administration of other protein-based drugs, such as anti-tumour necrosis factor-α antibodies. (socmucimm.org)
  • The pyrrolo-1, 5-benzoxazepines (PBOXs) are a structurally distinct novel group of anti-cancer agents, some of which target tubulin. (jcancer.org)
  • Here, we report the preclinical pharmacological profile of GSI-953 (begacestat), a novel thiophene sulfonamide γ-secretase inhibitor (GSI) that selectively inhibits cleavage of APP over Notch. (aspetjournals.org)
  • antibodies
  • By screening a melanoma cDNA expression library with postimmunization sera, we previously identified ATP6S1, a putative accessory unit of the vacuolar H + -ATPase complex, as a target for high-titer IgG antibodies in several vaccinated patients ( 16 ). (pnas.org)
  • Proliferation of CSCs was inhibited by SCF-neutralizing antibodies or by imatinib (Gleevec), an inhibitor of c-kit. (aacrjournals.org)
  • XIAP
  • Knocking down XIAP also increased the apoptotic response to a number of growth factor receptor-targeted therapies such as Herceptin, Iressa and Lapatinib. (biomedcentral.com)
  • Smac protein, in its dimeric form, effectively antagonizes XIAP by concurrently targeting both its BIR2 and BIR3 domains. (sigmaaldrich.com)
  • Here we describe the development of highly sensitive homogeneous time-resolved fluorescence resonance energy transfer (HTRF) assays to measure binding affinities of potent bivalent peptidomimetic inhibitors of XIAP. (sigmaaldrich.com)
  • endogenous
  • IAPs were inhibited using siRNA or cell-permeable mimics of endogenous inhibitors. (biomedcentral.com)
  • Significantly, small molecule pan-IAP antagonists that mimic an endogenous inhibitor of the IAPs, called Smac, have demonstrated an unexpected ability to sensitize cancer cells to tumor necrosis factor-alpha and to promote autocrine or paracrine production of this cytokine by the tumor cell and possibly, other cells too. (nih.gov)
  • subunit
  • The human SWI/SNF subunit BAF57 contains a HMG box domain similar to the one present in Nhp6, which is not found in the yeast complex and the Drosophila BRM component Bap111 is also a HMG-domain protein . (techuniq.com)
  • Your search returned 30 protein phosphatase 1 regulatory inhibitor subunit 14A ELISA ELISA Kit across 5 suppliers. (biocompare.com)
  • Smac
  • Our results indicate that these assays can differentiate Smac-mimetic inhibitors with a wide range of binding affinities down to the picomolar range. (sigmaaldrich.com)
  • thereby
  • We propose the use of RNA-aptamers in plants to suppress the functions of individual proteins, thereby achieving resistance to various biotic and abiotic stresses. (usda.gov)
  • homologous
  • The PSI homologous protein in S. litura (SlPSI) was purified and the binding of SlPSI and CE1 was verified. (mdpi.com)
  • mRNA
  • Zha, X.-F. P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura . (mdpi.com)
  • We consequently examined AXL and Gas6 mRNA and AXL protein manifestation levels inside a well-defined cohort of human being Sera specimens and correlated AXL protein manifestation levels to clinicopathological characteristics and patient end result. (conferencecallsworld.com)
  • Much MRS 2578 like Sera specimens AXL protein manifestation levels reflected AXL mRNA levels in Sera cell lines (Number 2A-C). BGB324 affected cell viability in all Sera cell lines inside a dose-dependent manner with IC50 ideals ranging from 0.79-2.13 μmol/L (Supplemental Table 2). (conferencecallsworld.com)
  • Here we take a genetic approach and discover an interplay between HMG proteins, chromatin remodeling factors and mRNA maturation. (techuniq.com)
  • gene
  • The chromatin architectural elements and histone modifiers Nhp6A/B are linked to the high-mobility group 1 (HMG1) category of little, abundant chromatin proteins that absence series specificity of DNA binding, but bend DNA sharply and modulate gene expression . (techuniq.com)
  • In BRCA-mutation related cancers, loss of both copies of the gene results in a non-functional protein and thus BRCA deficiency. (bio-medicine.org)
  • a href='/help/gene_ontology' target='_top'>More. (uniprot.org)
  • BL21(DE3)) transcription of a target gene from a T7 promoter may be too robust and it is not easily controlled. (neb.com)
  • In contrast, Lemo21(DE3) expresses a T7 RNA polymerase inhibitor protein (LysY) so that the level of target gene transcription may be precisely regulated. (neb.com)
  • characterization
  • The biochemical and structural characterization of this challenging class of protein represents an important frontier in both basic science and drug discovery research. (neb.com)
  • Sequence
  • Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human G protein alpha Inhibitor 2. (abcam.com)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • drug
  • For this good reason, membrane protein have become a significant class of protein with regards to current drug goals. (onetownmanyvoices.com)
  • A new drug that targets proteins res. (bio-medicine.org)
  • A new drug that targets proteins responsible for helping cancer cells to repair damage to their DNA has shown promising anti-tumour activity in its first trial in humans. (bio-medicine.org)
  • Laboratory studies of the drug, MK-4827, have shown that it inhibits proteins called PARP1 and PARP2 (poly(ADP)-ribose polymerase). (bio-medicine.org)
  • If the protein is required for survival of a species, inhibiting that protein could be a potential mechanism of action for a drug with activity against the parasite that causes Chagas disease. (eurekalert.org)
  • The in-house web-system iNTRODB facilitates the selection of drug target proteins for NTDs, particularly for trypanosomiasis. (eurekalert.org)
  • Following selection, potential drug candidate inhibitors were identified through a screening search known as docking simulation--a structure-based drug design approach using 3D simulations to computationally match drug compounds to SpdSyn. (eurekalert.org)
  • Scientists at Tokyo Tech, Nagasaki University have identified four potential protein inhibitors and unlocked drug discovery strategies for the treatment of Chagas disease by using advanced three-dimensional computer simulation by supercomputer TSUBAME in combination with in vitro experiments and X-ray crystallography. (titech.ac.jp)
  • Through this 'smart drug discovery' in which IT drug discovery and biochemical experiments cooperate, they identified hit compounds for target protein with a hit rate of 20 times or more than conventional High Throughput Screening (HTS) methods. (titech.ac.jp)
  • The first major trial (concluded in 2006) with the first CETP inhibitor drug, torcetrapib (from Pfizer), not only failed to show a reduction in risk when HDL was increased but actually showed an increase in cardiovascular risk. (verywellhealth.com)
  • family
  • Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis. (nih.gov)
  • strains
  • In the present studies, we show that important problems in membrane protein overproduction can be overcome by using different strains of the gram-positive bacterium as the expression host, and we identify two key mechanisms that set limits to membrane protein production in this organism. (onetownmanyvoices.com)
  • biological
  • Moreover, the accumulation of overproduced proteins in biological membranes may impact bilayer integrity, which would be harmful for the generating cell (33). (onetownmanyvoices.com)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • species
  • Through virtual screening by TSUBAME at Tokyo Tech, one of the world's top, large-scale supercomputers, they selected their target protein, T. cruzi spermidine synthase, based on specific structural features and properties indicating its importance for survival in another Trypanosoma species. (eurekalert.org)
  • Our G protein alpha inhibitor 1 RNAi can be used in a variety of model species: Human. (novusbio.com)