Target genes putative gene. Medical search. Frequent questions

MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
Finally, the calibrated model is used to study the effect of different miRNA expression profiles and cooperative target regulation on p21 expression levels in different biological contexts. (hindawi.com)
Most experimental approaches focus on the identification of miRNA targets and the investigation of physiological consequences when perturbing miRNA expressions but are unsuited to provide a system-level interpretation for observed phenomena. (hindawi.com)
The network combining putative targets of TF and miRNA regulation with experimentally proven molecular interactions was constructed and visualized. (hindawi.com)
Over the past few years, emerging numerous bioinformatic tools have been developed to identify candidate disease-causing genes [ 4 ], including microRNA (miRNA) genes. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
In the study, a total of 524 potential targets were identified for 124 putative miRNA families through degradome sequencing. (genomeweb.com)
In their study, northern blotting analysis showed that two 22-nucleotide miRNAs - tae-miR021b and tae-miR2003a - preferentially accumulated in the embryo rather than the endosperm, suggesting important roles for miRNA-mediated gene regulation in wheat grain. (genomeweb.com)
The nature of imperfect binding specificity means that a single miRNA can regulate a large number of mRNA targets involved in complex cellular processes, thereby tightly controlling genetic networks during development and in response to stress ( Pocock, 2011 ). (elifesciences.org)

Direct regulators of nuclear-encoded mitochondrial genes are members of the estrogen-related receptor (ERR) family, encoded by Esrra , Esrrb and Esrrg . (nature.com)
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. (yeastgenome.org)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
Unlike sequence-specific transcription factors, epigenetic regulators do not necessarily bind DNA at consensus sequences, but still achieve reproducible target binding in a manner that is cell and maturation-type specific. (frontiersin.org)
A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
Some have been shown to bind epigenetic regulators, and thus constitute attractive candidates to mediate epigenetic target specificity. (frontiersin.org)
While over half the genes are estimated to be regulated at the transcriptional level, few regulatory motifs and transcription regulators have been found. (biomedcentral.com)
Transcriptional regulation information for a gene, including any predicted DNA binding site motifs ( YeTFaSCo ) for the gene's protein product, as well as any of its targets (genes it regulates) or regulators (genes that regulate it), based on experimental evidence. (yeastgenome.org)
SOX genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. (thermofisher.com)

Leucine zipper putative tumor suppressor 1 is a protein that, in humans, is encoded by the LZTS1 gene. (wikipedia.org)
It can directly bind to the 3'-untranslated region of the target mRNA through its seed sequence and inhibit the expression of the encoded protein at the post-transcriptional level [3]. (scirp.org)
in an operon with an upstream PurR/LacI-type transcriptional regulator gene, named amlR ( ACSP50_2475 ), and a gene downstream ( ACSP50_2473 ) encoding a GGDEF-EAL-domain-containing protein putatively involved in c-di-GMP signaling. (frontiersin.org)
Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
A scaffold protein DAB2 and its interaction partner DAB2IP have putative tumor suppressor gene (TSG) functions. (nih.gov)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
Collection of domains associated with the protein based on various sources, including the protein coordinates for the domain, a domain Description, a Source and corresponding accession ID, and the number of S. cerevisiae genes that share the same domain. (yeastgenome.org)
Gene and protein expressions were analyzed by quantitative RT-PCR and immunoblotting, respectively. (bvsalud.org)
Markers of well-characterized aggregative adherence plasmids, present in typical EAEC strains, are aggregative adherence regulator gene aggR , anti-aggregative protein or dispersin gene aap, and empiric plasmid probe (CVD432) that represents part of the aat secretion system operon ( 6 ). (cdc.gov)

Conversely, actin signaling regulates neuronal SRF-mediated gene expression. (jneurosci.org)

For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
This extremely large set of miRNAs is likely associated with the polyploid nature of wheat, which is reasonably consistent with the higher gene numbers, ranging from 94,000 to 96,000, reported in bread wheat than its diploid progenitor and other species such as rice, maize, and Arabidopsis ," the scientists wrote in their paper. (genomeweb.com)
For highly conserved miRNAs, 122 target genes were identified, including 92 targets that are conserved among other species and 30 non-homologous target genes. (genomeweb.com)
These non-conserved targets of miRNAs might evolve specific properties and display unique functions in wheat growth and development," according to the BMC Plant Biology study. (genomeweb.com)
MicroRNAs (miRNAs) are ~22-nt non-coding RNAs that negatively regulate gene expression at the post-transciptional level via direct binding with the 3′ untranslated regions (UTR) of target mRNAs ( 16 , 17 ). (spandidos-publications.com)
miRNAs predominantly interact with mRNA targets through imperfect binding to motifs in target mRNA 3′-untranslated regions (3′UTRs) ( Bartel, 2009 ). (elifesciences.org)
MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals. (peerj.com)

Tumor suppressor gene. (nih.gov)

Although the genes that encode carotenogenesis and flavonoids enzymes are well characterized, the transcriptional regulatory mechanisms that are related to the pathway genes remain to be investigated. (researchsquare.com)
These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. (thermofisher.com)

In addition, the identified signature genes characterizing putative Pemetrexed responsiveness predicted therapeutic benefit in a subset of squamous cell carcinoma. (eur.nl)
Micro- array data from the ovalbumin and TMA model of asthma were also compared to previous data using Aspergillus as allergen to identify putative asthma `signature genes', i.e. genes up-regulated with all 3 allergens. (cdc.gov)

Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)

This table lists putative transcriptional regulatory targets for the central gene represented on this page. (yeastgenome.org)

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
Tricyclic antidepressants reverse egl-2(gf) mutant phenotypes, suggesting that EGL-2 is a tricyclic target. (jneurosci.org)

GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
In melanocytic cells LZTS1 gene expression may be regulated by MITF. (wikipedia.org)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)
NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. (senescence.info)
Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. (senescence.info)
Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. (nature.com)
We show that astrocyte maturation is promoted by extrinsic signals that induce multiple transcription factors that act largely independently to regulate distinct gene expression modules that together promote a mature astrocytic phenotype. (nature.com)
We demonstrate that deletion of ERRγ from DAergic neurons in adult mice was sufficient to cause a levodopa-responsive PD-like phenotype with reductions in mitochondrial gene expression and number, that partial deficiency of ERRγ hastens synuclein-mediated toxicity, and that ERRγ overexpression reduces inclusion load and delays synuclein-mediated cell loss. (nature.com)
Further evidence suggests that during PD progression, transcriptional programs for the expression of genes involved in mitochondrial structure and function are disrupted 11 . (nature.com)
Laser-captured microdissected (LCM) DAergic neurons from postmortem tissue of patients with Lewy-pathology revealed a deficiency in expression for nuclear-encoded genes involved in mitochondrial respiration and function 12 . (nature.com)
Expression data are derived from records contained in the Gene Expression Omnibus (GEO) , and are first log2 transformed and normalized. (yeastgenome.org)
Pemetrexed effectiveness has been related to the expression of its target thymidylate synthase. (eur.nl)
Gene expression was used to predict Pemetrexed responsiveness. (eur.nl)
Results: Ninety NSCLCs were divided into six subclasses by gene expression signatures. (eur.nl)
Conclusions: Gene expression signatures can be used to identify NSCLC subgroups and have potential to predict resistance to Pemetrexed therapy. (eur.nl)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. (jneurosci.org)
We present a hitherto unappreciated cross talk of actin signaling with gene expression governing neuronal motility. (jneurosci.org)
In addition to regulation of cytoplasmic cytoskeletal dynamics, a little appreciated property of actin signaling is modulation of gene expression so far only reported for non-neuronal cells. (jneurosci.org)
Maturation of BAT and WAT follow a similar adipogenic transcriptional program, albeit several genes show cell type-dependent expression. (biomedcentral.com)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
Regulation of gene expression in Plasmodium falciparum (Pf) remains poorly understood. (biomedcentral.com)
The transcriptome of the Pf asexual intraerythrocytic developmental cycle (IDC) has been analysed and transcriptional regulation has been shown to orchestrate a continuous cascade of gene expression, with genes being induced once per cycle, in a "just-in-time" manner, only when the gene product is required by the cell [ 3 ]. (biomedcentral.com)
The question then arises as to how such fine-tuned regulation of gene expression is achieved in this extreme parasite. (biomedcentral.com)
TFBMs act as binding sites for transcription factors and coordinate the expression of the genes in whose promoter regions they appear. (biomedcentral.com)
Attributed to the failure of neurons to clear dysfunctional mitochondria , loss of gene expression leads to loss of nigrostriatal neurons. (sdbonline.org)
Special areas of interest include signal transduction and information processing, gene expression and gene regulatory networks, metabolism, proliferation, differentiation and morphogenesis, among others, and the use of multi-scale modeling to connect molecular and cellular systems to the level of organisms and populations. (iospress.com)
Comparing gene expression between GD2+ cells and CD44 high/CD24 low cells revealed 100 percent correlation in the expression of 231 genes. (weeksmd.com)
This study was designed to examine the constrictive potential of C-Phycocyanin (C-PC) in regulating changes imposed on gene expression in the selenite-induced cataract model. (molvis.org)
Treatment with 200 mg/kg bodyweight C-PC (Group III) transcriptionally regulated the instability of the expression of these genes, thus ensuring C-PC is a prospective anticataractogenic agent that probably delays the onset and progression of cataractogenesis induced by sodium selenite. (molvis.org)
C-PC treatment possibly prevented cataractogenesis triggered by sodium selenite, by regulating the lens crystallin, redox genes, and apoptotic cascade mRNA expression and thus maintains lens transparency. (molvis.org)
Upon depletion of RBPJ using CRISPR/Cas9, we observed specific upregulation of Notch target gene expression. (mdpi.com)
Until recently, it was unknown how sexual differences in the behavior, physiology, and development of organisms are regulated by differential gene expression. (peerj.com)
Suspected resis-tant populations collected across Japan were investigated for herbicide sensitivity and ALSgene sequences, followed by functional characterization and ALS gene expression analysis. (weedscience.org)
Although the enzymatic properties of ALS encoded by these genes werenot markedly different, the expression of MvALS1 and MvALS3 was prominently higheramong all ALS genes. (weedscience.org)

a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
Therefore, identifying the crucial proteins and clarifying mechanisms that contribute to metastasis will be significant to provide biomarkers for prognosis and targets for treatment. (spandidos-publications.com)
The evolution of herbicide resistance in weeds is an example of parallel evolution, throughwhich genes encoding herbicide target proteins are repeatedly represented as evolutionarytargets. (weedscience.org)

Future studies should examine the potential mechanisms underlying miR-637 as a diagnostic marker and therapeutic target for gliomas. (scirp.org)
We discuss the value of lncRNAs as putative diagnostic, prognostic and therapeutic targets in myeloid leukemias and indicate novel directions in this exciting research field. (frontiersin.org)
Finally, we review the developing body of literature on the participation of lncRNAs in epigenetic regulation of AML, and discuss their putative therapeutic relevance. (frontiersin.org)
This study not only reveals the mechanism underlying the crosstalk between M2 macrophages and PC cells but also suggests a promising therapeutic target for PC. (bvsalud.org)

A putative late gene promoter motif sequence, AGTAT was found in the 3' upstream sequences of these genes. (umass.edu)
Twenty putative pre-microRNA sequences were predicted in Hz-2V by searching stem-loop structures with less than -25kcal/mol of free energy, and one of the microRNA candidates was predicted to target the Hz2V007 gene transcript, which codes for a putative juvenile hormone esterase. (umass.edu)

In future research, these new lines can be used to test transcript levels for putative WRKY75 target genes. (helsinki.fi)
These targets were identified based on the presence of predicted regulator binding sites or experimental regulator binding in the target promoter, and/or changes in the target gene's transcript levels in regulator mutant strains. (yeastgenome.org)

We employ screening and targeted testing (CRISPR and small molecule) to ask which genes and pathways are required in B cells and primary lymphoma cells for resistance to lymphoma drugs. (seattlechildrens.org)
In combination with integrated bioinformatics analysis, this approach identified aberrant cellular responses, transcriptional pathways and genes that shed new light on immune dysregulation in sJIA. (stanford.edu)
Two of these genes, arginase 1 and eotaxin 1 are the focus of continuing investigations in mouse models of asthma regarding differences in mechanistic pathways depending on the allergen. (cdc.gov)
Array studies provide candidate genes to identify common mechanistic pathways in the effector phase, as well as mechanistic pathways unique to individual allergens. (cdc.gov)

Four of structural genes, p11.7, p15.1, p28.4, and p31.7 were identified by matrix assisted laser desorption/ionization time-of-flight mass spectroscopy. (umass.edu)
Total RNA was isolated on P16, and the relative abundance of mRNA of the crystallin structural genes, redox components, and apoptotic cascade were ascertained with real-time PCR with reference to the internal control β-actin . (molvis.org)

The study seeks to identify putative regulatory motifs in the upstream regions of 13 functional groups of genes expressed in the intraerythrocytic developmental cycle of Pf . (biomedcentral.com)
The identification of positionally conserved over-represented upstream motifs throws light on putative regulatory elements for transcription in Pf . (biomedcentral.com)
They are about 6-8 nucleotides (nt) in length and occur upstream of the gene transcription start site (TSS). (biomedcentral.com)

Three motif-discovery programs were used for the purpose, and motifs were searched for only on the gene coding strand. (biomedcentral.com)

Although AmlR apparently is a local transcriptional regulator of the aml operon, the Δ amlR strain shows severe growth inhibitions on glucose and - concomitantly - differential transcription of several genes of various functional classes. (frontiersin.org)

Previous studies identified that both DAB2 and DAB2IP genes were inactivated by promoter hypermethylation in human cancers, but their mutational alterations in cancers remain largely unknown. (nih.gov)

14 ). It is important to identify the transcription factors involved in regulation of these genes to reveal potential avenues for modulating transcriptional programs that could be dysfunctional in PD. (nature.com)
Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus. (yeastgenome.org)
Continued studies focused on genes showing minimal changes in the TMA-induced model but with clear up-regulation in the ovalbumin model. (cdc.gov)

Clinical trial of gene-disease association and gene-environment interaction. (nih.gov)
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)

To understand drug resistance in lymphoma, the James lab collects primary samples from subjects with lymphoma treated with ibrutinib and other targeted agents. (seattlechildrens.org)
We use gene editing to introduce putative resistance-associated genetic variants into this lymphoma model. (seattlechildrens.org)

Dr. Feng's laboratory is interested in disease gene hunting, elucidation of disease mechanisms, clinical classification of genetic variants in genetic testing for cancers, clinical biomarker identification, early diagnostic and prognostic test development, and the implementation and dissemination of screening and diagnostic tools in a clinical setting. (utah.edu)

While ERRγ deletion did not fully recapitulate the transcriptional alterations observed in postmortem tissue, it caused reductions in genes involved in synaptic and mitochondrial function and autophagy. (nature.com)

GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)
Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)

in fact, these genes are targets of the transcriptional coactivator and master regulator of transcription of mitochondrial genes peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) 12 . (nature.com)

We identified three undifferentiated SG subsets at postnatal day 7, each of which expresses distinct genes, including transcription factor and signaling genes. (biologists.com)

Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Mutations in the USB1 gene are thought to lead to an enzyme whose function is impaired. (medlineplus.gov)
The specific connection between USB1 gene mutations and the signs and symptoms of PN is unknown. (medlineplus.gov)

A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
To investigate a gene regulatory network, an iterative process of four steps is needed. (hindawi.com)
In turn, these hypotheses, which provide reasonable explanations for the biological phenomenon, lead to an enhanced understanding of the gene regulatory network. (hindawi.com)
Finally, a hierarchical model for the regulatory network among the pathway genes and TFs was proposed. (researchsquare.com)

Genetic structures associated with the bla OXA-23 gene of Acinetobacter baumannii . (cdc.gov)
Based on these results, we formed a hypothesis that gene redundancy could influence genetic characterization of WRKY75. (helsinki.fi)
This framework is useful for both gene discovery research and clinical genetic testing. (utah.edu)

A curated database of candidate human ageing-related genes and genes associated with longevity and/or ageing in model organisms. (senescence.info)
Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (scirp.org)
Furthermore, 15/15 candidate TFs might regulate at least three key genes and contribute to carotenoids/flavonoids accumulation in CNO fruit. (researchsquare.com)
Different statistical methods with varying selection criteria resulted in identification of similar candidate genes. (cdc.gov)
Array data are intended to provide candidate genes for hypothesis generation and further experimentation. (cdc.gov)

We tested if routine immunohistochemical markers can be used to distinguish putative Pemetrexed responders, predicted by gene signatures, from nonresponders. (eur.nl)

The biosynthesis genes are encoded by the acb gene cluster, which was identified in 1999 by Stratmann et al. (frontiersin.org)
The highly complex group of SOX genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. (thermofisher.com)

SOX genes comprise a family of genes that are related to the mammalian sex determining gene SRY. (thermofisher.com)

PHTF, a novel atypical homeobox gene on chromosome 1p13, is evolutionarily conserved. (nih.gov)

The transcripts of five carotenogenesis genes were highly correlated with lycopene contents, and 16, 40, 48, 24 and 18 transcription factors (TFs) were predicted to potentially bind their promoters, respectively. (researchsquare.com)

Targeted gene deletion mutants of amlE and amlR were constructed by use of the CRISPR/Cas9 technology. (frontiersin.org)

This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. (nih.gov)

For genes with regulatory targets, shared GO Biological Process terms for these targets are listed. (yeastgenome.org)

The number of herbicide target-site genes differs among species, and little is knownregarding the effects of duplicate gene copies on the evolution of herbicide resistance. (weedscience.org)

Two of the subclasses correlated to putative Pemetrexed resistance. (eur.nl)
Andreeff and colleagues are refining the drug as a potential targeted therapy for breast cancer stem cells, which are thought to be crucial to therapy resistance, disease progression and spread to other organs. (weeksmd.com)
We investigated the evolution of herbicide resistance in Monochoria vaginalis, which car-ries ﬁve copies of sulfonylurea target-site acetolactate synthase (ALS) genes. (weedscience.org)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)

In this study, Cara cara navel orange fruit at four development stages were used to identify the key genes and TFs for carotenoids and flavonoids accumulation. (researchsquare.com)
Collectively, our results suggest that DXS1 , DXR , GGPPS2 , PSY1 and LCYB genes were the most important genes for carotenoids accumulation, while PAL-1 , PAL-4 , 4CL-2 , 4CL-5 , CHS-1 and CHI for flavonoids biosynthesis. (researchsquare.com)

It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. (researchgate.net)
new potential targets for the drugs which not only contro l the disease bu t also can treat it. (researchgate.net)

Database of human genes associated with cellular senescence. (senescence.info)

Curated mutant alleles for the specified gene, listed alphabetically. (yeastgenome.org)

Real-time PCR analysis showed the crystallin genes ( αA- , βB1- , γD- ) and redox cycle components ( Cat , SOD-1 , Gpx ) were downregulated, the apoptotic components were upregulated, and antiapoptotic Bcl-2 was downregulated in Group II. (molvis.org)

Thus, herein we provide first evidence that neuronal motility not only depends on cytoplasmic actin dynamics but also on the availability of actin to modulate nuclear functions such as gene transcription. (jneurosci.org)
similarly, it is thought to be likely that genes with similar functions are regulated by the same mechanism. (biomedcentral.com)
Homologies were found to 38 of the 113 ORFs predicted for genes with known functions. (umass.edu)
This gene provides instructions for making an enzyme that functions as an RNA exonuclease. (medlineplus.gov)

EAEC are heterogeneous, and the distribution of known virulence genes rarely correlates with phylogeny based on housekeeping loci ( 1 ). (cdc.gov)

Anatomy20

Organisms15

Diseases2

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes93

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science7

MiRNA10

Regulators9

Protein10

Regulates1

MiRNAs10

Tumor suppressor1

Encode2

Signature genes2

MicroRNAs2

Transcriptional regulatory1

Phenotypes3

Expression36

Proteins3

Therapeutic4

Sequences2

Transcript2

Pathways4

Structural genes2

Upstream3

Motifs1

Several genes1

Promoter1

Regulation3

Interaction2

Lymphoma2

Variants1

Mitochondrial function1

Ontology2

Peroxisome1

Distinct1

Mutations3

Regulatory network4

Genetic3

Candidate5

Markers1

Cluster2

Mammalian1

Chromosome1

Transcription factors1

CRISPR1

Proteasome1

Biological Process1

Species1

Resistance4

Accumulation2

Potential targets2

Cellular1

Alleles1

Analysis1

Functions4

Loci1