MutationPoint MutationMutation, MissenseBase SequenceFrameshift MutationPedigreeDNA Mutational AnalysisMolecular Sequence DataTranscription FactorsPhenotypeHeterozygoteGerm-Line MutationPolymerase Chain ReactionSignal TransductionExonsGenotypeGenetic TestingDNA-Binding ProteinsCell LineGene Expression RegulationPromoter Regions, GeneticRNA InterferenceSequence Analysis, DNAAllelesAmino Acid SequenceAmino Acid SubstitutionCell Line, TumorHomozygotePolymorphism, Single-Stranded ConformationalTranscription, GeneticDNA PrimersGenetic Predisposition to DiseaseCodon, NonsenseNuclear ProteinsProtein BindingMutation RateRNA, MessengerGene Knockdown TechniquesTransfectionProtein Structure, TertiaryReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingMice, KnockoutGenes, RecessiveGene SilencingGene Expression Regulation, NeoplasticGene Expression Regulation, DevelopmentalGenes, p53Gene Expression ProfilingModels, BiologicalMice, TransgenicBinding SitesFructose-1,6-Diphosphatase DeficiencyDNAMembrane ProteinsCells, CulturedModels, GeneticRepressor ProteinsGene DeletionMice, Inbred C57BLCell ProliferationDisease Models, AnimalOligonucleotide Array Sequence AnalysisTumor Suppressor Protein p53ZebrafishMutagenesis, Site-DirectedFamily HealthBlotting, WesternMutant ProteinsTranscriptional ActivationGene ExpressionTrans-ActivatorsChromosome MappingMutagenesisCell Transformation, NeoplasticApoptosisEpigenesis, GeneticHomeodomain ProteinsProto-Oncogene Proteins B-rafChromatin ImmunoprecipitationCarrier ProteinsDNA MethylationSyndromeDrosophila ProteinsDeafnessGenetic VariationGenetic LinkageNeoplasm ProteinsMicroRNAsMice, Mutant StrainsCell DifferentiationSequence DeletionEye ProteinsGenes, DominantImmunohistochemistryTime FactorsNerve Tissue ProteinsDNA, NeoplasmNeoplasmsTumor Suppressor Proteins