Ubiquitin-Protein LigasesLigasesUbiquitinUbiquitinsAngelman SyndromeUbiquitin-Conjugating EnzymesUbiquitin-Protein Ligase ComplexesUbiquitinationEndosomal Sorting Complexes Required for TransportProteasome Endopeptidase ComplexCullin ProteinsAnaphase-Promoting Complex-CyclosomeSKP Cullin F-Box Protein LigasesMolecular Sequence DataAmino Acid SequenceCarbon-Nitrogen LigasesProtein BindingF-Box ProteinsPolyubiquitinMutationUbiquitin-Activating EnzymesFatty Acid Synthase, Type IIS-Phase Kinase-Associated ProteinsBiotinylationSubstrate SpecificityProteolysisRNA Ligase (ATP)Ubiquitin ThiolesteraseCell LineSaccharomyces cerevisiae Proteinsbeta-Transducin Repeat-Containing ProteinsCell Cycle ProteinsProtein Structure, TertiaryBiotinSequence Homology, Amino AcidSaccharomyces cerevisiaeCysteine EndopeptidasesMultienzyme ComplexesF-Box MotifsPeptide SynthasesProtein Processing, Post-TranslationalCarrier ProteinsThioctic AcidHeLa CellsBase SequenceRecombinant Fusion ProteinsRepressor ProteinsAcetyl-CoA CarboxylaseDNA LigasesHydroxyapatitesMultiprotein ComplexesProteinsVon Hippel-Lindau Tumor Suppressor ProteinHEK293 CellsTranscription FactorsInhibitor of Apoptosis ProteinsAdenovirus E4 ProteinsProtein StabilityTwo-Hybrid System TechniquesDNA-Binding ProteinsRING Finger DomainsAmino Acid MotifsModels, MolecularImmunoprecipitationRecombinant ProteinsPolynucleotide LigasesNuclear ProteinsSignal TransductionEscherichia coliBacterial ProteinsRNA InterferenceModels, BiologicalPeptide HydrolasesProtein TransportUbiquitin CRNA, Small InterferingPhosphorylationCell Line, TumorProto-Oncogene Proteins c-cblvif Gene Products, Human Immunodeficiency VirusElectrophoresis, Polyacrylamide GelAdaptor Proteins, Signal TransducingEscherichia coli ProteinsIntracellular Signaling Peptides and ProteinsTumor Suppressor ProteinsCloning, MolecularImmunoblottingProteasome InhibitorsLysineBinding SitesCell CycleEndoplasmic ReticulumCells, CulturedGlutamate-Cysteine LigaseCyclin-Dependent Kinase Inhibitor ProteinsBiodegradation, EnvironmentalSuppressor of Cytokine Signaling ProteinsUbiquitinated ProteinsEndopeptidasesBlotting, Western