Tandem mass spectrometry with collision. Medical search. Frequent questions

Rapid Communications in Mass Spectrometry, 28 (7). (whiterose.ac.uk)
Rapid Communications in Mass Spectrometry , 18 (10), 1039-1046. (abo.fi)

Collision-induced dissociation tandem mass spectrometry was used in cases of ambiguity. (whiterose.ac.uk)
Toward full peptide sequence coverage by dual fragmentation combining electron-transfer and higher-energy collision dissociation tandem mass spectrometry. (analyteguru.com)

This method was based on headspace solid phase microextraction coupled to gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS/MS) (Silva et. (cdc.gov)
We have developed and validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantification of ertapenem in serum samples derived from patients with complicated urinary tract infections. (walshmedicalmedia.com)
We describe a novel method to measure selected terpenes in BAL fluid by gas chromatography-tandem mass spectrometry (GC/MS/MS). (cdc.gov)
myrcene, 3-carene, and limonene were measured in BAL fluid specimens by headspace solid-phase microextraction/gas chromatography/tandem mass spectrometry. (cdc.gov)
Terpenes are volatile organic compounds (VOCs), and can be analyzed using gas chromatography-tandem mass spectrometry (GC/MS/MS). (cdc.gov)
Five terpenes were measured in BAL fluid specimens by headspace solid-phase microextraction (SPME)/gas chromatography/ tandem mass spectrometry. (cdc.gov)

A variety of mass spectrometer types, including magnetic sector, quadrupole, time-of-flight, and ion trap, have and will continue to deepen our understanding of the formation and evolution of exploration targets like the surfaces and atmospheres of planets and their moons. (frontiersin.org)
The site(s) of diisocyanate conjugation upon the model protein(s) are characterized by enzymatic digestion of the conjugated protein, followed by fragmentation of the resultant enzymatic peptides by collision-induced dissociation (CID) in a quadrupole time-offlight (qTOF) mass spectrometer. (cdc.gov)
However, MS/MS using electron capture dissociation (ECD) in a Fourier transform mass spectrometer cleaves backbone bonds without ejecting CO 2 , allowing direct localization of this labile modification. (northwestern.edu)
The eluates were ionized at 70eV in the electron source of the mass spectrometer. (cdc.gov)
The tandem mass spectrometer ran in Multiple Reaction Monitoring (MRM) mode where the precursor ions fragmented with nitrogen gas in the collision cell at a defined electron voltage. (cdc.gov)
All experiments were performed using an LCQ ion trap All aconitines share a common C19-norditerpenoid skele- mass spectrometer (ThertmoFinnigan, San Jose, CA, USA) ton. (healthdrugpdf.com)
In general, an assay that uses a mass spectrometer as the final detection method will involve a sample preparation step, a chromatographic separation and measurement with a mass spectrometer. (myadlm.org)
The final stage of detection using a mass spectrometer is the focus of this portion of Pearls of Laboratory Medicine. (myadlm.org)
For analytes introduced into the mass spectrometer as a liquid, several types of sources exist including electrospray ionization and atmospheric pressure chemical ionization. (myadlm.org)
With the mass of our analyte known, we need to decide what type of mass spectrometer to use for analysis. (myadlm.org)
Although every type of mass spectrometer uses the same charged ions, how it separates individual analytes varies greatly. (myadlm.org)
How long the mass spectrometer sits at a voltage and frequency combination is called the dwell time, during which only a limited number of ions are successfully reaching the detector. (myadlm.org)
18] LC-MS LC-MS or HPLC-MS refers to the coupling of an LC with a mass spectrometer (MS) [Figure 3]. (pka-signal.com)
kinase inhibitor KPT-330 A typical automated LC-MS system consists of double three-way diverter in-line with an autosampler, an LC system, and the mass spectrometer. (pka-signal.com)
Furthermore, the results were confirmed by HPLC coupled to an electrospray ionisation tandem triple-quadrupole mass spectrometer ESI-MS performing low-energy collision induced dissociation (CID-MS/MS) in the collision cell (HPLC-ESI-MS/MS). Analyses were made in the multiple reaction monitory (MRM) mode. (utc.fr)
An Easy nL nano liquid chromatographic system is coupled to the mass spectrometer through the nanoelectrospray source for protein characterization. (boisestate.edu)
Bruker Q-TOF Mass Spectrometer is located in the mass spectrometer is located in the BRC, room 215 in the Mathematics Building on the campus of Boise State University. (boisestate.edu)
This mass spectrometer is coupled with a Dionex Ultimate 3000 HPLC system and an innovative Captive electrospray source. (boisestate.edu)
Bruker HCT Ion Trap Mass Spectrometer from Bruker Daltonics is located in the Analytical Lab, room 363 in the Science building on the Boise State University campus. (boisestate.edu)
The HCT is a robust and easy to use mass spectrometer. (boisestate.edu)
The Thermo Polaris Q GC/MSn Benchtop Ion Trap Mass Spectrometer complete with Thermo Trace Gas Chromatograph, external vacuum pump, and XCalibur PC workstation. (boisestate.edu)
HTX Imaging's patented TM-Sprayer™ Tissue MALDI Sample Preparation System is designed to provide the highest quality matrix deposition on the two-dimensional biological samples, and can be integrated with any MALDI Mass Spectrometer platform. (boisestate.edu)
METHODS:Water/methanol solutions of AOTNa and chloride salts of nickel, magnesium, calcium and manganese, with different AOTNa/metal salt ratios, were infused into the electrospray source of a LCQ DECA ion trap mass spectrometer, operating in negative ion mode, at a flow rate of 5 mL/min. (unipa.it)

Reproducibility of product ion spectra acquired using a liquid chromatography/triple-quadrupole mass spectrometry (LC/MS/MS) instrument over a 4-year period, and with three other LC/MS/MS instruments, one from the same manufacturer and two from a different manufacturer, was examined. (abo.fi)

The selected ions undergo collision-induced dissociation or other process to induce fragmentation. (wikipedia.org)
This is followed by tandem mass spectrometry, which implies that the activation of ions is distinct from the ionization step, and that the precursor and product ions are both characterized independently by their mass/charge ratios. (canada.ca)
In collision-induced dissociation (CID), activation of the selected ions occurs by collision(s) with neutral gas molecules in a collision cell. (canada.ca)
Collisional activation upon impact of precursor ions on solid surfaces, surface-induced dissociation (SID), is gaining importance as an alternative to gas targets and has been implemented in several different types of mass spectrometers. (canada.ca)
CID produces sequence-informative fragmentation and unambiguous determination of the conjugation site is possible on the basis of mass shifts of resultant fragment ions. (cdc.gov)
In these experiments, CID is performed in a multiplexed manner (e.g. alternating low and high collision energy scans) to allow high mass accuracy scans of parent and daughter fragment ions that may be temporally correlated in silico post run. (cdc.gov)
After an initial electron-transfer dissociation step, all ions including the unreacted precursor ions are subjected to collision induced dissociation which yields b/y- and c/z-type fragment ions in a single spectrum. (analyteguru.com)
In summary, although the metal ions influence the mass and charge state of the observed product ions, the metal ions had a negligible effect on the types of cross‐ring cleavages observed. (nsf.gov)
Once we have a way to get ions charged and into the gas phase, the most important aspect in the analysis is the mass-to-charge ratio, designated as m over z. (myadlm.org)
Since all ions are being accelerated by the same electric field, ions with a low mass-to-charge ratio will accelerate faster than ions with a high mass-to-charge ratio. (myadlm.org)
How long it takes a given ion to travel down the flight tube is how ions of different mass-to-charge ratios are distinguished. (myadlm.org)
However, this problem has now been tackled by the introduction of tandem mass spectrometry (MS-MS), which provides fragments through collision-induced dissociation of the molecular ions produced. (pka-signal.com)
The interfaces are designed in such a way that they offer adequate nebulization and vaporization of the liquid, ionization of the sample, removal of the excess solvent vapor, and extraction of the ions into the mass analyzer. (pka-signal.com)
Structural characterizations of each intact phospholipid were done in both positive and negative ion mode by electrospray ionization tandem-mass spectrometry (ESI-MS/MS). The MS/MS analyses of each protonated [M+H] + and deprotonated [M-H] - molecule were performed at various different collision off set values in order to obtain the intense characteristic fragment ions in the MS/MS spectra. (benthamopen.com)

Shotgun proteomics refers to the use of bottom-up proteomics techniques in identifying proteins in complex mixtures using a combination of high performance liquid chromatography combined with mass spectrometry. (wikipedia.org)
The studies presented here have applied modern analytical proteomics methodologies (in particular, multiplexed tandem mass spectrometry) to characterize the conjugation chemistry of industrially relevant diisocyanates on model proteins. (cdc.gov)

Single quadrupole and triple quadrupole mass analyzers are the most common mass spectrometers found in the clinical laboratory, but it's important to recognize that laboratories are also using time of flight analyzers for specific applications. (myadlm.org)

The "fingerprint" of each peptide's fragmentation mass spectrum is used to identify the protein from which they derive by searching against a sequence database with commercially available software (e.g. (wikipedia.org)
Inducing 2-fold fragmentation by combining electron-transfer and higher-energy collision dissociation (EThcD) generates dual fragment ion series and facilitates extensive peptide backbone fragmentation. (analyteguru.com)
It is possible to achieve glycopeptide fragmentation under standard collision induced dissociation (CID) conditions, in which the glycosidic bonds between carbohydrate bonds are favourably cleaved. (news-medical.net)
In the case of N-glycopeptide fragmentation, the higher collision energies, which are required for peptide moiety fragmentation, also bring about a characteristic fragmentation pattern, which has earlier been described for MALDI fragmentation 3 . (news-medical.net)
In these settings, (0,2)X-ring fragmentation of the innermost N-acetylglucosamine of the chitobiose core (+83 Da), and a loss of the complete N-glycan moiety by cleavage of both the N-glycosidic bond and the side-chain amide group of the N-glycosylated asparagine, produces a characteristic peak doublet with a mass difference of 17 Da. (news-medical.net)
Fragmentation pathways of aconitine-type alkaloids were investigated by electrospray ionization/ion trap multistage tandem mass spectrometry. (healthdrugpdf.com)
An ion gate for selecting the precursor ion, an ion fragmentation region (e. g. a collision cell) and an ion accelerator may be provided between the first and second TOF-MS. (unist.ac.kr)
A protein database containing 87,745 amino acid variant sequences and 73,910 UniProtKB/Swiss-Prot canonical protein entries was constructed for database search, and higher energy collisional dissociation combined with collision-induced dissociation fragmentation modes were applied to improve the quantification coverage of SAAVs. (nih.gov)

Until recently, classification of N-glycopeptide spectra in ProteinScape (detection of glycopeptide spectra and calculation of glycan and peptide moiety mass) has centered on glycan fragment distances and oxonium ion detection when using typical CID conditions on ion trap or qTof instruments (see application note LCMS-66)4. (news-medical.net)
Product ion spectra from collision-induced dissociation resulted principally from dissociations of the heptafluorobutyryl group. (johnshopkins.edu)
Low-energy collision-induced dissociation ofprotonated aconitines follows a dominant first step, the elimination of the C8-substituent as aceticacid or fatty acid in MS2 spectra. (healthdrugpdf.com)
Intact part II steroid metabolites have poor product ion mass spectra beneath collision induced dissociation (CID) situations. (n-egt.com)
The MS/MS spectra of 30 drug substances were generated in positive electrospray ionization mode at low, medium, and high collision energies (20, 35, and 50 eV). (abo.fi)
The average Fit and Purity scores of spectra from one library against the other were better than 93 and 91%, respectively, when the same collision energies were used. (abo.fi)
The average Fit scores of brand B spectra against the brand A spectral library varied between 79 and 85% at all three collision energies. (abo.fi)

Quintyn Royston S., Zhou Mowei, Dagan Shai, Finke John, Wysocki Vicki H.: Ligand binding and unfolding of tryptophan synthase revealed by ion mobility-tandem mass spectrometry employing collision and surface induced dissociation. (iupac.org)

Characterization of diisocyanate haptenation of serum albumin by multiplexed tandem mass spectrometry. (cdc.gov)

Tandem mass spectrometry is then used to identify the peptides. (wikipedia.org)
As the peptides elute from the column, they are ionized and separated by m/z in the first stage of tandem mass spectrometry. (wikipedia.org)
Tandem mass spectrometry (MS/MS) of 28 residue peptides harboring γ- carboxylated glutamic acid residues, a posttranslational modification of several proenzymes of the blood coagulation cascade, using either collisions or infrared photons results in complete ejection of the γ-CO 2 moieties (-44 Da) before cleavage of peptide-backbone bonds. (northwestern.edu)

Performance is optimized by tailoring the ionization method (APCI/ESI), de-clustering potentials, and collision energies for each specific analyte. (mit.edu)
This experiment can be done at high (keV) collision energies, using tandem sector and time-of-flight instruments, or at low (eV range) energies, in tandem quadrupole and ion trapping instruments. (canada.ca)
1,2 discussed a new glycopeptide instant expertise method which makes use of multiple collision energies to produce glycan fragments and peptide fragments inside the same MS/MS spectrum. (news-medical.net)
Figure 1C shows the ideal collision energies. (news-medical.net)
The application of these results into a consistent acquisition method was managed through the use of a timed stepping of collision energies and transfer settings (Figure 1A and B). (news-medical.net)
Collision energies for the MSn analyses ranged from variations lie in the substituents on the C3, C10 and N atoms 25±42% of maximum, depending on the mass of the (Table 1). (healthdrugpdf.com)

For glycopeptide characterization, mass spectrometry has arisen as the go-to methodology. (news-medical.net)
Alkali and alkaline earth metal adducts of a branched glycan, XXXG, were analyzed with helium charge transfer dissociation (He‐CTD) and low‐energy collision‐induced dissociation (LE‐CID) to investigate if metalation would impact the type of fragments generated and the structural characterization of the analyte. (nsf.gov)
Mass spectrometry(MS) methods, particularly with the development of softionization techniques, such as electrospray (ESI) and matrix- assisted laser desorption/ionization (MALDI), have played an important role in the characterization of isolated Roots of aconite were purchased from a drug store. (healthdrugpdf.com)
collision-induced dissociation (CID) conditions are still notsufficiently clear to assist characterization of unknown aconitine-type alkaloids in aconite extracts. (healthdrugpdf.com)

Tandem quadrupole mass spectrometry HPLC-ESI-MS/MS CID-MS/MS Multiple reaction monitory (MRM) Quercetin Apigenin Kaempferol a b s t r a c t The presence of three flavonols (quercetin, kaempferol, myricetin) and two flavones (apigenin, luteolin) were investigated in the extract of fresh spinach leaves. (utc.fr)

Noncovalent nano-electrospray ionisation mass spectrometry was conducted in the presence and absence of short RNA oligonucleotides. (whiterose.ac.uk)
Here, we have used electrospray ionisation mass spectrometry (ESI-MS) to determine the patterns of alteration to individual molecular species compositions of PC, PE and phosphatidylinositol (PI) in response to gradually decreasing temperature. (silverchair.com)

Reaction gas methods can use either on-mass or mass-shift measurement. (spectroscopyonline.com)
Topics for discussion will include ionization methods, the different types of mass spectrometers used clinically, different methods of analysis, and highlight some future areas where mass spectrometry will most likely be applied. (myadlm.org)
Normally, the structural analysis of complex lipids relies on tandem mass spectrometry (MS/MS) or the activation methods based on collision, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD). (ebclink.com)
Matrix-assisted laser desorption/ionization (MALDI) is a soft ionization technique used in mass spectrometry, allowing the analysis of biomolecules and large organic molecules which tend to be fragile and fragment when ionized by more conventional ionization methods. (unist.ac.kr)
Several methods of liquid chromatography coupled to either UV absorbance or mass spectrometry detection have been developed for the quantification of ertapenem in human plasma. (walshmedicalmedia.com)

SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)
It offers Trap-HCD (Higher-Energy Collisional Dissociation) combined with CID (Collision-Induced Dissociation), and PQD (Pulsed-Q Dissociation) to enhance coverage and sensitivity of proteomic analysis. (boisestate.edu)

Modern flight-capable mass spectrometers, in combination with various sample processing, separation, and ionization techniques enable sensitive detection of chemical biosignatures. (frontiersin.org)
TOF/TOF is a tandem mass spectrometry method where two time-of-flight mass spectrometers are used consecutively. (unist.ac.kr)

TSA (50 μM) was readily and completely metabolized by rat hepatocytes in suspension (2 × 10 6 cells/ml), whereafter its phase I metabolites were separated by high-performance liquid chromatography and detected with simultaneous UV and electrospray ionization mass spectrometry (ESI-MS). ESI tandem mass spectrometry (ESI-MS/MS) was used to identify the metabolites. (aspetjournals.org)
Ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry revealed 10 metabolites. (aspetjournals.org)
Due to this fact, we current herein the liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/(MS)) habits of intact part II metabolites of oxosteroids after derivatization. (n-egt.com)

Djordjevic S, Kovacevic I, Miljkovic B, Vuksanovic J, Pokrajak M. Liquid chromatographic-mass spectrometric method for the determination of fluoxetine and norfluoxetine in human plasma: application to clinical study. (scielo.br)
Simultaneous pulsed flame photometric and mass spectrometric detection for enhanced pesticide analysis capabilities. (cdc.gov)

The charged fragments are separated in the second stage of tandem mass spectrometry. (wikipedia.org)

Abstract The combination of helium charge transfer dissociation mass spectrometry (He-CTD-MS) with ultrahigh performance liquid chromatography (UHPLC) is presented for the analysis of a complex mixture of acidic and neutral human milk oligosaccharides (HMOs). (nsf.gov)

ICP-QMS with collision-reaction cell (CRC) technology operating in helium (He) mode is able to reduce most common polyatomic overlaps to background or negligible levels (3). (spectroscopyonline.com)
Low energy collision-induced dissociations were carried out by using helium with collision energy in the range 1-5 eV. (unipa.it)

Here, we delve into the search for extraterrestrial chemical and morphological biosignatures and examine several possible approaches to agnostic life detection using mass spectrometry. (frontiersin.org)

Mass Spectrom. (healthdrugpdf.com)

Tandem mass spectrometry is a method to further enhance the specificity of mass spectrometry. (myadlm.org)

This MS/MS method was integrated on a reversed-phase liquid chromatography-mass spectrometry workflow and further applied for in-depth profiling of total sphingoid bases in bovine heart and Caenorhabditis elegans. (bvsalud.org)
The combination method of ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry was used to assess the quality of BZXD. (biomedcentral.com)

It also avoids the modest separation efficiency and poor mass spectral sensitivity associated with intact protein analysis. (wikipedia.org)
The resulting protein-protein and protein-RNA complexes were identified and their stoichiometries verified by their mass. (whiterose.ac.uk)

The molecular anion for buprenorphine was used as a precursor ion, whereas the [M-197] - was used as a precursor ion for norbuprenorphine in tandem mass spectrometry. (johnshopkins.edu)

Hyphenated techniques such as HPLC coupled to UV and mass spectrometry (LC-UV-MS) have proved to be extremely useful in combination with biological screening for a rapid survey of natural products. (pka-signal.com)

In tandem with cutting-edge instrument platforms, research in data processing and data analysis on Earth-based (Terran) astrobiology analogs and on extraterrestrial materials also serves to increase the breadth of interpretations possible with mission data. (frontiersin.org)

To test this hypothesis, we applied high-resolution mass spectrometry analysis to lipid samples obtained from the WT and evol40 strains grown in 1 g/L glucose (glucose), 0.75 g/L phenol (low phenol), or 1.5 g/L phenol (high phenol, evol40 only) as a sole carbon source. (biomedcentral.com)

Increasing peptide sequence coverage by tandem mass spectrometry improves confidence in database search-based peptide identification and facilitates mapping of post-translational modifications and de novo sequencing. (analyteguru.com)

CONCLUSIONS: Noncovalent mass spectrometry has provided the first detailed analysis of the co-populated oligomeric species formed by these important viral proteins and revealed insights into their assembly pathways. (whiterose.ac.uk)
A flow-injection analysis tandem mass spectrometry (FIA MSMS) method was developed for rapid quantitative analysis of 10 different inorganic and organic explosives. (mit.edu)
aconitines,2±4 the quantitative analysis and the stereo- Authentic samples of aconitine (AC), hypaconitine (HC) chemistry of aconitines,5±7 and the direct analysis of and mesaconitine (MA) were purchased from China Drug aconitine mixtures. (healthdrugpdf.com)

This application is difficult for conventional quadrupole inductively coupled plasma-mass spectrometry (ICP-MS) because of the presence of matrix-based spectral interferences on the isotopes of Ti. (spectroscopyonline.com)
However, conventional tandem mass spectrometry (MS/MS) via collision-induced dissociation (CID) faces challenges in characterizing these modifications. (bvsalud.org)

Homopolymers and copolymers of alkylisocyanates having n-hexyl, 2,6-dimethylheptyl, 3,7-dimethyloctyl, and (2,2-dimethyl-1,3-dioxolan-4-yl)methyl substituents underwent thermal degradation in the course of desorption electron ionization to yield trimers and monomers that were characterized in situ by tandem mass spectrometry. (nyu.edu)

In this light, assembling and chelating properties of sodium bis(2-ethylhexyl)sulfosuccinate (AOTNa) towards divalent metal ion chlorides have been investigated in the gas phase by electrospray ionization mass spectrometry in negative ion mode, tandem mass spectrometry and energy-resolved mass spectrometry. (unipa.it)

The molecular mass of SARS-CoV-2 M pro as determined by mass spectroscopy is 33797.0 Da, consistent with its theoretical molecular mass of 33796.8 Da. (nature.com)

2023 Hong Kong Society of Mass Spectrometry. (hksms.org)

In order for an analyte to be measured using mass spectrometry it must carry a charge and be in the gas phase. (myadlm.org)
An analyte with a molecular weight of 415 and a charge of +1 will have a mass-to-charge ratio of 415. (myadlm.org)
For an analyte at a known mass-to-charge ratio, the amount of positive or negative charge and the frequency at which the diagonal pairs switch their sign is optimized to produce a successful ion flight path through the quadrupole. (myadlm.org)

TOF analyzers have essentially an unlimited mass-to-charge range, very high sensitivity, very high mass accuracy, high transmission percentage but a limited dynamic range. (myadlm.org)
Quadrupoles have a limited mass-to- charge range, high sensitivity, high mass accuracy, but a low ion transmission percentage. (myadlm.org)
Each of these analyzers, however, offers varying degree of mass accuracy and resolution. (pka-signal.com)

Despite the fact that the classification workflow in ProteinScape has an explicit parameter to address this issue, the peptide mass of low abundant N-glycopeptides can be miscalculated at times, which can result in no or incorrect identifications. (news-medical.net)

Collision energy stepping implemented in the Glycopeptide Instant Expertise™ method. (news-medical.net)
A method for the simultaneous measurement of buprenorphine and its N- dealkylated metabolite, norbuprenorphine, in human plasma was developed with negative chemical ionization tandem mass spectrometry. (johnshopkins.edu)

AC, HC and both ESI and MALDI-MS were applied to analyze complex MA were dissolved in chloroform to obtain a solution of mixtures of alkaloids from aconite.8,9 However, to our concentration of approx. (healthdrugpdf.com)

collision energy. (aspetjournals.org)
It can be performed using either single or multiple collisions with a selected gas and each of these factors influences the distribution of internal energy that the activated ion will possess. (canada.ca)
1,2 employed synthetic, and therefore well-defined, N-glycopeptides for the optimization of CID energy parameters, so as to attain the greatest possible quantities of data on both the glycan and peptide moiety within just one tandem MS experiment. (news-medical.net)

Likewise, a molecule with a molecular weight of 15000 and a charge of +3 will have a mass to charge ratio of 500. (myadlm.org)

Anatomy9

Organisms12

Diseases7

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment69

Phenomena and Processes46

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture9

Information Science10

Named Groups1

Health Care14

Geographicals1

Rapid Communicatio2

Dissociation tandem mass spectro2

Chromatography-tandem mass spectro6

Spectrometer23

Acquired using a liquid chromato1

Ions14

Proteomics2

Triple quadrupole mass1

Fragmentation8

Spectra7

Surface-induced dissociation1

Serum albumin1

Peptides3

Energies6

Characterization4

Quadrupole mass1

Electrospray ionisation2

Methods5

Proteomic2

Spectrometers2

Metabolites3

Spectrometric2

Fragments1

Abstract1

Helium2

Detection1

Spectrom1

Specificity1

Liquid2

Protein2

Precursor ion1

HPLC1

Instrument1

Lipid1

Identification1

Analysis3

Conventional2

Electron1

Negative ion mode1

Spectroscopy1

20231

Analyte3

Accuracy3

Peptide mass1

Method2

MALDI1

Energy3

Molecular1