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  • side effects
  • 3. Are there emotional/mood side effects of the tamoxifen? (medhelp.org)
  • A study has found that many men have problems while taking tamoxifen and about 20% of them stop taking it (either on their own or as directed by their doctors) because of unacceptable side effects. (breastcancer.org)
  • Currently, tamoxifen is only recommended for women who have a 4% or higher risk of developing breast cancer within 10 years because of severe side effects such as a higher risk of uterine cancer and blood clots. (prweb.com)
  • active metabolites
  • It is metabolized by the cytochrome P450 family (more specifically CYP2D6) to active metabolites such as endoxifen (4-OH-N-desmethyl-tamoxifen). (news-medical.net)
  • Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. (sigmaaldrich.com)
  • anovulatory disorders
  • Tamoxifen is used to treat infertility in women with anovulatory disorders. (wikipedia.org)
  • Today tamoxifen is the most widely used anticancer drug and is sometimes used to treat other conditions, such as gynecomastia in men undergoing antiandrogen therapy for prostate cancer and infertility in women affected by anovulatory disorders. (britannica.com)
  • medications
  • If you have already finished tamoxifen and you were taking other medications at the same time, make an appointment to talk with your doctor about whether any of your other medications may have interfered with CYP2D6 and the potential benefit you received from tamoxifen. (breastcancer.org)
  • tissue
  • Tamoxifen is taken orally and works by competing with endogenous estrogens for receptor sites in breast tissue where the estrogens normally exert their actions. (britannica.com)
  • fertility
  • Tamoxifen improves fertility in males with infertility by disinhibiting the hypothalamic-pituitary-adrenal axis (via ER antagonism) and thereby increasing the secretion of luteinizing hormone and follicle-stimulating hormone and increasing testicular testosterone production. (wikipedia.org)
  • Your fertility, meaning your ability to conceive or father a child, may be affected by tamoxifen. (chemocare.com)